SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ft2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_A_TESA903_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 4ft2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Zea
mays) 		4 / 6 TYR A 620
VAL A 562
ILE A 564
LEU A 557
 None
 1.15A 1j96A-4ft2A:
undetectable		 1j96A-4ft2A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 4ft2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Zea
mays) 		4 / 7 VAL A 237
VAL A 581
TYR A 302
CYH A 640
 None
 1.29A 1t46A-4ft2A:
undetectable		 1t46A-4ft2A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)		 4ft2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Zea
mays) 		4 / 6 LEU A 608
ALA A 587
LEU A 589
SER A 303
 None
 1.03A 1tyrA-4ft2A:
undetectable		 1tyrA-4ft2A:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_1
(PHOSPHOLIPASE A2
HOMOLOG 2)		 4ft2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Zea
mays) 		5 / 12 LEU A 882
GLY A 862
LEU A 359
GLY A 356
TYR A 597
 None
 1.24A 1y4lA-4ft2A:
undetectable		 1y4lA-4ft2A:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_1
(PHOSPHOLIPASE A2
HOMOLOG 2)		 4ft2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Zea
mays) 		5 / 12 LEU A 882
GLY A 866
GLY A 862
LEU A 359
GLY A 356
 None
 1.16A 1y4lA-4ft2A:
undetectable		 1y4lA-4ft2A:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 4ft2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Zea
mays) 		5 / 11 VAL A 798
ALA A 661
PRO A 815
ILE A 691
PRO A 600
 None
 1.18A 2admB-4ft2A:
8.6		 2admB-4ft2A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4ft2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Zea
mays) 		4 / 6 TYR A 776
PRO A 788
ILE A 733
LEU A 772
 None
 1.38A 2wekB-4ft2A:
4.8		 2wekB-4ft2A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		 4ft2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Zea
mays) 		4 / 7 PHE A 703
ASP A 710
TYR A 835
ARG A 837
 None
 1.20A 3aruA-4ft2A:
undetectable		 3aruA-4ft2A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 4ft2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Zea
mays) 		6 / 12 GLY A 349
GLY A 352
PRO A 516
ASN A 851
ALA A 852
VAL A 853
 SAH  A1000 ( 4.1A)
SAH  A1000 (-3.9A)
SAH  A1000 (-4.5A)
SAH  A1000 ( 4.3A)
SAH  A1000 (-2.9A)
SAH  A1000 (-3.6A)
 0.36A 3av6A-4ft2A:
26.4		 3av6A-4ft2A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)		 4ft2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Zea
mays) 		4 / 6 LEU A 608
ALA A 587
LEU A 589
SER A 303
 None
 0.98A 3cfqA-4ft2A:
undetectable		 3cfqA-4ft2A:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_A_KANA2001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4ft2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Zea
mays) 		5 / 11 VAL A 855
GLN A 848
ALA A 380
SER A 383
ASN A 387
 None
None
SAH  A1000 ( 4.9A)
None
None
 1.43A 3kp5A-4ft2A:
undetectable		 3kp5A-4ft2A:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_B_T44B128_1
(TRANSTHYRETIN)		 4ft2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Zea
mays) 		4 / 7 LEU A 608
ALA A 587
LEU A 589
SER A 303
 None
 1.04A 3ozkB-4ft2A:
undetectable		 3ozkB-4ft2A:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1002_1
(HEMOLYTIC LECTIN
CEL-III)		 4ft2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Zea
mays) 		3 / 3 ASP A 474
GLU A 473
GLY A 470
 None
 0.61A 3w9tA-4ft2A:
undetectable		 3w9tA-4ft2A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_C_MIYC392_1
(TETX2 PROTEIN)		 4ft2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Zea
mays) 		5 / 12 PRO A 841
GLU A 844
ILE A 842
ILE A 847
TYR A 846
 None
 1.37A 4a99A-4ft2A:
3.8
4a99C-4ft2A:
3.2		 4a99A-4ft2A:
18.83
4a99C-4ft2A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_C_MIYC392_1
(TETX2 PROTEIN)		 4ft2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Zea
mays) 		5 / 12 TYR A 836
GLU A 844
ILE A 842
ILE A 847
TYR A 846
 None
 1.34A 4a99A-4ft2A:
3.8
4a99C-4ft2A:
3.2		 4a99A-4ft2A:
18.83
4a99C-4ft2A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQ7_A_LEUA902_0
(LEUCINE--TRNA LIGASE)		 4ft2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Zea
mays) 		4 / 7 LEU A 170
ASP A 259
GLU A 212
HIS A 175
 None
 1.13A 4aq7A-4ft2A:
undetectable		 4aq7A-4ft2A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQ7_D_LEUD902_0
(LEUCINE--TRNA LIGASE)		 4ft2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Zea
mays) 		5 / 9 LEU A 170
ASP A 259
TYR A 155
GLU A 212
HIS A 175
 None
 1.32A 4aq7D-4ft2A:
1.0		 4aq7D-4ft2A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_F_ACTF402_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 4ft2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Zea
mays) 		3 / 3 PHE A 687
ASP A 664
ARG A 828
 None
 0.88A 4eahF-4ft2A:
1.6		 4eahF-4ft2A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_G_ACTG401_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 4ft2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Zea
mays) 		3 / 3 PHE A 687
ASP A 664
ARG A 828
 None
 0.89A 4eahG-4ft2A:
1.3		 4eahG-4ft2A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 4ft2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Zea
mays) 		4 / 6 LEU A 608
ALA A 587
LEU A 589
SER A 303
 None
 1.02A 4ikiB-4ft2A:
undetectable		 4ikiB-4ft2A:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_A_SUZA201_1
(TRANSTHYRETIN)		 4ft2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Zea
mays) 		4 / 7 LEU A 608
ALA A 587
LEU A 589
SER A 303
 None
 1.03A 4iklA-4ft2A:
undetectable
4iklB-4ft2A:
undetectable		 4iklA-4ft2A:
10.80
4iklB-4ft2A:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4ft2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Zea
mays) 		4 / 8 ASN A 670
ARG A 819
LEU A 720
ASP A 726
 None
 1.08A 4l7iA-4ft2A:
undetectable		 4l7iA-4ft2A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_2
(ADENOSINE KINASE)		 4ft2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Zea
mays) 		4 / 5 CYH A 512
SER A 354
LEU A 359
LEU A 865
 None
 0.86A 4n09D-4ft2A:
5.6		 4n09D-4ft2A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4ft2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Zea
mays) 		4 / 7 GLU A 559
THR A 370
HIS A 388
LEU A 384
 None
 1.13A 4pfjA-4ft2A:
2.3		 4pfjA-4ft2A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_A_HQEA503_1
(CATALASE)		 4ft2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Zea
mays) 		5 / 9 ILE A 511
PRO A 503
PHE A 401
LEU A 346
LEU A 405
 None
 1.39A 4qopA-4ft2A:
undetectable		 4qopA-4ft2A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_B_HQEB503_1
(CATALASE)		 4ft2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Zea
mays) 		5 / 9 ILE A 511
PRO A 503
PHE A 401
LEU A 346
LEU A 405
 None
 1.40A 4qopB-4ft2A:
undetectable		 4qopB-4ft2A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4ft2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Zea
mays) 		4 / 5 LYS A 552
PRO A 553
LEU A 580
TYR A 585
 None
 1.30A 4w5qA-4ft2A:
3.5		 4w5qA-4ft2A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 4ft2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Zea
mays) 		3 / 3 ILE A 287
MET A 296
ASP A 247
 None
 0.73A 5h2uA-4ft2A:
undetectable		 5h2uA-4ft2A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_A_SAMA801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 4ft2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Zea
mays) 		5 / 12 GLY A 352
THR A 355
ASP A 345
ALA A 858
GLU A 559
 SAH  A1000 (-3.9A)
None
SAH  A1000 ( 4.9A)
None
None
 1.19A 5hw4A-4ft2A:
undetectable		 5hw4A-4ft2A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 4ft2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Zea
mays) 		5 / 12 CYH A 187
ALA A 179
GLY A 139
ILE A 265
GLY A 189
 None
 1.07A 5wwsB-4ft2A:
8.4		 5wwsB-4ft2A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4ft2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Zea
mays) 		3 / 3 SER A 309
HIS A 273
TYR A 294
 None
 0.92A 5y2tA-4ft2A:
undetectable		 5y2tA-4ft2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4ft2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Zea
mays) 		3 / 3 SER A 354
HIS A 388
TYR A 836
 None
 0.86A 5y2tA-4ft2A:
undetectable		 5y2tA-4ft2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4ft2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Zea
mays) 		5 / 9 ASP A 375
ASN A 395
SER A 348
GLY A 352
THR A 803
 SAH  A1000 (-2.5A)
None
None
SAH  A1000 (-3.9A)
None
 1.32A 6awpA-4ft2A:
undetectable		 6awpA-4ft2A:
21.43