SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ft6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_B_DVAB6_0
(GRAMICIDIN D)		 4ft6 PROBABLE PORIN
(Pseudomonas
aeruginosa) 		3 / 3 TRP A 361
ALA A 318
VAL A 343
 None
C8E  A 404 ( 4.5A)
C8E  A 404 ( 4.9A)
 0.85A 2izqA-4ft6A:
undetectable
2izqB-4ft6A:
undetectable		 2izqA-4ft6A:
3.39
2izqB-4ft6A:
3.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 4ft6 PROBABLE PORIN
(Pseudomonas
aeruginosa) 		3 / 3 THR A 254
SER A 259
PHE A 250
 None
 0.71A 3d4sA-4ft6A:
undetectable		 3d4sA-4ft6A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		 4ft6 PROBABLE PORIN
(Pseudomonas
aeruginosa) 		3 / 3 ASP A 122
ARG A 120
ARG A 360
 None
 1.04A 3k37A-4ft6A:
undetectable		 3k37A-4ft6A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 4ft6 PROBABLE PORIN
(Pseudomonas
aeruginosa) 		4 / 8 SER A 210
SER A 225
GLY A 227
PRO A 282
 None
 0.67A 3lslA-4ft6A:
undetectable
3lslD-4ft6A:
undetectable		 3lslA-4ft6A:
19.20
3lslD-4ft6A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 4ft6 PROBABLE PORIN
(Pseudomonas
aeruginosa) 		4 / 8 PRO A 282
SER A 210
SER A 225
GLY A 227
 None
 0.70A 3lslA-4ft6A:
undetectable
3lslD-4ft6A:
undetectable		 3lslA-4ft6A:
19.20
3lslD-4ft6A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)		 4ft6 PROBABLE PORIN
(Pseudomonas
aeruginosa) 		4 / 8 ARG A  20
ARG A 378
ARG A 362
ASP A 286
 None
 1.32A 4kr4C-4ft6A:
6.8		 4kr4C-4ft6A:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4ft6 PROBABLE PORIN
(Pseudomonas
aeruginosa) 		3 / 3 ILE A 380
ASP A 344
ARG A 124
 None
 0.78A 4pstA-4ft6A:
undetectable		 4pstA-4ft6A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4ft6 PROBABLE PORIN
(Pseudomonas
aeruginosa) 		3 / 3 ASP A 167
ARG A 378
ARG A  20
 None
 0.97A 4x5iA-4ft6A:
undetectable		 4x5iA-4ft6A:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)		 4ft6 PROBABLE PORIN
(Pseudomonas
aeruginosa) 		4 / 5 ASP A 271
VAL A 166
ASP A 167
GLY A 168
 None
 1.24A 4xp6A-4ft6A:
undetectable		 4xp6A-4ft6A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_A_ACRA1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)		 4ft6 PROBABLE PORIN
(Pseudomonas
aeruginosa) 		4 / 6 GLU A 105
PHE A   3
THR A  48
TYR A  47
 None
 1.37A 5lrbA-4ft6A:
undetectable		 5lrbA-4ft6A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0
(SWI5-DEPENDENT HO
EXPRESSION PROTEIN 2)		 4ft6 PROBABLE PORIN
(Pseudomonas
aeruginosa) 		4 / 5 THR A 293
ASN A 291
ASP A 286
LEU A 283
 None
 1.27A 5m0iB-4ft6A:
undetectable		 5m0iB-4ft6A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJZ_A_BEZA302_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 4ft6 PROBABLE PORIN
(Pseudomonas
aeruginosa) 		3 / 3 MET A 319
GLU A 340
ARG A 321
 None
 0.94A 5tjzA-4ft6A:
undetectable		 5tjzA-4ft6A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_A_ACTA404_0
(L-LYSINE
3-HYDROXYLASE)		 4ft6 PROBABLE PORIN
(Pseudomonas
aeruginosa) 		4 / 6 ILE A 203
LEU A 242
VAL A 166
ARG A 169
 None
 1.29A 6f6jA-4ft6A:
undetectable		 6f6jA-4ft6A:
undetectable