SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ftw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4003_1
(SERUM ALBUMIN)		 4ftw PHOSPHOLIPASE/CARBOX
YLESTERASE
(Rhodobacter
sphaeroides) 		4 / 6 VAL A 186
GLY A 187
ALA A 258
LEU A 262
 None
 0.81A 1e7bB-4ftwA:
undetectable		 1e7bB-4ftwA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		 4ftw PHOSPHOLIPASE/CARBOX
YLESTERASE
(Rhodobacter
sphaeroides) 		5 / 9 LEU A 255
VAL A 162
VAL A 211
GLY A 187
LEU A  85
 None
 1.40A 1ikvA-4ftwA:
undetectable		 1ikvA-4ftwA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 4ftw PHOSPHOLIPASE/CARBOX
YLESTERASE
(Rhodobacter
sphaeroides) 		5 / 12 VAL A 242
GLY A 240
GLY A 184
VAL A 257
LEU A 262
 None
 1.07A 1jg4A-4ftwA:
undetectable		 1jg4A-4ftwA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 4ftw PHOSPHOLIPASE/CARBOX
YLESTERASE
(Rhodobacter
sphaeroides) 		5 / 11 LEU A 255
VAL A 162
VAL A 211
GLY A 187
LEU A  85
 None
 1.37A 1lwcA-4ftwA:
undetectable		 1lwcA-4ftwA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB8_0
(GRAMICIDIN A)		 4ftw PHOSPHOLIPASE/CARBOX
YLESTERASE
(Rhodobacter
sphaeroides) 		4 / 5 VAL A 186
GLY A 187
VAL A 162
TRP A 116
 None
 1.29A 1tkqB-4ftwA:
undetectable		 1tkqB-4ftwA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HND_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4ftw PHOSPHOLIPASE/CARBOX
YLESTERASE
(Rhodobacter
sphaeroides) 		5 / 10 LEU A 255
VAL A 162
VAL A 211
GLY A 187
LEU A  85
 None
 1.40A 2hndA-4ftwA:
undetectable		 2hndA-4ftwA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HNY_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4ftw PHOSPHOLIPASE/CARBOX
YLESTERASE
(Rhodobacter
sphaeroides) 		5 / 10 LEU A 255
VAL A 162
VAL A 211
GLY A 187
LEU A  85
 None
 1.37A 2hnyA-4ftwA:
undetectable		 2hnyA-4ftwA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA502_0
(FERROCHELATASE)		 4ftw PHOSPHOLIPASE/CARBOX
YLESTERASE
(Rhodobacter
sphaeroides) 		4 / 8 MET A 134
PRO A 120
SER A 125
TRP A 121
 None
 1.10A 2qd3A-4ftwA:
3.5		 2qd3A-4ftwA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4ftw PHOSPHOLIPASE/CARBOX
YLESTERASE
(Rhodobacter
sphaeroides) 		4 / 5 ILE A 182
THR A  96
PHE A  98
PHE A  71
 None
 1.36A 3em0A-4ftwA:
undetectable		 3em0A-4ftwA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP0_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4ftw PHOSPHOLIPASE/CARBOX
YLESTERASE
(Rhodobacter
sphaeroides) 		5 / 9 LEU A 255
VAL A 162
VAL A 211
GLY A 187
LEU A  85
 None
 1.35A 3lp0A-4ftwA:
undetectable		 3lp0A-4ftwA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4ftw PHOSPHOLIPASE/CARBOX
YLESTERASE
(Rhodobacter
sphaeroides) 		5 / 10 LEU A 255
VAL A 162
VAL A 211
GLY A 187
LEU A  85
 None
 1.36A 3lp1A-4ftwA:
undetectable		 3lp1A-4ftwA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QIP_A_NVPA561_1
(REVERSE HIV-1
REVERSE
TRANSCRIPTASE P66)		 4ftw PHOSPHOLIPASE/CARBOX
YLESTERASE
(Rhodobacter
sphaeroides) 		5 / 10 LEU A 255
VAL A 162
VAL A 211
GLY A 187
LEU A  85
 None
 1.39A 3qipA-4ftwA:
undetectable		 3qipA-4ftwA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J14_A_X2NA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 4ftw PHOSPHOLIPASE/CARBOX
YLESTERASE
(Rhodobacter
sphaeroides) 		5 / 10 ALA A 230
LEU A 231
PHE A 236
VAL A 208
ALA A 171
 None
 0.99A 4j14A-4ftwA:
undetectable		 4j14A-4ftwA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4ftw PHOSPHOLIPASE/CARBOX
YLESTERASE
(Rhodobacter
sphaeroides) 		4 / 7 MET A 134
PRO A 120
SER A 125
TRP A 121
 None
 1.14A 4kmmA-4ftwA:
3.5		 4kmmA-4ftwA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4ftw PHOSPHOLIPASE/CARBOX
YLESTERASE
(Rhodobacter
sphaeroides) 		5 / 11 LEU A 255
VAL A 162
VAL A 211
GLY A 187
LEU A  85
 None
 1.39A 5hbmA-4ftwA:
undetectable		 5hbmA-4ftwA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 4ftw PHOSPHOLIPASE/CARBOX
YLESTERASE
(Rhodobacter
sphaeroides) 		5 / 10 ALA A 260
LEU A 259
VAL A 257
LEU A  93
GLU A 264
 None
 1.10A 5v02B-4ftwA:
undetectable
5v02R-4ftwA:
undetectable		 5v02B-4ftwA:
13.68
5v02R-4ftwA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_1
(CYTOCHROME P450 3A4)		 4ftw PHOSPHOLIPASE/CARBOX
YLESTERASE
(Rhodobacter
sphaeroides) 		5 / 12 ARG A 139
LEU A 231
ILE A 185
PHE A 236
ALA A 179
 None
 1.18A 5vc0A-4ftwA:
undetectable		 5vc0A-4ftwA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4ftw PHOSPHOLIPASE/CARBOX
YLESTERASE
(Rhodobacter
sphaeroides) 		5 / 9 ASP A  81
ALA A 251
PHE A  71
GLY A 163
GLY A 249
 3CM  A 302 (-3.7A)
None
None
None
3CM  A 302 (-3.5A)
 1.30A 6awoA-4ftwA:
undetectable		 6awoA-4ftwA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4ftw PHOSPHOLIPASE/CARBOX
YLESTERASE
(Rhodobacter
sphaeroides) 		5 / 9 ASP A  81
ALA A 251
PHE A  71
GLY A 163
GLY A 249
 3CM  A 302 (-3.7A)
None
None
None
3CM  A 302 (-3.5A)
 1.30A 6awqA-4ftwA:
undetectable		 6awqA-4ftwA:
18.18