SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fu0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 4fu0 D-ALANINE--D-ALANINE
LIGASE 7
(Enterococcus
faecalis) 		3 / 3 ALA A 143
HIS A 144
VAL A 147
 None
 0.45A 1lqtB-4fu0A:
undetectable		 1lqtB-4fu0A:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 4fu0 D-ALANINE--D-ALANINE
LIGASE 7
(Enterococcus
faecalis) 		3 / 3 ALA A 143
HIS A 144
VAL A 147
 None
 0.47A 1lquB-4fu0A:
undetectable		 1lquB-4fu0A:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4fu0 D-ALANINE--D-ALANINE
LIGASE 7
(Enterococcus
faecalis) 		5 / 11 SER A 296
LEU A 290
VAL A 147
PHE A 310
VAL A 313
 None
 1.20A 1q23J-4fu0A:
undetectable		 1q23J-4fu0A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 4fu0 D-ALANINE--D-ALANINE
LIGASE 7
(Enterococcus
faecalis) 		4 / 4 GLY A  11
SER A  20
ILE A 316
HIS A 106
 None
 1.16A 1yajJ-4fu0A:
undetectable		 1yajJ-4fu0A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 4fu0 D-ALANINE--D-ALANINE
LIGASE 7
(Enterococcus
faecalis) 		5 / 12 VAL A  27
PHE A 102
ILE A   6
VAL A 127
LEU A 343
 None
 1.21A 2jn3A-4fu0A:
undetectable		 2jn3A-4fu0A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)		 4fu0 D-ALANINE--D-ALANINE
LIGASE 7
(Enterococcus
faecalis) 		3 / 3 TYR A 287
TYR A 325
GLY A 233
 None
 0.71A 3eteB-4fu0A:
3.2
3eteD-4fu0A:
3.2
3eteF-4fu0A:
3.1		 3eteB-4fu0A:
22.24
3eteD-4fu0A:
22.24
3eteF-4fu0A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC608_0
(GBAA_1210 PROTEIN)		 4fu0 D-ALANINE--D-ALANINE
LIGASE 7
(Enterococcus
faecalis) 		4 / 5 ARG A 324
LYS A 261
ARG A 297
GLU A 312
 SO4  A 402 ( 4.9A)
ADP  A 401 (-2.5A)
SO4  A 402 (-3.7A)
ADP  A 401 (-3.3A)
 1.50A 3tj7C-4fu0A:
undetectable		 3tj7C-4fu0A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4fu0 D-ALANINE--D-ALANINE
LIGASE 7
(Enterococcus
faecalis) 		3 / 3 ASP A 141
LYS A 140
ASP A 139
 None
ADP  A 401 (-2.7A)
None
 0.83A 4a7tA-4fu0A:
undetectable		 4a7tA-4fu0A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4fu0 D-ALANINE--D-ALANINE
LIGASE 7
(Enterococcus
faecalis) 		5 / 12 ASN A 314
ASP A 243
GLY A 228
ILE A 265
GLU A 312
 SO4  A 402 (-3.9A)
None
None
None
ADP  A 401 (-3.3A)
 0.92A 4jksA-4fu0A:
2.4		 4jksA-4fu0A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4fu0 D-ALANINE--D-ALANINE
LIGASE 7
(Enterococcus
faecalis) 		5 / 12 ASN A 314
ASP A 243
GLY A 228
ILE A 265
GLU A 312
 SO4  A 402 (-3.9A)
None
None
None
ADP  A 401 (-3.3A)
 0.92A 4jksB-4fu0A:
2.5		 4jksB-4fu0A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_A_ADNA500_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4fu0 D-ALANINE--D-ALANINE
LIGASE 7
(Enterococcus
faecalis) 		5 / 12 ASN A 314
ASP A 243
GLY A 228
ILE A 265
GLU A 312
 SO4  A 402 (-3.9A)
None
None
None
ADP  A 401 (-3.3A)
 0.92A 4jkuA-4fu0A:
2.4		 4jkuA-4fu0A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_1
(SUGAR KINASE)		 4fu0 D-ALANINE--D-ALANINE
LIGASE 7
(Enterococcus
faecalis) 		5 / 12 ASN A 314
ASP A 243
GLY A 228
ILE A 265
GLU A 312
 SO4  A 402 (-3.9A)
None
None
None
ADP  A 401 (-3.3A)
 0.91A 4k8cA-4fu0A:
2.5		 4k8cA-4fu0A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_B_ADNB401_1
(SUGAR KINASE)		 4fu0 D-ALANINE--D-ALANINE
LIGASE 7
(Enterococcus
faecalis) 		5 / 12 ASN A 314
ASP A 243
GLY A 228
ILE A 265
GLU A 312
 SO4  A 402 (-3.9A)
None
None
None
ADP  A 401 (-3.3A)
 0.91A 4k8cB-4fu0A:
2.5		 4k8cB-4fu0A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_A_ADNA401_1
(SUGAR KINASE)		 4fu0 D-ALANINE--D-ALANINE
LIGASE 7
(Enterococcus
faecalis) 		5 / 12 ASN A 314
ASP A 243
GLY A 228
ILE A 265
GLU A 312
 SO4  A 402 (-3.9A)
None
None
None
ADP  A 401 (-3.3A)
 0.93A 4k8kA-4fu0A:
2.4		 4k8kA-4fu0A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_B_ADNB403_1
(SUGAR KINASE)		 4fu0 D-ALANINE--D-ALANINE
LIGASE 7
(Enterococcus
faecalis) 		5 / 12 ASN A 314
ASP A 243
GLY A 228
ILE A 265
GLU A 312
 SO4  A 402 (-3.9A)
None
None
None
ADP  A 401 (-3.3A)
 0.93A 4k8kB-4fu0A:
2.6		 4k8kB-4fu0A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4fu0 D-ALANINE--D-ALANINE
LIGASE 7
(Enterococcus
faecalis) 		5 / 12 ASN A 314
ASP A 243
GLY A 228
ILE A 265
GLU A 312
 SO4  A 402 (-3.9A)
None
None
None
ADP  A 401 (-3.3A)
 0.93A 4kahA-4fu0A:
2.8		 4kahA-4fu0A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4fu0 D-ALANINE--D-ALANINE
LIGASE 7
(Enterococcus
faecalis) 		5 / 12 ASN A 314
ASP A 243
GLY A 228
ILE A 265
GLU A 312
 SO4  A 402 (-3.9A)
None
None
None
ADP  A 401 (-3.3A)
 0.92A 4kahB-4fu0A:
2.4		 4kahB-4fu0A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4fu0 D-ALANINE--D-ALANINE
LIGASE 7
(Enterococcus
faecalis) 		5 / 12 ASN A 314
ASP A 243
GLY A 228
ILE A 265
GLU A 312
 SO4  A 402 (-3.9A)
None
None
None
ADP  A 401 (-3.3A)
 0.91A 4kalA-4fu0A:
2.3		 4kalA-4fu0A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4fu0 D-ALANINE--D-ALANINE
LIGASE 7
(Enterococcus
faecalis) 		5 / 12 ASN A 314
ASP A 243
GLY A 228
ILE A 265
GLU A 312
 SO4  A 402 (-3.9A)
None
None
None
ADP  A 401 (-3.3A)
 0.92A 4kalB-4fu0A:
2.3		 4kalB-4fu0A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4fu0 D-ALANINE--D-ALANINE
LIGASE 7
(Enterococcus
faecalis) 		5 / 12 ASN A 314
ASP A 243
GLY A 228
ILE A 265
GLU A 312
 SO4  A 402 (-3.9A)
None
None
None
ADP  A 401 (-3.3A)
 0.92A 4kanA-4fu0A:
2.5		 4kanA-4fu0A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4fu0 D-ALANINE--D-ALANINE
LIGASE 7
(Enterococcus
faecalis) 		5 / 12 ASN A 314
ASP A 243
GLY A 228
ILE A 265
GLU A 312
 SO4  A 402 (-3.9A)
None
None
None
ADP  A 401 (-3.3A)
 0.91A 4kanB-4fu0A:
2.1		 4kanB-4fu0A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4fu0 D-ALANINE--D-ALANINE
LIGASE 7
(Enterococcus
faecalis) 		5 / 12 ASN A 314
ASP A 243
GLY A 228
ILE A 265
GLU A 312
 SO4  A 402 (-3.9A)
None
None
None
ADP  A 401 (-3.3A)
 0.92A 4kbeA-4fu0A:
2.5		 4kbeA-4fu0A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4fu0 D-ALANINE--D-ALANINE
LIGASE 7
(Enterococcus
faecalis) 		5 / 12 ASN A 314
ASP A 243
GLY A 228
ILE A 265
GLU A 312
 SO4  A 402 (-3.9A)
None
None
None
ADP  A 401 (-3.3A)
 0.93A 4kbeB-4fu0A:
2.7		 4kbeB-4fu0A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4fu0 D-ALANINE--D-ALANINE
LIGASE 7
(Enterococcus
faecalis) 		5 / 12 ASN A 314
ASP A 243
GLY A 228
ILE A 265
GLU A 312
 SO4  A 402 (-3.9A)
None
None
None
ADP  A 401 (-3.3A)
 0.92A 4lbgA-4fu0A:
2.4		 4lbgA-4fu0A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4fu0 D-ALANINE--D-ALANINE
LIGASE 7
(Enterococcus
faecalis) 		5 / 12 ASN A 314
ASP A 243
GLY A 228
ILE A 265
GLU A 312
 SO4  A 402 (-3.9A)
None
None
None
ADP  A 401 (-3.3A)
 0.92A 4lbgB-4fu0A:
2.6		 4lbgB-4fu0A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4fu0 D-ALANINE--D-ALANINE
LIGASE 7
(Enterococcus
faecalis) 		5 / 12 ASN A 314
ASP A 243
GLY A 228
ILE A 265
GLU A 312
 SO4  A 402 (-3.9A)
None
None
None
ADP  A 401 (-3.3A)
 0.92A 4lcaA-4fu0A:
2.6		 4lcaA-4fu0A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4fu0 D-ALANINE--D-ALANINE
LIGASE 7
(Enterococcus
faecalis) 		5 / 12 ASN A 314
ASP A 243
GLY A 228
ILE A 265
GLU A 312
 SO4  A 402 (-3.9A)
None
None
None
ADP  A 401 (-3.3A)
 0.92A 4lcaB-4fu0A:
2.3		 4lcaB-4fu0A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_J_SPMJ202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4fu0 D-ALANINE--D-ALANINE
LIGASE 7
(Enterococcus
faecalis) 		4 / 7 GLU A  16
TYR A  17
GLU A  18
ARG A  45
 None
 1.48A 4r87J-4fu0A:
undetectable
4r87L-4fu0A:
undetectable		 4r87J-4fu0A:
20.57
4r87L-4fu0A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_B_SAMB303_0
(CATECHOL
O-METHYLTRANSFERASE)		 4fu0 D-ALANINE--D-ALANINE
LIGASE 7
(Enterococcus
faecalis) 		5 / 12 MET A 138
SER A 190
ASN A 109
SER A  20
HIS A 106
 None
ADP  A 401 (-2.4A)
None
None
None
 1.42A 4xueB-4fu0A:
2.5		 4xueB-4fu0A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 4fu0 D-ALANINE--D-ALANINE
LIGASE 7
(Enterococcus
faecalis) 		5 / 12 VAL A   8
PHE A 102
ILE A   6
ASN A  30
VAL A 104
 None
 0.90A 5uvmB-4fu0A:
undetectable		 5uvmB-4fu0A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 4fu0 D-ALANINE--D-ALANINE
LIGASE 7
(Enterococcus
faecalis) 		6 / 12 VAL A   8
PHE A 102
ILE A   6
ILE A 344
LEU A 340
VAL A 104
 None
 1.30A 5uvmB-4fu0A:
undetectable		 5uvmB-4fu0A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEH_A_RPTA601_1
(SCAFFOLD PROTEIN D13)		 4fu0 D-ALANINE--D-ALANINE
LIGASE 7
(Enterococcus
faecalis) 		5 / 10 PRO A 317
SER A 134
VAL A 127
PHE A 295
PHE A 102
 SO4  A 402 (-4.5A)
None
None
None
None
 1.45A 6behA-4fu0A:
0.0
6behB-4fu0A:
0.0
6behC-4fu0A:
0.0		 6behA-4fu0A:
21.78
6behB-4fu0A:
21.78
6behC-4fu0A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 4fu0 D-ALANINE--D-ALANINE
LIGASE 7
(Enterococcus
faecalis) 		5 / 12 ASP A 299
ALA A 283
GLY A 228
SER A 323
VAL A 239
 None
 1.28A 6clxA-4fu0A:
undetectable		 6clxA-4fu0A:
21.65