SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fuk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4fuk METHIONINE
AMINOPEPTIDASE
(Trypanosoma
brucei) 		5 / 11 GLY A 221
HIS A 220
THR A 316
THR A 351
GLY A 286
 None
None
ZN  A 401 ( 3.6A)
None
None
 1.02A 1c9sP-4fukA:
undetectable
1c9sQ-4fukA:
undetectable		 1c9sP-4fukA:
11.94
1c9sQ-4fukA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4fuk METHIONINE
AMINOPEPTIDASE
(Trypanosoma
brucei) 		5 / 10 GLY A 286
GLY A 221
HIS A 220
THR A 316
THR A 351
 None
None
None
ZN  A 401 ( 3.6A)
None
 1.05A 1gtfJ-4fukA:
undetectable
1gtfK-4fukA:
undetectable		 1gtfJ-4fukA:
11.94
1gtfK-4fukA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4fuk METHIONINE
AMINOPEPTIDASE
(Trypanosoma
brucei) 		5 / 11 GLY A 221
HIS A 220
THR A 316
THR A 351
GLY A 286
 None
None
ZN  A 401 ( 3.6A)
None
None
 1.02A 1gtfQ-4fukA:
undetectable
1gtfR-4fukA:
undetectable		 1gtfQ-4fukA:
11.94
1gtfR-4fukA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_S_TRPS81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4fuk METHIONINE
AMINOPEPTIDASE
(Trypanosoma
brucei) 		5 / 11 GLY A 221
HIS A 220
THR A 316
THR A 351
GLY A 286
 None
None
ZN  A 401 ( 3.6A)
None
None
 1.01A 1gtfS-4fukA:
undetectable
1gtfT-4fukA:
undetectable		 1gtfS-4fukA:
11.94
1gtfT-4fukA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4fuk METHIONINE
AMINOPEPTIDASE
(Trypanosoma
brucei) 		5 / 11 GLY A 221
HIS A 220
THR A 316
THR A 351
GLY A 286
 None
None
ZN  A 401 ( 3.6A)
None
None
 1.02A 1gtnT-4fukA:
undetectable
1gtnU-4fukA:
undetectable		 1gtnT-4fukA:
11.94
1gtnU-4fukA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4fuk METHIONINE
AMINOPEPTIDASE
(Trypanosoma
brucei) 		5 / 12 GLY A 286
GLY A 221
HIS A 220
THR A 316
THR A 351
 None
None
None
ZN  A 401 ( 3.6A)
None
 1.04A 1gtnL-4fukA:
undetectable
1gtnV-4fukA:
undetectable		 1gtnL-4fukA:
11.94
1gtnV-4fukA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)		 4fuk METHIONINE
AMINOPEPTIDASE
(Trypanosoma
brucei) 		3 / 3 ASP A 222
LEU A 223
HIS A 162
 ZN  A 402 ( 2.3A)
None
None
 0.79A 1qknA-4fukA:
undetectable		 1qknA-4fukA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_E_TRPE81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4fuk METHIONINE
AMINOPEPTIDASE
(Trypanosoma
brucei) 		5 / 10 GLY A 221
HIS A 220
THR A 316
THR A 351
GLY A 286
 None
None
ZN  A 401 ( 3.6A)
None
None
 1.05A 1utdE-4fukA:
undetectable
1utdF-4fukA:
undetectable		 1utdE-4fukA:
11.94
1utdF-4fukA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_H_TRPH81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4fuk METHIONINE
AMINOPEPTIDASE
(Trypanosoma
brucei) 		5 / 10 GLY A 221
HIS A 220
THR A 316
THR A 351
GLY A 286
 None
None
ZN  A 401 ( 3.6A)
None
None
 1.04A 1utdH-4fukA:
undetectable
1utdI-4fukA:
undetectable		 1utdH-4fukA:
11.94
1utdI-4fukA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_L_TRPL81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4fuk METHIONINE
AMINOPEPTIDASE
(Trypanosoma
brucei) 		5 / 12 GLY A 221
HIS A 220
THR A 316
THR A 351
GLY A 286
 None
None
ZN  A 401 ( 3.6A)
None
None
 1.01A 1utdL-4fukA:
undetectable
1utdM-4fukA:
undetectable		 1utdL-4fukA:
11.94
1utdM-4fukA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_O_TRPO81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4fuk METHIONINE
AMINOPEPTIDASE
(Trypanosoma
brucei) 		5 / 12 GLY A 221
HIS A 220
THR A 316
THR A 351
GLY A 286
 None
None
ZN  A 401 ( 3.6A)
None
None
 1.02A 1utdO-4fukA:
undetectable
1utdP-4fukA:
undetectable		 1utdO-4fukA:
11.94
1utdP-4fukA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_S_TRPS81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4fuk METHIONINE
AMINOPEPTIDASE
(Trypanosoma
brucei) 		5 / 11 GLY A 221
HIS A 220
THR A 316
THR A 351
GLY A 286
 None
None
ZN  A 401 ( 3.6A)
None
None
 1.02A 1utdS-4fukA:
undetectable
1utdT-4fukA:
undetectable		 1utdS-4fukA:
11.94
1utdT-4fukA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_V_TRPV81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4fuk METHIONINE
AMINOPEPTIDASE
(Trypanosoma
brucei) 		5 / 11 GLY A 286
GLY A 221
HIS A 220
THR A 316
THR A 351
 None
None
None
ZN  A 401 ( 3.6A)
None
 1.03A 1utdL-4fukA:
undetectable
1utdV-4fukA:
undetectable		 1utdL-4fukA:
11.94
1utdV-4fukA:
11.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YVM_A_TMGA501_1
(METHIONINE
AMINOPEPTIDASE)		 4fuk METHIONINE
AMINOPEPTIDASE
(Trypanosoma
brucei) 		5 / 7 TYR A 177
CYH A 185
HIS A 194
HIS A 292
TRP A 335
 None
UNX  A 404 ( 3.8A)
None
None
None
 0.73A 1yvmA-4fukA:
36.5		 1yvmA-4fukA:
35.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_B_ACTB2002_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 4fuk METHIONINE
AMINOPEPTIDASE
(Trypanosoma
brucei) 		4 / 6 TYR A 178
SER A 100
ALA A  99
SER A  98
 None
 0.96A 1yvpB-4fukA:
undetectable		 1yvpB-4fukA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4fuk METHIONINE
AMINOPEPTIDASE
(Trypanosoma
brucei) 		5 / 12 THR A 293
GLY A 286
GLY A 284
THR A 316
GLU A 349
 None
None
None
ZN  A 401 ( 3.6A)
ZN  A 402 ( 2.5A)
 1.25A 2akeA-4fukA:
undetectable		 2akeA-4fukA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4fuk METHIONINE
AMINOPEPTIDASE
(Trypanosoma
brucei) 		5 / 12 THR A 293
GLY A 286
GLY A 284
THR A 316
GLU A 349
 None
None
None
ZN  A 401 ( 3.6A)
ZN  A 402 ( 2.5A)
 1.28A 2azxA-4fukA:
undetectable		 2azxA-4fukA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4fuk METHIONINE
AMINOPEPTIDASE
(Trypanosoma
brucei) 		5 / 12 THR A 293
GLY A 286
GLY A 284
THR A 316
GLU A 349
 None
None
None
ZN  A 401 ( 3.6A)
ZN  A 402 ( 2.5A)
 1.27A 2azxB-4fukA:
undetectable		 2azxB-4fukA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 4fuk METHIONINE
AMINOPEPTIDASE
(Trypanosoma
brucei) 		4 / 7 TYR A 178
SER A 100
ALA A  99
SER A  98
 None
 0.97A 2i91A-4fukA:
undetectable		 2i91A-4fukA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 4fuk METHIONINE
AMINOPEPTIDASE
(Trypanosoma
brucei) 		4 / 7 TYR A 178
SER A 100
ALA A  99
SER A  98
 None
 0.99A 2i91B-4fukA:
undetectable		 2i91B-4fukA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROP_A_NCAA302_0
(ADP-RIBOSYL CYCLASE
1)		 4fuk METHIONINE
AMINOPEPTIDASE
(Trypanosoma
brucei) 		4 / 6 TRP A 365
LEU A 141
GLU A 225
THR A 363
 None
 1.09A 3ropA-4fukA:
undetectable		 3ropA-4fukA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4fuk METHIONINE
AMINOPEPTIDASE
(Trypanosoma
brucei) 		3 / 3 HIS A 299
SER A 345
ASN A 224
 None
None
ZN  A 402 ( 4.9A)
 0.79A 3s8pB-4fukA:
undetectable		 3s8pB-4fukA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_A_PXLA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4fuk METHIONINE
AMINOPEPTIDASE
(Trypanosoma
brucei) 		4 / 7 GLY A 288
ASP A 222
GLY A 221
CYH A 134
 None
ZN  A 402 ( 2.3A)
None
None
 0.90A 4c5nA-4fukA:
undetectable		 4c5nA-4fukA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4fuk METHIONINE
AMINOPEPTIDASE
(Trypanosoma
brucei) 		3 / 3 HIS A 299
SER A 345
ASN A 224
 None
None
ZN  A 402 ( 4.9A)
 0.84A 5cprB-4fukA:
undetectable		 5cprB-4fukA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4fuk METHIONINE
AMINOPEPTIDASE
(Trypanosoma
brucei) 		5 / 10 GLY A 286
GLY A 221
HIS A 220
THR A 316
THR A 351
 None
None
None
ZN  A 401 ( 3.6A)
None
 1.06A 5eevA-4fukA:
undetectable
5eevB-4fukA:
undetectable		 5eevA-4fukA:
11.94
5eevB-4fukA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4fuk METHIONINE
AMINOPEPTIDASE
(Trypanosoma
brucei) 		5 / 10 GLY A 286
GLY A 221
HIS A 220
THR A 316
THR A 351
 None
None
None
ZN  A 401 ( 3.6A)
None
 1.06A 5eewA-4fukA:
undetectable
5eewB-4fukA:
undetectable		 5eewA-4fukA:
11.94
5eewB-4fukA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4fuk METHIONINE
AMINOPEPTIDASE
(Trypanosoma
brucei) 		5 / 10 GLY A 286
GLY A 221
HIS A 220
THR A 316
THR A 351
 None
None
None
ZN  A 401 ( 3.6A)
None
 1.06A 5eexA-4fukA:
undetectable
5eexB-4fukA:
undetectable		 5eexA-4fukA:
11.94
5eexB-4fukA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4fuk METHIONINE
AMINOPEPTIDASE
(Trypanosoma
brucei) 		5 / 10 GLY A 286
GLY A 221
HIS A 220
THR A 316
THR A 351
 None
None
None
ZN  A 401 ( 3.6A)
None
 1.06A 5eeyA-4fukA:
undetectable
5eeyB-4fukA:
undetectable		 5eeyA-4fukA:
11.94
5eeyB-4fukA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4fuk METHIONINE
AMINOPEPTIDASE
(Trypanosoma
brucei) 		5 / 10 GLY A 286
GLY A 221
HIS A 220
THR A 316
THR A 351
 None
None
None
ZN  A 401 ( 3.6A)
None
 1.06A 5eezA-4fukA:
undetectable
5eezB-4fukA:
undetectable		 5eezA-4fukA:
11.94
5eezB-4fukA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4fuk METHIONINE
AMINOPEPTIDASE
(Trypanosoma
brucei) 		5 / 10 GLY A 286
GLY A 221
HIS A 220
THR A 316
THR A 351
 None
None
None
ZN  A 401 ( 3.6A)
None
 1.06A 5ef0A-4fukA:
undetectable
5ef0B-4fukA:
undetectable		 5ef0A-4fukA:
11.94
5ef0B-4fukA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4fuk METHIONINE
AMINOPEPTIDASE
(Trypanosoma
brucei) 		5 / 10 GLY A 286
GLY A 221
HIS A 220
THR A 316
THR A 351
 None
None
None
ZN  A 401 ( 3.6A)
None
 1.06A 5ef1A-4fukA:
undetectable
5ef1B-4fukA:
undetectable		 5ef1A-4fukA:
11.94
5ef1B-4fukA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4fuk METHIONINE
AMINOPEPTIDASE
(Trypanosoma
brucei) 		5 / 10 GLY A 286
GLY A 221
HIS A 220
THR A 316
THR A 351
 None
None
None
ZN  A 401 ( 3.6A)
None
 1.06A 5ef2A-4fukA:
undetectable
5ef2B-4fukA:
undetectable		 5ef2A-4fukA:
11.94
5ef2B-4fukA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4fuk METHIONINE
AMINOPEPTIDASE
(Trypanosoma
brucei) 		5 / 10 GLY A 286
GLY A 221
HIS A 220
THR A 316
THR A 351
 None
None
None
ZN  A 401 ( 3.6A)
None
 1.06A 5ef3A-4fukA:
undetectable
5ef3B-4fukA:
undetectable		 5ef3A-4fukA:
11.94
5ef3B-4fukA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNW_D_GCSD302_1
(25 KDA PROTEIN
ELICITOR)		 4fuk METHIONINE
AMINOPEPTIDASE
(Trypanosoma
brucei) 		4 / 7 GLY A 284
HIS A 285
ASP A 222
HIS A 194
 None
ZN  A 401 (-3.2A)
ZN  A 402 ( 2.3A)
None
 0.67A 5nnwD-4fukA:
undetectable		 5nnwD-4fukA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		 4fuk METHIONINE
AMINOPEPTIDASE
(Trypanosoma
brucei) 		4 / 7 GLY A 284
HIS A 285
ASP A 222
HIS A 194
 None
ZN  A 401 (-3.2A)
ZN  A 402 ( 2.3A)
None
 0.69A 5no9D-4fukA:
undetectable		 5no9D-4fukA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 4fuk METHIONINE
AMINOPEPTIDASE
(Trypanosoma
brucei) 		5 / 11 GLU A 156
ALA A 144
ALA A 148
ILE A 229
VAL A 227
 None
 1.17A 5yk2A-4fukA:
undetectable		 5yk2A-4fukA:
21.29