SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fuu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GEB_A_CAMA418_0
(CYTOCHROME P450-CAM)		 4fuu LEUCINE
AMINOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		5 / 9 PHE A 218
LEU A 121
ILE A 288
VAL A 249
ILE A 245
 None
 1.34A 1gebA-4fuuA:
undetectable		 1gebA-4fuuA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4fuu LEUCINE
AMINOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		4 / 7 VAL A 323
LEU A 324
ALA A 156
LEU A 222
 None
 0.65A 1pthA-4fuuA:
undetectable		 1pthA-4fuuA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4fuu LEUCINE
AMINOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		4 / 7 VAL A 323
LEU A 324
ALA A 156
LEU A 222
 None
 0.66A 1pthB-4fuuA:
undetectable		 1pthB-4fuuA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_A_SAMA501_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 4fuu LEUCINE
AMINOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A 219
ALA A 216
ALA A 120
ASP A 174
TYR A 214
 None
 1.13A 2avdA-4fuuA:
undetectable		 2avdA-4fuuA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 4fuu LEUCINE
AMINOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 HIS A 302
GLY A 184
GLU A 181
HIS A 124
ASP A 149
 ZN  A 403 (-3.1A)
None
UNL  A 401 ( 3.0A)
UNL  A 401 ( 4.4A)
ZN  A 403 (-2.3A)
 1.39A 2pgfA-4fuuA:
undetectable		 2pgfA-4fuuA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 4fuu LEUCINE
AMINOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 LEU A  80
ILE A 107
ALA A 161
VAL A 164
HIS A 210
 None
 1.21A 2qo4A-4fuuA:
undetectable		 2qo4A-4fuuA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 4fuu LEUCINE
AMINOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 HIS A 302
GLY A 150
ASP A 182
GLY A 155
ASP A 149
 ZN  A 403 (-3.1A)
None
ZN  A 403 (-2.1A)
None
ZN  A 403 (-2.3A)
 0.90A 3bwcB-4fuuA:
undetectable		 3bwcB-4fuuA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4fuu LEUCINE
AMINOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		4 / 7 ARG A 118
ALA A 120
ILE A 173
GLY A 109
 None
 1.00A 3v4tH-4fuuA:
undetectable		 3v4tH-4fuuA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_B_SORB397_0
(D-XYLOSE ISOMERASE)		 4fuu LEUCINE
AMINOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 GLU A 181
HIS A 124
ASP A 273
ASP A 149
ASP A 272
 UNL  A 401 ( 3.0A)
UNL  A 401 ( 4.4A)
None
ZN  A 403 (-2.3A)
UNL  A 401 ( 3.7A)
 1.50A 3ximB-4fuuA:
undetectable		 3ximB-4fuuA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_C_SORC397_0
(D-XYLOSE ISOMERASE)		 4fuu LEUCINE
AMINOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 GLU A 181
HIS A 124
ASP A 273
ASP A 149
ASP A 272
 UNL  A 401 ( 3.0A)
UNL  A 401 ( 4.4A)
None
ZN  A 403 (-2.3A)
UNL  A 401 ( 3.7A)
 1.47A 3ximC-4fuuA:
undetectable		 3ximC-4fuuA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_D_SORD397_0
(D-XYLOSE ISOMERASE)		 4fuu LEUCINE
AMINOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 GLU A 181
HIS A 124
ASP A 273
ASP A 149
ASP A 272
 UNL  A 401 ( 3.0A)
UNL  A 401 ( 4.4A)
None
ZN  A 403 (-2.3A)
UNL  A 401 ( 3.7A)
 1.49A 3ximD-4fuuA:
undetectable		 3ximD-4fuuA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFB_B_KANB401_1
(APH(2')-ID)		 4fuu LEUCINE
AMINOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		5 / 10 ASP A 287
SER A 238
HIS A 274
ASP A 223
GLU A 265
 None
None
None
UNL  A 401 ( 2.9A)
None
 1.48A 4dfbB-4fuuA:
0.1		 4dfbB-4fuuA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4fuu LEUCINE
AMINOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		4 / 7 GLY A 153
VAL A 154
PHE A  44
ILE A 160
 None
 0.86A 4fglC-4fuuA:
3.0		 4fglC-4fuuA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 4fuu LEUCINE
AMINOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		4 / 6 ASP A 149
ASN A 148
ALA A 147
ASP A 126
 ZN  A 403 (-2.3A)
None
None
None
 1.10A 4mdaA-4fuuA:
undetectable		 4mdaA-4fuuA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 4fuu LEUCINE
AMINOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		4 / 6 ASP A 182
ASP A 149
ASN A 148
ALA A 147
 ZN  A 403 (-2.1A)
ZN  A 403 (-2.3A)
None
None
 1.15A 4mdaA-4fuuA:
undetectable		 4mdaA-4fuuA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 4fuu LEUCINE
AMINOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		4 / 6 ASP A 149
ASP A 182
ALA A 180
ASP A 223
 ZN  A 403 (-2.3A)
ZN  A 403 (-2.1A)
None
UNL  A 401 ( 2.9A)
 1.20A 4mdbA-4fuuA:
undetectable		 4mdbA-4fuuA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 4fuu LEUCINE
AMINOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		4 / 6 ASP A 182
ASP A 149
ASN A 148
ALA A 147
 ZN  A 403 (-2.1A)
ZN  A 403 (-2.3A)
None
None
 1.21A 4mdbA-4fuuA:
undetectable		 4mdbA-4fuuA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)		 4fuu LEUCINE
AMINOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		5 / 9 LEU A 222
GLY A 155
VAL A 319
VAL A 323
LEU A 324
 None
 1.15A 4qd3A-4fuuA:
5.6		 4qd3A-4fuuA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4fuu LEUCINE
AMINOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		5 / 11 HIS A 310
THR A 127
THR A 303
GLY A 150
ALA A 147
 PO4  A 402 (-3.7A)
None
None
None
None
 1.34A 4qwuV-4fuuA:
undetectable
4qwub-4fuuA:
undetectable		 4qwuV-4fuuA:
23.32
4qwub-4fuuA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4fuu LEUCINE
AMINOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		5 / 11 HIS A 310
THR A 127
THR A 303
GLY A 150
ALA A 147
 PO4  A 402 (-3.7A)
None
None
None
None
 1.35A 4qwuH-4fuuA:
undetectable
4qwuN-4fuuA:
undetectable		 4qwuH-4fuuA:
23.32
4qwuN-4fuuA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		 4fuu LEUCINE
AMINOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 PRO A 290
SER A 152
GLY A 153
ASP A 273
HIS A 124
 None
None
None
None
UNL  A 401 ( 4.4A)
 1.45A 5eeiA-4fuuA:
undetectable		 5eeiA-4fuuA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 4fuu LEUCINE
AMINOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 VAL A 319
ILE A 160
ILE A 220
LEU A 157
VAL A 225
 None
 0.92A 5uvmB-4fuuA:
undetectable		 5uvmB-4fuuA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 4fuu LEUCINE
AMINOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A 226
GLY A 155
GLY A 153
ILE A 160
ALA A  49
 None
 0.94A 5x7fA-4fuuA:
undetectable		 5x7fA-4fuuA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_A_SORA397_0
(D-XYLOSE ISOMERASE)		 4fuu LEUCINE
AMINOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 GLU A 181
HIS A 124
ASP A 273
ASP A 149
ASP A 272
 UNL  A 401 ( 3.0A)
UNL  A 401 ( 4.4A)
None
ZN  A 403 (-2.3A)
UNL  A 401 ( 3.7A)
 1.47A 5ximA-4fuuA:
undetectable		 5ximA-4fuuA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_B_SORB397_0
(D-XYLOSE ISOMERASE)		 4fuu LEUCINE
AMINOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 GLU A 181
HIS A 124
ASP A 273
ASP A 149
ASP A 272
 UNL  A 401 ( 3.0A)
UNL  A 401 ( 4.4A)
None
ZN  A 403 (-2.3A)
UNL  A 401 ( 3.7A)
 1.48A 5ximB-4fuuA:
undetectable		 5ximB-4fuuA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_C_SORC397_0
(D-XYLOSE ISOMERASE)		 4fuu LEUCINE
AMINOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 GLU A 181
HIS A 124
ASP A 273
ASP A 149
ASP A 272
 UNL  A 401 ( 3.0A)
UNL  A 401 ( 4.4A)
None
ZN  A 403 (-2.3A)
UNL  A 401 ( 3.7A)
 1.46A 5ximC-4fuuA:
undetectable		 5ximC-4fuuA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_D_SORD397_0
(D-XYLOSE ISOMERASE)		 4fuu LEUCINE
AMINOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 GLU A 181
HIS A 124
ASP A 273
ASP A 149
ASP A 272
 UNL  A 401 ( 3.0A)
UNL  A 401 ( 4.4A)
None
ZN  A 403 (-2.3A)
UNL  A 401 ( 3.7A)
 1.46A 5ximD-4fuuA:
undetectable		 5ximD-4fuuA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XPR_A_K86A1201_1
(ENDOTHELIN B
RECEPTOR,ENDOLYSIN,E
NDOTHELIN B RECEPTOR)		 4fuu LEUCINE
AMINOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 VAL A 225
LEU A 221
LEU A 157
ILE A 160
ALA A 156
 None
 1.25A 5xprA-4fuuA:
undetectable		 5xprA-4fuuA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4fuu LEUCINE
AMINOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		5 / 10 LEU A 121
LEU A  80
ILE A 119
SER A 110
GLY A 172
 None
 1.28A 6dm0B-4fuuA:
2.2
6dm0C-4fuuA:
undetectable		 6dm0B-4fuuA:
14.44
6dm0C-4fuuA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4fuu LEUCINE
AMINOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		5 / 10 LEU A 121
LEU A  80
PRO A 169
SER A 110
GLY A 172
 None
 1.24A 6dm0B-4fuuA:
2.2
6dm0C-4fuuA:
undetectable		 6dm0B-4fuuA:
14.44
6dm0C-4fuuA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4fuu LEUCINE
AMINOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		5 / 9 PRO A 169
SER A 110
GLY A 172
LEU A 121
LEU A  80
 None
 1.24A 6dm0A-4fuuA:
1.7
6dm0D-4fuuA:
1.4		 6dm0A-4fuuA:
14.44
6dm0D-4fuuA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_C_GLYC713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4fuu LEUCINE
AMINOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 GLN A  90
TYR A 204
ASN A 106
 None
 1.00A 6dwdC-4fuuA:
undetectable		 6dwdC-4fuuA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_1
(CYTOCHROME P450 1A1)		 4fuu LEUCINE
AMINOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		4 / 7 ASN A 106
GLY A 150
ALA A 151
LEU A  76
 None
 0.69A 6dwnB-4fuuA:
undetectable		 6dwnB-4fuuA:
15.58