SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fva'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		 4fva 5'-TYROSYL-DNA
PHOSPHODIESTERASE
(Caenorhabditis
elegans) 		3 / 3 ASP A 252
PHE A 247
VAL A 282
 None
 0.72A 1kijB-4fvaA:
undetectable		 1kijB-4fvaA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4fva 5'-TYROSYL-DNA
PHOSPHODIESTERASE
(Caenorhabditis
elegans) 		5 / 12 VAL A 226
LEU A 217
LEU A 228
LEU A 154
TYR A 174
 None
None
None
None
EDO  A 404 ( 3.4A)
 1.47A 1mmkA-4fvaA:
undetectable		 1mmkA-4fvaA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA2_0
(FERROCHELATASE)		 4fva 5'-TYROSYL-DNA
PHOSPHODIESTERASE
(Caenorhabditis
elegans) 		4 / 8 LEU A 154
PRO A 350
SER A 351
MET A 139
 None
 1.20A 2qd2A-4fvaA:
undetectable		 2qd2A-4fvaA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)		 4fva 5'-TYROSYL-DNA
PHOSPHODIESTERASE
(Caenorhabditis
elegans) 		4 / 5 TYR A 178
MET A 139
ILE A 127
HIS A 353
 None
 1.23A 3eteB-4fvaA:
undetectable
3eteC-4fvaA:
undetectable		 3eteB-4fvaA:
19.76
3eteC-4fvaA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 4fva 5'-TYROSYL-DNA
PHOSPHODIESTERASE
(Caenorhabditis
elegans) 		4 / 8 HIS A 200
SER A 179
ASP A 161
LEU A 164
 None
 1.26A 3n2oC-4fvaA:
undetectable
3n2oD-4fvaA:
undetectable		 3n2oC-4fvaA:
17.39
3n2oD-4fvaA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE)		 4fva 5'-TYROSYL-DNA
PHOSPHODIESTERASE
(Caenorhabditis
elegans) 		4 / 8 SER A 280
ARG A 281
GLN A 246
PHE A 247
 None
 1.29A 3n62A-4fvaA:
1.8		 3n62A-4fvaA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 4fva 5'-TYROSYL-DNA
PHOSPHODIESTERASE
(Caenorhabditis
elegans) 		4 / 8 SER A 280
ARG A 281
GLN A 246
PHE A 247
 None
 1.33A 3n66B-4fvaA:
undetectable		 3n66B-4fvaA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 4fva 5'-TYROSYL-DNA
PHOSPHODIESTERASE
(Caenorhabditis
elegans) 		4 / 8 ASP A 271
ASP A 322
GLU A 278
GLU A 277
 MLI  A 403 ( 4.5A)
None
None
None
 1.13A 3sg9B-4fvaA:
undetectable		 3sg9B-4fvaA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 4fva 5'-TYROSYL-DNA
PHOSPHODIESTERASE
(Caenorhabditis
elegans) 		4 / 8 ASP A 271
HIS A 232
ASP A 322
GLU A 277
 MLI  A 403 ( 4.5A)
MLI  A 403 (-4.1A)
None
None
 1.11A 3sg9B-4fvaA:
undetectable		 3sg9B-4fvaA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 4fva 5'-TYROSYL-DNA
PHOSPHODIESTERASE
(Caenorhabditis
elegans) 		5 / 12 LEU A 228
LEU A 190
ILE A 189
ALA A 188
ILE A 356
 None
 0.90A 3vrmA-4fvaA:
undetectable		 3vrmA-4fvaA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 4fva 5'-TYROSYL-DNA
PHOSPHODIESTERASE
(Caenorhabditis
elegans) 		3 / 3 ARG A 342
PHE A 349
PRO A 350
 None
 0.51A 3zoaB-4fvaA:
undetectable		 3zoaB-4fvaA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_A_TYLA1188_1
(BROMODOMAIN
CONTAINING 2)		 4fva 5'-TYROSYL-DNA
PHOSPHODIESTERASE
(Caenorhabditis
elegans) 		4 / 5 VAL A 146
LEU A 154
LEU A 190
ILE A 127
 None
 0.92A 4a9jA-4fvaA:
undetectable		 4a9jA-4fvaA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4fva 5'-TYROSYL-DNA
PHOSPHODIESTERASE
(Caenorhabditis
elegans) 		4 / 7 LEU A 154
PRO A 350
SER A 351
MET A 139
 None
 1.25A 4klrA-4fvaA:
undetectable		 4klrA-4fvaA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)		 4fva 5'-TYROSYL-DNA
PHOSPHODIESTERASE
(Caenorhabditis
elegans) 		5 / 12 PHE A 267
LEU A 228
GLY A 222
ALA A 264
VAL A 122
 None
 0.95A 4wnwB-4fvaA:
undetectable		 4wnwB-4fvaA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4fva 5'-TYROSYL-DNA
PHOSPHODIESTERASE
(Caenorhabditis
elegans) 		4 / 7 VAL A 122
ILE A 189
ASN A 261
PHE A 267
 None
 0.71A 5hieC-4fvaA:
undetectable		 5hieC-4fvaA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4fva 5'-TYROSYL-DNA
PHOSPHODIESTERASE
(Caenorhabditis
elegans) 		5 / 12 VAL A 226
VAL A 122
LEU A 272
GLY A 269
LEU A 228
 None
 1.09A 5iktA-4fvaA:
undetectable		 5iktA-4fvaA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODC_G_ACTG703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A
HETERODISULFIDE
REDUCTASE, SUBUNIT B
HETERODISULFIDE
REDUCTASE, SUBUNIT C)		 4fva 5'-TYROSYL-DNA
PHOSPHODIESTERASE
(Caenorhabditis
elegans) 		4 / 4 GLU A 277
ARG A 240
ARG A 243
GLU A 278
 None
 1.42A 5odcB-4fvaA:
0.0
5odcC-4fvaA:
undetectable
5odcG-4fvaA:
0.6		 5odcB-4fvaA:
25.00
5odcC-4fvaA:
19.70
5odcG-4fvaA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAC_C_RFPC3001_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 4fva 5'-TYROSYL-DNA
PHOSPHODIESTERASE
(Caenorhabditis
elegans) 		5 / 12 GLN A 157
GLN A 215
HIS A 200
LEU A 156
ILE A 176
 None
 1.06A 5uacC-4fvaA:
undetectable		 5uacC-4fvaA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4fva 5'-TYROSYL-DNA
PHOSPHODIESTERASE
(Caenorhabditis
elegans) 		4 / 5 ASN A 273
ASP A 271
ASN A 126
ASP A 128
 MLI  A 403 (-3.2A)
MLI  A 403 ( 4.5A)
MLI  A 403 (-4.2A)
MG  A 402 (-3.3A)
 1.23A 5vooE-4fvaA:
undetectable		 5vooE-4fvaA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4fva 5'-TYROSYL-DNA
PHOSPHODIESTERASE
(Caenorhabditis
elegans) 		3 / 3 ASP A 271
ASN A 126
ASP A 128
 MLI  A 403 ( 4.5A)
MLI  A 403 (-4.2A)
MG  A 402 (-3.3A)
 0.88A 5vopB-4fvaA:
undetectable		 5vopB-4fvaA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_MTLA805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4fva 5'-TYROSYL-DNA
PHOSPHODIESTERASE
(Caenorhabditis
elegans) 		4 / 8 SER A 280
ARG A 281
GLN A 246
PHE A 247
 None
 1.29A 5vunA-4fvaA:
undetectable		 5vunA-4fvaA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4fva 5'-TYROSYL-DNA
PHOSPHODIESTERASE
(Caenorhabditis
elegans) 		4 / 8 SER A 280
ARG A 281
GLN A 246
PHE A 247
 None
 1.34A 5vunB-4fvaA:
undetectable		 5vunB-4fvaA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4fva 5'-TYROSYL-DNA
PHOSPHODIESTERASE
(Caenorhabditis
elegans) 		4 / 8 SER A 280
ARG A 281
GLN A 246
PHE A 247
 None
 1.35A 5vuoB-4fvaA:
undetectable		 5vuoB-4fvaA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA816_0
(UNCHARACTERIZED
PROTEIN)		 4fva 5'-TYROSYL-DNA
PHOSPHODIESTERASE
(Caenorhabditis
elegans) 		3 / 3 ARG A 138
ARG A 133
ASP A 131
 None
 0.95A 6d8pA-4fvaA:
undetectable		 6d8pA-4fvaA:
16.62