SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fvl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 4fvl COLLAGENASE 3
(Homo
sapiens) 		5 / 12 ILE A 163
ALA A 188
PHE A 224
PHE A 217
ILE A 165
 None
 1.09A 1cd2A-4fvlA:
undetectable		 1cd2A-4fvlA:
22.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		 4fvl COLLAGENASE 3
(Homo
sapiens) 		4 / 5 HIS A 187
HIS A 222
HIS A 226
HIS A 232
 ZN  A 502 (-3.3A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.1A)
ZN  A 501 (-3.2A)
 0.31A 1os2A-4fvlA:
28.7		 1os2A-4fvlA:
32.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 4fvl COLLAGENASE 3
(Homo
sapiens) 		4 / 6 HIS A 187
HIS A 222
HIS A 226
HIS A 232
 ZN  A 502 (-3.3A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.1A)
ZN  A 501 (-3.2A)
 0.36A 1y93A-4fvlA:
28.4		 1y93A-4fvlA:
55.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDK_A_C2FA1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 4fvl COLLAGENASE 3
(Homo
sapiens) 		5 / 11 LEU A 239
HIS A 222
MET A 240
LEU A 254
HIS A 277
 None
ZN  A 501 (-3.3A)
None
None
None
 1.39A 2idkA-4fvlA:
undetectable
2idkB-4fvlA:
undetectable
2idkC-4fvlA:
undetectable
2idkD-4fvlA:
undetectable		 2idkA-4fvlA:
20.26
2idkB-4fvlA:
20.26
2idkC-4fvlA:
20.26
2idkD-4fvlA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDK_A_C2FA1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 4fvl COLLAGENASE 3
(Homo
sapiens) 		5 / 11 LEU A 239
MET A 240
SER A 227
LEU A 254
HIS A 277
 None
 1.13A 2idkA-4fvlA:
undetectable
2idkB-4fvlA:
undetectable
2idkC-4fvlA:
undetectable
2idkD-4fvlA:
undetectable		 2idkA-4fvlA:
20.26
2idkB-4fvlA:
20.26
2idkC-4fvlA:
20.26
2idkD-4fvlA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDK_A_C2FA1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 4fvl COLLAGENASE 3
(Homo
sapiens) 		5 / 11 LEU A 254
HIS A 277
LEU A 239
HIS A 222
MET A 240
 None
None
None
ZN  A 501 (-3.3A)
None
 1.38A 2idkA-4fvlA:
undetectable
2idkB-4fvlA:
undetectable
2idkC-4fvlA:
undetectable
2idkD-4fvlA:
undetectable		 2idkA-4fvlA:
20.26
2idkB-4fvlA:
20.26
2idkC-4fvlA:
20.26
2idkD-4fvlA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		 4fvl COLLAGENASE 3
(Homo
sapiens) 		4 / 8 LEU A 185
HIS A 222
HIS A 226
HIS A 232
 None
ZN  A 501 (-3.3A)
ZN  A 501 (-3.1A)
ZN  A 501 (-3.2A)
 0.39A 2jihB-4fvlA:
9.8		 2jihB-4fvlA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_E_CUE801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 4fvl COLLAGENASE 3
COLLAGENASE 3,
PRO-DOMAIN PEPTIDE
(Homo
sapiens;
Homo
sapiens) 		4 / 4 LEU C  43
HIS A 172
HIS A 187
HIS A 200
 None
ZN  A 502 (-3.0A)
ZN  A 502 (-3.3A)
ZN  A 502 (-3.1A)
 1.16A 2oqeE-4fvlC:
undetectable		 2oqeE-4fvlC:
8.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		 4fvl COLLAGENASE 3
(Homo
sapiens) 		5 / 6 LEU A 184
HIS A 187
HIS A 222
HIS A 226
HIS A 232
 None
ZN  A 502 (-3.3A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.1A)
ZN  A 501 (-3.2A)
 0.85A 2ow9A-4fvlA:
29.7		 2ow9A-4fvlA:
99.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		 4fvl COLLAGENASE 3
(Homo
sapiens) 		3 / 3 HIS A 222
HIS A 226
HIS A 232
 ZN  A 501 (-3.3A)
ZN  A 501 (-3.1A)
ZN  A 501 (-3.2A)
 0.28A 2ozrF-4fvlA:
29.2		 2ozrF-4fvlA:
99.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_1
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 4fvl COLLAGENASE 3
(Homo
sapiens) 		3 / 3 SER A 398
ASP A 432
ASP A 335
 None
GOL  A 512 ( 3.2A)
None
 0.81A 2plwA-4fvlA:
undetectable		 2plwA-4fvlA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 4fvl COLLAGENASE 3
(Homo
sapiens) 		4 / 7 ILE A 163
LEU A 228
GLY A 225
PHE A 224
 None
 0.90A 2tsrA-4fvlA:
undetectable		 2tsrA-4fvlA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2002_1
(SERUM ALBUMIN)		 4fvl COLLAGENASE 3
(Homo
sapiens) 		4 / 9 ILE A 441
PHE A 397
ALA A 385
VAL A 434
 None
None
CA  A 506 ( 4.8A)
CA  A 506 ( 4.6A)
 0.73A 2vufA-4fvlA:
undetectable		 2vufA-4fvlA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_F_RTLF178_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4fvl COLLAGENASE 3
(Homo
sapiens) 		5 / 11 LEU A 239
ALA A 223
PHE A 201
ALA A 186
TYR A 244
 None
 1.30A 3bszF-4fvlA:
undetectable		 3bszF-4fvlA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 4fvl COLLAGENASE 3
(Homo
sapiens) 		5 / 9 LEU A 185
HIS A 222
HIS A 226
HIS A 232
ILE A 243
 None
ZN  A 501 (-3.3A)
ZN  A 501 (-3.1A)
ZN  A 501 (-3.2A)
None
 0.50A 3hy7B-4fvlA:
10.1		 3hy7B-4fvlA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX1_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4fvl COLLAGENASE 3
(Homo
sapiens) 		4 / 8 PHE A 138
GLU A 133
SER A 132
MET A 129
 None
 1.24A 3jx1A-4fvlA:
undetectable
3jx1B-4fvlA:
undetectable		 3jx1A-4fvlA:
23.61
3jx1B-4fvlA:
23.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 4fvl COLLAGENASE 3
(Homo
sapiens) 		4 / 5 HIS A 187
HIS A 222
HIS A 226
HIS A 232
 ZN  A 502 (-3.3A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.1A)
ZN  A 501 (-3.2A)
 0.51A 3likA-4fvlA:
28.6		 3likA-4fvlA:
55.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 4fvl COLLAGENASE 3
(Homo
sapiens) 		4 / 5 HIS A 187
HIS A 222
HIS A 226
HIS A 232
 ZN  A 502 (-3.3A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.1A)
ZN  A 501 (-3.2A)
 0.47A 3lkaA-4fvlA:
28.6		 3lkaA-4fvlA:
55.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_C_9PLC501_1
(CYTOCHROME P450 2E1)		 4fvl COLLAGENASE 3
(Homo
sapiens) 		4 / 5 PHE A 201
PHE A 224
ALA A 221
LEU A 216
 None
 1.14A 3t3zC-4fvlA:
undetectable		 3t3zC-4fvlA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_D_C2FD1200_0
(GLYCINE
N-METHYLTRANSFERASE)		 4fvl COLLAGENASE 3
(Homo
sapiens) 		5 / 12 LEU A 254
HIS A 277
SER A 227
LEU A 239
HIS A 222
 None
None
None
None
ZN  A 501 (-3.3A)
 1.34A 3thrA-4fvlA:
undetectable
3thrB-4fvlA:
undetectable
3thrC-4fvlA:
undetectable
3thrD-4fvlA:
undetectable		 3thrA-4fvlA:
20.41
3thrB-4fvlA:
20.41
3thrC-4fvlA:
20.41
3thrD-4fvlA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_D_C2FD1200_0
(GLYCINE
N-METHYLTRANSFERASE)		 4fvl COLLAGENASE 3
(Homo
sapiens) 		5 / 12 LEU A 254
HIS A 277
SER A 227
LEU A 239
MET A 240
 None
 1.11A 3thrA-4fvlA:
undetectable
3thrB-4fvlA:
undetectable
3thrC-4fvlA:
undetectable
3thrD-4fvlA:
undetectable		 3thrA-4fvlA:
20.41
3thrB-4fvlA:
20.41
3thrC-4fvlA:
20.41
3thrD-4fvlA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_D_ADND301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4fvl COLLAGENASE 3
(Homo
sapiens) 		5 / 10 ALA A 465
LEU A 290
ASP A 432
ASN A 445
ILE A 293
 None
None
GOL  A 512 ( 3.2A)
None
None
 1.12A 3wdmD-4fvlA:
undetectable		 3wdmD-4fvlA:
21.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		 4fvl COLLAGENASE 3
(Homo
sapiens) 		4 / 6 HIS A 187
HIS A 222
HIS A 226
HIS A 232
 ZN  A 502 (-3.3A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.1A)
ZN  A 501 (-3.2A)
 0.46A 4a7bA-4fvlA:
29.7		 4a7bA-4fvlA:
99.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		 4fvl COLLAGENASE 3
(Homo
sapiens) 		4 / 6 LEU A 184
HIS A 187
HIS A 222
HIS A 232
 None
ZN  A 502 (-3.3A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.2A)
 0.86A 4a7bA-4fvlA:
29.7		 4a7bA-4fvlA:
99.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 4fvl COLLAGENASE 3
(Homo
sapiens) 		4 / 5 LEU A 184
HIS A 187
HIS A 222
HIS A 226
 None
ZN  A 502 (-3.3A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.1A)
 0.72A 4a7bB-4fvlA:
29.3		 4a7bB-4fvlA:
99.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HDL_A_DXCA75_0
(PPCA)		 4fvl COLLAGENASE 3
(Homo
sapiens) 		4 / 8 ILE A 346
ILE A 334
PHE A 349
LYS A 369
 None
 0.98A 4hdlA-4fvlA:
undetectable		 4hdlA-4fvlA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI506_0
(RNA POLYMERASE
3D-POL)		 4fvl COLLAGENASE 3
(Homo
sapiens) 		3 / 3 ARG A 352
LYS A 381
LYS A 380
 None
 1.34A 4k50I-4fvlA:
undetectable		 4k50I-4fvlA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 4fvl COLLAGENASE 3
(Homo
sapiens) 		5 / 10 ILE A 163
ALA A 188
PHE A 224
LEU A 216
ILE A 165
 None
 1.09A 4km0A-4fvlA:
undetectable		 4km0A-4fvlA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 4fvl COLLAGENASE 3
(Homo
sapiens) 		5 / 12 ILE A 163
ALA A 188
PHE A 224
LEU A 216
ILE A 165
 None
 1.10A 4km0B-4fvlA:
undetectable		 4km0B-4fvlA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 4fvl COLLAGENASE 3
(Homo
sapiens) 		4 / 5 GLN A 263
THR A 149
LEU A 239
LEU A 254
 None
 1.00A 4lvcB-4fvlA:
undetectable		 4lvcB-4fvlA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 4fvl COLLAGENASE 3
(Homo
sapiens) 		4 / 5 GLN A 401
THR A 394
LEU A 373
LEU A 375
 PGO  A 522 (-2.9A)
None
None
None
 0.85A 4lvcB-4fvlA:
undetectable		 4lvcB-4fvlA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 4fvl COLLAGENASE 3
(Homo
sapiens) 		5 / 12 ILE A 163
ALA A 188
PHE A 224
LEU A 216
ILE A 165
 None
 0.99A 4m2xA-4fvlA:
undetectable		 4m2xA-4fvlA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)		 4fvl COLLAGENASE 3
(Homo
sapiens) 		3 / 3 ARG A 461
TYR A 442
GLU A 451
 None
 0.67A 4zzbE-4fvlA:
undetectable		 4zzbE-4fvlA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4fvl COLLAGENASE 3
(Homo
sapiens) 		4 / 4 GLN A 263
THR A 149
LEU A 239
LEU A 254
 None
 1.00A 5m5kB-4fvlA:
undetectable		 5m5kB-4fvlA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_B_SALB203_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4fvl COLLAGENASE 3
(Homo
sapiens) 		4 / 6 PRO A 376
GLY A 374
LEU A 396
VAL A 379
 PGO  A 522 ( 4.6A)
None
None
None
 0.95A 5x80A-4fvlA:
undetectable
5x80B-4fvlA:
undetectable		 5x80A-4fvlA:
19.02
5x80B-4fvlA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4fvl COLLAGENASE 3
(Homo
sapiens) 		5 / 12 LEU A 239
PHE A 224
VAL A 144
PHE A 201
THR A 126
 None
 1.28A 5xiqA-4fvlA:
undetectable		 5xiqA-4fvlA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4fvl COLLAGENASE 3
(Homo
sapiens) 		5 / 12 LEU A 239
PHE A 224
VAL A 144
PHE A 201
THR A 126
 None
 1.31A 5xiqD-4fvlA:
undetectable		 5xiqD-4fvlA:
20.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)		 4fvl COLLAGENASE 3
(Homo
sapiens) 		3 / 3 TYR A 176
HIS A 187
PHE A 189
 None
ZN  A 502 (-3.3A)
None
 0.56A 6esmA-4fvlA:
27.3		 6esmA-4fvlA:
53.75