SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fvv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA6_0
(GRAMICIDIN A)		 4fvv NEUROTOXIN
(Clostridium
botulinum) 		3 / 3 ALA A 997
VAL A 946
TRP A 945
 None
 1.00A 1c4dA-4fvvA:
undetectable
1c4dB-4fvvA:
undetectable		 1c4dA-4fvvA:
2.82
1c4dB-4fvvA:
2.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_B_ESTB1600_1
(ESTROGEN RECEPTOR)		 4fvv NEUROTOXIN
(Clostridium
botulinum) 		5 / 12 LEU A1224
LEU A1164
MET A1110
ILE A1144
LEU A1193
 None
 1.05A 1g50B-4fvvA:
undetectable		 1g50B-4fvvA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_C_ESTC2600_1
(ESTROGEN RECEPTOR)		 4fvv NEUROTOXIN
(Clostridium
botulinum) 		5 / 11 LEU A1224
LEU A1164
MET A1110
ILE A1144
LEU A1193
 None
 1.05A 1g50C-4fvvA:
undetectable		 1g50C-4fvvA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_1
(HIV-1 PROTEASE)		 4fvv NEUROTOXIN
(Clostridium
botulinum) 		5 / 12 ASP A 986
ILE A1008
GLY A 967
ILE A 968
ILE A1018
 None
 0.98A 2hs1A-4fvvA:
undetectable		 2hs1A-4fvvA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 4fvv NEUROTOXIN
(Clostridium
botulinum) 		5 / 12 LEU A 870
ILE A 936
ILE A 954
PHE A1069
VAL A 889
 None
 1.02A 2ygoA-4fvvA:
undetectable		 2ygoA-4fvvA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 4fvv NEUROTOXIN
(Clostridium
botulinum) 		5 / 12 LEU A 870
ILE A 936
ILE A 954
PHE A1069
VAL A 889
 None
 0.92A 2ygqA-4fvvA:
undetectable		 2ygqA-4fvvA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA1_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 4fvv NEUROTOXIN
(Clostridium
botulinum) 		3 / 3 GLY A 884
ASP A 881
SER A 871
 None
 0.59A 3brfA-4fvvA:
7.2		 3brfA-4fvvA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_1
(PROTEASE)		 4fvv NEUROTOXIN
(Clostridium
botulinum) 		5 / 9 ILE A1008
GLY A 967
ILE A 968
ILE A1020
ILE A1018
 None
 1.03A 3s45A-4fvvA:
undetectable		 3s45A-4fvvA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4fvv NEUROTOXIN
(Clostridium
botulinum) 		5 / 12 ILE A1008
ILE A 968
ILE A 966
ILE A 969
ASP A1026
 None
 0.95A 3uj6A-4fvvA:
undetectable		 3uj6A-4fvvA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		 4fvv NEUROTOXIN
(Clostridium
botulinum) 		5 / 12 ARG A1132
ASN A1135
GLY A 999
ALA A1282
GLU A1107
 None
 1.18A 3v3oB-4fvvA:
undetectable		 3v3oB-4fvvA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 4fvv NEUROTOXIN
(Clostridium
botulinum) 		4 / 8 VAL A 889
VAL A 917
ILE A1066
PHE A1044
 None
 0.76A 3warA-4fvvA:
undetectable		 3warA-4fvvA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		 4fvv NEUROTOXIN
(Clostridium
botulinum) 		5 / 11 ARG A1132
ASN A1135
GLY A 999
ALA A1282
GLU A1107
 None
 1.27A 4a6nA-4fvvA:
undetectable		 4a6nA-4fvvA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_A_NCTA501_1
(CYTOCHROME P450 2A6)		 4fvv NEUROTOXIN
(Clostridium
botulinum) 		4 / 7 PHE A 934
ASN A1011
ILE A1036
PHE A1038
 None
 0.81A 4ejjA-4fvvA:
undetectable		 4ejjA-4fvvA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 4fvv NEUROTOXIN
(Clostridium
botulinum) 		4 / 7 PHE A 934
ASN A1011
ILE A1036
PHE A1038
 None
 0.82A 4ejjD-4fvvA:
undetectable		 4ejjD-4fvvA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HDL_A_DXCA75_0
(PPCA)		 4fvv NEUROTOXIN
(Clostridium
botulinum) 		4 / 8 ILE A1144
ILE A1211
PHE A1209
GLY A1207
 None
 0.96A 4hdlA-4fvvA:
undetectable		 4hdlA-4fvvA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K37_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 4fvv NEUROTOXIN
(Clostridium
botulinum) 		5 / 11 ASN A1125
LEU A1193
VAL A1191
ILE A1261
LEU A1235
 None
 1.45A 4k37B-4fvvA:
undetectable		 4k37B-4fvvA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)		 4fvv NEUROTOXIN
(Clostridium
botulinum) 		5 / 12 SER A 957
GLY A 963
ALA A 929
PHE A1038
GLU A 923
 None
 1.22A 4r29C-4fvvA:
undetectable		 4r29C-4fvvA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)		 4fvv NEUROTOXIN
(Clostridium
botulinum) 		4 / 7 SER A1242
ARG A1253
SER A1244
GLU A1255
 None
SO4  A1303 (-3.7A)
None
None
 1.43A 4xzkA-4fvvA:
undetectable		 4xzkA-4fvvA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)		 4fvv NEUROTOXIN
(Clostridium
botulinum) 		4 / 7 SER A1242
TYR A1243
ARG A1184
GLU A1255
 None
 1.39A 4xzkA-4fvvA:
undetectable		 4xzkA-4fvvA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_B_TESB502_1
(-)		 4fvv NEUROTOXIN
(Clostridium
botulinum) 		5 / 12 VAL A 974
LEU A 973
ILE A 936
MET A1016
LEU A 977
 None
 1.17A 5og9B-4fvvA:
undetectable		 5og9B-4fvvA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 4fvv NEUROTOXIN
(Clostridium
botulinum) 		4 / 8 ASP A 881
THR A 882
VAL A 926
TYR A 927
 None
 1.14A 5ov9B-4fvvA:
undetectable		 5ov9B-4fvvA:
19.04