SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fwm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMY_A_AZMA400_1
(MURINE CARBONIC
ANHYDRASE V)		 4fwm PROPIONATE KINASE
(Salmonella
enterica) 		5 / 11 HIS A 147
HIS A 179
TYR A 187
SER A 197
LEU A 199
 None
 1.40A 1dmyA-4fwmA:
undetectable		 1dmyA-4fwmA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4fwm PROPIONATE KINASE
(Salmonella
enterica) 		3 / 3 GLN A 148
ILE A 126
HIS A  85
 None
 0.74A 1k74A-4fwmA:
undetectable		 1k74A-4fwmA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4fwm PROPIONATE KINASE
(Salmonella
enterica) 		3 / 3 HIS A 360
ASP A 350
ASN A 368
 None
 0.83A 1wg8B-4fwmA:
2.3		 1wg8B-4fwmA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		 4fwm PROPIONATE KINASE
(Salmonella
enterica) 		4 / 7 THR A 177
SER A  97
VAL A 139
LEU A  22
 None
 0.99A 2hdnE-4fwmA:
undetectable
2hdnF-4fwmA:
3.0
2hdnH-4fwmA:
2.9		 2hdnE-4fwmA:
9.59
2hdnF-4fwmA:
20.33
2hdnH-4fwmA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		 4fwm PROPIONATE KINASE
(Salmonella
enterica) 		4 / 7 VAL A 139
LEU A  22
THR A 177
SER A  97
 None
 0.96A 2hdnF-4fwmA:
3.0
2hdnG-4fwmA:
undetectable
2hdnH-4fwmA:
2.7		 2hdnF-4fwmA:
20.33
2hdnG-4fwmA:
9.59
2hdnH-4fwmA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 4fwm PROPIONATE KINASE
(Salmonella
enterica) 		5 / 12 VAL A 182
ILE A 321
LEU A 315
ALA A 375
ASP A 220
 None
 1.44A 2iyfB-4fwmA:
undetectable		 2iyfB-4fwmA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_2
(PROTEASE)		 4fwm PROPIONATE KINASE
(Salmonella
enterica) 		5 / 11 ALA A 386
VAL A  24
GLY A 393
VAL A  80
VAL A   7
 None
 1.09A 2nnpB-4fwmA:
undetectable		 2nnpB-4fwmA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4fwm PROPIONATE KINASE
(Salmonella
enterica) 		5 / 12 ILE A 327
GLY A 328
PHE A 323
LEU A 231
ILE A 304
 ATP  A 405 (-4.6A)
None
None
None
None
 1.22A 2y7kD-4fwmA:
undetectable		 2y7kD-4fwmA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN0_A_DMOA551_1
(ARGINASE-1)		 4fwm PROPIONATE KINASE
(Salmonella
enterica) 		5 / 9 HIS A 175
ASP A 143
HIS A 147
GLY A 176
GLU A 381
 ATP  A 405 ( 3.7A)
EDO  A 401 (-4.2A)
None
None
None
 1.31A 3gn0A-4fwmA:
undetectable		 3gn0A-4fwmA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN0_B_DMOB552_1
(ARGINASE-1)		 4fwm PROPIONATE KINASE
(Salmonella
enterica) 		5 / 9 HIS A 175
ASP A 143
HIS A 147
GLY A 176
GLU A 381
 ATP  A 405 ( 3.7A)
EDO  A 401 (-4.2A)
None
None
None
 1.28A 3gn0B-4fwmA:
undetectable		 3gn0B-4fwmA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 4fwm PROPIONATE KINASE
(Salmonella
enterica) 		5 / 9 ALA A 312
LEU A 342
ILE A 304
LEU A 204
ILE A 210
 None
 1.23A 3jw3B-4fwmA:
undetectable		 3jw3B-4fwmA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_H_SAMH226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4fwm PROPIONATE KINASE
(Salmonella
enterica) 		6 / 12 LEU A 282
GLY A 268
VAL A 263
VAL A 262
GLY A 238
ALA A 296
 None
 1.16A 3ku1H-4fwmA:
undetectable		 3ku1H-4fwmA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_D_CAMD502_0
(CAMPHOR
5-MONOOXYGENASE)		 4fwm PROPIONATE KINASE
(Salmonella
enterica) 		4 / 5 LEU A 204
GLY A 325
THR A 379
VAL A 182
 None
ATP  A 405 ( 4.5A)
None
None
 0.99A 3wrkD-4fwmA:
undetectable		 3wrkD-4fwmA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4fwm PROPIONATE KINASE
(Salmonella
enterica) 		4 / 7 GLY A  91
GLY A  90
ASN A 119
GLU A  92
 None
 1.11A 4fgkB-4fwmA:
undetectable		 4fgkB-4fwmA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4fwm PROPIONATE KINASE
(Salmonella
enterica) 		4 / 5 GLY A  91
GLY A  90
ASN A 119
GLU A  92
 None
 1.06A 4fglC-4fwmA:
undetectable		 4fglC-4fwmA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4fwm PROPIONATE KINASE
(Salmonella
enterica) 		4 / 8 GLY A 343
VAL A 344
ILE A 308
PHE A 323
 None
 0.95A 4fglD-4fwmA:
undetectable		 4fglD-4fwmA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD302_0
(GLUTATHIONE
TRANSFERASE GTE1)		 4fwm PROPIONATE KINASE
(Salmonella
enterica) 		3 / 3 TYR A 187
PHE A 146
ARG A 184
 None
 1.11A 4g19D-4fwmA:
undetectable		 4g19D-4fwmA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		 4fwm PROPIONATE KINASE
(Salmonella
enterica) 		5 / 11 VAL A 213
ALA A 212
GLY A 176
PHE A 146
SER A 209
 None
 1.28A 4mm9A-4fwmA:
undetectable		 4mm9A-4fwmA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 4fwm PROPIONATE KINASE
(Salmonella
enterica) 		5 / 12 GLY A 207
ALA A 208
GLY A 205
LEU A 204
GLY A 234
 ATP  A 405 ( 3.4A)
None
ATP  A 405 ( 3.8A)
None
None
 0.94A 4o33A-4fwmA:
undetectable		 4o33A-4fwmA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 4fwm PROPIONATE KINASE
(Salmonella
enterica) 		5 / 12 GLY A 207
ALA A 208
GLY A 205
LEU A 204
LEU A 279
 ATP  A 405 ( 3.4A)
None
ATP  A 405 ( 3.8A)
None
ATP  A 405 (-4.2A)
 0.93A 4o33A-4fwmA:
undetectable		 4o33A-4fwmA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 4fwm PROPIONATE KINASE
(Salmonella
enterica) 		5 / 12 GLY A 207
ALA A 208
GLY A 205
LEU A 204
LEU A 279
 ATP  A 405 ( 3.4A)
None
ATP  A 405 ( 3.8A)
None
ATP  A 405 (-4.2A)
 0.77A 4o3fA-4fwmA:
undetectable		 4o3fA-4fwmA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4fwm PROPIONATE KINASE
(Salmonella
enterica) 		4 / 5 THR A 379
THR A 324
THR A 221
HIS A 147
 None
 1.19A 4pgfB-4fwmA:
2.8		 4pgfB-4fwmA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_A_PZAA1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 4fwm PROPIONATE KINASE
(Salmonella
enterica) 		4 / 7 VAL A 182
SER A 183
ALA A 186
GLY A 320
 None
 0.78A 5fpdA-4fwmA:
5.4		 5fpdA-4fwmA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4fwm PROPIONATE KINASE
(Salmonella
enterica) 		4 / 7 ASP A 196
ASP A 319
GLY A 198
ASN A 215
 None
 1.14A 5x7pA-4fwmA:
undetectable		 5x7pA-4fwmA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA819_0
(GEPHYRIN)		 4fwm PROPIONATE KINASE
(Salmonella
enterica) 		3 / 3 ARG A 363
GLY A 361
GLU A 362
 None
 0.47A 6fgdA-4fwmA:
undetectable		 6fgdA-4fwmA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_2
(-)		 4fwm PROPIONATE KINASE
(Salmonella
enterica) 		4 / 5 THR A 324
THR A 221
HIS A 147
GLY A 207
 None
None
None
ATP  A 405 ( 3.4A)
 1.08A 6gbnC-4fwmA:
2.4		 6gbnC-4fwmA:
21.95