SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fwt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4001_1
(SERUM ALBUMIN)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		4 / 5 LYS A 461
ALA A 459
ASP A 423
GLY A 457
 None
 1.19A 1e7cA-4fwtA:
4.1		 1e7cA-4fwtA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_C_9CRC502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		5 / 10 ALA A1114
LEU A1148
LEU A 709
ALA A 712
ILE A1188
 None
 1.25A 1g5yC-4fwtA:
undetectable		 1g5yC-4fwtA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		3 / 3 ARG A1125
THR A1156
VAL A1167
 A  G2005 ( 4.7A)
None
None
 1.00A 1hxbA-4fwtA:
undetectable		 1hxbA-4fwtA:
6.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_A_BEZA349_0
(D-AMINO ACID OXIDASE)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		4 / 5 TYR A 616
ILE A1239
ARG A 573
GLY A 574
 None
 1.05A 1kifA-4fwtA:
undetectable		 1kifA-4fwtA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_B_BEZB349_0
(D-AMINO ACID OXIDASE)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		4 / 5 TYR A 616
ILE A1239
ARG A 573
GLY A 574
 None
 1.05A 1kifB-4fwtA:
undetectable		 1kifB-4fwtA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_C_BEZC349_0
(D-AMINO ACID OXIDASE)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		4 / 5 TYR A 616
ILE A1239
ARG A 573
GLY A 574
 None
 1.05A 1kifC-4fwtA:
undetectable		 1kifC-4fwtA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_D_BEZD349_0
(D-AMINO ACID OXIDASE)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		4 / 5 TYR A 616
ILE A1239
ARG A 573
GLY A 574
 None
 1.05A 1kifD-4fwtA:
undetectable		 1kifD-4fwtA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_E_BEZE349_0
(D-AMINO ACID OXIDASE)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		4 / 5 TYR A 616
ILE A1239
ARG A 573
GLY A 574
 None
 1.05A 1kifE-4fwtA:
undetectable		 1kifE-4fwtA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_F_BEZF349_0
(D-AMINO ACID OXIDASE)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		4 / 5 TYR A 616
ILE A1239
ARG A 573
GLY A 574
 None
 1.05A 1kifF-4fwtA:
undetectable		 1kifF-4fwtA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_G_BEZG349_0
(D-AMINO ACID OXIDASE)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		4 / 5 TYR A 616
ILE A1239
ARG A 573
GLY A 574
 None
 1.04A 1kifG-4fwtA:
undetectable		 1kifG-4fwtA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_H_BEZH349_0
(D-AMINO ACID OXIDASE)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		4 / 5 TYR A 616
ILE A1239
ARG A 573
GLY A 574
 None
 1.04A 1kifH-4fwtA:
2.8		 1kifH-4fwtA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1864_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		3 / 3 TRP A1181
HIS A 168
MET A 236
 None
 1.49A 1l5qB-4fwtA:
undetectable		 1l5qB-4fwtA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_1
(ADENOSINE KINASE)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		5 / 12 ILE A 930
LEU A 985
GLY A 929
GLY A 931
LEU A 993
 None
 0.98A 1liiA-4fwtA:
undetectable		 1liiA-4fwtA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		4 / 8 ASP A 621
ILE A 532
GLY A 624
ARG A 612
 None
 0.94A 1meiA-4fwtA:
undetectable		 1meiA-4fwtA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		4 / 7 VAL A 593
GLY A 671
ILE A 626
VAL A 645
 None
 0.71A 1p2yA-4fwtA:
undetectable		 1p2yA-4fwtA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QCA_A_FUAA221_1
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		4 / 7 PHE A 890
SER A 864
PHE A 503
LEU A 562
 None
 0.97A 1qcaA-4fwtA:
undetectable		 1qcaA-4fwtA:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T03_P_TFOP822_1
(POL POLYPROTEIN
SYNTHETIC
OLIGONUCLEOTIDE
PRIMER)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		4 / 7 TYR A1051
ASP A1053
ASP A1054
HIS A1094
 C  G2008 ( 4.8A)
CA  A2502 (-2.7A)
CA  A2503 (-3.5A)
None
 1.32A 1t03A-4fwtA:
5.4		 1t03A-4fwtA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE9_A_BEZA352_0
(D-AMINO ACID OXIDASE)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		4 / 5 TYR A 616
ILE A1239
ARG A 573
GLY A 574
 None
 1.13A 1ve9A-4fwtA:
undetectable		 1ve9A-4fwtA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		4 / 4 LEU A1123
PRO A 739
ILE A 762
LEU A 765
 None
 1.13A 1ya4B-4fwtA:
undetectable		 1ya4B-4fwtA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_A_NCAA1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		4 / 7 SER A 998
SER A1015
GLN A 927
GLU A 919
 None
 1.25A 2c8aA-4fwtA:
undetectable		 2c8aA-4fwtA:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1321_0
(CHLOROPEROXIDASE)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		4 / 5 LEU A1057
PHE A1069
VAL A1037
ALA A1061
 None
 1.16A 2cizA-4fwtA:
undetectable		 2cizA-4fwtA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_G_BEZG2352_0
(D-AMINO-ACID OXIDASE)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		4 / 5 TYR A 616
ILE A1239
ARG A 573
GLY A 574
 None
 1.15A 2du8G-4fwtA:
2.7		 2du8G-4fwtA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_2
(POL PROTEIN)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		4 / 7 ALA A 370
ASP A 371
GLY A 638
ILE A 595
 None
 0.90A 2fxdB-4fwtA:
undetectable		 2fxdB-4fwtA:
6.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		5 / 12 ASN A 558
ALA A 490
ILE A 491
VAL A 516
ILE A 521
 None
 0.91A 2h42B-4fwtA:
undetectable		 2h42B-4fwtA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		4 / 8 ILE A 491
GLU A 552
ILE A 520
GLU A 557
 None
 0.71A 2j9dJ-4fwtA:
1.8
2j9dK-4fwtA:
undetectable
2j9dL-4fwtA:
undetectable		 2j9dJ-4fwtA:
7.08
2j9dK-4fwtA:
7.08
2j9dL-4fwtA:
7.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_A_ANWA99_0
(PROTEIN S100-A13)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		4 / 7 VAL A 645
THR A 646
PHE A 589
LYS A 675
 None
 1.24A 2kotA-4fwtA:
undetectable		 2kotA-4fwtA:
5.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		5 / 12 TYR A 735
LEU A 731
ILE A 769
ALA A1137
ARG A 761
 None
 1.34A 2qo4A-4fwtA:
undetectable		 2qo4A-4fwtA:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		5 / 12 TYR A 735
LEU A 731
ILE A 769
ALA A1137
ARG A 761
 None
 1.32A 2qo6A-4fwtA:
undetectable		 2qo6A-4fwtA:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		3 / 3 LEU A 934
GLU A1026
ILE A1029
 None
GTP  A2501 (-2.5A)
None
 0.56A 3czhA-4fwtA:
undetectable		 3czhA-4fwtA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		4 / 5 ALA A 314
ALA A 362
TYR A 361
MET A 383
 None
 1.03A 3d91A-4fwtA:
undetectable		 3d91A-4fwtA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		3 / 3 ALA A 660
THR A 667
CYH A1240
 None
 0.80A 3e4eA-4fwtA:
undetectable		 3e4eA-4fwtA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		5 / 12 PHE A 589
VAL A 645
LEU A 647
ILE A 626
TYR A 611
 None
 1.36A 3elzA-4fwtA:
undetectable		 3elzA-4fwtA:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_B_ICFB2_1
(INTEGRIN ALPHA-L)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		5 / 9 ILE A1117
ILE A1188
LEU A1152
LEU A1148
TYR A1141
 None
 1.40A 3f78B-4fwtA:
4.2		 3f78B-4fwtA:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		4 / 8 GLY A 669
ILE A 626
PHE A 659
PHE A 617
 None
 0.88A 3ko0B-4fwtA:
undetectable
3ko0J-4fwtA:
undetectable		 3ko0B-4fwtA:
6.15
3ko0J-4fwtA:
6.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		5 / 12 ALA A1165
PRO A1158
GLY A1160
PRO A1186
LEU A 709
 None
 1.09A 3m6vB-4fwtA:
undetectable		 3m6vB-4fwtA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_2
(HIV-1 PROTEASE)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		5 / 11 LEU A 388
ASP A 446
GLY A 411
VAL A 410
ILE A 415
 None
 0.95A 3oxxD-4fwtA:
undetectable		 3oxxD-4fwtA:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		5 / 12 ALA A 386
HIS A 403
ASP A 384
MET A 383
HIS A 363
 None
 1.41A 3pfgA-4fwtA:
undetectable		 3pfgA-4fwtA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S68_A_SAMA228_0
(CATECHOL
O-METHYLTRANSFERASE)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		5 / 10 GLU A 470
GLY A 465
SER A 283
GLN A 282
ASP A 466
 None
 1.24A 3s68A-4fwtA:
2.5		 3s68A-4fwtA:
11.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		5 / 9 THR A1022
TYR A1051
GLY A1052
ASP A1053
ASP A1054
 None
C  G2008 ( 4.8A)
C  G2008 ( 4.0A)
CA  A2502 (-2.7A)
CA  A2503 (-3.5A)
 1.05A 3sfuA-4fwtA:
11.0		 3sfuA-4fwtA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		5 / 12 VAL A 455
ILE A 387
ILE A 316
VAL A 319
LEU A 320
 None
 1.03A 3w68D-4fwtA:
3.7		 3w68D-4fwtA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_A_CCSA109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		4 / 8 PHE A  89
VAL A  83
ILE A 126
ALA A 121
 None
 0.89A 4eyzA-4fwtA:
undetectable		 4eyzA-4fwtA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_B_CCSB109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		4 / 8 PHE A  89
VAL A  83
ILE A 126
ALA A 121
 None
 0.88A 4eyzB-4fwtA:
undetectable		 4eyzB-4fwtA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		4 / 5 ALA A  30
ILE A  38
LEU A  12
ASN A  40
 None
 1.20A 4g19A-4fwtA:
undetectable		 4g19A-4fwtA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J14_A_X2NA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		5 / 10 ALA A 251
LEU A 246
VAL A 242
ILE A 181
ALA A 170
 None
 0.99A 4j14A-4fwtA:
undetectable		 4j14A-4fwtA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8W_G_MTXG301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		5 / 9 PHE A 659
GLY A 602
GLY A 669
LEU A 596
GLU A 600
 None
 1.18A 4l8wG-4fwtA:
4.3		 4l8wG-4fwtA:
12.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8W_I_MTXI301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		5 / 9 PHE A 659
GLY A 602
GLY A 669
LEU A 596
GLU A 600
 None
 1.10A 4l8wI-4fwtA:
4.2		 4l8wI-4fwtA:
12.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		4 / 6 GLU A 260
ASP A  59
ASP A  81
ASN A 640
 None
 1.41A 4ntxA-4fwtA:
undetectable
4ntxC-4fwtA:
2.2		 4ntxA-4fwtA:
16.72
4ntxC-4fwtA:
6.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		4 / 6 ILE A 415
GLY A 385
ILE A 316
ILE A 302
 None
 0.69A 4o8fB-4fwtA:
undetectable		 4o8fB-4fwtA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_0
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		5 / 12 ARG A 151
GLY A 149
ALA A 150
ALA A 370
VAL A 373
 None
 1.35A 4ryaA-4fwtA:
undetectable		 4ryaA-4fwtA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		4 / 6 SER A 458
GLY A 465
GLU A 464
ASP A 466
 None
 0.92A 4uckB-4fwtA:
undetectable		 4uckB-4fwtA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		5 / 12 MET A 171
VAL A 173
GLY A 144
TYR A 146
ILE A  66
 None
 1.38A 4xucA-4fwtA:
undetectable		 4xucA-4fwtA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		4 / 6 ASN A 420
ASP A 306
THR A 301
VAL A 389
 None
 1.14A 4yoaA-4fwtA:
undetectable		 4yoaA-4fwtA:
5.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKW_A_TESA601_1
(AROMATASE)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		5 / 11 ASP A1255
THR A1189
VAL A1187
VAL A1185
LEU A 709
 None
 1.40A 5jkwA-4fwtA:
undetectable		 5jkwA-4fwtA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		4 / 5 ALA A 315
ALA A 462
ILE A 473
LEU A 474
 None
 0.79A 5jncD-4fwtA:
undetectable		 5jncD-4fwtA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		4 / 6 THR A 254
GLY A 255
PHE A 256
ILE A  73
 None
 0.88A 5kmfA-4fwtA:
undetectable
5kmfC-4fwtA:
undetectable		 5kmfA-4fwtA:
12.17
5kmfC-4fwtA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUK_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		5 / 10 ALA A 578
VAL A 527
ILE A 566
ILE A 571
VAL A 512
 None
 1.22A 5nukA-4fwtA:
undetectable		 5nukA-4fwtA:
5.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_2
(WTFP-TAG,GP41)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		3 / 3 LEU A1120
LEU A1123
TRP A1126
 None
 0.82A 5nwuA-4fwtA:
undetectable		 5nwuA-4fwtA:
2.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_1
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		4 / 5 GLY A 638
ASP A 639
MET A 636
GLN A 147
 None
 1.47A 5ubbA-4fwtA:
undetectable		 5ubbA-4fwtA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_0
(REGULATORY PROTEIN
TETR)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		5 / 12 ALA A1031
LEU A 832
ILE A 833
TYR A1021
CYH A 981
 None
 1.28A 5vlmA-4fwtA:
2.5		 5vlmA-4fwtA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7J_A_TESA502_0
(CYTOCHROME P450)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		4 / 7 LEU A  74
LEU A  97
ALA A  99
ALA A 100
 None
 0.85A 6a7jA-4fwtA:
undetectable		 6a7jA-4fwtA:
5.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		5 / 12 VAL A1050
LEU A 980
LEU A1033
LEU A 984
LEU A 934
 None
 0.97A 6b0cD-4fwtA:
3.6		 6b0cD-4fwtA:
4.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		5 / 12 VAL A 235
GLY A 602
VAL A 668
PRO A 613
GLY A1180
 None
 1.11A 6brdC-4fwtA:
undetectable		 6brdC-4fwtA:
4.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		5 / 9 LEU A 419
PRO A 396
VAL A 417
SER A 443
LEU A 441
 None
 1.18A 6fdyU-4fwtA:
undetectable		 6fdyU-4fwtA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA812_0
(GEPHYRIN)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		4 / 6 GLU A 263
ARG A 134
PHE A 259
VAL A 154
 None
 1.08A 6fgdA-4fwtA:
undetectable		 6fgdA-4fwtA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		3 / 3 ASP A 968
ASP A 974
ASN A 901
 CA  A2502 (-2.7A)
None
None
 0.72A 6gngB-4fwtA:
4.1		 6gngB-4fwtA:
19.02