SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fwv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_1
(ESTROGEN RECEPTOR)		 4fwv TTC1975 PEPTIDASE
(Meiothermus
taiwanensis) 		5 / 12 GLU A  98
LEU A  79
LEU A 255
LEU A 228
LEU A 217
 None
 1.11A 1errB-4fwvA:
undetectable		 1errB-4fwvA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_C_9PLC1_1
(CYTOCHROME P450 2A13)		 4fwv TTC1975 PEPTIDASE
(Meiothermus
taiwanensis) 		4 / 7 PHE A 278
PHE A 326
ALA A 272
LEU A 310
 None
 0.99A 3t3sC-4fwvA:
undetectable		 3t3sC-4fwvA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K13_A_ETSA304_1
(CARBONIC ANHYDRASE 2)		 4fwv TTC1975 PEPTIDASE
(Meiothermus
taiwanensis) 		5 / 12 HIS A 303
VAL A  88
LEU A 347
VAL A 349
LEU A 281
 None
 1.00A 4k13A-4fwvA:
undetectable		 4k13A-4fwvA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2W_A_ETSA302_1
(CARBONIC ANHYDRASE 2)		 4fwv TTC1975 PEPTIDASE
(Meiothermus
taiwanensis) 		5 / 12 HIS A 303
VAL A  88
LEU A 347
VAL A 349
LEU A 281
 None
 0.96A 4m2wA-4fwvA:
undetectable		 4m2wA-4fwvA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XIW_G_AZMG402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 4fwv TTC1975 PEPTIDASE
(Meiothermus
taiwanensis) 		5 / 12 HIS A 303
VAL A  88
LEU A 347
VAL A 349
LEU A 281
 None
 0.95A 4xiwG-4fwvA:
undetectable		 4xiwG-4fwvA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1007_1
(SERUM ALBUMIN)		 4fwv TTC1975 PEPTIDASE
(Meiothermus
taiwanensis) 		5 / 9 ARG A  36
LEU A  39
LEU A  67
ILE A 311
ALA A  62
 None
 1.36A 4z69A-4fwvA:
3.1		 4z69A-4fwvA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4fwv TTC1975 PEPTIDASE
(Meiothermus
taiwanensis) 		4 / 6 SER A 316
ARG A 276
GLU A 269
TYR A 271
 None
 1.47A 5x7pB-4fwvA:
undetectable		 5x7pB-4fwvA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Q_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4fwv TTC1975 PEPTIDASE
(Meiothermus
taiwanensis) 		4 / 6 SER A 316
ARG A 276
GLU A 269
TYR A 271
 None
 1.49A 5x7qA-4fwvA:
undetectable		 5x7qA-4fwvA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7R_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4fwv TTC1975 PEPTIDASE
(Meiothermus
taiwanensis) 		4 / 6 SER A 316
ARG A 276
GLU A 269
TYR A 271
 None
 1.49A 5x7rA-4fwvA:
undetectable		 5x7rA-4fwvA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BER_A_DVAA2_0
(E(DVA)DP(DGL)(DHI)(D
PR)N(DAL)(DPR))		 4fwv TTC1975 PEPTIDASE
(Meiothermus
taiwanensis) 		3 / 3 GLU A 320
ASP A 313
PRO A 270
 None
SO4  A 401 ( 4.9A)
None
 0.74A 6berA-4fwvA:
undetectable		 6berA-4fwvA:
3.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_B_STRB502_1
(CYTOCHROME P450
CYP260A1)		 4fwv TTC1975 PEPTIDASE
(Meiothermus
taiwanensis) 		4 / 6 LEU A 310
ALA A 301
LEU A 317
THR A 322
 None
 0.92A 6f88B-4fwvA:
undetectable		 6f88B-4fwvA:
14.16