SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fww'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX8_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO)		 4fww MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		5 / 12 LEU A 346
ALA A 324
ARG A 185
TYR A 249
PHE A 400
 None
None
EDO  A 616 ( 3.3A)
None
SO4  A 605 (-4.7A)
 1.26A 1mx8A-4fwwA:
undetectable		 1mx8A-4fwwA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4fww MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		5 / 12 PHE A 439
SER A 364
LEU A 451
VAL A 453
VAL A 366
 None
 1.30A 1q23B-4fwwA:
undetectable		 1q23B-4fwwA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4fww MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		5 / 12 PHE A 439
SER A 364
LEU A 451
VAL A 453
VAL A 366
 None
 1.27A 1q23C-4fwwA:
undetectable		 1q23C-4fwwA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4fww MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		5 / 10 PHE A 439
SER A 364
LEU A 451
VAL A 453
VAL A 366
 None
 1.28A 1q23E-4fwwA:
undetectable		 1q23E-4fwwA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_F_FUAF704_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4fww MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		5 / 11 PHE A 439
SER A 364
LEU A 451
VAL A 453
VAL A 366
 None
 1.25A 1q23F-4fwwA:
undetectable		 1q23F-4fwwA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4fww MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		5 / 11 PHE A 439
SER A 364
LEU A 451
VAL A 453
VAL A 366
 None
 1.28A 1q23I-4fwwA:
undetectable		 1q23I-4fwwA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4fww MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		5 / 10 PHE A 439
SER A 364
LEU A 451
VAL A 453
VAL A 366
 None
 1.36A 1q23K-4fwwA:
undetectable		 1q23K-4fwwA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 4fww MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		5 / 11 LEU A 296
LEU A 298
SER A 326
LEU A 346
LEU A 280
 None
 1.03A 2ceoA-4fwwA:
undetectable		 2ceoA-4fwwA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 4fww MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		5 / 12 LEU A 235
LEU A 398
ILE A 247
THR A 263
ILE A 218
 None
SO4  A 605 (-4.6A)
None
None
None
 1.10A 2jn3A-4fwwA:
undetectable		 2jn3A-4fwwA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 4fww MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		5 / 10 LEU A 296
LEU A 298
SER A 326
LEU A 346
LEU A 280
 None
 1.00A 2xn7A-4fwwA:
undetectable
2xn7B-4fwwA:
undetectable		 2xn7A-4fwwA:
20.48
2xn7B-4fwwA:
7.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		 4fww MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		4 / 7 SER A 134
HIS A 146
THR A  93
LEU A  91
 ACT  A 610 (-3.1A)
None
ACT  A 610 (-3.7A)
None
 1.21A 3arrA-4fwwA:
undetectable		 3arrA-4fwwA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4fww MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		3 / 3 SER A 513
GLY A 495
GLY A 492
 None
 0.42A 3bogA-4fwwA:
undetectable
3bogC-4fwwA:
undetectable		 3bogA-4fwwA:
undetectable
3bogC-4fwwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 4fww MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		5 / 12 THR A 255
LEU A 374
ALA A 324
ALA A 327
VAL A 329
 None
 1.13A 3czhB-4fwwA:
undetectable		 3czhB-4fwwA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IEO_A_AMJA300_0
(CARBONIC ANHYDRASE 2)		 4fww MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		4 / 4 ILE A 471
GLN A 473
VAL A 520
PHE A 511
 None
 1.45A 3ieoA-4fwwA:
undetectable		 3ieoA-4fwwA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 4fww MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		4 / 8 ALA A 327
SER A 326
ARG A 504
TYR A 452
 None
None
None
EDO  A 617 (-4.8A)
 1.16A 4ijiF-4fwwA:
undetectable		 4ijiF-4fwwA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 4fww MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		5 / 12 PHE A 258
TYR A 260
PHE A 253
LEU A 298
LEU A 262
 None
 1.28A 4j03A-4fwwA:
undetectable		 4j03A-4fwwA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4fww MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		3 / 3 LEU A 262
ARG A 185
MET A  58
 None
EDO  A 616 ( 3.3A)
None
 0.99A 4m11C-4fwwA:
undetectable		 4m11C-4fwwA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4fww MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		5 / 9 ALA A  73
ALA A  57
GLY A  52
GLY A  53
ASP A 119
 None
ACT  A 611 ( 3.7A)
None
None
None
 1.17A 4qwuK-4fwwA:
undetectable
4qwuL-4fwwA:
undetectable		 4qwuK-4fwwA:
16.35
4qwuL-4fwwA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4fww MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		4 / 5 GLN A 519
PRO A 521
ILE A 522
ASP A 507
 None
 1.37A 4z4hA-4fwwA:
undetectable		 4z4hA-4fwwA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_C_FUAC1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4fww MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		3 / 3 VAL A 498
HIS A 463
VAL A 520
 None
 0.70A 5jmnC-4fwwA:
undetectable		 5jmnC-4fwwA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 4fww MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		4 / 8 THR A 263
HIS A 277
PHE A 400
TYR A 249
 None
None
SO4  A 605 (-4.7A)
None
 1.24A 5v4vA-4fwwA:
undetectable		 5v4vA-4fwwA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 4fww MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		4 / 8 THR A 263
HIS A 277
PHE A 400
TYR A 249
 None
None
SO4  A 605 (-4.7A)
None
 1.25A 5v4vB-4fwwA:
undetectable		 5v4vB-4fwwA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 4fww MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens) 		5 / 12 VAL A 461
THR A 454
LEU A 483
LEU A 443
VAL A 366
 None
 1.27A 6a93B-4fwwA:
undetectable		 6a93B-4fwwA:
21.03