SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fx0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_C_DVAC6_0
(GRAMICIDIN A)		 4fx0 PROBABLE
TRANSCRIPTIONAL
REPRESSOR PROTEIN
(Mycobacterium
tuberculosis) 		3 / 3 ALA A 138
VAL A 133
TRP A 130
 None
 0.86A 1av2C-4fx0A:
undetectable
1av2D-4fx0A:
undetectable		 1av2C-4fx0A:
7.97
1av2D-4fx0A:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_1
(FK506-BINDING
PROTEIN)		 4fx0 PROBABLE
TRANSCRIPTIONAL
REPRESSOR PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 GLU A  69
VAL A  68
ILE A  66
ILE A  99
ILE A  46
 None
 0.93A 1fapA-4fx0A:
undetectable		 1fapA-4fx0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKL_A_RAPA108_1
(FK506 BINDING
PROTEIN)		 4fx0 PROBABLE
TRANSCRIPTIONAL
REPRESSOR PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 GLU A  69
VAL A  68
ILE A  66
ILE A  99
ILE A  46
 None
 1.06A 1fklA-4fx0A:
undetectable		 1fklA-4fx0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 4fx0 PROBABLE
TRANSCRIPTIONAL
REPRESSOR PROTEIN
(Mycobacterium
tuberculosis) 		5 / 11 GLY A  23
ALA A  25
ALA A  29
LEU A  30
VAL A 123
 None
 1.07A 1ukbA-4fx0A:
undetectable		 1ukbA-4fx0A:
20.85