SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fx5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_2
(PROTEIN (PROTEASE))		 4fx5 VON WILLEBRAND
FACTOR TYPE A
(Catenulispora
acidiphila) 		5 / 12 ALA A 159
VAL A  96
ILE A 148
GLY A 146
ILE A  59
 None
 0.90A 1c6zB-4fx5A:
undetectable		 1c6zB-4fx5A:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_1
(HIV-1 PROTEASE)		 4fx5 VON WILLEBRAND
FACTOR TYPE A
(Catenulispora
acidiphila) 		5 / 10 ALA A 159
VAL A  96
ILE A 148
GLY A 146
ILE A  59
 None
 0.91A 1hsgA-4fx5A:
undetectable		 1hsgA-4fx5A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)		 4fx5 VON WILLEBRAND
FACTOR TYPE A
(Catenulispora
acidiphila) 		5 / 12 ILE A  11
GLN A  13
ALA A 333
ARG A 312
GLU A 328
 None
 1.36A 1ki7B-4fx5A:
undetectable		 1ki7B-4fx5A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_2
(PROTEASE)		 4fx5 VON WILLEBRAND
FACTOR TYPE A
(Catenulispora
acidiphila) 		5 / 11 ALA A 159
VAL A  96
ILE A 148
GLY A 146
ILE A  59
 None
 0.93A 1n49B-4fx5A:
undetectable		 1n49B-4fx5A:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_1
(PROTEASE)		 4fx5 VON WILLEBRAND
FACTOR TYPE A
(Catenulispora
acidiphila) 		5 / 11 ALA A 159
VAL A  96
ILE A 148
GLY A 146
ILE A  59
 None
 0.90A 1n49C-4fx5A:
undetectable		 1n49C-4fx5A:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 4fx5 VON WILLEBRAND
FACTOR TYPE A
(Catenulispora
acidiphila) 		4 / 7 ALA A 132
ASP A  67
ILE A  60
ASP A  61
 None
None
None
NA  A 501 ( 3.8A)
 0.95A 1yc5A-4fx5A:
4.8		 1yc5A-4fx5A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_1
(PROTEASE RETROPEPSIN)		 4fx5 VON WILLEBRAND
FACTOR TYPE A
(Catenulispora
acidiphila) 		5 / 12 ALA A 159
VAL A  96
ILE A 148
GLY A 146
ILE A  59
 None
 0.93A 2q64A-4fx5A:
undetectable		 2q64A-4fx5A:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_NCAA493_0
(CHORISMATE SYNTHASE)		 4fx5 VON WILLEBRAND
FACTOR TYPE A
(Catenulispora
acidiphila) 		5 / 11 ARG A 147
ALA A 102
ILE A  59
ALA A 143
ALA A 145
 None
 1.15A 2qhfA-4fx5A:
undetectable		 2qhfA-4fx5A:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4fx5 VON WILLEBRAND
FACTOR TYPE A
(Catenulispora
acidiphila) 		4 / 5 ILE A 216
ARG A 227
MET A 229
THR A 230
 None
 1.27A 3abkN-4fx5A:
undetectable
3abkW-4fx5A:
undetectable		 3abkN-4fx5A:
21.46
3abkW-4fx5A:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 4fx5 VON WILLEBRAND
FACTOR TYPE A
(Catenulispora
acidiphila) 		3 / 3 SER A  65
GLU A 168
ASP A 196
 NA  A 501 (-2.2A)
None
None
 0.73A 3bwmA-4fx5A:
undetectable		 3bwmA-4fx5A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 4fx5 VON WILLEBRAND
FACTOR TYPE A
(Catenulispora
acidiphila) 		3 / 3 SER A  65
GLU A 168
ASP A 196
 NA  A 501 (-2.2A)
None
None
 0.77A 3bwyA-4fx5A:
undetectable		 3bwyA-4fx5A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_2
(CYTOCHROME P450 2R1)		 4fx5 VON WILLEBRAND
FACTOR TYPE A
(Catenulispora
acidiphila) 		3 / 3 MET A 358
VAL A 435
GLU A 390
 None
 0.77A 3c6gA-4fx5A:
undetectable		 3c6gA-4fx5A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_2
(PROTEASE)		 4fx5 VON WILLEBRAND
FACTOR TYPE A
(Catenulispora
acidiphila) 		5 / 9 LEU A 161
VAL A  96
ILE A 148
GLY A 146
ILE A  59
 None
 1.06A 3ekqB-4fx5A:
undetectable		 3ekqB-4fx5A:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_2
(PROTEASE)		 4fx5 VON WILLEBRAND
FACTOR TYPE A
(Catenulispora
acidiphila) 		5 / 11 ALA A 159
VAL A  96
ILE A 148
GLY A 146
ILE A  59
 None
 0.96A 3ekxB-4fx5A:
undetectable		 3ekxB-4fx5A:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA424_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4fx5 VON WILLEBRAND
FACTOR TYPE A
(Catenulispora
acidiphila) 		4 / 8 LEU A 400
ARG A 380
ARG A 383
GLY A 354
 None
 1.04A 3hcrA-4fx5A:
4.8		 3hcrA-4fx5A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 4fx5 VON WILLEBRAND
FACTOR TYPE A
(Catenulispora
acidiphila) 		5 / 10 PHE A 186
ALA A 143
ILE A  59
VAL A  96
VAL A  57
 None
 1.06A 3me6A-4fx5A:
undetectable		 3me6A-4fx5A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4fx5 VON WILLEBRAND
FACTOR TYPE A
(Catenulispora
acidiphila) 		5 / 12 GLY A 284
ILE A 179
GLY A 184
PHE A 186
ALA A 188
 None
 0.91A 3sudB-4fx5A:
undetectable		 3sudB-4fx5A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4fx5 VON WILLEBRAND
FACTOR TYPE A
(Catenulispora
acidiphila) 		5 / 12 GLY A 284
ILE A 179
GLY A 184
PHE A 186
ALA A 188
 None
 0.92A 3sudC-4fx5A:
undetectable		 3sudC-4fx5A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4fx5 VON WILLEBRAND
FACTOR TYPE A
(Catenulispora
acidiphila) 		5 / 12 GLY A 284
ILE A 179
GLY A 184
PHE A 186
ALA A 188
 None
 0.91A 3sueA-4fx5A:
undetectable		 3sueA-4fx5A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4fx5 VON WILLEBRAND
FACTOR TYPE A
(Catenulispora
acidiphila) 		5 / 12 GLY A 284
ILE A 179
GLY A 184
PHE A 186
ALA A 188
 None
 0.93A 3sufB-4fx5A:
undetectable		 3sufB-4fx5A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4fx5 VON WILLEBRAND
FACTOR TYPE A
(Catenulispora
acidiphila) 		5 / 12 GLY A 284
ILE A 179
GLY A 184
PHE A 186
ALA A 188
 None
 0.93A 3sufD-4fx5A:
undetectable		 3sufD-4fx5A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPN_B_ZMRB700_1
(NEURAMINIDASE)		 4fx5 VON WILLEBRAND
FACTOR TYPE A
(Catenulispora
acidiphila) 		5 / 12 ASP A 189
ARG A 191
ALA A 285
GLU A 289
ARG A 291
 None
 1.45A 4cpnB-4fx5A:
undetectable		 4cpnB-4fx5A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 4fx5 VON WILLEBRAND
FACTOR TYPE A
(Catenulispora
acidiphila) 		5 / 12 GLY A 135
LEU A 162
GLY A 192
ASP A 167
LEU A 202
 None
 0.91A 4fp9A-4fx5A:
undetectable		 4fp9A-4fx5A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 4fx5 VON WILLEBRAND
FACTOR TYPE A
(Catenulispora
acidiphila) 		5 / 12 GLY A 135
LEU A 162
GLY A 192
ASP A 167
LEU A 202
 None
 0.90A 4fp9C-4fx5A:
undetectable		 4fp9C-4fx5A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 4fx5 VON WILLEBRAND
FACTOR TYPE A
(Catenulispora
acidiphila) 		5 / 12 GLY A 135
LEU A 162
GLY A 192
ASP A 167
LEU A 202
 None
 0.90A 4fp9F-4fx5A:
undetectable		 4fp9F-4fx5A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4fx5 VON WILLEBRAND
FACTOR TYPE A
(Catenulispora
acidiphila) 		3 / 3 PRO A 301
VAL A  24
HIS A  25
 None
 0.61A 4pevC-4fx5A:
3.1		 4pevC-4fx5A:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_2
(PROTEASE)		 4fx5 VON WILLEBRAND
FACTOR TYPE A
(Catenulispora
acidiphila) 		5 / 11 ALA A 159
VAL A  96
ILE A 148
GLY A 146
ILE A  59
 None
 0.90A 4qgiB-4fx5A:
undetectable		 4qgiB-4fx5A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_J_SPMJ202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4fx5 VON WILLEBRAND
FACTOR TYPE A
(Catenulispora
acidiphila) 		4 / 7 TRP A 141
GLU A 201
GLU A 198
ARG A 203
 None
 1.46A 4r87J-4fx5A:
undetectable
4r87L-4fx5A:
undetectable		 4r87J-4fx5A:
15.95
4r87L-4fx5A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4fx5 VON WILLEBRAND
FACTOR TYPE A
(Catenulispora
acidiphila) 		3 / 3 SER A  65
GLU A 168
ASP A 196
 NA  A 501 (-2.2A)
None
None
 0.80A 4xudA-4fx5A:
undetectable		 4xudA-4fx5A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_2
(PROTEASE E35D-SQV)		 4fx5 VON WILLEBRAND
FACTOR TYPE A
(Catenulispora
acidiphila) 		5 / 9 LEU A 161
VAL A  96
ILE A 148
GLY A 146
ILE A  59
 None
 1.13A 5kqxB-4fx5A:
undetectable		 5kqxB-4fx5A:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_B_PQNB1844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4fx5 VON WILLEBRAND
FACTOR TYPE A
(Catenulispora
acidiphila) 		5 / 10 MET A 229
ILE A  60
ALA A  76
LEU A 222
ALA A 223
 None
 1.49A 5oy0b-4fx5A:
undetectable		 5oy0b-4fx5A:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 4fx5 VON WILLEBRAND
FACTOR TYPE A
(Catenulispora
acidiphila) 		5 / 12 ALA A  34
GLY A 287
GLY A 235
ILE A 156
GLU A  53
 None
 1.15A 5ul4A-4fx5A:
4.1		 5ul4A-4fx5A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 4fx5 VON WILLEBRAND
FACTOR TYPE A
(Catenulispora
acidiphila) 		4 / 7 ILE A 216
ARG A 227
MET A 229
THR A 230
 None
 0.98A 5xdxA-4fx5A:
2.6
5xdxJ-4fx5A:
undetectable		 5xdxA-4fx5A:
21.46
5xdxJ-4fx5A:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)		 4fx5 VON WILLEBRAND
FACTOR TYPE A
(Catenulispora
acidiphila) 		5 / 12 GLY A 284
ILE A 179
GLY A 184
PHE A 186
ALA A 188
 None
 0.91A 6c2mA-4fx5A:
undetectable		 6c2mA-4fx5A:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 4fx5 VON WILLEBRAND
FACTOR TYPE A
(Catenulispora
acidiphila) 		5 / 12 GLY A 284
ILE A 179
GLY A 184
PHE A 186
ALA A 188
 None
 0.89A 6c2mB-4fx5A:
undetectable		 6c2mB-4fx5A:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_0
(NS3 PROTEASE)		 4fx5 VON WILLEBRAND
FACTOR TYPE A
(Catenulispora
acidiphila) 		5 / 12 GLY A 284
ILE A 179
GLY A 184
PHE A 186
ALA A 188
 None
 0.96A 6c2mD-4fx5A:
undetectable		 6c2mD-4fx5A:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_0
(PROTEASE)		 4fx5 VON WILLEBRAND
FACTOR TYPE A
(Catenulispora
acidiphila) 		5 / 12 ALA A 159
VAL A  96
ILE A 148
GLY A 146
ILE A  59
 None
 0.99A 6dh6A-4fx5A:
undetectable		 6dh6A-4fx5A:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA825_0
(GEPHYRIN)		 4fx5 VON WILLEBRAND
FACTOR TYPE A
(Catenulispora
acidiphila) 		3 / 3 LYS A 318
VAL A 316
ASP A 240
 None
 0.71A 6fgdA-4fx5A:
3.7		 6fgdA-4fx5A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_B_PQNB2002_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4fx5 VON WILLEBRAND
FACTOR TYPE A
(Catenulispora
acidiphila) 		5 / 9 MET A 229
ILE A  60
ALA A  76
LEU A 222
ALA A 223
 None
 1.42A 6hqbB-4fx5A:
undetectable		 6hqbB-4fx5A:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J21_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 4fx5 VON WILLEBRAND
FACTOR TYPE A
(Catenulispora
acidiphila) 		5 / 12 ILE A  59
VAL A  95
ILE A 205
HIS A 158
PHE A 226
 None
 1.49A 6j21A-4fx5A:
undetectable		 6j21A-4fx5A:
22.67