SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fxb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_2
(ESTROGEN RECEPTOR)		 4fxb PUTATIVE CYTOCHROME
P450
(Streptomyces
coelicolor) 		4 / 6 LEU A 265
ASP A 267
MET A 257
LEU A 370
 None
 1.01A 1errB-4fxbA:
2.1		 1errB-4fxbA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J78_B_VDYB500_1
(VITAMIN D BINDING
PROTEIN)		 4fxb PUTATIVE CYTOCHROME
P450
(Streptomyces
coelicolor) 		5 / 10 GLU A 375
LEU A 138
TYR A 154
LEU A 150
SER A 261
 None
 1.41A 1j78B-4fxbA:
1.9		 1j78B-4fxbA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_2
(ESTROGEN RECEPTOR)		 4fxb PUTATIVE CYTOCHROME
P450
(Streptomyces
coelicolor) 		4 / 5 LEU A 265
ASP A 267
MET A 257
LEU A 370
 None
 1.06A 2jfaA-4fxbA:
undetectable		 2jfaA-4fxbA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4fxb PUTATIVE CYTOCHROME
P450
(Streptomyces
coelicolor) 		3 / 3 VAL A 286
ASP A 287
GLU A 371
 None
 0.75A 2qeuC-4fxbA:
undetectable		 2qeuC-4fxbA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_2
(ESTROGEN RECEPTOR)		 4fxb PUTATIVE CYTOCHROME
P450
(Streptomyces
coelicolor) 		4 / 5 LEU A 265
ASP A 267
MET A 257
LEU A 370
 None
 0.98A 2qxsA-4fxbA:
1.1		 2qxsA-4fxbA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_2
(ESTROGEN RECEPTOR)		 4fxb PUTATIVE CYTOCHROME
P450
(Streptomyces
coelicolor) 		4 / 5 LEU A 265
ASP A 267
MET A 257
LEU A 370
 None
 0.99A 2qxsB-4fxbA:
2.0		 2qxsB-4fxbA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAT_A_CLMA301_0
(XENOBIOTIC
ACETYLTRANSFERASE)		 4fxb PUTATIVE CYTOCHROME
P450
(Streptomyces
coelicolor) 		3 / 3 GLY A 356
TYR A 355
SER A  69
 None
 0.66A 2xatA-4fxbA:
undetectable		 2xatA-4fxbA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 4fxb PUTATIVE CYTOCHROME
P450
(Streptomyces
coelicolor) 		3 / 3 ALA A 249
THR A 253
CYH A 360
 HEM  A 501 (-3.1A)
HEM  A 501 (-3.9A)
HEM  A 501 (-2.1A)
 0.54A 3e4eA-4fxbA:
27.8		 3e4eA-4fxbA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 4fxb PUTATIVE CYTOCHROME
P450
(Streptomyces
coelicolor) 		3 / 3 ALA A 249
THR A 253
CYH A 360
 HEM  A 501 (-3.1A)
HEM  A 501 (-3.9A)
HEM  A 501 (-2.1A)
 0.49A 3e4eB-4fxbA:
27.7		 3e4eB-4fxbA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 4fxb PUTATIVE CYTOCHROME
P450
(Streptomyces
coelicolor) 		5 / 12 LEU A 325
GLN A 359
LEU A  68
GLY A 356
HIS A 358
 HEM  A 501 (-4.8A)
None
None
None
HEM  A 501 (-3.2A)
 1.24A 3g1uB-4fxbA:
undetectable		 3g1uB-4fxbA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_A_ADNA439_1
(ADENOSYLHOMOCYSTEINA
SE)		 4fxb PUTATIVE CYTOCHROME
P450
(Streptomyces
coelicolor) 		5 / 10 LEU A 325
GLN A 359
LEU A  68
GLY A 356
HIS A 358
 HEM  A 501 (-4.8A)
None
None
None
HEM  A 501 (-3.2A)
 1.29A 3h9uA-4fxbA:
undetectable		 3h9uA-4fxbA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 4fxb PUTATIVE CYTOCHROME
P450
(Streptomyces
coelicolor) 		5 / 10 LEU A 325
GLN A 359
LEU A  68
GLY A 356
HIS A 358
 HEM  A 501 (-4.8A)
None
None
None
HEM  A 501 (-3.2A)
 1.29A 3h9uD-4fxbA:
undetectable		 3h9uD-4fxbA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 4fxb PUTATIVE CYTOCHROME
P450
(Streptomyces
coelicolor) 		5 / 10 LEU A 205
ILE A 169
PRO A 170
SER A 222
GLY A 168
 None
 1.28A 3ijxB-4fxbA:
undetectable
3ijxD-4fxbA:
undetectable		 3ijxB-4fxbA:
19.95
3ijxD-4fxbA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 4fxb PUTATIVE CYTOCHROME
P450
(Streptomyces
coelicolor) 		4 / 5 LEU A 198
LEU A 201
LEU A 240
SER A 241
 None
 0.90A 3vhuA-4fxbA:
undetectable		 3vhuA-4fxbA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 4fxb PUTATIVE CYTOCHROME
P450
(Streptomyces
coelicolor) 		4 / 6 GLU A 270
ASP A 337
GLU A 339
ARG A 345
 None
 1.41A 4ntxA-4fxbA:
0.8
4ntxC-4fxbA:
undetectable		 4ntxA-4fxbA:
20.75
4ntxC-4fxbA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_2
(CYTOCHROME P450 2D6)		 4fxb PUTATIVE CYTOCHROME
P450
(Streptomyces
coelicolor) 		3 / 3 GLU A  91
ILE A 322
ALA A  75
 None
 0.65A 4wnwB-4fxbA:
29.6		 4wnwB-4fxbA:
26.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4fxb PUTATIVE CYTOCHROME
P450
(Streptomyces
coelicolor) 		3 / 3 VAL A 409
LEU A 293
MET A 257
 None
 0.65A 5ikrA-4fxbA:
undetectable		 5ikrA-4fxbA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4fxb PUTATIVE CYTOCHROME
P450
(Streptomyces
coelicolor) 		4 / 5 TYR A  35
ASP A 331
PRO A 332
ALA A 328
 None
 1.01A 5otrA-4fxbA:
undetectable		 5otrA-4fxbA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4fxb PUTATIVE CYTOCHROME
P450
(Streptomyces
coelicolor) 		4 / 7 ILE A 163
LEU A 167
ARG A 182
LEU A 201
 HEM  A 501 ( 4.7A)
None
None
None
 0.96A 5zcqA-4fxbA:
undetectable
5zcqJ-4fxbA:
undetectable		 5zcqA-4fxbA:
21.70
5zcqJ-4fxbA:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AOG_A_CP6A704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4fxb PUTATIVE CYTOCHROME
P450
(Streptomyces
coelicolor) 		5 / 10 VAL A 158
THR A 376
VAL A 134
TYR A 154
THR A 254
 None
None
None
None
HEM  A 501 (-4.0A)
 1.46A 6aogA-4fxbA:
undetectable		 6aogA-4fxbA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AOG_B_CP6B704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4fxb PUTATIVE CYTOCHROME
P450
(Streptomyces
coelicolor) 		5 / 10 VAL A 158
THR A 376
VAL A 134
TYR A 154
THR A 254
 None
None
None
None
HEM  A 501 (-4.0A)
 1.43A 6aogB-4fxbA:
undetectable		 6aogB-4fxbA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_D_LLLD301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4fxb PUTATIVE CYTOCHROME
P450
(Streptomyces
coelicolor) 		4 / 6 ASP A 267
ARG A 390
GLU A 389
ASP A 391
 None
 1.45A 6mn5D-4fxbA:
undetectable		 6mn5D-4fxbA:
13.29