SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fxd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))		 4fxd DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 791
ASN A 701
GLY A 790
TRP A 785
 None
 0.91A 1dbbH-4fxdA:
undetectable
1dbbL-4fxdA:
undetectable		 1dbbH-4fxdA:
13.42
1dbbL-4fxdA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)		 4fxd DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 668
THR A 365
VAL A 362
 None
 0.93A 1hxbA-4fxdA:
undetectable		 1hxbA-4fxdA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_1
(NEURAMINIDASE)		 4fxd DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 916
ARG A 807
ARG A 939
 None
 0.95A 1l7fA-4fxdA:
undetectable		 1l7fA-4fxdA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_1
(NEURAMINIDASE)		 4fxd DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 916
ARG A 807
ARG A 939
 None
 0.96A 1l7hA-4fxdA:
undetectable		 1l7hA-4fxdA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O5Y_H_STRH249_1
(CHIMERIC ANTIBODY
FAB 1E9-DB3)		 4fxd DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		4 / 7 ASN A 701
GLY A 790
THR A 788
TRP A 785
 None
 0.94A 2o5yH-4fxdA:
undetectable
2o5yL-4fxdA:
undetectable		 2o5yH-4fxdA:
12.76
2o5yL-4fxdA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4fxd DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		5 / 10 THR A 708
SER A 761
SER A 540
GLY A 704
ALA A 700
 None
 1.41A 2x2iB-4fxdA:
undetectable		 2x2iB-4fxdA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4fxd DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 880
ALA A 911
ALA A 963
ALA A 967
THR A 971
 None
 1.29A 2x2nB-4fxdA:
undetectable		 2x2nB-4fxdA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_3
(PHOSPHOLIPASE A2)		 4fxd DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		5 / 11 VAL A 586
LEU A 585
ILE A 543
SER A 542
SER A 540
 None
 1.32A 3bjwH-4fxdA:
undetectable		 3bjwH-4fxdA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_A_GW6A1_1
(GLUCOCORTICOID
RECEPTOR)		 4fxd DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		5 / 12 ASN A 783
GLY A 493
LEU A 357
LEU A 789
THR A 792
 None
 1.50A 3cldA-4fxdA:
undetectable		 3cldA-4fxdA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_A_ADNA438_1
(ADENOSYLHOMOCYSTEINA
SE)		 4fxd DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		5 / 12 ASN A 980
LEU A1030
LEU A 868
GLY A 974
PHE A 849
 None
 1.35A 3g1uA-4fxdA:
undetectable		 3g1uA-4fxdA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_1
(DIHYDROFOLATE
REDUCTASE)		 4fxd DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 556
LEU A 541
SER A 662
ILE A 663
LEU A 645
 None
 1.08A 3ia4D-4fxdA:
undetectable		 3ia4D-4fxdA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4fxd DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		6 / 12 GLY A 637
SER A 761
SER A 562
ILE A 635
ARG A 639
LEU A 640
 None
 1.43A 3iv6D-4fxdA:
undetectable		 3iv6D-4fxdA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_B_URFB400_1
(URIDINE
PHOSPHORYLASE 1)		 4fxd DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		4 / 8 THR A1004
MET A 988
LEU A 861
ILE A1034
 None
 0.95A 3nbqB-4fxdA:
undetectable		 3nbqB-4fxdA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_C_URFC400_1
(URIDINE
PHOSPHORYLASE 1)		 4fxd DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		4 / 8 THR A1004
MET A 988
LEU A 861
ILE A1034
 None
 0.86A 3nbqC-4fxdA:
undetectable		 3nbqC-4fxdA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4fxd DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 859
LEU A1022
LYS A1020
 None
 0.67A 3sueD-4fxdA:
undetectable		 3sueD-4fxdA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 4fxd DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		5 / 12 MET A1001
GLY A 995
THR A 997
VAL A 860
LEU A1041
 None
 1.18A 3v8vA-4fxdA:
undetectable		 3v8vA-4fxdA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_F_CAMF502_0
(CAMPHOR
5-MONOOXYGENASE)		 4fxd DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		4 / 4 TYR A1213
THR A1173
VAL A1189
ILE A1129
 None
 1.50A 4jx1F-4fxdA:
undetectable		 4jx1F-4fxdA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4fxd DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 734
GLN A 590
VAL A 557
THR A 545
 None
 1.05A 4lnwA-4fxdA:
undetectable		 4lnwA-4fxdA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)		 4fxd DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		5 / 9 LEU A1110
VAL A1085
SER A1086
VAL A1089
LEU A1090
 None
 0.87A 4qd3A-4fxdA:
undetectable		 4qd3A-4fxdA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 4fxd DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		5 / 12 THR A 778
LEU A 780
ALA A 781
LEU A 945
GLY A 791
 None
 1.05A 5gs4A-4fxdA:
undetectable		 5gs4A-4fxdA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 4fxd DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 466
PHE A 471
LEU A 446
VAL A 448
TYR A 418
 None
 1.34A 5i8fA-4fxdA:
undetectable		 5i8fA-4fxdA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 4fxd DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 764
GLN A 721
CYH A 724
 None
 0.52A 5icxA-4fxdA:
undetectable
5icxE-4fxdA:
undetectable		 5icxA-4fxdA:
14.05
5icxE-4fxdA:
3.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 4fxd DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 764
GLN A 721
CYH A 724
 None
 0.85A 5icxC-4fxdA:
undetectable
5icxF-4fxdA:
undetectable		 5icxC-4fxdA:
14.05
5icxF-4fxdA:
3.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_A_SAMA501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4fxd DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 536
PRO A 534
GLY A 370
SER A 568
LEU A 569
 None
 1.06A 5o96A-4fxdA:
undetectable
5o96B-4fxdA:
undetectable		 5o96A-4fxdA:
14.81
5o96B-4fxdA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)		 4fxd DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		4 / 6 PRO A 897
TYR A 951
PRO A 907
LEU A 906
 None
 0.72A 5tl8A-4fxdA:
undetectable		 5tl8A-4fxdA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_A_6J3A201_0
(TRANSTHYRETIN)		 4fxd DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		4 / 4 LYS A1040
LEU A 855
ALA A1051
LEU A1042
 None
 1.37A 6gnrA-4fxdA:
undetectable		 6gnrA-4fxdA:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_B_6J3B201_0
(TRANSTHYRETIN)		 4fxd DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		4 / 4 LYS A1040
LEU A 855
ALA A1051
LEU A1042
 None
 1.36A 6gnrB-4fxdA:
undetectable		 6gnrB-4fxdA:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HZP_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 4fxd DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 799
VAL A 486
ASN A 480
GLU A 361
 None
 1.11A 6hzpA-4fxdA:
undetectable		 6hzpA-4fxdA:
20.89