SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fxg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN

(Homo
sapiens)
6 / 8 HIS H 483
ASP H 627
SER H 628
VAL H 653
GLY H 656
GLY H 667
None
0.56A 1aq7A-4fxgH:
32.9
1aq7A-4fxgH:
36.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN

(Homo
sapiens)
5 / 9 ASP H 627
VAL H 653
TRP H 655
GLY H 656
GLY H 667
None
0.37A 1bcuH-4fxgH:
36.1
1bcuH-4fxgH:
35.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN

(Homo
sapiens)
6 / 12 HIS H 483
ASP H 627
VAL H 653
TRP H 655
GLY H 656
GLY H 667
None
0.55A 1etrH-4fxgH:
34.7
1etrH-4fxgH:
34.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN

(Homo
sapiens)
5 / 8 ASP H 627
SER H 628
VAL H 653
GLY H 656
GLY H 667
None
0.36A 1f5lA-4fxgH:
32.9
1f5lA-4fxgH:
31.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN

(Homo
sapiens)
4 / 7 THR H 670
LEU H 637
GLY H 635
LEU H 479
None
0.99A 1gtiE-4fxgH:
undetectable
1gtiE-4fxgH:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN

(Homo
sapiens)
5 / 12 ILE H 652
ILE H 548
ILE H 536
LEU H 538
VAL H 542
None
1.03A 1oipA-4fxgH:
undetectable
1oipA-4fxgH:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_1
(PROTEASE RETROPEPSIN)
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN

(Homo
sapiens)
5 / 11 ALA H 619
GLY H 650
GLY H 651
VAL H 588
ILE H 590
None
0.89A 1sduA-4fxgH:
undetectable
1sduA-4fxgH:
14.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TNL_A_TPAA900_1
(TRYPSIN)
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN

(Homo
sapiens)
5 / 6 ASP H 627
SER H 628
VAL H 653
GLY H 656
GLY H 667
None
0.38A 1tnlA-4fxgH:
33.4
1tnlA-4fxgH:
36.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN

(Homo
sapiens)
5 / 12 LYS H 445
GLY H 631
ASP H 632
ALA H 633
ALA H 481
None
0.91A 2br4B-4fxgH:
undetectable
2br4B-4fxgH:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN

(Homo
sapiens)
5 / 12 LYS H 445
GLY H 631
ASP H 632
ALA H 633
ALA H 481
None
0.89A 2br4E-4fxgH:
undetectable
2br4E-4fxgH:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN

(Homo
sapiens)
5 / 12 ALA H 636
GLY H 470
LEU H 472
VAL H 653
GLY H 651
None
1.12A 2f8lA-4fxgH:
undetectable
2f8lA-4fxgH:
22.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN

(Homo
sapiens)
5 / 6 ASP H 627
SER H 628
VAL H 653
GLY H 656
GLY H 667
None
0.33A 2otvA-4fxgH:
33.5
2otvA-4fxgH:
36.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN

(Homo
sapiens)
6 / 12 ASP H 627
VAL H 653
TRP H 655
GLY H 656
GLY H 667
TYR H 669
None
0.32A 2p16A-4fxgH:
34.1
2p16A-4fxgH:
34.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN

(Homo
sapiens)
5 / 8 ASP H 627
SER H 628
VAL H 653
GLY H 656
GLY H 667
None
0.41A 2vinA-4fxgH:
33.5
2vinA-4fxgH:
31.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN

(Homo
sapiens)
6 / 12 ASP H 627
VAL H 653
TRP H 655
GLY H 656
GLY H 667
TYR H 669
None
0.35A 2w26A-4fxgH:
34.0
2w26A-4fxgH:
34.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_1
(HIV-1 PROTEASE)
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN

(Homo
sapiens)
5 / 12 GLY H 667
ALA H 619
GLY H 651
VAL H 588
ILE H 590
None
1.05A 2z54A-4fxgH:
undetectable
2z54A-4fxgH:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN

(Homo
sapiens)
4 / 6 TRP H 573
SER H 571
ALA H 570
ASP H 632
None
1.17A 3aruA-4fxgH:
undetectable
3aruA-4fxgH:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_1
(PROTEASE)
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN

(Homo
sapiens)
5 / 10 GLY H 667
ALA H 619
GLY H 651
VAL H 588
ILE H 590
None
0.95A 3ekyA-4fxgH:
undetectable
3ekyA-4fxgH:
16.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN

(Homo
sapiens)
6 / 11 HIS H 483
ASP H 627
SER H 628
TRP H 655
GLY H 656
GLY H 667
None
0.59A 3gy3A-4fxgH:
32.8
3gy3A-4fxgH:
36.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN

(Homo
sapiens)
3 / 3 SER H 493
ASP H 491
ASP H 496
None
0.87A 3iv6A-4fxgH:
undetectable
3iv6A-4fxgH:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN

(Homo
sapiens)
3 / 3 SER H 493
ASP H 491
ASP H 496
None
0.93A 3iv6C-4fxgH:
undetectable
3iv6C-4fxgH:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_F_URFF254_1
(URIDINE
PHOSPHORYLASE)
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN

(Homo
sapiens)
4 / 6 GLY H 634
GLN H 459
ILE H 652
VAL H 653
None
1.16A 3kvvF-4fxgH:
undetectable
3kvvF-4fxgH:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD8_0
(GRAMICIDIN D)
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN

(Homo
sapiens)
3 / 3 VAL H 668
VAL H 653
TRP H 655
None
0.89A 3l8lC-4fxgH:
undetectable
3l8lD-4fxgH:
undetectable
3l8lC-4fxgH:
5.45
3l8lD-4fxgH:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_1
(PROTEASE)
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN

(Homo
sapiens)
5 / 12 ALA H 633
ASP H 632
GLY H 470
ASP H 532
ALA H 482
None
1.22A 3n3iA-4fxgH:
undetectable
3n3iA-4fxgH:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN

(Homo
sapiens)
5 / 12 LYS H 445
GLY H 635
ILE H 652
ALA H 481
ASP H 632
None
1.05A 3nvkI-4fxgH:
undetectable
3nvkI-4fxgH:
22.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN

(Homo
sapiens)
5 / 6 SER H 628
VAL H 653
TRP H 655
GLY H 656
GLY H 667
None
0.44A 3rxfA-4fxgH:
14.4
3rxfA-4fxgH:
36.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN

(Homo
sapiens)
4 / 5 ASP H 627
SER H 628
VAL H 653
GLY H 667
None
0.40A 3rxhA-4fxgH:
33.4
3rxhA-4fxgH:
36.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN

(Homo
sapiens)
3 / 3 PHE H 529
TYR H 486
TYR H 523
None
1.00A 4ffwA-4fxgH:
undetectable
4ffwA-4fxgH:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GBO_B_CUB301_0
(E7)
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN

(Homo
sapiens)
4 / 5 HIS H 525
ALA H 484
HIS H 483
TYR H 523
None
1.43A 4gboB-4fxgH:
undetectable
4gboB-4fxgH:
19.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_D_15UD402_1
(PROTHROMBIN)
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN

(Homo
sapiens)
6 / 12 HIS H 483
ASP H 627
ALA H 633
VAL H 653
TRP H 655
GLY H 667
None
0.54A 4hfpD-4fxgH:
35.0
4hfpD-4fxgH:
35.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN

(Homo
sapiens)
5 / 12 LEU H 473
LEU H 472
LEU H 538
ILE H 679
ILE H 682
None
1.13A 4j24A-4fxgH:
undetectable
4j24A-4fxgH:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN

(Homo
sapiens)
5 / 12 LEU H 473
LEU H 472
LEU H 538
ILE H 679
ILE H 682
None
1.11A 4j24B-4fxgH:
undetectable
4j24B-4fxgH:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_2
(PROTEASE)
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN

(Homo
sapiens)
5 / 12 ALA H 481
ILE H 652
GLY H 470
VAL H 517
ILE H 536
None
0.99A 4q5mA-4fxgH:
undetectable
4q5mA-4fxgH:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN

(Homo
sapiens)
5 / 10 ALA H 484
ALA H 469
ALA H 633
GLY H 464
THR H 466
None
1.03A 4qvyK-4fxgH:
undetectable
4qvyL-4fxgH:
undetectable
4qvyK-4fxgH:
24.02
4qvyL-4fxgH:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN

(Homo
sapiens)
5 / 10 ALA H 484
ALA H 469
ALA H 633
GLY H 464
THR H 466
None
1.01A 4qvyY-4fxgH:
undetectable
4qvyZ-4fxgH:
undetectable
4qvyY-4fxgH:
24.02
4qvyZ-4fxgH:
24.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN

(Homo
sapiens)
6 / 12 HIS H 483
ALA H 633
VAL H 653
TRP H 655
GLY H 656
GLY H 667
None
0.58A 4rn6B-4fxgH:
30.0
4rn6B-4fxgH:
35.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 A CHAIN

(Homo
sapiens)
5 / 12 GLU G 413
ASP G 415
ASP G 407
GLN G 393
ILE G 392
None
1.08A 4uroA-4fxgG:
undetectable
4uroA-4fxgG:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN

(Homo
sapiens)
4 / 6 TRP H 678
ILE H 533
ILE H 497
VAL H 460
None
1.00A 4zj8A-4fxgH:
undetectable
4zj8A-4fxgH:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_J_EDTJ301_0
(TCRBETA CHAIN)
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 A CHAIN

(Homo
sapiens)
4 / 5 TYR G 410
GLU G 424
GLY G 423
SER G 421
None
1.45A 5jhdJ-4fxgG:
undetectable
5jhdJ-4fxgG:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 A CHAIN

(Homo
sapiens)
5 / 12 THR G 419
VAL G 411
LYS G 409
VAL G 364
GLU G 333
None
1.02A 6bzoC-4fxgG:
undetectable
6bzoC-4fxgG:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_0
(HIV-1 PROTEASE)
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN

(Homo
sapiens)
5 / 12 GLY H 667
GLY H 650
GLY H 651
VAL H 588
ILE H 590
None
0.80A 6dj1A-4fxgH:
undetectable
6dj1A-4fxgH:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN

(Homo
sapiens)
5 / 11 GLY H 635
GLY H 470
LEU H 479
VAL H 478
ASP H 532
None
1.26A 6i5zD-4fxgH:
undetectable
6i5zD-4fxgH:
22.94