SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fxp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 4fxp ADENYLYL-SULFATE
KINASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 8 GLU A 157
ARG A 160
ARG A 161
LEU A 148
 None
 0.85A 1cmaA-4fxpA:
undetectable
1cmaB-4fxpA:
undetectable		 1cmaA-4fxpA:
20.94
1cmaB-4fxpA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		 4fxp ADENYLYL-SULFATE
KINASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 8 CYH A 176
LEU A 121
ALA A 118
LEU A 117
 None
 0.88A 1hwiD-4fxpA:
undetectable		 1hwiD-4fxpA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_2
(POL PROTEIN)		 4fxp ADENYLYL-SULFATE
KINASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 7 ARG A 185
ASP A 187
ALA A 156
PRO A 238
 None
 0.92A 2fxdB-4fxpA:
undetectable		 2fxdB-4fxpA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_1
(PROTEASE)		 4fxp ADENYLYL-SULFATE
KINASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 11 ARG A 185
ASP A 187
ALA A 156
ASP A 154
PRO A 238
 None
 0.92A 2o4pA-4fxpA:
undetectable		 2o4pA-4fxpA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_2
(POL POLYPROTEIN)		 4fxp ADENYLYL-SULFATE
KINASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 9 ARG A 185
ASP A 187
ALA A 156
ASP A 154
PRO A 238
 None
 1.07A 3u7sB-4fxpA:
undetectable		 3u7sB-4fxpA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_2
(PROTEASE)		 4fxp ADENYLYL-SULFATE
KINASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 9 ARG A 185
ASP A 187
ALA A 156
ASP A 154
PRO A 238
 None
 1.05A 4ll3B-4fxpA:
undetectable		 4ll3B-4fxpA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_1
(PROTEASE)		 4fxp ADENYLYL-SULFATE
KINASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 ARG A 185
ASP A 187
ALA A 156
ASP A 154
PRO A 238
 None
 0.99A 4njuA-4fxpA:
undetectable		 4njuA-4fxpA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_1
(PROTEASE)		 4fxp ADENYLYL-SULFATE
KINASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 ARG A 185
ASP A 187
ALA A 156
ASP A 154
PRO A 238
 None
 0.97A 4njuC-4fxpA:
undetectable		 4njuC-4fxpA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4fxp ADENYLYL-SULFATE
KINASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 4 LEU A 220
ARG A 225
ILE A 229
PHE A 232
 ADX  A 301 ( 4.7A)
None
ADX  A 301 (-4.8A)
ADX  A 301 (-4.1A)
 1.10A 5kirB-4fxpA:
undetectable		 5kirB-4fxpA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4fxp ADENYLYL-SULFATE
KINASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 LEU A 109
GLY A 250
ILE A 181
VAL A 106
GLY A 113
 None
None
ADX  A 301 (-3.9A)
None
SO4  A 302 (-3.2A)
 1.07A 5wyqA-4fxpA:
undetectable		 5wyqA-4fxpA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_0
(HIV-1 PROTEASE)		 4fxp ADENYLYL-SULFATE
KINASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 ARG A 185
ASP A 187
ALA A 156
ASP A 154
PRO A 238
 None
 0.93A 6dilA-4fxpA:
undetectable		 6dilA-4fxpA:
18.13