SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fxs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 11 PHE A 461
ALA A 354
ALA A 352
VAL A 362
GLN A 436
 None
None
None
IMP  A 701 ( 4.6A)
None
 1.26A 1hbpA-4fxsA:
undetectable		 1hbpA-4fxsA:
14.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 11 ASP A 250
SER A 251
GLY A 302
CYH A 307
THR A 309
 MOA  A 702 (-3.2A)
MOA  A 702 (-3.7A)
MOA  A 702 ( 3.9A)
IMP  A 701 (-3.0A)
MOA  A 702 (-3.4A)
 1.12A 1jr1A-4fxsA:
53.2		 1jr1A-4fxsA:
38.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 11 ASP A 250
SER A 252
GLY A 302
CYH A 307
THR A 309
 MOA  A 702 (-3.2A)
MOA  A 702 (-2.8A)
MOA  A 702 ( 3.9A)
IMP  A 701 (-3.0A)
MOA  A 702 (-3.4A)
 0.93A 1jr1A-4fxsA:
53.2		 1jr1A-4fxsA:
38.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		6 / 11 SER A 251
ASN A 279
GLY A 302
CYH A 307
THR A 309
GLY A 391
 MOA  A 702 (-3.7A)
MOA  A 702 (-3.5A)
MOA  A 702 ( 3.9A)
IMP  A 701 (-3.0A)
MOA  A 702 (-3.4A)
IMP  A 701 (-3.2A)
 0.80A 1jr1A-4fxsA:
53.2		 1jr1A-4fxsA:
38.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		6 / 11 SER A 252
ASN A 279
GLY A 302
CYH A 307
THR A 309
GLY A 391
 MOA  A 702 (-2.8A)
MOA  A 702 (-3.5A)
MOA  A 702 ( 3.9A)
IMP  A 701 (-3.0A)
MOA  A 702 (-3.4A)
IMP  A 701 (-3.2A)
 0.64A 1jr1A-4fxsA:
53.2		 1jr1A-4fxsA:
38.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 8 ASN A 279
GLY A 302
THR A 309
GLY A 391
 MOA  A 702 (-3.5A)
MOA  A 702 ( 3.9A)
MOA  A 702 (-3.4A)
IMP  A 701 (-3.2A)
 0.39A 1jr1B-4fxsA:
53.3		 1jr1B-4fxsA:
38.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 8 SER A 252
ASN A 279
GLY A 302
GLY A 391
 MOA  A 702 (-2.8A)
MOA  A 702 (-3.5A)
MOA  A 702 ( 3.9A)
IMP  A 701 (-3.2A)
 0.63A 1jr1B-4fxsA:
53.3		 1jr1B-4fxsA:
38.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 8 ASN A 279
ILE A 301
GLY A 302
GLY A 389
 MOA  A 702 (-3.5A)
MOA  A 702 (-4.1A)
MOA  A 702 ( 3.9A)
IMP  A 701 (-3.1A)
 0.78A 1me7A-4fxsA:
50.2		 1me7A-4fxsA:
36.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 8 ASP A 250
SER A 251
SER A 252
CYH A 307
 MOA  A 702 (-3.2A)
MOA  A 702 (-3.7A)
MOA  A 702 (-2.8A)
IMP  A 701 (-3.0A)
 0.67A 1me7A-4fxsA:
50.2		 1me7A-4fxsA:
36.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		7 / 8 SER A 251
SER A 252
ASN A 279
ILE A 301
GLY A 302
CYH A 307
GLY A 391
 MOA  A 702 (-3.7A)
MOA  A 702 (-2.8A)
MOA  A 702 (-3.5A)
MOA  A 702 (-4.1A)
MOA  A 702 ( 3.9A)
IMP  A 701 (-3.0A)
IMP  A 701 (-3.2A)
 0.52A 1me7A-4fxsA:
50.2		 1me7A-4fxsA:
36.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 10 ASP A 250
SER A 251
SER A 252
ILE A 301
GLY A 302
 MOA  A 702 (-3.2A)
MOA  A 702 (-3.7A)
MOA  A 702 (-2.8A)
MOA  A 702 (-4.1A)
MOA  A 702 ( 3.9A)
 0.82A 1mehA-4fxsA:
48.3		 1mehA-4fxsA:
36.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		6 / 10 SER A 251
SER A 252
ASN A 279
ILE A 301
GLY A 302
GLY A 391
 MOA  A 702 (-3.7A)
MOA  A 702 (-2.8A)
MOA  A 702 (-3.5A)
MOA  A 702 (-4.1A)
MOA  A 702 ( 3.9A)
IMP  A 701 (-3.2A)
 0.47A 1mehA-4fxsA:
48.3		 1mehA-4fxsA:
36.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 10 SER A 252
ASN A 279
ILE A 301
GLY A 302
GLY A 418
 MOA  A 702 (-2.8A)
MOA  A 702 (-3.5A)
MOA  A 702 (-4.1A)
MOA  A 702 ( 3.9A)
IMP  A 701 (-3.3A)
 1.29A 1mehA-4fxsA:
48.3		 1mehA-4fxsA:
36.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 8 SER A 251
SER A 252
ASN A 279
ILE A 301
GLY A 391
 MOA  A 702 (-3.7A)
MOA  A 702 (-2.8A)
MOA  A 702 (-3.5A)
MOA  A 702 (-4.1A)
IMP  A 701 (-3.2A)
 0.47A 1meiA-4fxsA:
49.7		 1meiA-4fxsA:
36.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 12 PHE A 461
ALA A 354
ALA A 352
VAL A 362
GLN A 436
 None
None
None
IMP  A 701 ( 4.6A)
None
 1.20A 1rbpA-4fxsA:
undetectable		 1rbpA-4fxsA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 8 THR A 266
GLY A 293
ILE A 275
VAL A 294
 None
 0.93A 1rxcB-4fxsA:
undetectable		 1rxcB-4fxsA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_E_URFE2031_1
(URIDINE
PHOSPHORYLASE)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 8 THR A 266
GLY A 293
ILE A 275
VAL A 294
 None
 0.98A 1rxcE-4fxsA:
undetectable		 1rxcE-4fxsA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_I_URFI2041_1
(URIDINE
PHOSPHORYLASE)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 8 THR A 266
GLY A 293
ILE A 275
VAL A 294
 None
 0.92A 1rxcI-4fxsA:
undetectable		 1rxcI-4fxsA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_K_URFK2061_1
(URIDINE
PHOSPHORYLASE)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 8 THR A 266
GLY A 293
ILE A 275
VAL A 294
 None
 0.96A 1rxcK-4fxsA:
undetectable		 1rxcK-4fxsA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_C_SAMC303_0
(HEMK PROTEIN)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 12 ILE A 276
GLY A 254
ALA A 288
SER A 252
ALA A 228
 None
None
None
MOA  A 702 (-2.8A)
None
 1.06A 1sg9C-4fxsA:
undetectable		 1sg9C-4fxsA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 10 ALA A 281
THR A 282
ALA A 326
ALA A 322
GLY A 254
 None
 1.05A 2f16Y-4fxsA:
undetectable
2f16Z-4fxsA:
undetectable		 2f16Y-4fxsA:
18.25
2f16Z-4fxsA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 12 ASN A  43
LEU A  32
VAL A 337
LEU A  36
GLY A 356
 None
 1.12A 2f8lA-4fxsA:
undetectable		 2f8lA-4fxsA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RDD_A_AICA1110_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 4 LYS A 385
ALA A 367
PHE A 366
GLY A 363
 None
None
None
IMP  A 701 (-3.7A)
 1.30A 2rddA-4fxsA:
undetectable		 2rddA-4fxsA:
19.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 8 SER A 251
SER A 252
ASN A 279
GLY A 391
 MOA  A 702 (-3.7A)
MOA  A 702 (-2.8A)
MOA  A 702 (-3.5A)
IMP  A 701 (-3.2A)
 0.50A 4af0A-4fxsA:
51.3		 4af0A-4fxsA:
37.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AF0_B_MOAB1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 10 SER A 251
SER A 252
ASN A 279
MET A 390
GLY A 391
 MOA  A 702 (-3.7A)
MOA  A 702 (-2.8A)
MOA  A 702 (-3.5A)
None
IMP  A 701 (-3.2A)
 0.54A 4af0B-4fxsA:
51.3		 4af0B-4fxsA:
37.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 6 ALA A 296
PRO A 336
LEU A  36
THR A  37
 None
 0.91A 4dtzA-4fxsA:
undetectable		 4dtzA-4fxsA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 7 ALA A 296
PRO A 336
LEU A  36
THR A  37
 None
 0.86A 4du2B-4fxsA:
undetectable		 4du2B-4fxsA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_C_URFC1301_1
(URIDINE
PHOSPHORYLASE)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 8 THR A 266
GLY A 293
ILE A 275
VAL A 294
 None
 0.98A 4e1vC-4fxsA:
undetectable		 4e1vC-4fxsA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_D_URFD1301_1
(URIDINE
PHOSPHORYLASE)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 8 THR A 266
GLY A 293
ILE A 275
VAL A 294
 None
 0.99A 4e1vD-4fxsA:
undetectable		 4e1vD-4fxsA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_G_URFG1301_1
(URIDINE
PHOSPHORYLASE)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 8 THR A 266
GLY A 293
ILE A 275
VAL A 294
 None
 0.99A 4e1vG-4fxsA:
undetectable		 4e1vG-4fxsA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_H_URFH1301_1
(URIDINE
PHOSPHORYLASE)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 8 THR A 266
GLY A 293
ILE A 275
VAL A 294
 None
 0.99A 4e1vH-4fxsA:
undetectable		 4e1vH-4fxsA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_2
(SUGAR KINASE PROTEIN)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 4 SER A 305
TYR A 387
GLY A 341
PRO A 303
 IMP  A 701 (-2.6A)
IMP  A 701 (-4.6A)
IMP  A 701 (-3.5A)
None
 1.50A 4e3aA-4fxsA:
undetectable		 4e3aA-4fxsA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_2
(SUGAR KINASE PROTEIN)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 4 SER A 305
TYR A 387
GLY A 342
PRO A 303
 IMP  A 701 (-2.6A)
IMP  A 701 (-4.6A)
IMP  A 701 (-3.5A)
None
 1.34A 4e3aA-4fxsA:
undetectable		 4e3aA-4fxsA:
21.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		6 / 8 ASP A 250
SER A 251
SER A 252
THR A 309
MET A 390
GLY A 391
 MOA  A 702 (-3.2A)
MOA  A 702 (-3.7A)
MOA  A 702 (-2.8A)
MOA  A 702 (-3.4A)
None
IMP  A 701 (-3.2A)
 0.86A 4fo4A-4fxsA:
59.8		 4fo4A-4fxsA:
74.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		7 / 8 SER A 251
SER A 252
ASN A 279
CYH A 307
THR A 309
MET A 390
GLY A 391
 MOA  A 702 (-3.7A)
MOA  A 702 (-2.8A)
MOA  A 702 (-3.5A)
IMP  A 701 (-3.0A)
MOA  A 702 (-3.4A)
None
IMP  A 701 (-3.2A)
 0.16A 4fo4A-4fxsA:
59.8		 4fo4A-4fxsA:
74.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 8 ASN A 279
GLY A 341
MET A 390
GLY A 389
 MOA  A 702 (-3.5A)
IMP  A 701 (-3.5A)
None
IMP  A 701 (-3.1A)
 0.88A 4fo4B-4fxsA:
59.5		 4fo4B-4fxsA:
74.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		8 / 8 SER A 251
SER A 252
ASN A 279
GLY A 302
CYH A 307
THR A 309
MET A 390
GLY A 391
 MOA  A 702 (-3.7A)
MOA  A 702 (-2.8A)
MOA  A 702 (-3.5A)
MOA  A 702 ( 3.9A)
IMP  A 701 (-3.0A)
MOA  A 702 (-3.4A)
None
IMP  A 701 (-3.2A)
 0.23A 4fo4B-4fxsA:
59.5		 4fo4B-4fxsA:
74.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 12 ALA A  57
GLY A 223
LEU A 247
LEU A 239
ALA A  60
 None
 1.14A 4lg1B-4fxsA:
undetectable		 4lg1B-4fxsA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 12 ALA A  57
GLY A 223
LEU A 247
LEU A 239
ALA A  60
 None
 1.12A 4lg1C-4fxsA:
undetectable		 4lg1C-4fxsA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 7 THR A  53
GLY A 363
ALA A 367
ILE A 423
 None
IMP  A 701 (-3.7A)
None
None
 0.90A 4txnA-4fxsA:
undetectable		 4txnA-4fxsA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 7 THR A  53
GLY A 363
ALA A 367
ILE A 423
 None
IMP  A 701 (-3.7A)
None
None
 0.91A 4txnB-4fxsA:
undetectable		 4txnB-4fxsA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 7 THR A  53
GLY A 363
ALA A 367
ILE A 423
 None
IMP  A 701 (-3.7A)
None
None
 0.95A 4txnC-4fxsA:
undetectable		 4txnC-4fxsA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_D_URFD302_1
(URIDINE
PHOSPHORYLASE)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 7 THR A  53
GLY A 363
ALA A 367
ILE A 423
 None
IMP  A 701 (-3.7A)
None
None
 0.89A 4txnD-4fxsA:
undetectable		 4txnD-4fxsA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 7 ILE A  69
LEU A  63
GLY A  67
GLY A  68
 None
 0.79A 5a06B-4fxsA:
undetectable		 5a06B-4fxsA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		3 / 3 THR A 156
HIS A  98
LEU A 194
 None
 0.78A 5axdA-4fxsA:
undetectable		 5axdA-4fxsA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 12 MET A 437
ILE A 433
LEU A 440
VAL A 360
GLY A  70
 None
 1.10A 5byjA-4fxsA:
undetectable		 5byjA-4fxsA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA403_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 4 LEU A 260
LEU A 289
GLY A 285
GLU A 284
 None
 1.16A 5hhjA-4fxsA:
undetectable		 5hhjA-4fxsA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 8 SER A 449
THR A 447
ARG A 456
ILE A 353
 None
 1.06A 5jhdE-4fxsA:
undetectable
5jhdG-4fxsA:
undetectable		 5jhdE-4fxsA:
16.53
5jhdG-4fxsA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_E_Z80E401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 12 ILE A  69
VAL A  47
ASP A 250
ILE A 338
ALA A 296
 None
None
MOA  A 702 (-3.2A)
None
None
 1.11A 5lg3E-4fxsA:
undetectable		 5lg3E-4fxsA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 11 VAL A  25
GLY A 445
ASP A 454
ALA A 450
SER A  23
 None
 1.17A 5x6yA-4fxsA:
undetectable		 5x6yA-4fxsA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_B_SAMB901_0
(MRNA CAPPING ENZYME
P5)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 10 VAL A  25
GLY A 445
ASP A 454
ALA A 450
SER A  23
 None
 1.14A 5x6yB-4fxsA:
undetectable		 5x6yB-4fxsA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)		 4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 11 VAL A  25
GLY A 445
ASP A 454
ALA A 450
SER A  23
 None
 1.18A 5x6yC-4fxsA:
undetectable		 5x6yC-4fxsA:
19.54