SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fyc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4fyc THIOL:DISULFIDE
INTERCHANGE PROTEIN
(DSBC)
(Helicobacter
pylori) 		4 / 7 PHE A  67
TYR A 116
VAL A  83
ILE A 158
 None
 1.02A 4a97E-4fycA:
undetectable		 4a97E-4fycA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4fyc THIOL:DISULFIDE
INTERCHANGE PROTEIN
(DSBC)
(Helicobacter
pylori) 		4 / 8 PHE A  67
TYR A 116
VAL A  83
ILE A 158
 None
 0.99A 4a97C-4fycA:
undetectable		 4a97C-4fycA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4fyc THIOL:DISULFIDE
INTERCHANGE PROTEIN
(DSBC)
(Helicobacter
pylori) 		4 / 8 PHE A  67
TYR A 116
VAL A  83
ILE A 158
 None
 0.96A 4a97G-4fycA:
undetectable		 4a97G-4fycA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4fyc THIOL:DISULFIDE
INTERCHANGE PROTEIN
(DSBC)
(Helicobacter
pylori) 		4 / 8 PHE A  67
TYR A 116
VAL A  83
ILE A 158
 None
 0.97A 4a97I-4fycA:
undetectable		 4a97I-4fycA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4fyc THIOL:DISULFIDE
INTERCHANGE PROTEIN
(DSBC)
(Helicobacter
pylori) 		4 / 6 GLU A 138
ILE A 139
GLU A 144
VAL A 118
 None
 0.94A 4ejwB-4fycA:
undetectable		 4ejwB-4fycA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_2
(ESTROGEN RECEPTOR)		 4fyc THIOL:DISULFIDE
INTERCHANGE PROTEIN
(DSBC)
(Helicobacter
pylori) 		4 / 5 LEU A 184
LEU A 205
PHE A 180
LEU A 171
 None
 0.86A 5gtrA-4fycA:
undetectable		 5gtrA-4fycA:
21.60