SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fye'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)		 4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3
(Legionella
pneumophila) 		3 / 3 MET A 630
LEU A 633
SER A 634
 None
 0.35A 1ee2A-4fyeA:
2.9		 1ee2A-4fyeA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3
(Legionella
pneumophila) 		4 / 5 LEU A 144
GLU A  73
ALA A 126
LEU A 141
 None
 1.09A 1eta1-4fyeA:
undetectable		 1eta1-4fyeA:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3
(Legionella
pneumophila) 		4 / 5 LEU A 144
GLU A  73
ALA A 126
LEU A 141
 None
 1.12A 1eta2-4fyeA:
undetectable		 1eta2-4fyeA:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3
(Legionella
pneumophila) 		4 / 6 LEU A 144
GLU A  73
ALA A 126
LEU A 141
 None
 1.08A 1etb1-4fyeA:
undetectable		 1etb1-4fyeA:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3
(Legionella
pneumophila) 		5 / 12 SER A 714
VAL A 713
TYR A  33
PHE A 140
PHE A 738
 None
 1.38A 1fdsA-4fyeA:
undetectable		 1fdsA-4fyeA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		 4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3
(Legionella
pneumophila) 		4 / 7 VAL A 361
SER A 645
ASN A 648
ASP A 650
 None
PO4  A 801 (-2.4A)
None
PO4  A 801 (-3.4A)
 1.36A 1hwiC-4fyeA:
undetectable		 1hwiC-4fyeA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		 4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3
(Legionella
pneumophila) 		4 / 7 VAL A 361
SER A 645
ASN A 648
ASP A 650
 None
PO4  A 801 (-2.4A)
None
PO4  A 801 (-3.4A)
 1.37A 1hwiD-4fyeA:
undetectable		 1hwiD-4fyeA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_A_VIBA502_1
(THIAMIN
PYROPHOSPHOKINASE)		 4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3
(Legionella
pneumophila) 		4 / 8 SER A 244
SER A 647
ASN A 648
GLN A 375
 None
PO4  A 801 ( 3.7A)
None
None
 1.14A 1ig3A-4fyeA:
undetectable
1ig3B-4fyeA:
undetectable		 1ig3A-4fyeA:
17.06
1ig3B-4fyeA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		 4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3
(Legionella
pneumophila) 		5 / 12 MET A 245
ASN A 648
GLY A 644
GLN A 359
VAL A 360
 None
 1.36A 1nhzA-4fyeA:
undetectable		 1nhzA-4fyeA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3
(Legionella
pneumophila) 		5 / 12 ILE A 119
ASP A  69
ILE A  78
LEU A 151
ILE A 115
 None
 0.88A 1ra2A-4fyeA:
undetectable		 1ra2A-4fyeA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3
(Legionella
pneumophila) 		5 / 12 ILE A 119
ASP A  69
ILE A  78
LEU A 151
ILE A 115
 None
 0.83A 1rb2A-4fyeA:
2.4		 1rb2A-4fyeA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3
(Legionella
pneumophila) 		5 / 12 ILE A 119
ASP A  69
ILE A  78
LEU A 151
ILE A 115
 None
 0.79A 1rd7B-4fyeA:
undetectable		 1rd7B-4fyeA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3
(Legionella
pneumophila) 		5 / 12 ILE A 119
ASP A  69
ILE A  78
LEU A 151
ILE A 115
 None
 0.78A 1rx7A-4fyeA:
undetectable		 1rx7A-4fyeA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_O_CHDO3085_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE II
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART)		 4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3
(Legionella
pneumophila) 		5 / 11 GLY A 270
GLY A 241
GLN A 297
GLU A 299
THR A 303
 None
 1.48A 1v54G-4fyeA:
undetectable
1v54N-4fyeA:
2.8
1v54O-4fyeA:
undetectable		 1v54G-4fyeA:
7.39
1v54N-4fyeA:
18.73
1v54O-4fyeA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3
(Legionella
pneumophila) 		5 / 12 ILE A 119
ASP A  69
ILE A  78
LEU A 151
ILE A 115
 None
 0.90A 2drcB-4fyeA:
undetectable		 2drcB-4fyeA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_F_ADNF906_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3
(Legionella
pneumophila) 		5 / 11 ILE A 741
THR A 711
VAL A 147
PHE A 738
HIS A 707
 None
 1.37A 2gl0D-4fyeA:
undetectable
2gl0F-4fyeA:
undetectable		 2gl0D-4fyeA:
12.50
2gl0F-4fyeA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_2
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3
(Legionella
pneumophila) 		3 / 3 ASN A 662
ILE A 201
MET A 248
 None
 0.83A 2h42C-4fyeA:
undetectable		 2h42C-4fyeA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		 4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3
(Legionella
pneumophila) 		5 / 12 MET A 382
LEU A 294
THR A 293
LEU A 238
LEU A 287
 None
 1.02A 2ouzA-4fyeA:
undetectable		 2ouzA-4fyeA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)		 4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3
(Legionella
pneumophila) 		3 / 3 ARG A 272
THR A 303
VAL A 300
 None
 0.83A 2q64A-4fyeA:
undetectable		 2q64A-4fyeA:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3
(Legionella
pneumophila) 		3 / 3 ASN A 623
ASN A 725
ARG A 682
 None
 0.75A 2rlcA-4fyeA:
undetectable		 2rlcA-4fyeA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_GLYA502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3
(Legionella
pneumophila) 		4 / 7 SER A 267
HIS A 263
LYS A 643
TYR A 203
 None
 1.45A 2vmyA-4fyeA:
undetectable
2vmyB-4fyeA:
undetectable		 2vmyA-4fyeA:
19.63
2vmyB-4fyeA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3
(Legionella
pneumophila) 		3 / 3 ASN A  76
ASP A 182
GLN A  49
 None
 0.68A 3eeyC-4fyeA:
undetectable		 3eeyC-4fyeA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3
(Legionella
pneumophila) 		3 / 3 ASN A  76
ASP A 182
GLN A  49
 None
 0.67A 3eeyD-4fyeA:
undetectable		 3eeyD-4fyeA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3
(Legionella
pneumophila) 		3 / 3 ASN A  76
ASP A 182
GLN A  49
 None
 0.68A 3eeyE-4fyeA:
undetectable		 3eeyE-4fyeA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_1
(REPRESSOR PROTEIN
MPHR(A))		 4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3
(Legionella
pneumophila) 		4 / 5 ASN A 242
ASN A 710
HIS A 706
ALA A 246
 None
 0.94A 3frqA-4fyeA:
0.0		 3frqA-4fyeA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3
(Legionella
pneumophila) 		4 / 7 ASN A 242
ASN A 710
HIS A 706
ALA A 246
 None
 0.92A 3frqB-4fyeA:
undetectable		 3frqB-4fyeA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3
(Legionella
pneumophila) 		5 / 11 ALA A 291
GLY A 241
ILE A 289
LEU A 238
VAL A 239
 None
 1.10A 3gyqB-4fyeA:
undetectable		 3gyqB-4fyeA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA303_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3
(Legionella
pneumophila) 		4 / 4 GLN A 657
GLN A 703
GLY A 716
HIS A 707
 None
 1.46A 3huoA-4fyeA:
undetectable		 3huoA-4fyeA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		 4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3
(Legionella
pneumophila) 		4 / 8 TYR A 508
LEU A 524
ASP A 525
LYS A 528
 None
 0.87A 3lsfH-4fyeA:
undetectable		 3lsfH-4fyeA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		 4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3
(Legionella
pneumophila) 		4 / 7 TYR A 508
LEU A 524
ASP A 525
LYS A 528
 None
 0.99A 3lslA-4fyeA:
undetectable
3lslD-4fyeA:
undetectable		 3lslA-4fyeA:
16.16
3lslD-4fyeA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3
(Legionella
pneumophila) 		4 / 7 TYR A 508
LEU A 524
ASP A 525
LYS A 528
 None
 0.97A 3lslA-4fyeA:
undetectable
3lslD-4fyeA:
undetectable		 3lslA-4fyeA:
16.16
3lslD-4fyeA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		 4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3
(Legionella
pneumophila) 		4 / 6 TYR A 508
LEU A 524
ASP A 525
LYS A 528
 None
 0.93A 3lslG-4fyeA:
undetectable		 3lslG-4fyeA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3
(Legionella
pneumophila) 		3 / 3 SER A 634
SER A 632
HIS A 597
 None
 0.81A 3mzeA-4fyeA:
2.3		 3mzeA-4fyeA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ9_A_MTXA2001_1
(DIHYDROFOLATE
REDUCTASE)		 4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3
(Legionella
pneumophila) 		5 / 12 ILE A 119
ASP A  69
ILE A  78
LEU A 151
ILE A 115
 None
 0.88A 3tq9A-4fyeA:
undetectable		 3tq9A-4fyeA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		 4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3
(Legionella
pneumophila) 		4 / 7 ILE A   8
ILE A 204
LEU A  16
VAL A 259
 None
 0.79A 3ua5B-4fyeA:
undetectable		 3ua5B-4fyeA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_C_MIYC392_1
(TETX2 PROTEIN)		 4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3
(Legionella
pneumophila) 		5 / 12 GLU A 299
VAL A 407
ILE A 393
GLN A 302
GLU A 355
 None
 1.22A 4a99A-4fyeA:
0.4
4a99C-4fyeA:
undetectable		 4a99A-4fyeA:
19.35
4a99C-4fyeA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_B_MTXB162_1
(DIHYDROFOLATE
REDUCTASE)		 4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3
(Legionella
pneumophila) 		5 / 12 ILE A 119
ASP A  69
ILE A  78
LEU A 151
ILE A 115
 None
 0.90A 4dfrB-4fyeA:
undetectable		 4dfrB-4fyeA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3
(Legionella
pneumophila) 		4 / 6 LEU A 294
TYR A 378
LYS A 290
GLU A 535
 None
 1.16A 4f3tA-4fyeA:
undetectable		 4f3tA-4fyeA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD302_0
(GLUTATHIONE
TRANSFERASE GTE1)		 4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3
(Legionella
pneumophila) 		3 / 3 TYR A 546
PHE A 376
ARG A 380
 None
 1.21A 4g19D-4fyeA:
undetectable		 4g19D-4fyeA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_B_1FLB201_1
(TRANSTHYRETIN)		 4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3
(Legionella
pneumophila) 		4 / 4 LYS A 740
ALA A 739
SER A 714
THR A 711
 None
 1.46A 4i89B-4fyeA:
undetectable		 4i89B-4fyeA:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3
(Legionella
pneumophila) 		3 / 3 SER A 415
MET A 413
ASP A 553
 None
 0.95A 4mm4B-4fyeA:
undetectable		 4mm4B-4fyeA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCU_A_SAMA603_0
(CYSTATHIONINE
BETA-SYNTHASE)		 4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3
(Legionella
pneumophila) 		4 / 7 GLN A 609
THR A 448
ILE A 452
ASP A 449
 None
 1.01A 4pcuA-4fyeA:
4.0		 4pcuA-4fyeA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3
(Legionella
pneumophila) 		4 / 5 LEU A  16
SER A  17
ASP A  42
ASP A  46
 None
 1.14A 4qtuD-4fyeA:
undetectable		 4qtuD-4fyeA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA302_0
(THAUMATIN-1)		 4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3
(Legionella
pneumophila) 		3 / 3 ARG A  37
GLN A  72
GLU A  73
 None
 0.94A 4tvtA-4fyeA:
undetectable		 4tvtA-4fyeA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3
(Legionella
pneumophila) 		4 / 6 ILE A  71
GLN A  72
ILE A  78
ASP A  79
 None
 1.18A 4w5qA-4fyeA:
2.5		 4w5qA-4fyeA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3
(Legionella
pneumophila) 		4 / 6 ILE A  71
GLN A  72
ILE A  78
ASP A  79
 None
 1.17A 4z4dA-4fyeA:
undetectable		 4z4dA-4fyeA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3
(Legionella
pneumophila) 		4 / 6 LEU A 294
TYR A 378
LYS A 290
GLU A 535
 None
 1.17A 4z4gA-4fyeA:
2.3		 4z4gA-4fyeA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3
(Legionella
pneumophila) 		4 / 4 CYH A 602
LEU A 471
LEU A 571
ALA A 570
 None
 0.94A 5hpuA-4fyeA:
undetectable
5hpuB-4fyeA:
undetectable		 5hpuA-4fyeA:
2.79
5hpuB-4fyeA:
3.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3
(Legionella
pneumophila) 		5 / 12 PHE A 129
LEU A 699
PRO A  63
SER A  55
PHE A 188
 None
 1.34A 5ljbA-4fyeA:
undetectable		 5ljbA-4fyeA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3
(Legionella
pneumophila) 		3 / 3 MET A 413
GLU A 377
ARG A 380
 None
 1.08A 5tjyA-4fyeA:
undetectable		 5tjyA-4fyeA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJZ_A_BEZA302_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3
(Legionella
pneumophila) 		3 / 3 MET A 413
GLU A 377
ARG A 380
 None
 1.09A 5tjzA-4fyeA:
undetectable		 5tjzA-4fyeA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3
(Legionella
pneumophila) 		4 / 7 GLU A 355
ARG A 307
THR A 303
PRO A 269
 None
 1.42A 6a4iB-4fyeA:
4.0		 6a4iB-4fyeA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_1
(SERUM ALBUMIN)		 4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3
(Legionella
pneumophila) 		4 / 5 ASN A 242
TYR A 357
VAL A 360
LEU A 655
 None
 1.30A 6a7pA-4fyeA:
2.6		 6a7pA-4fyeA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA607_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3
(Legionella
pneumophila) 		4 / 4 GLY A 712
ARG A  37
ASN A  76
LEU A  29
 None
 1.38A 6b58A-4fyeA:
5.8		 6b58A-4fyeA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3
(Legionella
pneumophila) 		5 / 12 LEU A 548
HIS A 549
GLN A 541
VAL A 497
ASP A 384
 None
 1.14A 6bxlB-4fyeA:
3.4		 6bxlB-4fyeA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_2
(-)		 4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3
(Legionella
pneumophila) 		4 / 6 TYR A 612
HIS A 549
ASN A 438
GLU A 547
 None
 1.35A 6gneA-4fyeA:
undetectable		 6gneA-4fyeA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3
(Legionella
pneumophila) 		4 / 8 TYR A 612
HIS A 549
ASN A 438
GLU A 547
 None
 1.34A 6gneB-4fyeA:
undetectable		 6gneB-4fyeA:
19.75