SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fym'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 4fym OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Plasmodium
falciparum) 		5 / 12 PHE A  98
LEU A 116
GLY A 137
GLY A 101
LEU A 103
 None
 1.10A 1fe2A-4fymA:
undetectable		 1fe2A-4fymA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 4fym OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Plasmodium
falciparum) 		5 / 12 PHE A  98
LEU A 116
GLY A 137
GLY A 101
LEU A 103
 None
 1.13A 1igxA-4fymA:
undetectable		 1igxA-4fymA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA699_1
(ADENOSINE KINASE)		 4fym OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Plasmodium
falciparum) 		5 / 12 ILE A 207
LEU A 148
GLY A 137
GLY A 132
THR A 144
 None
 1.04A 1likA-4fymA:
undetectable		 1likA-4fymA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OSV_B_CHCB201_1
(BILE ACID RECEPTOR)		 4fym OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Plasmodium
falciparum) 		5 / 12 LEU A 116
MET A 140
PHE A  19
ILE A 270
MET A  67
 None
 1.03A 1osvB-4fymA:
undetectable		 1osvB-4fymA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4fym OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Plasmodium
falciparum) 		4 / 6 VAL A 141
SER A 145
LEU A 160
PHE A 127
 None
 1.28A 2f8dA-4fymA:
undetectable		 2f8dA-4fymA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4fym OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Plasmodium
falciparum) 		4 / 4 ASN A 104
GLY A 101
ASP A 276
ASP A 209
 None
 1.18A 4n49A-4fymA:
undetectable		 4n49A-4fymA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 2)		 4fym OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Plasmodium
falciparum) 		3 / 3 PHE A  98
THR A 144
LEU A  71
 None
 0.77A 4qztA-4fymA:
undetectable		 4qztA-4fymA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_C_ACTC201_0
(NITROGEN REGULATORY
PROTEIN P-II)		 4fym OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Plasmodium
falciparum) 		4 / 5 VAL A 232
VAL A 263
GLY A 264
PHE A 235
 None
 0.92A 5d4nA-4fymA:
undetectable
5d4nC-4fymA:
undetectable		 5d4nA-4fymA:
18.42
5d4nC-4fymA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 4fym OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Plasmodium
falciparum) 		5 / 12 ILE A 112
LEU A 103
PRO A 139
ASP A 208
GLY A 137
 None
 1.21A 5nnaC-4fymA:
undetectable		 5nnaC-4fymA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YVN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 4fym OROTATE
PHOSPHORIBOSYLTRANSF
ERASE
(Plasmodium
falciparum) 		4 / 6 LEU A 271
LYS A  72
LEU A  76
LEU A  81
 None
 1.15A 5yvnA-4fymA:
undetectable		 5yvnA-4fymA:
22.18