SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fyp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M2Z_D_DEXD401_1
(GLUCOCORTICOID
RECEPTOR)		 4fyp VEGETATIVE STORAGE
PROTEIN 1
(Arabidopsis
thaliana) 		5 / 12 ASN A 242
GLY A 244
THR A 254
ILE A 239
LEU A 250
 None
 0.94A 1m2zD-4fypA:
undetectable		 1m2zD-4fypA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1357_1
(PROSTAGLANDIN
REDUCTASE 2)		 4fyp VEGETATIVE STORAGE
PROTEIN 1
(Arabidopsis
thaliana) 		4 / 6 LYS A 260
TYR A  86
LEU A 265
ASP A 124
 None
None
None
MG  A 301 (-2.5A)
 1.29A 2w98A-4fypA:
4.4
2w98B-4fypA:
4.4		 2w98A-4fypA:
22.55
2w98B-4fypA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1357_1
(PROSTAGLANDIN
REDUCTASE 2)		 4fyp VEGETATIVE STORAGE
PROTEIN 1
(Arabidopsis
thaliana) 		4 / 6 TYR A  86
LEU A 265
ASN A 263
ASP A 124
 None
None
None
MG  A 301 (-2.5A)
 1.34A 2w98A-4fypA:
4.4
2w98B-4fypA:
4.4		 2w98A-4fypA:
22.55
2w98B-4fypA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_A_PXLA400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 4fyp VEGETATIVE STORAGE
PROTEIN 1
(Arabidopsis
thaliana) 		5 / 11 ASP A 186
SER A 185
VAL A 268
TYR A 266
ASP A 249
 None
None
None
None
MG  A 301 ( 4.2A)
 1.46A 3mbhA-4fypA:
2.5		 3mbhA-4fypA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_B_PXLB400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 4fyp VEGETATIVE STORAGE
PROTEIN 1
(Arabidopsis
thaliana) 		5 / 12 ASP A 186
SER A 185
VAL A 268
TYR A 266
ASP A 249
 None
None
None
None
MG  A 301 ( 4.2A)
 1.45A 3mbhB-4fypA:
undetectable		 3mbhB-4fypA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4fyp VEGETATIVE STORAGE
PROTEIN 1
(Arabidopsis
thaliana) 		4 / 6 LEU A 164
SER A 132
PRO A 134
GLU A 159
 None
 1.28A 5b8iA-4fypA:
undetectable		 5b8iA-4fypA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4fyp VEGETATIVE STORAGE
PROTEIN 1
(Arabidopsis
thaliana) 		4 / 8 TYR A  86
TYR A  82
GLY A  63
THR A  66
 None
 0.90A 5esfA-4fypA:
undetectable		 5esfA-4fypA:
19.96