SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fys'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AX9_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		4 / 8 GLU A 493
PHE A 328
PHE A 327
HIS A 331
 None
 0.98A 1ax9A-4fysA:
undetectable		 1ax9A-4fysA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_1
(PROTEIN (PROTEASE))		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		6 / 11 LEU A 390
ALA A 317
VAL A 382
GLY A 345
ILE A 344
ILE A 386
 None
 1.30A 1c6yA-4fysA:
undetectable		 1c6yA-4fysA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D0V_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		4 / 8 THR A 928
GLY A 933
PHE A 930
GLY A 893
 None
 0.77A 1d0vA-4fysA:
undetectable		 1d0vA-4fysA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		3 / 3 GLN A 393
TYR A 362
ARG A 363
 None
 0.81A 1gtbA-4fysA:
undetectable		 1gtbA-4fysA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		4 / 6 ASN A 516
ILE A 401
ASN A 405
SER A 456
 None
 1.15A 1h7xA-4fysA:
undetectable		 1h7xA-4fysA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		4 / 6 ASN A 516
ILE A 401
ASN A 405
SER A 456
 None
 1.13A 1h7xB-4fysA:
undetectable		 1h7xB-4fysA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		4 / 6 ASN A 516
ILE A 401
ASN A 405
SER A 456
 None
 1.14A 1h7xC-4fysA:
undetectable		 1h7xC-4fysA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		4 / 6 ASN A 516
ILE A 401
ASN A 405
SER A 456
 None
 1.15A 1h7xD-4fysA:
undetectable		 1h7xD-4fysA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		4 / 8 ASN A 925
LEU A 937
ALA A 940
LEU A 941
 None
 0.87A 1hwiB-4fysA:
undetectable		 1hwiB-4fysA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		4 / 8 ASN A 925
LEU A 937
ALA A 940
LEU A 941
 None
 0.84A 1hwiD-4fysA:
undetectable		 1hwiD-4fysA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		4 / 8 ASN A 925
LEU A 937
ALA A 940
LEU A 941
 None
 0.85A 1hwiC-4fysA:
undetectable		 1hwiC-4fysA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		5 / 12 HIS A 388
GLU A 389
HIS A 392
GLU A 411
TYR A 477
 None
 0.81A 1j36A-4fysA:
3.8		 1j36A-4fysA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		5 / 12 HIS A 388
GLU A 389
HIS A 392
GLU A 411
TYR A 477
 None
 0.81A 1j36B-4fysA:
3.4		 1j36B-4fysA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		5 / 11 HIS A 388
GLU A 389
HIS A 392
GLU A 411
TYR A 477
 None
 0.79A 1j37A-4fysA:
3.3		 1j37A-4fysA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		5 / 11 HIS A 388
GLU A 389
HIS A 392
GLU A 411
TYR A 477
 None
 0.79A 1j37B-4fysA:
3.3		 1j37B-4fysA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHA_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		4 / 8 THR A 928
GLY A 933
PHE A 930
GLY A 893
 None
 0.76A 1jhaA-4fysA:
undetectable		 1jhaA-4fysA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT5_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		5 / 12 LEU A 409
LEU A 407
ALA A 351
MET A 354
TYR A 278
 None
 1.39A 1kt5A-4fysA:
undetectable		 1kt5A-4fysA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4G_A_RIOA500_0
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		5 / 9 GLU A 618
GLY A 616
SER A 613
SER A 557
ASP A 610
 None
 1.36A 1m4gA-4fysA:
0.0		 1m4gA-4fysA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_2
(PROTEASE)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		5 / 11 GLY A 345
ALA A 304
ASP A 288
VAL A 290
ILE A 302
 None
 0.87A 1n49B-4fysA:
undetectable		 1n49B-4fysA:
8.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_1
(PROTEASE)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		5 / 11 GLY A 345
ALA A 304
ASP A 288
VAL A 290
ILE A 302
 None
 0.87A 1n49C-4fysA:
undetectable		 1n49C-4fysA:
8.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA140_0
(LYSOZYME C)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		3 / 3 ASN A 900
ALA A 904
ASN A 868
 None
 0.66A 1n4fA-4fysA:
undetectable		 1n4fA-4fysA:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		5 / 12 HIS A 388
GLU A 389
HIS A 392
GLU A 411
TYR A 477
 None
 0.79A 1o86A-4fysA:
4.0		 1o86A-4fysA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		4 / 8 GLU A 411
HIS A 388
HIS A 392
GLU A 389
 None
 0.86A 1v7zA-4fysA:
undetectable		 1v7zA-4fysA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		4 / 8 GLU A 411
HIS A 388
HIS A 392
GLU A 389
 None
 0.86A 1v7zB-4fysA:
undetectable		 1v7zB-4fysA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		4 / 8 GLU A 411
HIS A 388
HIS A 392
GLU A 389
 None
 0.87A 1v7zC-4fysA:
undetectable		 1v7zC-4fysA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		4 / 8 GLU A 411
HIS A 388
HIS A 392
GLU A 389
 None
 0.88A 1v7zD-4fysA:
undetectable		 1v7zD-4fysA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		4 / 8 GLU A 411
HIS A 388
HIS A 392
GLU A 389
 None
 0.88A 1v7zE-4fysA:
undetectable		 1v7zE-4fysA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		4 / 8 GLU A 411
HIS A 388
HIS A 392
GLU A 389
 None
 0.87A 1v7zF-4fysA:
undetectable		 1v7zF-4fysA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_C_ADNC2502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		3 / 3 GLU A 742
THR A 737
LEU A 792
 None
 0.46A 1v8bC-4fysA:
undetectable		 1v8bC-4fysA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		6 / 12 ALA A 353
HIS A 388
GLU A 389
HIS A 392
GLU A 411
TYR A 477
 None
 0.74A 2c6nA-4fysA:
3.8		 2c6nA-4fysA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		5 / 12 HIS A 388
GLU A 389
HIS A 392
GLU A 411
TYR A 477
 None
 0.83A 2c6nB-4fysA:
2.9		 2c6nB-4fysA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_A_BEZA352_0
(D-AMINO-ACID OXIDASE)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		4 / 6 LEU A 346
TYR A 194
ILE A 283
GLY A 192
 None
 0.95A 2du8A-4fysA:
undetectable		 2du8A-4fysA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		5 / 12 PHE A 898
THR A 906
VAL A 905
LEU A 845
ILE A 863
 None
 1.23A 2fj1A-4fysA:
undetectable		 2fj1A-4fysA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_B_NCAB901_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		4 / 5 ILE A 585
PRO A 533
PHE A 490
VAL A 536
 None
 1.48A 2hjhB-4fysA:
undetectable		 2hjhB-4fysA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		6 / 12 LEU A 390
ALA A 317
VAL A 382
GLY A 345
ILE A 344
ILE A 386
 None
 1.32A 2qakA-4fysA:
undetectable		 2qakA-4fysA:
7.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		3 / 3 ASN A 378
ARG A 381
ASP A 858
 SO4  A1016 ( 4.0A)
None
None
 0.78A 2qe6A-4fysA:
undetectable		 2qe6A-4fysA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		3 / 3 ASN A 378
ARG A 381
ASP A 858
 SO4  A1016 ( 4.0A)
None
None
 0.80A 2qe6B-4fysA:
undetectable		 2qe6B-4fysA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		5 / 11 HIS A 388
GLU A 389
HIS A 392
GLU A 411
TYR A 477
 None
 0.73A 2x8zA-4fysA:
4.4		 2x8zA-4fysA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		5 / 12 HIS A 388
GLU A 389
HIS A 392
GLU A 411
TYR A 477
 None
 0.75A 2x91A-4fysA:
3.3		 2x91A-4fysA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		4 / 8 GLU A 411
HIS A 388
HIS A 392
GLU A 389
 None
 0.86A 3a6jA-4fysA:
undetectable		 3a6jA-4fysA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		4 / 7 GLU A 411
HIS A 388
HIS A 392
GLU A 389
 None
 0.83A 3a6jB-4fysA:
undetectable		 3a6jB-4fysA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		4 / 8 GLU A 411
HIS A 388
HIS A 392
GLU A 389
 None
 0.84A 3a6jC-4fysA:
undetectable		 3a6jC-4fysA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		4 / 8 GLU A 411
HIS A 388
HIS A 392
GLU A 389
 None
 0.87A 3a6jE-4fysA:
undetectable		 3a6jE-4fysA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		4 / 8 GLU A 411
HIS A 388
HIS A 392
GLU A 389
 None
 0.84A 3a6jF-4fysA:
undetectable		 3a6jF-4fysA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		3 / 3 ARG A 640
VAL A 554
THR A 556
 None
 0.83A 3cyxA-4fysA:
undetectable		 3cyxA-4fysA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_2
(PROTEASE)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		6 / 10 LEU A 390
ALA A 317
VAL A 382
GLY A 345
ILE A 344
ILE A 386
 None
 1.34A 3ekpB-4fysA:
undetectable		 3ekpB-4fysA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_1
(PROTEASE)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		6 / 10 LEU A 390
ALA A 317
VAL A 382
GLY A 345
ILE A 344
ILE A 386
 None
 1.35A 3ekpC-4fysA:
undetectable		 3ekpC-4fysA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_2
(PROTEASE)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		6 / 10 LEU A 390
ALA A 317
VAL A 382
GLY A 345
ILE A 344
ILE A 386
 None
 1.35A 3ekpD-4fysA:
undetectable		 3ekpD-4fysA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_1
(PROTEASE)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		6 / 11 LEU A 390
ALA A 317
VAL A 382
GLY A 345
ILE A 344
ILE A 386
 None
 1.31A 3ektC-4fysA:
undetectable		 3ektC-4fysA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		4 / 6 GLN A 916
LEU A 918
GLU A 919
LEU A 941
 None
 0.90A 3h5gA-4fysA:
undetectable
3h5gC-4fysA:
undetectable		 3h5gA-4fysA:
2.77
3h5gC-4fysA:
2.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		3 / 3 HIS A 388
GLU A 389
HIS A 392
 None
 0.19A 3kecB-4fysA:
2.2		 3kecB-4fysA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		5 / 12 PHE A 395
GLY A 499
ALA A 501
THR A 334
ILE A 324
 None
NAG  A1010 ( 4.4A)
None
None
None
 1.14A 3ld6A-4fysA:
undetectable		 3ld6A-4fysA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_2
(PROTEASE)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		3 / 3 ARG A 640
VAL A 620
THR A 556
 None
 0.78A 3ndtA-4fysA:
undetectable		 3ndtA-4fysA:
8.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		4 / 4 LEU A 875
GLY A 874
GLY A 872
THR A 867
 None
 0.71A 3si7A-4fysA:
undetectable		 3si7A-4fysA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		5 / 12 GLY A 412
ARG A 485
ASP A 439
SER A 415
MET A 435
 None
 1.33A 3tkaA-4fysA:
undetectable		 3tkaA-4fysA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		5 / 12 GLY A 480
ARG A 485
ASP A 439
SER A 415
MET A 435
 None
 1.19A 3tkaA-4fysA:
undetectable		 3tkaA-4fysA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_C_SALC404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		4 / 7 ALA A 466
TYR A  74
ARG A  75
ARG A 218
 None
 1.11A 3twpC-4fysA:
undetectable		 3twpC-4fysA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG306_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		3 / 3 ARG A 204
ARG A 855
ASP A 852
 None
SO4  A1014 (-3.9A)
None
 0.92A 3wipG-4fysA:
1.8
3wipH-4fysA:
undetectable		 3wipG-4fysA:
13.60
3wipH-4fysA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		4 / 7 LEU A 622
VAL A 586
TYR A 600
LEU A 561
 None
 1.15A 4b3qA-4fysA:
undetectable		 4b3qA-4fysA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		5 / 11 HIS A 388
GLU A 389
HIS A 392
GLU A 411
TYR A 477
 None
 0.81A 4c2pA-4fysA:
4.0		 4c2pA-4fysA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DPR_A_X8ZA702_1
(LEUKOTRIENE A-4
HYDROLASE)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		5 / 9 GLY A 352
HIS A 388
GLU A 389
GLU A 411
TYR A 477
 None
 0.35A 4dprA-4fysA:
21.6		 4dprA-4fysA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DPR_A_X8ZA702_1
(LEUKOTRIENE A-4
HYDROLASE)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		5 / 9 HIS A 388
GLU A 389
GLU A 411
TYR A 477
ARG A 381
 None
 1.36A 4dprA-4fysA:
21.6		 4dprA-4fysA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_1
(ASPARTYL PROTEASE)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		6 / 11 LEU A 390
ALA A 317
VAL A 382
GLY A 345
ILE A 344
ILE A 386
 None
 1.34A 4dqeA-4fysA:
undetectable		 4dqeA-4fysA:
8.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		4 / 8 ASN A 296
ALA A 294
SER A 295
TYR A 424
 None
 1.07A 4ijiF-4fysA:
undetectable		 4ijiF-4fysA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		3 / 4 SER A 469
GLY A 192
GLU A 185
 None
 0.54A 4juoA-4fysA:
undetectable
4juoC-4fysA:
undetectable		 4juoA-4fysA:
19.45
4juoC-4fysA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		5 / 12 LEU A 390
ALA A 281
ILE A 300
LEU A 338
GLY A 297
 None
 1.27A 4l9qA-4fysA:
undetectable		 4l9qA-4fysA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_2
(PROTEASE)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		6 / 10 LEU A 390
ALA A 317
VAL A 382
GLY A 345
ILE A 344
ILE A 386
 None
 1.32A 4ll3B-4fysA:
undetectable		 4ll3B-4fysA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_1
(PROTEASE)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		6 / 10 LEU A 390
ALA A 317
VAL A 382
GLY A 345
ILE A 344
ILE A 386
 None
 1.33A 4ll3A-4fysA:
undetectable		 4ll3A-4fysA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_1
(PROTEASE)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		6 / 11 LEU A 390
ALA A 317
VAL A 382
GLY A 345
ILE A 344
ILE A 386
 None
 1.40A 4njtA-4fysA:
undetectable		 4njtA-4fysA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_2
(ANDROGEN RECEPTOR)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		4 / 6 LEU A 747
ASN A 746
LEU A 434
VAL A 655
 None
None
None
SO4  A1020 ( 4.8A)
 0.96A 4okbA-4fysA:
undetectable		 4okbA-4fysA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAE_A_NIZA804_1
(CATALASE-PEROXIDASE)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		4 / 6 ASP A 473
TYR A 477
HIS A 453
THR A 457
 None
 1.29A 4paeA-4fysA:
undetectable		 4paeA-4fysA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA303_1
(CHITOSANASE)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		4 / 6 GLU A 355
ILE A 401
THR A 400
TYR A 477
 None
 1.15A 4qwpA-4fysA:
undetectable		 4qwpA-4fysA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		8 / 12 GLN A 213
ALA A 214
HIS A 388
GLU A 389
HIS A 392
TRP A 404
GLU A 411
TYR A 477
 None
 0.46A 4r7lA-4fysA:
24.5		 4r7lA-4fysA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		7 / 12 GLN A 213
GLU A 389
HIS A 392
TRP A 404
PHE A 472
GLU A 411
TYR A 477
 None
 1.28A 4r7lA-4fysA:
24.5		 4r7lA-4fysA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_1
(HIV-1 PROTEASE)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		6 / 11 LEU A 390
ALA A 317
VAL A 382
GLY A 345
ILE A 344
ILE A 386
 None
 1.41A 4rvjC-4fysA:
undetectable		 4rvjC-4fysA:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		3 / 3 MET A 444
GLN A 546
TYR A 582
 None
 1.00A 4udcA-4fysA:
undetectable		 4udcA-4fysA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		4 / 8 GLY A 548
GLN A 546
SER A 452
HIS A 565
 None
 0.96A 4wryA-4fysA:
undetectable		 4wryA-4fysA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		4 / 8 GLY A 548
GLN A 546
SER A 452
HIS A 565
 None
 0.95A 4wrzA-4fysA:
undetectable		 4wrzA-4fysA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		3 / 3 ASP A 406
ARG A 935
ARG A 576
 None
 0.90A 4x5iA-4fysA:
undetectable		 4x5iA-4fysA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		3 / 3 ASP A 406
ARG A 935
ARG A 576
 None
 0.98A 5eajB-4fysA:
undetectable		 5eajB-4fysA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		3 / 3 ASP A 858
ARG A 204
ARG A 305
 None
None
SO4  A1014 (-3.0A)
 0.92A 5eajB-4fysA:
undetectable		 5eajB-4fysA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		4 / 8 LEU A 521
LEU A 484
THR A 544
TYR A 514
 None
 1.10A 5hbsA-4fysA:
undetectable		 5hbsA-4fysA:
8.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_2
(CDL2.2)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		5 / 12 LEU A 398
LEU A 484
LEU A 504
THR A 512
LEU A 521
 None
 1.22A 5ienB-4fysA:
2.0		 5ienB-4fysA:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_2
(ADENOSINE KINASE)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		4 / 4 ASN A 869
LEU A 841
SER A 865
LEU A 832
 None
 1.29A 5kb5A-4fysA:
undetectable		 5kb5A-4fysA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_1
(PROTEASE E35D-DRV)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		5 / 12 LEU A 390
ALA A 317
GLY A 345
ILE A 344
ILE A 386
 None
 1.08A 5kqyA-4fysA:
undetectable		 5kqyA-4fysA:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_2
(PROTEASE)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		6 / 12 LEU A 390
ALA A 317
VAL A 382
GLY A 345
ILE A 344
ILE A 386
 None
 1.33A 5t2zB-4fysA:
undetectable		 5t2zB-4fysA:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		5 / 12 GLU A 523
LEU A 487
GLY A 499
SER A 502
PHE A 507
 NAG  A1010 (-3.9A)
None
NAG  A1010 ( 4.4A)
NAG  A1010 (-4.1A)
None
 0.86A 5vooA-4fysA:
undetectable		 5vooA-4fysA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		5 / 12 GLU A 523
LEU A 487
GLY A 499
SER A 502
PHE A 507
 NAG  A1010 (-3.9A)
None
NAG  A1010 ( 4.4A)
NAG  A1010 (-4.1A)
None
 0.70A 5vooD-4fysA:
undetectable		 5vooD-4fysA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		5 / 12 GLU A 523
LEU A 487
GLY A 499
SER A 502
PHE A 507
 NAG  A1010 (-3.9A)
None
NAG  A1010 ( 4.4A)
NAG  A1010 (-4.1A)
None
 0.66A 5vooF-4fysA:
undetectable		 5vooF-4fysA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		5 / 12 GLU A 523
LEU A 487
VAL A 495
GLY A 499
SER A 502
 NAG  A1010 (-3.9A)
None
None
NAG  A1010 ( 4.4A)
NAG  A1010 (-4.1A)
 0.81A 5vopA-4fysA:
undetectable		 5vopA-4fysA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		3 / 3 LEU A  80
VAL A 119
ASP A 118
 None
 0.53A 5x23A-4fysA:
undetectable		 5x23A-4fysA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA503_1
(CYTOCHROME P450 2C9)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		5 / 12 ILE A 863
PHE A 909
GLN A 881
LEU A 937
LEU A 901
 None
 1.22A 5xxiA-4fysA:
undetectable		 5xxiA-4fysA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		3 / 3 TYR A 176
PRO A 148
LEU A 166
 None
 0.94A 6beoA-4fysA:
undetectable		 6beoA-4fysA:
3.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		5 / 12 LEU A 325
ALA A 414
ASN A 397
VAL A 360
TYR A 362
 None
 1.39A 6drxA-4fysA:
undetectable		 6drxA-4fysA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_1
(CYTOCHROME P450 1A1)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		3 / 3 SER A 373
SER A 374
ALA A 308
 None
 0.62A 6dwnC-4fysA:
0.0		 6dwnC-4fysA:
6.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCO_A_FY5A1003_0
(ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		5 / 11 ASN A 365
VAL A 360
THR A 321
THR A 384
VAL A 382
 None
 1.32A 6hcoA-4fysA:
undetectable
6hcoB-4fysA:
undetectable		 6hcoA-4fysA:
21.66
6hcoB-4fysA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLP_A_GAWA1501_1
(SUBSTANCE-P
RECEPTOR,SUBSTANCE-P
RECEPTOR)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		4 / 5 ASN A 248
GLN A 211
TYR A 477
MET A 275
 None
 0.86A 6hlpA-4fysA:
0.0		 6hlpA-4fysA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		4 / 7 TRP A 303
THR A 244
ARG A 305
HIS A 313
 None
None
SO4  A1014 (-3.0A)
None
 1.25A 6mn4E-4fysA:
undetectable		 6mn4E-4fysA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		4 / 6 LEU A 484
HIS A 392
HIS A 388
GLU A 411
 None
 1.00A 6pahA-4fysA:
undetectable		 6pahA-4fysA:
16.12