SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fyu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 4fyu THIOREDOXIN
(Wuchereria
bancrofti) 		5 / 12 ILE A   8
ALA A   6
LEU A  24
LEU A  32
ILE A 114
 None
 1.12A 1xzxX-4fyuA:
undetectable		 1xzxX-4fyuA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H77_A_T3A1_1
(THRA PROTEIN)		 4fyu THIOREDOXIN
(Wuchereria
bancrofti) 		5 / 12 ILE A   8
ALA A   6
LEU A  24
LEU A  32
ILE A 114
 None
 1.15A 2h77A-4fyuA:
undetectable		 2h77A-4fyuA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQ7_A_LEUA902_0
(LEUCINE--TRNA LIGASE)		 4fyu THIOREDOXIN
(Wuchereria
bancrofti) 		4 / 7 LEU A  75
ASP A  69
GLU A  81
HIS A  83
 None
 1.20A 4aq7A-4fyuA:
undetectable		 4aq7A-4fyuA:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX5_B_MIYB1103_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4fyu THIOREDOXIN
(Wuchereria
bancrofti) 		5 / 12 GLY A  20
SER A  21
ASN A   7
ILE A   8
VAL A  89
 None
 1.14A 4dx5B-4fyuA:
undetectable		 4dx5B-4fyuA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4fyu THIOREDOXIN
(Wuchereria
bancrofti) 		5 / 12 ILE A   8
ALA A   6
LEU A  24
LEU A  32
ILE A 114
 None
 1.16A 4lnxA-4fyuA:
undetectable		 4lnxA-4fyuA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8V_B_MIYB1103_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4fyu THIOREDOXIN
(Wuchereria
bancrofti) 		5 / 12 GLY A  20
SER A  21
ASN A   7
ILE A   8
VAL A  89
 None
 1.15A 4u8vB-4fyuA:
undetectable		 4u8vB-4fyuA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8Y_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4fyu THIOREDOXIN
(Wuchereria
bancrofti) 		5 / 12 GLY A  20
SER A  21
ASN A   7
ILE A   8
VAL A  89
 None
 1.12A 4u8yB-4fyuA:
undetectable		 4u8yB-4fyuA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U95_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4fyu THIOREDOXIN
(Wuchereria
bancrofti) 		5 / 12 GLY A  20
SER A  21
ASN A   7
ILE A   8
VAL A  89
 None
 1.10A 4u95B-4fyuA:
undetectable		 4u95B-4fyuA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 4fyu THIOREDOXIN
(Wuchereria
bancrofti) 		5 / 9 VAL A  66
VAL A  30
LEU A  99
GLY A 118
LEU A   4
 None
 1.24A 6czmB-4fyuA:
undetectable
6czmC-4fyuA:
undetectable		 6czmB-4fyuA:
17.63
6czmC-4fyuA:
17.63