SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fz8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 4fz8 FAB HEAVY CHAIN OF
HUMAN ANTI-HIV-1 ENV
ANTIBODY C11
(Homo
sapiens) 		5 / 12 TRP H  47
SER H  50
TYR H  58
ALA H  95
GLY H 100
 None
 1.00A 1vpoH-4fz8H:
20.8
1vpoL-4fz8H:
13.7		 1vpoH-4fz8H:
63.56
1vpoL-4fz8H:
26.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPY_A_ACTA408_0
(THIOREDOXIN
REDUCTASE)		 4fz8 FAB HEAVY CHAIN OF
HUMAN ANTI-HIV-1 ENV
ANTIBODY C11
(Homo
sapiens) 		3 / 3 PRO H 185
SER H 187
SER H 188
 None
 0.61A 6bpyA-4fz8H:
undetectable		 6bpyA-4fz8H:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)		 4fz8 FAB HEAVY CHAIN OF
HUMAN ANTI-HIV-1 ENV
ANTIBODY C11
(Homo
sapiens) 		3 / 3 TYR H  56
HIS H 100
PHE H  99
 None
 0.67A 6esmA-4fz8H:
undetectable		 6esmA-4fz8H:
13.92