SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fzd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 4fzd SERINE/THREONINE-PRO
TEIN KINASE MST4
(Homo
sapiens) 		5 / 11 ALA B 213
ARG B 290
LEU B 287
ALA B 107
LEU B 111
 None
 1.33A 1mjlA-4fzdB:
undetectable
1mjlB-4fzdB:
undetectable		 1mjlA-4fzdB:
19.40
1mjlB-4fzdB:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_1
(HEMK PROTEIN)		 4fzd SERINE/THREONINE-PRO
TEIN KINASE MST4
(Homo
sapiens) 		4 / 4 THR B  83
GLY B 105
ASP B 109
ALA B 148
 None
GOL  B1000 ( 3.9A)
None
None
 1.20A 1sg9A-4fzdB:
undetectable		 1sg9A-4fzdB:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1352_1
(PROSTAGLANDIN
REDUCTASE 2)		 4fzd SERINE/THREONINE-PRO
TEIN KINASE MST4
(Homo
sapiens) 		4 / 7 TYR B 101
LEU B 102
LYS B 159
TYR B  86
 GOL  B1000 (-4.0A)
GOL  B1000 (-4.7A)
None
None
 1.42A 2w98A-4fzdB:
undetectable
2w98B-4fzdB:
undetectable		 2w98A-4fzdB:
21.98
2w98B-4fzdB:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GVU_A_STIA1001_2
(TYROSINE-PROTEIN
KINASE ABL2)		 4fzd SERINE/THREONINE-PRO
TEIN KINASE MST4
(Homo
sapiens) 		4 / 5 LYS B  53
VAL B  73
ILE B  97
TYR B 101
 None
None
None
GOL  B1000 (-4.0A)
 1.05A 3gvuA-4fzdB:
25.0		 3gvuA-4fzdB:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4fzd SERINE/THREONINE-PRO
TEIN KINASE MST4
(Homo
sapiens) 		4 / 6 VAL B  38
LYS B  53
VAL B  73
ILE B  97
 None
 0.76A 3mssD-4fzdB:
18.5		 3mssD-4fzdB:
27.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 4fzd SERINE/THREONINE-PRO
TEIN KINASE MST4
(Homo
sapiens) 		7 / 12 VAL B  38
ALA B  51
LEU B  74
TYR B 101
LEU B 135
HIS B 142
ALA B 161
 None
GOL  B1000 ( 4.3A)
None
GOL  B1000 (-4.0A)
None
None
None
 0.92A 3rgfA-4fzdB:
18.2		 3rgfA-4fzdB:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 4fzd SERINE/THREONINE-PRO
TEIN KINASE MST4
(Homo
sapiens) 		5 / 12 PHE B 116
LEU B 152
LEU B 284
ILE B 288
GLY B 105
 None
None
None
None
GOL  B1000 ( 3.9A)
 1.07A 4dm8B-4fzdB:
undetectable		 4dm8B-4fzdB:
23.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4fzd SERINE/THREONINE-PRO
TEIN KINASE MST4
(Homo
sapiens) 		8 / 12 ALA B  51
LYS B  53
THR B  83
ILE B  97
MET B  99
TYR B 101
LEU B 151
ALA B 161
 GOL  B1000 ( 4.3A)
None
None
None
None
GOL  B1000 (-4.0A)
GOL  B1000 ( 4.4A)
None
 0.97A 4qmnA-4fzdB:
37.0		 4qmnA-4fzdB:
82.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4fzd SERINE/THREONINE-PRO
TEIN KINASE MST4
(Homo
sapiens) 		7 / 12 ALA B  51
THR B  83
MET B  99
TYR B 101
LEU B 102
GLY B 103
LEU B 151
 GOL  B1000 ( 4.3A)
None
None
GOL  B1000 (-4.0A)
GOL  B1000 (-4.7A)
None
GOL  B1000 ( 4.4A)
 0.75A 4qmzA-4fzdB:
29.6		 4qmzA-4fzdB:
82.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4fzd SERINE/THREONINE-PRO
TEIN KINASE MST4
(Homo
sapiens) 		6 / 12 GLY B  31
ALA B  51
THR B  83
MET B  99
TYR B 101
LEU B 151
 None
GOL  B1000 ( 4.3A)
None
None
GOL  B1000 (-4.0A)
GOL  B1000 ( 4.4A)
 0.87A 4qmzA-4fzdB:
29.6		 4qmzA-4fzdB:
82.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4fzd SERINE/THREONINE-PRO
TEIN KINASE MST4
(Homo
sapiens) 		7 / 12 ILE B  30
ALA B  51
MET B  99
TYR B 101
LEU B 102
GLY B 103
LEU B 151
 GOL  B1000 (-4.1A)
GOL  B1000 ( 4.3A)
None
GOL  B1000 (-4.0A)
GOL  B1000 (-4.7A)
None
GOL  B1000 ( 4.4A)
 1.03A 4qmzA-4fzdB:
29.6		 4qmzA-4fzdB:
82.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4fzd SERINE/THREONINE-PRO
TEIN KINASE MST4
(Homo
sapiens) 		7 / 12 ILE B  30
VAL B  38
ALA B  51
MET B  99
TYR B 101
LEU B 102
LEU B 151
 GOL  B1000 (-4.1A)
None
GOL  B1000 ( 4.3A)
None
GOL  B1000 (-4.0A)
GOL  B1000 (-4.7A)
GOL  B1000 ( 4.4A)
 1.07A 4qmzA-4fzdB:
29.6		 4qmzA-4fzdB:
82.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4fzd SERINE/THREONINE-PRO
TEIN KINASE MST4
(Homo
sapiens) 		7 / 12 VAL B  38
ALA B  51
THR B  83
MET B  99
TYR B 101
LEU B 102
LEU B 151
 None
GOL  B1000 ( 4.3A)
None
None
GOL  B1000 (-4.0A)
GOL  B1000 (-4.7A)
GOL  B1000 ( 4.4A)
 0.80A 4qmzA-4fzdB:
29.6		 4qmzA-4fzdB:
82.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WAN_C_ACTC303_0
(BRANCHPOINT-BRIDGING
PROTEIN)		 4fzd SERINE/THREONINE-PRO
TEIN KINASE MST4
(Homo
sapiens) 		3 / 3 ASP B 197
ARG B 262
PRO B 259
 None
 0.98A 4wanC-4fzdB:
undetectable		 4wanC-4fzdB:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 4fzd SERINE/THREONINE-PRO
TEIN KINASE MST4
(Homo
sapiens) 		5 / 9 ILE B 210
GLY B 206
LEU B 255
TRP B 203
ASN B 219
 None
 1.41A 5fhzB-4fzdB:
undetectable		 5fhzB-4fzdB:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		 4fzd SERINE/THREONINE-PRO
TEIN KINASE MST4
(Homo
sapiens) 		5 / 12 PRO B 115
PHE B 273
ILE B 121
GLN B 120
PHE B 247
 None
 1.40A 5hgcA-4fzdB:
undetectable		 5hgcA-4fzdB:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		 4fzd SERINE/THREONINE-PRO
TEIN KINASE MST4
(Homo
sapiens) 		5 / 12 THR B 244
PHE B 273
ILE B 121
GLN B 120
PHE B 247
 None
 1.36A 5hgcA-4fzdB:
undetectable		 5hgcA-4fzdB:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 4fzd SERINE/THREONINE-PRO
TEIN KINASE MST4
(Homo
sapiens) 		6 / 12 ILE B  30
GLY B  31
VAL B  38
ALA B  51
LEU B 151
ALA B 161
 GOL  B1000 (-4.1A)
None
None
GOL  B1000 ( 4.3A)
GOL  B1000 ( 4.4A)
None
 0.64A 5l2tA-4fzdB:
23.8		 5l2tA-4fzdB:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NR3_A_95EA401_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3B)		 4fzd SERINE/THREONINE-PRO
TEIN KINASE MST4
(Homo
sapiens) 		4 / 7 ILE B  52
PHE B  39
TRP B  96
LYS B  94
 None
 1.38A 5nr3A-4fzdB:
undetectable		 5nr3A-4fzdB:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_A_NIZA807_1
(CATALASE-PEROXIDASE)		 4fzd SERINE/THREONINE-PRO
TEIN KINASE MST4
(Homo
sapiens) 		4 / 8 GLU B 211
VAL B 150
GLY B 206
LEU B 205
 None
 1.00A 5sxtA-4fzdB:
undetectable		 5sxtA-4fzdB:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_B_NIZB808_1
(CATALASE-PEROXIDASE)		 4fzd SERINE/THREONINE-PRO
TEIN KINASE MST4
(Homo
sapiens) 		4 / 8 GLU B 211
VAL B 150
GLY B 206
LEU B 205
 None
 0.97A 5sxtB-4fzdB:
undetectable		 5sxtB-4fzdB:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 4fzd SERINE/THREONINE-PRO
TEIN KINASE MST4
(Homo
sapiens) 		4 / 8 GLU B 211
VAL B 150
GLY B 206
LEU B 205
 None
 0.99A 5syjB-4fzdB:
undetectable		 5syjB-4fzdB:
18.08