SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fzi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)		 4fzi PROSTAGLANDIN F
SYNTHASE
(Trypanosoma
cruzi) 		6 / 12 GLU A  65
GLY A  62
GLY A  58
ILE A  47
ILE A  40
ASN A  34
 None
 1.34A 1qaoA-4fziA:
undetectable		 1qaoA-4fziA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 4fzi PROSTAGLANDIN F
SYNTHASE
(Trypanosoma
cruzi) 		5 / 12 GLU A  65
ALA A  39
GLY A  58
GLY A  62
ILE A  47
 None
 0.99A 1x1aA-4fziA:
undetectable		 1x1aA-4fziA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4fzi PROSTAGLANDIN F
SYNTHASE
(Trypanosoma
cruzi) 		5 / 12 GLY A  22
LEU A  21
GLY A  62
ALA A  33
ALA A  30
 None
 0.93A 2bm9F-4fziA:
undetectable		 2bm9F-4fziA:
18.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2INE_A_PACA317_0
(ALDOSE REDUCTASE)		 4fzi PROSTAGLANDIN F
SYNTHASE
(Trypanosoma
cruzi) 		4 / 5 TRP A  24
TYR A  53
HIS A 111
TRP A 112
 GLU  A 301 (-3.5A)
GLU  A 301 (-4.4A)
GLU  A 301 (-3.8A)
GLU  A 301 (-4.1A)
 0.45A 2ineA-4fziA:
37.3		 2ineA-4fziA:
38.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ISF_A_PACA317_0
(ALDOSE REDUCTASE)		 4fzi PROSTAGLANDIN F
SYNTHASE
(Trypanosoma
cruzi) 		4 / 5 TRP A  24
TYR A  53
HIS A 111
TRP A 112
 GLU  A 301 (-3.5A)
GLU  A 301 (-4.4A)
GLU  A 301 (-3.8A)
GLU  A 301 (-4.1A)
 0.50A 2isfA-4fziA:
37.0		 2isfA-4fziA:
38.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)		 4fzi PROSTAGLANDIN F
SYNTHASE
(Trypanosoma
cruzi) 		3 / 3 ARG A 135
THR A   9
VAL A  14
 None
 0.98A 2q64A-4fziA:
undetectable		 2q64A-4fziA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		 4fzi PROSTAGLANDIN F
SYNTHASE
(Trypanosoma
cruzi) 		4 / 6 LEU A 147
LEU A 150
ILE A 183
ARG A 157
 None
 0.87A 2rlfC-4fziA:
undetectable
2rlfD-4fziA:
undetectable		 2rlfC-4fziA:
14.44
2rlfD-4fziA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 4fzi PROSTAGLANDIN F
SYNTHASE
(Trypanosoma
cruzi) 		4 / 5 HIS A 145
HIS A 146
ASP A 274
ASP A 272
 None
 1.17A 3c0zA-4fziA:
undetectable		 3c0zA-4fziA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 4fzi PROSTAGLANDIN F
SYNTHASE
(Trypanosoma
cruzi) 		4 / 6 HIS A 145
HIS A 146
ASP A 274
ASP A 272
 None
 1.15A 3c0zC-4fziA:
undetectable		 3c0zC-4fziA:
17.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R43_A_ID8A332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4fzi PROSTAGLANDIN F
SYNTHASE
(Trypanosoma
cruzi) 		5 / 12 TYR A  53
TRP A  80
HIS A 111
ASN A 141
PHE A 276
 GLU  A 301 (-4.4A)
None
GLU  A 301 (-3.8A)
GLU  A 301 (-3.7A)
None
 0.63A 3r43A-4fziA:
36.9		 3r43A-4fziA:
35.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R6I_A_JMSA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4fzi PROSTAGLANDIN F
SYNTHASE
(Trypanosoma
cruzi) 		5 / 12 TYR A  53
TRP A  80
HIS A 111
ASN A 141
PHE A 276
 GLU  A 301 (-4.4A)
None
GLU  A 301 (-3.8A)
GLU  A 301 (-3.7A)
None
 0.67A 3r6iA-4fziA:
37.1		 3r6iA-4fziA:
35.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R7M_A_SUZA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4fzi PROSTAGLANDIN F
SYNTHASE
(Trypanosoma
cruzi) 		5 / 10 TYR A  53
TRP A  80
HIS A 111
ASN A 141
PHE A 276
 GLU  A 301 (-4.4A)
None
GLU  A 301 (-3.8A)
GLU  A 301 (-3.7A)
None
 0.64A 3r7mA-4fziA:
37.0		 3r7mA-4fziA:
35.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3S3G_A_TLTA317_1
(ALDOSE REDUCTASE)		 4fzi PROSTAGLANDIN F
SYNTHASE
(Trypanosoma
cruzi) 		4 / 7 TRP A  24
TYR A  53
HIS A 111
PHE A 276
 GLU  A 301 (-3.5A)
GLU  A 301 (-4.4A)
GLU  A 301 (-3.8A)
None
 1.22A 3s3gA-4fziA:
37.3		 3s3gA-4fziA:
39.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3S3G_A_TLTA317_1
(ALDOSE REDUCTASE)		 4fzi PROSTAGLANDIN F
SYNTHASE
(Trypanosoma
cruzi) 		4 / 7 TRP A  24
TYR A  53
HIS A 111
TRP A 112
 GLU  A 301 (-3.5A)
GLU  A 301 (-4.4A)
GLU  A 301 (-3.8A)
GLU  A 301 (-4.1A)
 0.40A 3s3gA-4fziA:
37.3		 3s3gA-4fziA:
39.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		 4fzi PROSTAGLANDIN F
SYNTHASE
(Trypanosoma
cruzi) 		4 / 5 ILE A 232
SER A 235
LYS A 234
GLY A  22
 None
 0.85A 3tkdB-4fziA:
undetectable		 3tkdB-4fziA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		 4fzi PROSTAGLANDIN F
SYNTHASE
(Trypanosoma
cruzi) 		4 / 5 ILE A 232
SER A 235
LYS A 234
GLY A  22
 None
 0.86A 3tkdA-4fziA:
undetectable		 3tkdA-4fziA:
22.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 4fzi PROSTAGLANDIN F
SYNTHASE
(Trypanosoma
cruzi) 		4 / 8 TRP A  24
TRP A  80
HIS A 111
TRP A 112
 GLU  A 301 (-3.5A)
None
GLU  A 301 (-3.8A)
GLU  A 301 (-4.1A)
 0.50A 3v35A-4fziA:
37.8		 3v35A-4fziA:
39.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_D_CAMD502_0
(CAMPHOR
5-MONOOXYGENASE)		 4fzi PROSTAGLANDIN F
SYNTHASE
(Trypanosoma
cruzi) 		4 / 5 PHE A 277
GLY A  85
THR A  89
VAL A  79
 None
 1.00A 3wrkD-4fziA:
undetectable		 3wrkD-4fziA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4fzi PROSTAGLANDIN F
SYNTHASE
(Trypanosoma
cruzi) 		5 / 12 THR A 186
VAL A 247
ASP A 224
ILE A 221
GLU A 243
 None
 1.30A 4i41A-4fziA:
undetectable		 4i41A-4fziA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4fzi PROSTAGLANDIN F
SYNTHASE
(Trypanosoma
cruzi) 		4 / 5 THR A  49
ALA A  50
THR A  77
TYR A 108
 None
 1.01A 5ecmA-4fziA:
undetectable		 5ecmA-4fziA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4fzi PROSTAGLANDIN F
SYNTHASE
(Trypanosoma
cruzi) 		4 / 6 THR A  49
ALA A  50
THR A  77
TYR A 108
 None
 0.96A 5ecoA-4fziA:
2.0		 5ecoA-4fziA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_2
(ENVELOPE
GLYCOPROTEIN 2)		 4fzi PROSTAGLANDIN F
SYNTHASE
(Trypanosoma
cruzi) 		4 / 7 LEU A 128
TYR A 108
THR A  77
THR A  49
 None
 1.10A 5jq7B-4fziA:
undetectable		 5jq7B-4fziA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 4fzi PROSTAGLANDIN F
SYNTHASE
(Trypanosoma
cruzi) 		5 / 12 GLU A  41
LEU A  21
GLY A  62
ASN A  34
ALA A  26
 None
 1.41A 5kbwA-4fziA:
undetectable		 5kbwA-4fziA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 4fzi PROSTAGLANDIN F
SYNTHASE
(Trypanosoma
cruzi) 		5 / 12 GLU A  41
LEU A  21
GLY A  62
ASN A  34
ALA A  26
 None
 1.45A 5kc0A-4fziA:
undetectable		 5kc0A-4fziA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)		 4fzi PROSTAGLANDIN F
SYNTHASE
(Trypanosoma
cruzi) 		4 / 7 GLN A  84
GLY A 114
GLN A 171
TRP A 112
 None
None
None
GLU  A 301 (-4.1A)
 1.11A 5vlmC-4fziA:
undetectable		 5vlmC-4fziA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4fzi PROSTAGLANDIN F
SYNTHASE
(Trypanosoma
cruzi) 		4 / 6 TYR A 108
GLN A 162
GLU A  56
ALA A  92
 None
 1.23A 6djzB-4fziA:
undetectable		 6djzB-4fziA:
19.93