SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fzl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 4fzl BACTERIOCIN
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 8 TYR A 261
ASP A  87
ALA A  84
TYR A 120
 None
 1.08A 3rodA-4fzlA:
undetectable		 3rodA-4fzlA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4fzl BACTERIOCIN
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 VAL A 185
LEU A 207
ILE A 172
ILE A 162
VAL A 160
 EDO  A 305 (-4.9A)
None
None
None
None
 1.07A 3w67D-4fzlA:
undetectable		 3w67D-4fzlA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)		 4fzl BACTERIOCIN
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 10 TRP A 244
LEU A  80
LEU A 149
ALA A 147
GLY A 141
 None
 1.06A 4rn6A-4fzlA:
undetectable		 4rn6A-4fzlA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 4fzl BACTERIOCIN
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 8 ILE A 213
TRP A 221
ARG A 176
VAL A 168
 None
 1.16A 5vlmF-4fzlA:
1.9		 5vlmF-4fzlA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4fzl BACTERIOCIN
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 PRO A 152
ILE A 263
VAL A 126
LEU A 127
GLY A 129
 None
 1.07A 5wyqA-4fzlA:
undetectable		 5wyqA-4fzlA:
21.75