SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fzv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		6 / 12 PRO A 185
GLY A 185
GLY A 186
LEU A 205
ARG A 239
LEU A 291
 SAM  A 401 (-3.6A)
SAM  A 401 (-3.7A)
SAM  A 401 (-3.9A)
SAM  A 401 (-3.8A)
None
None
 0.91A 1eizA-4fzvA:
9.0		 1eizA-4fzvA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_1
(FTSJ)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		3 / 3 ASP A 204
ASP A 237
ASP A 255
 SAM  A 401 (-2.9A)
SAM  A 401 (-3.5A)
SAM  A 401 (-3.7A)
 0.57A 1eizA-4fzvA:
9.1		 1eizA-4fzvA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_0
(FTSJ)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		6 / 12 PRO A 185
GLY A 185
GLY A 186
LEU A 205
ARG A 239
LEU A 291
 SAM  A 401 (-3.6A)
SAM  A 401 (-3.7A)
SAM  A 401 (-3.9A)
SAM  A 401 (-3.8A)
None
None
 0.89A 1ej0A-4fzvA:
9.0		 1ej0A-4fzvA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_1
(FTSJ)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		3 / 3 ASP A 204
ASP A 237
ASP A 255
 SAM  A 401 (-2.9A)
SAM  A 401 (-3.5A)
SAM  A 401 (-3.7A)
 0.61A 1ej0A-4fzvA:
9.0		 1ej0A-4fzvA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4fzv MTERF
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 12 GLU B 323
HIS B 265
GLU B 269
TYR B 232
TYR B 236
 None
 1.43A 1o86A-4fzvB:
undetectable		 1o86A-4fzvB:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		9 / 12 CYH A 181
ALA A 183
GLY A 185
GLY A 186
LYS A 187
ASP A 237
GLY A 238
ARG A 239
PRO A 257
 SAM  A 401 (-3.9A)
SAM  A 401 (-4.1A)
SAM  A 401 (-3.7A)
SAM  A 401 (-3.9A)
SAM  A 401 (-3.5A)
SAM  A 401 (-3.5A)
SAM  A 401 (-3.5A)
None
SAM  A 401 (-4.0A)
 0.67A 1sqfA-4fzvA:
27.2		 1sqfA-4fzvA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_1
(SUN PROTEIN)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		3 / 3 PRO A 185
ASP A 204
ASP A 255
 SAM  A 401 (-3.6A)
SAM  A 401 (-2.9A)
SAM  A 401 (-3.7A)
 0.25A 1sqfA-4fzvA:
27.1		 1sqfA-4fzvA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		3 / 3 ASP A 204
ARG A 209
ASP A 255
 SAM  A 401 (-2.9A)
SAM  A 401 (-3.6A)
SAM  A 401 (-3.7A)
 0.39A 1vptA-4fzvA:
6.4		 1vptA-4fzvA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		5 / 12 HIS A 105
LEU A 164
THR A 342
SER A 356
PHE A 354
 None
 1.41A 1xlxA-4fzvA:
undetectable		 1xlxA-4fzvA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B9E_A_SAMA1201_0
(NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		7 / 12 CYH A 181
PRO A 185
GLY A 185
LYS A 187
LEU A 205
ARG A 209
ASP A 237
 SAM  A 401 (-3.9A)
SAM  A 401 (-3.6A)
SAM  A 401 (-3.7A)
SAM  A 401 (-3.5A)
SAM  A 401 (-3.8A)
SAM  A 401 (-3.6A)
SAM  A 401 (-3.5A)
 0.80A 2b9eA-4fzvA:
23.2		 2b9eA-4fzvA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_0
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		5 / 12 ASP A 179
ALA A 183
ASN A 203
SER A 206
ASP A 255
 SAM  A 401 ( 4.2A)
SAM  A 401 (-4.1A)
SAM  A 401 ( 4.6A)
SAM  A 401 (-4.8A)
SAM  A 401 (-3.7A)
 0.90A 2ejtA-4fzvA:
11.6		 2ejtA-4fzvA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		3 / 3 ASP A 204
ASP A 237
ASP A 255
 SAM  A 401 (-2.9A)
SAM  A 401 (-3.5A)
SAM  A 401 (-3.7A)
 0.63A 2igtA-4fzvA:
11.9		 2igtA-4fzvA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		3 / 3 ASP A 204
ASP A 237
ASP A 255
 SAM  A 401 (-2.9A)
SAM  A 401 (-3.5A)
SAM  A 401 (-3.7A)
 0.65A 2igtB-4fzvA:
11.6		 2igtB-4fzvA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		4 / 4 PRO A 185
ASP A 204
ASP A 237
ASP A 179
 SAM  A 401 (-3.6A)
SAM  A 401 (-2.9A)
SAM  A 401 (-3.5A)
SAM  A 401 ( 4.2A)
 1.09A 2nyuA-4fzvA:
9.4		 2nyuA-4fzvA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		4 / 4 PRO A 185
ASP A 204
ASP A 237
ASP A 255
 SAM  A 401 (-3.6A)
SAM  A 401 (-2.9A)
SAM  A 401 (-3.5A)
SAM  A 401 (-3.7A)
 0.46A 2nyuA-4fzvA:
9.4		 2nyuA-4fzvA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		4 / 5 PRO A 185
ASP A 204
ASP A 237
ASP A 179
 SAM  A 401 (-3.6A)
SAM  A 401 (-2.9A)
SAM  A 401 (-3.5A)
SAM  A 401 ( 4.2A)
 1.13A 2nyuB-4fzvA:
9.4		 2nyuB-4fzvA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		4 / 5 PRO A 185
ASP A 204
ASP A 237
ASP A 255
 SAM  A 401 (-3.6A)
SAM  A 401 (-2.9A)
SAM  A 401 (-3.5A)
SAM  A 401 (-3.7A)
 0.42A 2nyuB-4fzvA:
9.4		 2nyuB-4fzvA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4fzv MTERF
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		3 / 3 GLY B 135
GLY B 172
GLY B 174
 None
 0.42A 3bogD-4fzvB:
undetectable		 3bogD-4fzvB:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)		 4fzv MTERF
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		3 / 3 ARG B 162
VAL B 222
THR B 197
 None
 0.54A 3cyxA-4fzvB:
undetectable		 3cyxA-4fzvB:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		3 / 3 ASP A 204
ASP A 237
ASP A 255
 SAM  A 401 (-2.9A)
SAM  A 401 (-3.5A)
SAM  A 401 (-3.7A)
 0.52A 3douA-4fzvA:
8.4		 3douA-4fzvA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		5 / 12 GLY A 186
ASN A 203
ASP A 237
PRO A 257
LEU A 291
 SAM  A 401 (-3.9A)
SAM  A 401 ( 4.6A)
SAM  A 401 (-3.5A)
SAM  A 401 (-4.0A)
None
 1.05A 3eeoA-4fzvA:
8.0		 3eeoA-4fzvA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		6 / 12 GLY A 186
LYS A 187
ARG A 209
ASP A 255
PRO A 257
LEU A 291
 SAM  A 401 (-3.9A)
SAM  A 401 (-3.5A)
SAM  A 401 (-3.6A)
SAM  A 401 (-3.7A)
SAM  A 401 (-4.0A)
None
 1.00A 3m6vA-4fzvA:
28.9		 3m6vA-4fzvA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		8 / 12 PRO A 185
GLY A 185
GLY A 186
LYS A 187
ARG A 209
ASP A 255
PRO A 257
LEU A 291
 SAM  A 401 (-3.6A)
SAM  A 401 (-3.7A)
SAM  A 401 (-3.9A)
SAM  A 401 (-3.5A)
SAM  A 401 (-3.6A)
SAM  A 401 (-3.7A)
SAM  A 401 (-4.0A)
None
 0.43A 3m6vA-4fzvA:
28.9		 3m6vA-4fzvA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		5 / 12 GLY A 186
LYS A 187
ASP A 255
PRO A 257
LEU A 291
 SAM  A 401 (-3.9A)
SAM  A 401 (-3.5A)
SAM  A 401 (-3.7A)
SAM  A 401 (-4.0A)
None
 1.02A 3m6vB-4fzvA:
28.7		 3m6vB-4fzvA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		8 / 12 PRO A 185
GLY A 185
GLY A 186
LYS A 187
ARG A 209
ASP A 255
PRO A 257
LEU A 291
 SAM  A 401 (-3.6A)
SAM  A 401 (-3.7A)
SAM  A 401 (-3.9A)
SAM  A 401 (-3.5A)
SAM  A 401 (-3.6A)
SAM  A 401 (-3.7A)
SAM  A 401 (-4.0A)
None
 0.48A 3m6vB-4fzvA:
28.7		 3m6vB-4fzvA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		7 / 12 PRO A 185
GLY A 185
GLY A 186
LYS A 187
ARG A 209
PRO A 257
LEU A 291
 SAM  A 401 (-3.6A)
SAM  A 401 (-3.7A)
SAM  A 401 (-3.9A)
SAM  A 401 (-3.5A)
SAM  A 401 (-3.6A)
SAM  A 401 (-4.0A)
None
 0.54A 3m6wA-4fzvA:
28.8		 3m6wA-4fzvA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_D_NCAD302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		4 / 7 LEU A 180
ASP A 179
ALA A 201
TYR A 249
 None
SAM  A 401 ( 4.2A)
None
None
 1.16A 3rodD-4fzvA:
9.9		 3rodD-4fzvA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_A_9PLA501_1
(CYTOCHROME P450 2A6)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		5 / 10 PHE A 348
VAL A 364
PHE A 354
PHE A  98
PHE A 344
 None
 1.48A 3t3qA-4fzvA:
undetectable		 3t3qA-4fzvA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_B_9PLB501_1
(CYTOCHROME P450 2A6)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		5 / 10 PHE A 348
VAL A 364
PHE A 354
PHE A  98
PHE A 344
 None
 1.47A 3t3qB-4fzvA:
undetectable		 3t3qB-4fzvA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_C_9PLC501_1
(CYTOCHROME P450 2A6)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		5 / 10 PHE A 348
VAL A 364
PHE A 354
PHE A  98
PHE A 344
 None
 1.49A 3t3qC-4fzvA:
undetectable		 3t3qC-4fzvA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_D_9PLD501_1
(CYTOCHROME P450 2A6)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		5 / 10 PHE A 348
VAL A 364
PHE A 354
PHE A  98
PHE A 344
 None
 1.49A 3t3qD-4fzvA:
undetectable		 3t3qD-4fzvA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		5 / 12 PRO A 185
GLY A 185
GLY A 186
ASP A 204
ASP A 255
 SAM  A 401 (-3.6A)
SAM  A 401 (-3.7A)
SAM  A 401 (-3.9A)
SAM  A 401 (-2.9A)
SAM  A 401 (-3.7A)
 0.47A 4b17A-4fzvA:
9.2		 4b17A-4fzvA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		5 / 12 ASP A 179
GLY A 186
LEU A 205
GLY A 238
ASP A 255
 SAM  A 401 ( 4.2A)
SAM  A 401 (-3.9A)
SAM  A 401 (-3.8A)
SAM  A 401 (-3.5A)
SAM  A 401 (-3.7A)
 0.79A 4blvB-4fzvA:
8.7		 4blvB-4fzvA:
22.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		6 / 12 CYH A 181
GLY A 186
LYS A 187
ASP A 255
PRO A 257
LEU A 291
 SAM  A 401 (-3.9A)
SAM  A 401 (-3.9A)
SAM  A 401 (-3.5A)
SAM  A 401 (-3.7A)
SAM  A 401 (-4.0A)
None
 1.07A 4fp9A-4fzvA:
59.1		 4fp9A-4fzvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		12 / 12 CYH A 181
PRO A 185
GLY A 185
GLY A 186
LYS A 187
ASN A 203
LEU A 205
SER A 206
GLY A 238
ASP A 255
PRO A 257
LEU A 291
 SAM  A 401 (-3.9A)
SAM  A 401 (-3.6A)
SAM  A 401 (-3.7A)
SAM  A 401 (-3.9A)
SAM  A 401 (-3.5A)
SAM  A 401 ( 4.6A)
SAM  A 401 (-3.8A)
SAM  A 401 (-4.8A)
SAM  A 401 (-3.5A)
SAM  A 401 (-3.7A)
SAM  A 401 (-4.0A)
None
 0.18A 4fp9A-4fzvA:
59.1		 4fp9A-4fzvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		5 / 12 PRO A 185
GLY A 185
GLY A 186
LYS A 187
SER A 208
 SAM  A 401 (-3.6A)
SAM  A 401 (-3.7A)
SAM  A 401 (-3.9A)
SAM  A 401 (-3.5A)
None
 1.01A 4fp9A-4fzvA:
59.1		 4fp9A-4fzvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FP9_A_SAMA401_1
(METHYLTRANSFERASE
NSUN4)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		3 / 3 ASP A 204
ARG A 209
ASP A 237
 SAM  A 401 (-2.9A)
SAM  A 401 (-3.6A)
SAM  A 401 (-3.5A)
 0.18A 4fp9A-4fzvA:
59.1		 4fp9A-4fzvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		12 / 12 CYH A 181
PRO A 185
GLY A 185
GLY A 186
LYS A 187
ASN A 203
LEU A 205
SER A 206
GLY A 238
ASP A 255
PRO A 257
LEU A 291
 SAM  A 401 (-3.9A)
SAM  A 401 (-3.6A)
SAM  A 401 (-3.7A)
SAM  A 401 (-3.9A)
SAM  A 401 (-3.5A)
SAM  A 401 ( 4.6A)
SAM  A 401 (-3.8A)
SAM  A 401 (-4.8A)
SAM  A 401 (-3.5A)
SAM  A 401 (-3.7A)
SAM  A 401 (-4.0A)
None
 0.20A 4fp9C-4fzvA:
59.2		 4fp9C-4fzvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		5 / 12 PRO A 185
GLY A 185
GLY A 186
LYS A 187
SER A 208
 SAM  A 401 (-3.6A)
SAM  A 401 (-3.7A)
SAM  A 401 (-3.9A)
SAM  A 401 (-3.5A)
None
 1.01A 4fp9C-4fzvA:
59.2		 4fp9C-4fzvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FP9_C_SAMC401_1
(METHYLTRANSFERASE
NSUN4)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		3 / 3 ASP A 204
ARG A 209
ASP A 237
 SAM  A 401 (-2.9A)
SAM  A 401 (-3.6A)
SAM  A 401 (-3.5A)
 0.30A 4fp9C-4fzvA:
59.2		 4fp9C-4fzvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		12 / 12 CYH A 181
PRO A 185
GLY A 185
GLY A 186
LYS A 187
ASN A 203
LEU A 205
SER A 206
ASP A 237
GLY A 238
PRO A 257
LEU A 291
 SAM  A 401 (-3.9A)
SAM  A 401 (-3.6A)
SAM  A 401 (-3.7A)
SAM  A 401 (-3.9A)
SAM  A 401 (-3.5A)
SAM  A 401 ( 4.6A)
SAM  A 401 (-3.8A)
SAM  A 401 (-4.8A)
SAM  A 401 (-3.5A)
SAM  A 401 (-3.5A)
SAM  A 401 (-4.0A)
None
 0.21A 4fp9D-4fzvA:
57.7		 4fp9D-4fzvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		5 / 12 PRO A 185
GLY A 185
GLY A 186
LYS A 187
SER A 208
 SAM  A 401 (-3.6A)
SAM  A 401 (-3.7A)
SAM  A 401 (-3.9A)
SAM  A 401 (-3.5A)
None
 1.01A 4fp9D-4fzvA:
57.7		 4fp9D-4fzvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FP9_D_SAMD401_1
(METHYLTRANSFERASE
NSUN4)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		3 / 3 ASP A 204
ARG A 209
ASP A 255
 SAM  A 401 (-2.9A)
SAM  A 401 (-3.6A)
SAM  A 401 (-3.7A)
 0.34A 4fp9D-4fzvA:
57.7		 4fp9D-4fzvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		12 / 12 CYH A 181
PRO A 185
GLY A 185
GLY A 186
LYS A 187
ASN A 203
LEU A 205
SER A 206
GLY A 238
ASP A 255
PRO A 257
LEU A 291
 SAM  A 401 (-3.9A)
SAM  A 401 (-3.6A)
SAM  A 401 (-3.7A)
SAM  A 401 (-3.9A)
SAM  A 401 (-3.5A)
SAM  A 401 ( 4.6A)
SAM  A 401 (-3.8A)
SAM  A 401 (-4.8A)
SAM  A 401 (-3.5A)
SAM  A 401 (-3.7A)
SAM  A 401 (-4.0A)
None
 0.19A 4fp9F-4fzvA:
59.3		 4fp9F-4fzvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		5 / 12 PRO A 185
GLY A 185
GLY A 186
LYS A 187
SER A 208
 SAM  A 401 (-3.6A)
SAM  A 401 (-3.7A)
SAM  A 401 (-3.9A)
SAM  A 401 (-3.5A)
None
 1.01A 4fp9F-4fzvA:
59.3		 4fp9F-4fzvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FP9_F_SAMF401_1
(METHYLTRANSFERASE
NSUN4)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		3 / 3 ASP A 204
ARG A 209
ASP A 237
 SAM  A 401 (-2.9A)
SAM  A 401 (-3.6A)
SAM  A 401 (-3.5A)
 0.29A 4fp9F-4fzvA:
59.3		 4fp9F-4fzvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		12 / 12 CYH A 181
PRO A 185
GLY A 185
GLY A 186
LYS A 187
ASN A 203
LEU A 205
SER A 206
ASP A 237
GLY A 238
PRO A 257
LEU A 291
 SAM  A 401 (-3.9A)
SAM  A 401 (-3.6A)
SAM  A 401 (-3.7A)
SAM  A 401 (-3.9A)
SAM  A 401 (-3.5A)
SAM  A 401 ( 4.6A)
SAM  A 401 (-3.8A)
SAM  A 401 (-4.8A)
SAM  A 401 (-3.5A)
SAM  A 401 (-3.5A)
SAM  A 401 (-4.0A)
None
 0.04A 4fzvA-4fzvA:
63.9		 4fzvA-4fzvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		5 / 12 PRO A 185
GLY A 185
GLY A 186
LYS A 187
SER A 208
 SAM  A 401 (-3.6A)
SAM  A 401 (-3.7A)
SAM  A 401 (-3.9A)
SAM  A 401 (-3.5A)
None
 1.06A 4fzvA-4fzvA:
63.9		 4fzvA-4fzvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		3 / 3 ASP A 204
ARG A 209
ASP A 255
 SAM  A 401 (-2.9A)
SAM  A 401 (-3.6A)
SAM  A 401 (-3.7A)
 0.02A 4fzvA-4fzvA:
63.9		 4fzvA-4fzvA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA604_1
(TRANSPORTER)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		4 / 7 ILE A  63
LEU A  67
ASP A 261
THR A 259
 None
 1.08A 4mmcA-4fzvA:
undetectable		 4mmcA-4fzvA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_2
(ADENOSINE KINASE)		 4fzv MTERF
DOMAIN-CONTAINING
PROTEIN 2
PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		4 / 4 LEU A  68
SER A  66
LEU B 271
LEU A  45
 None
 1.11A 4n09A-4fzvA:
3.4		 4n09A-4fzvA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		4 / 5 PRO A 185
GLY A 186
ASP A 237
ASP A 255
 SAM  A 401 (-3.6A)
SAM  A 401 (-3.9A)
SAM  A 401 (-3.5A)
SAM  A 401 (-3.7A)
 0.67A 4n48B-4fzvA:
8.9		 4n48B-4fzvA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB302_1
(CHITOSANASE)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		4 / 5 ARG A 281
THR A 259
ASP A 261
TYR A  52
 None
 0.96A 4oltB-4fzvA:
undetectable		 4oltB-4fzvA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		3 / 3 GLN A 316
SER A 264
ASP A 261
 None
 0.94A 4qwpA-4fzvA:
undetectable
4qwpB-4fzvA:
undetectable		 4qwpA-4fzvA:
21.94
4qwpB-4fzvA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		4 / 7 ARG A 281
THR A 259
ASP A 261
TYR A  52
 None
 0.86A 5hwaA-4fzvA:
undetectable		 5hwaA-4fzvA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		5 / 12 VAL A 336
GLY A 295
GLU A 243
ALA A 298
TYR A 249
 None
 1.13A 5n5dA-4fzvA:
11.5		 5n5dA-4fzvA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		10 / 12 CYH A 181
ALA A 183
PRO A 185
GLY A 186
ASP A 204
ASP A 237
GLY A 238
ASP A 255
LEU A 287
LEU A 291
 SAM  A 401 (-3.9A)
SAM  A 401 (-4.1A)
SAM  A 401 (-3.6A)
SAM  A 401 (-3.9A)
SAM  A 401 (-2.9A)
SAM  A 401 (-3.5A)
SAM  A 401 (-3.5A)
SAM  A 401 (-3.7A)
None
None
 0.46A 5wwsA-4fzvA:
26.9		 5wwsA-4fzvA:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		5 / 12 CYH A 181
GLY A 185
ASP A 255
LEU A 287
LEU A 291
 SAM  A 401 (-3.9A)
SAM  A 401 (-3.7A)
SAM  A 401 (-3.7A)
None
None
 0.91A 5wwsA-4fzvA:
26.9		 5wwsA-4fzvA:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		9 / 12 CYH A 181
ALA A 183
PRO A 185
GLY A 186
LYS A 187
ASP A 204
ASP A 237
GLY A 238
ASP A 255
 SAM  A 401 (-3.9A)
SAM  A 401 (-4.1A)
SAM  A 401 (-3.6A)
SAM  A 401 (-3.9A)
SAM  A 401 (-3.5A)
SAM  A 401 (-2.9A)
SAM  A 401 (-3.5A)
SAM  A 401 (-3.5A)
SAM  A 401 (-3.7A)
 0.42A 5wwsB-4fzvA:
26.8		 5wwsB-4fzvA:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YN6_A_SAMA401_0
(NSP16 PROTEIN)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		5 / 12 GLY A 186
ASN A 203
LEU A 205
ASP A 237
ASP A 255
 SAM  A 401 (-3.9A)
SAM  A 401 ( 4.6A)
SAM  A 401 (-3.8A)
SAM  A 401 (-3.5A)
SAM  A 401 (-3.7A)
 0.97A 5yn6A-4fzvA:
undetectable		 5yn6A-4fzvA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		6 / 12 GLY A 186
ASN A 203
ASP A 204
LEU A 205
ASP A 237
ASP A 255
 SAM  A 401 (-3.9A)
SAM  A 401 ( 4.6A)
SAM  A 401 (-2.9A)
SAM  A 401 (-3.8A)
SAM  A 401 (-3.5A)
SAM  A 401 (-3.7A)
 0.91A 5yniA-4fzvA:
7.6		 5yniA-4fzvA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		6 / 12 GLY A 186
ASN A 203
ASP A 204
LEU A 205
ASP A 237
ASP A 255
 SAM  A 401 (-3.9A)
SAM  A 401 ( 4.6A)
SAM  A 401 (-2.9A)
SAM  A 401 (-3.8A)
SAM  A 401 (-3.5A)
SAM  A 401 (-3.7A)
 0.90A 5ynmA-4fzvA:
7.6		 5ynmA-4fzvA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		7 / 12 PRO A 185
GLY A 186
LYS A 187
SER A 206
ASP A 237
ARG A 239
PRO A 257
 SAM  A 401 (-3.6A)
SAM  A 401 (-3.9A)
SAM  A 401 (-3.5A)
SAM  A 401 (-4.8A)
SAM  A 401 (-3.5A)
None
SAM  A 401 (-4.0A)
 0.42A 5zvgA-4fzvA:
28.7		 5zvgA-4fzvA:
27.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		3 / 3 ASP A 204
ARG A 209
ASP A 255
 SAM  A 401 (-2.9A)
SAM  A 401 (-3.6A)
SAM  A 401 (-3.7A)
 0.34A 5zvgA-4fzvA:
28.5		 5zvgA-4fzvA:
27.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		7 / 12 PRO A 185
GLY A 186
LYS A 187
SER A 206
ASP A 237
ARG A 239
PRO A 257
 SAM  A 401 (-3.6A)
SAM  A 401 (-3.9A)
SAM  A 401 (-3.5A)
SAM  A 401 (-4.8A)
SAM  A 401 (-3.5A)
None
SAM  A 401 (-4.0A)
 0.44A 5zvgB-4fzvA:
28.6		 5zvgB-4fzvA:
27.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		3 / 3 ASP A 204
ARG A 209
ASP A 255
 SAM  A 401 (-2.9A)
SAM  A 401 (-3.6A)
SAM  A 401 (-3.7A)
 0.34A 5zvgB-4fzvA:
28.5		 5zvgB-4fzvA:
27.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_D_AQ4D602_0
(CYTOCHROME P450 1A1)		 4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4
(Homo
sapiens) 		5 / 12 SER A 162
PHE A  98
ASP A 159
GLY A  74
PHE A 142
 None
 1.04A 6dwnD-4fzvA:
undetectable		 6dwnD-4fzvA:
13.41