SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fzw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 4fzw 1,2-EPOXYPHENYLACETY
L-COA ISOMERASE
(Escherichia
coli) 		5 / 11 LEU C  18
ASN C 107
VAL C 106
GLY C 108
LEU C  53
 None
 1.20A 1fkpA-4fzwC:
undetectable		 1fkpA-4fzwC:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGS_A_SALA256_1
(MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR)		 4fzw 2,3-DEHYDROADIPYL-CO
A HYDRATASE
(Escherichia
coli) 		4 / 7 VAL A  51
LEU A  14
THR A  16
LEU A  17
 None
 0.96A 1jgsA-4fzwA:
undetectable		 1jgsA-4fzwA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4fzw 1,2-EPOXYPHENYLACETY
L-COA ISOMERASE
(Escherichia
coli) 		4 / 5 LEU C  95
VAL C 102
CYH C  50
ALA C 198
 None
 1.11A 1mz9D-4fzwC:
undetectable		 1mz9D-4fzwC:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4fzw 1,2-EPOXYPHENYLACETY
L-COA ISOMERASE
(Escherichia
coli) 		4 / 4 LEU C  95
VAL C 102
CYH C  50
ALA C 198
 None
 1.14A 1mz9E-4fzwC:
undetectable		 1mz9E-4fzwC:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 4fzw 1,2-EPOXYPHENYLACETY
L-COA ISOMERASE
(Escherichia
coli) 		5 / 12 LEU C  18
GLY C 108
GLY C  59
LEU C 117
ALA C 118
 None
 0.97A 1v2xA-4fzwC:
undetectable		 1v2xA-4fzwC:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4fzw 2,3-DEHYDROADIPYL-CO
A HYDRATASE
(Escherichia
coli) 		5 / 12 LEU A  34
LEU A   4
GLY A  54
ASN A  24
ALA A 103
 None
 1.29A 2bm9B-4fzwA:
undetectable		 2bm9B-4fzwA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4fzw 2,3-DEHYDROADIPYL-CO
A HYDRATASE
(Escherichia
coli) 		6 / 12 LEU A  31
LEU A 110
GLY A  62
ARG A  81
ALA A  25
ALA A  22
 None
None
None
GOL  A 301 (-3.5A)
None
None
 1.50A 2bm9D-4fzwA:
undetectable		 2bm9D-4fzwA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4fzw 2,3-DEHYDROADIPYL-CO
A HYDRATASE
(Escherichia
coli) 		6 / 12 LEU A  31
LEU A 110
GLY A  62
ARG A  81
ALA A  25
ALA A  22
 None
None
None
GOL  A 301 (-3.5A)
None
None
 1.46A 2br4A-4fzwA:
undetectable		 2br4A-4fzwA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4fzw 2,3-DEHYDROADIPYL-CO
A HYDRATASE
(Escherichia
coli) 		6 / 12 LEU A  31
LEU A 110
GLY A  62
ARG A  81
ALA A  25
ALA A  22
 None
None
None
GOL  A 301 (-3.5A)
None
None
 1.44A 2br4D-4fzwA:
undetectable		 2br4D-4fzwA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4fzw 2,3-DEHYDROADIPYL-CO
A HYDRATASE
(Escherichia
coli) 		6 / 12 LEU A  31
LEU A 110
GLY A  62
ARG A  81
ALA A  25
ALA A  22
 None
None
None
GOL  A 301 (-3.5A)
None
None
 1.46A 2br4E-4fzwA:
undetectable		 2br4E-4fzwA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4fzw 1,2-EPOXYPHENYLACETY
L-COA ISOMERASE
(Escherichia
coli) 		5 / 12 LEU C  66
LEU C 139
PHE C 136
SER C 137
TYR C  88
 None
 1.30A 2oipB-4fzwC:
undetectable		 2oipB-4fzwC:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 4fzw 1,2-EPOXYPHENYLACETY
L-COA ISOMERASE
(Escherichia
coli) 		5 / 10 MET C 134
ALA C 110
ALA C 118
LEU C 150
VAL C 154
 None
 1.42A 2wuzB-4fzwC:
undetectable		 2wuzB-4fzwC:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX94_0
(PROTEIN S100-B)		 4fzw 1,2-EPOXYPHENYLACETY
L-COA ISOMERASE
(Escherichia
coli) 		3 / 3 PHE C  27
CYH C  61
PHE C  60
 None
 1.14A 3cr5X-4fzwC:
undetectable		 3cr5X-4fzwC:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWW_A_SFXA801_1
(TRANSPORTER)		 4fzw 1,2-EPOXYPHENYLACETY
L-COA ISOMERASE
(Escherichia
coli) 		5 / 12 GLY C 120
LEU C 119
ILE C 181
ALA C 110
PHE C 132
 None
 0.96A 3gwwA-4fzwC:
undetectable		 3gwwA-4fzwC:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWW_A_SFXA801_1
(TRANSPORTER)		 4fzw 1,2-EPOXYPHENYLACETY
L-COA ISOMERASE
(Escherichia
coli) 		5 / 12 GLY C 121
LEU C 119
ILE C 181
ALA C 110
PHE C 132
 None
 0.97A 3gwwA-4fzwC:
undetectable		 3gwwA-4fzwC:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM201_1
(PROTEIN S100-A4)		 4fzw 1,2-EPOXYPHENYLACETY
L-COA ISOMERASE
(Escherichia
coli) 		4 / 7 GLY C  55
PHE C  87
PHE C  27
GLY C 114
 None
 0.83A 3ko0M-4fzwC:
undetectable
3ko0P-4fzwC:
undetectable		 3ko0M-4fzwC:
14.39
3ko0P-4fzwC:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP201_1
(PROTEIN S100-A4)		 4fzw 1,2-EPOXYPHENYLACETY
L-COA ISOMERASE
(Escherichia
coli) 		4 / 7 PHE C  27
GLY C 114
GLY C  55
PHE C  87
 None
 0.82A 3ko0M-4fzwC:
undetectable
3ko0P-4fzwC:
undetectable		 3ko0M-4fzwC:
14.39
3ko0P-4fzwC:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_H_SAMH226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4fzw 2,3-DEHYDROADIPYL-CO
A HYDRATASE
(Escherichia
coli) 		5 / 12 ARG A  81
GLY A 105
VAL A 157
ALA A  63
LEU A 132
 GOL  A 301 (-3.5A)
None
None
GOL  A 301 ( 4.4A)
None
 1.06A 3ku1H-4fzwA:
undetectable		 3ku1H-4fzwA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_D_VIBD223_1
(THIAMINE
PYROPHOSPHOKINASE)		 4fzw 2,3-DEHYDROADIPYL-CO
A HYDRATASE
(Escherichia
coli) 		5 / 8 ASP A 115
LEU A  38
LEU A  95
CYH A  50
SER A  48
 None
 1.37A 3lm8B-4fzwA:
2.5
3lm8D-4fzwA:
undetectable		 3lm8B-4fzwA:
22.71
3lm8D-4fzwA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_1
(HIV-1 PROTEASE)		 4fzw 2,3-DEHYDROADIPYL-CO
A HYDRATASE
(Escherichia
coli) 		5 / 10 GLY A 101
ALA A 123
ILE A 163
GLY A 126
VAL A 117
 None
 1.02A 3oxwC-4fzwA:
undetectable		 3oxwC-4fzwA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_D_MTXD2000_2
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4fzw 2,3-DEHYDROADIPYL-CO
A HYDRATASE
(Escherichia
coli) 		3 / 3 LEU A  15
ARG A  87
ASN A  92
 None
 0.58A 3qxvD-4fzwA:
undetectable		 3qxvD-4fzwA:
18.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R9T_C_BEZC264_0
(ECHA1_1)		 4fzw 2,3-DEHYDROADIPYL-CO
A HYDRATASE
(Escherichia
coli) 		4 / 5 ALA A  63
GLU A 109
GLU A 129
ALA A 138
 GOL  A 301 ( 4.4A)
GOL  A 301 (-3.8A)
GOL  A 301 (-4.0A)
GOL  A 301 ( 4.6A)
 0.68A 3r9tC-4fzwA:
28.8		 3r9tC-4fzwA:
37.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 4fzw 2,3-DEHYDROADIPYL-CO
A HYDRATASE
(Escherichia
coli) 		4 / 5 LEU A 112
LEU A 127
GLY A 126
GLY A 105
 None
 0.78A 3si7C-4fzwA:
undetectable
3si7D-4fzwA:
undetectable		 3si7C-4fzwA:
22.98
3si7D-4fzwA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_B_9PLB501_1
(CYTOCHROME P450 2A6)		 4fzw 1,2-EPOXYPHENYLACETY
L-COA ISOMERASE
(Escherichia
coli) 		5 / 10 PHE C  60
ASN C 107
ALA C 127
ILE C 181
PHE C 132
 None
 1.35A 3t3qB-4fzwC:
undetectable		 3t3qB-4fzwC:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 4fzw 1,2-EPOXYPHENYLACETY
L-COA ISOMERASE
(Escherichia
coli) 		3 / 3 LEU C  35
HIS C  32
MET C  31
 None
 0.64A 3thrD-4fzwC:
undetectable		 3thrD-4fzwC:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 4fzw 1,2-EPOXYPHENYLACETY
L-COA ISOMERASE
(Escherichia
coli) 		4 / 5 LEU C  18
LEU C   6
SER C   7
MET C  14
 None
 0.93A 3vhuA-4fzwC:
undetectable		 3vhuA-4fzwC:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4fzw 2,3-DEHYDROADIPYL-CO
A HYDRATASE
(Escherichia
coli) 		4 / 5 GLY A 137
THR A 141
ILE A 130
VAL A 157
 GOL  A 301 ( 4.5A)
None
None
None
 0.87A 3wriA-4fzwA:
undetectable		 3wriA-4fzwA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 4fzw 2,3-DEHYDROADIPYL-CO
A HYDRATASE
(Escherichia
coli) 		4 / 5 GLY A 137
THR A 141
ILE A 130
VAL A 157
 GOL  A 301 ( 4.5A)
None
None
None
 0.86A 3wriB-4fzwA:
undetectable		 3wriB-4fzwA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 4fzw 2,3-DEHYDROADIPYL-CO
A HYDRATASE
(Escherichia
coli) 		4 / 7 ALA A 119
PHE A 125
ALA A 103
ALA A  97
 None
 0.81A 4du2A-4fzwA:
undetectable		 4du2A-4fzwA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 4fzw 2,3-DEHYDROADIPYL-CO
A HYDRATASE
(Escherichia
coli) 		4 / 7 ALA A 119
PHE A 125
ALA A 103
ALA A  97
 None
 0.75A 4du2B-4fzwA:
undetectable		 4du2B-4fzwA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 4fzw 2,3-DEHYDROADIPYL-CO
A HYDRATASE
(Escherichia
coli) 		5 / 12 LEU A  17
ILE A  52
ALA A  97
GLY A 126
ALA A  60
 None
 1.01A 4enhA-4fzwA:
undetectable		 4enhA-4fzwA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KT0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4fzw 2,3-DEHYDROADIPYL-CO
A HYDRATASE
(Escherichia
coli) 		5 / 11 MET A 156
GLY A 105
ALA A 111
LEU A 112
GLY A 140
 None
 1.00A 4kt0A-4fzwA:
undetectable
4kt0J-4fzwA:
undetectable		 4kt0A-4fzwA:
15.95
4kt0J-4fzwA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_2
(BIFUNCTIONAL AAC/APH)		 4fzw 1,2-EPOXYPHENYLACETY
L-COA ISOMERASE
(Escherichia
coli) 		3 / 3 LEU C 230
ASP C 233
TYR C 234
 None
 0.66A 4qc6B-4fzwC:
undetectable		 4qc6B-4fzwC:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4fzw 2,3-DEHYDROADIPYL-CO
A HYDRATASE
(Escherichia
coli) 		5 / 10 ALA A 165
THR A 164
ALA A 168
VAL A 177
GLY A 101
 None
 0.95A 4qvyK-4fzwA:
undetectable
4qvyL-4fzwA:
undetectable		 4qvyK-4fzwA:
24.54
4qvyL-4fzwA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4fzw 2,3-DEHYDROADIPYL-CO
A HYDRATASE
(Escherichia
coli) 		5 / 10 ALA A 165
THR A 164
ALA A 168
VAL A 177
GLY A 101
 None
 0.95A 4qvyY-4fzwA:
undetectable
4qvyZ-4fzwA:
undetectable		 4qvyY-4fzwA:
24.54
4qvyZ-4fzwA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA302_0
(THAUMATIN-1)		 4fzw 2,3-DEHYDROADIPYL-CO
A HYDRATASE
(Escherichia
coli) 		3 / 3 ARG A 210
GLN A 213
GLU A 214
 None
 0.89A 4tvtA-4fzwA:
undetectable		 4tvtA-4fzwA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4fzw 2,3-DEHYDROADIPYL-CO
A HYDRATASE
(Escherichia
coli) 		5 / 11 LEU A  31
LEU A  34
LEU A  26
GLU A 109
LEU A 110
 None
None
None
GOL  A 301 (-3.8A)
None
 1.05A 4wg0H-4fzwA:
undetectable
4wg0I-4fzwA:
undetectable
4wg0J-4fzwA:
undetectable		 4wg0H-4fzwA:
4.65
4wg0I-4fzwA:
4.65
4wg0J-4fzwA:
4.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4fzw 2,3-DEHYDROADIPYL-CO
A HYDRATASE
(Escherichia
coli) 		5 / 11 GLU A 109
LEU A 110
LEU A  26
LEU A  31
LEU A  34
 GOL  A 301 (-3.8A)
None
None
None
None
 1.03A 4wg0K-4fzwA:
undetectable
4wg0L-4fzwA:
undetectable
4wg0M-4fzwA:
undetectable		 4wg0K-4fzwA:
4.65
4wg0L-4fzwA:
4.65
4wg0M-4fzwA:
4.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_1
(ESTROGEN RECEPTOR)		 4fzw 2,3-DEHYDROADIPYL-CO
A HYDRATASE
(Escherichia
coli) 		5 / 12 ALA A 106
GLU A 109
LEU A 104
LEU A 113
LEU A  17
 GOL  A 301 ( 4.7A)
GOL  A 301 (-3.8A)
None
None
None
 1.27A 4xi3D-4fzwA:
undetectable		 4xi3D-4fzwA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XOY_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 4fzw 2,3-DEHYDROADIPYL-CO
A HYDRATASE
(Escherichia
coli) 		4 / 6 ALA A 168
GLN A 170
LEU A 173
LEU A 152
 None
 0.93A 4xoyA-4fzwA:
undetectable		 4xoyA-4fzwA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 4fzw 2,3-DEHYDROADIPYL-CO
A HYDRATASE
(Escherichia
coli) 		4 / 6 ALA A 168
GLN A 170
LEU A 173
LEU A 152
 None
 1.01A 4xp3A-4fzwA:
undetectable		 4xp3A-4fzwA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSH_B_ACTB401_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4fzw 2,3-DEHYDROADIPYL-CO
A HYDRATASE
(Escherichia
coli) 		4 / 5 ARG A  87
LEU A  84
ASN A  36
VAL A  35
 None
 1.39A 5cshB-4fzwA:
undetectable		 5cshB-4fzwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 4fzw 2,3-DEHYDROADIPYL-CO
A HYDRATASE
(Escherichia
coli) 		5 / 12 LEU A 127
LEU A  31
TRP A  85
LEU A  88
ALA A  60
 None
 1.35A 5ieoA-4fzwA:
undetectable		 5ieoA-4fzwA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8R_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4fzw 2,3-DEHYDROADIPYL-CO
A HYDRATASE
(Escherichia
coli) 		5 / 9 MET A 156
GLY A 105
ALA A 111
LEU A 112
GLY A 140
 None
 1.11A 5l8rA-4fzwA:
undetectable		 5l8rA-4fzwA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_B_ACTB401_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4fzw 2,3-DEHYDROADIPYL-CO
A HYDRATASE
(Escherichia
coli) 		4 / 5 ARG A  87
LEU A  84
ASN A  36
VAL A  35
 None
 1.38A 5os7B-4fzwA:
undetectable		 5os7B-4fzwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 4fzw 2,3-DEHYDROADIPYL-CO
A HYDRATASE
(Escherichia
coli) 		5 / 10 CYH A 108
VAL A 157
VAL A 148
ALA A 153
LEU A 127
 None
 1.02A 6czmA-4fzwA:
undetectable
6czmC-4fzwA:
undetectable		 6czmA-4fzwA:
22.46
6czmC-4fzwA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4fzw 2,3-DEHYDROADIPYL-CO
A HYDRATASE
(Escherichia
coli) 		4 / 6 MET A 156
GLY A 105
ALA A 111
LEU A 112
 None
 1.07A 6fosA-4fzwA:
undetectable		 6fosA-4fzwA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_B_ACTB403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 4fzw 1,2-EPOXYPHENYLACETY
L-COA ISOMERASE
(Escherichia
coli) 		3 / 3 PHE C 259
ARG C  49
GLN C 204
 None
 1.18A 6g1pB-4fzwC:
undetectable		 6g1pB-4fzwC:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_A_ACTA401_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4fzw 2,3-DEHYDROADIPYL-CO
A HYDRATASE
(Escherichia
coli) 		4 / 5 ARG A  87
LEU A  84
ASN A  36
VAL A  35
 None
 1.38A 6gmdA-4fzwA:
undetectable		 6gmdA-4fzwA:
20.00