SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fzy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_A_ACTA1397_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 4fzy EXODEOXYRIBONUCLEASE
10
(Escherichia
coli) 		3 / 3 PRO A  93
GLY A  73
TYR A  77
 None
 0.70A 2vouA-4fzyA:
undetectable		 2vouA-4fzyA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 4fzy EXODEOXYRIBONUCLEASE
10
(Escherichia
coli) 		3 / 3 PRO A  93
GLY A  73
TYR A  77
 None
 0.71A 2vouB-4fzyA:
undetectable		 2vouB-4fzyA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 4fzy EXODEOXYRIBONUCLEASE
10
(Escherichia
coli) 		3 / 3 PRO A  93
GLY A  73
TYR A  77
 None
 0.70A 2vouC-4fzyA:
undetectable		 2vouC-4fzyA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_1
(UNCHARACTERIZED
PROTEIN PH0793)		 4fzy EXODEOXYRIBONUCLEASE
10
(Escherichia
coli) 		3 / 3 MET A  57
GLU A  18
ASP A 139
 None
None
NA  A 201 (-3.1A)
 1.05A 3a25A-4fzyA:
undetectable		 3a25A-4fzyA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1103_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4fzy EXODEOXYRIBONUCLEASE
10
(Escherichia
coli) 		4 / 5 ASN A  81
ARG A 104
MET A 100
LEU A 146
 None
 1.20A 4g5jA-4fzyA:
undetectable		 4g5jA-4fzyA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4fzy EXODEOXYRIBONUCLEASE
10
(Escherichia
coli) 		4 / 7 ILE A 142
VAL A  88
ILE A   5
PHE A  84
 None
 0.92A 5hieC-4fzyA:
undetectable		 5hieC-4fzyA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_A_PFLA412_1
(PROTON-GATED ION
CHANNEL)		 4fzy EXODEOXYRIBONUCLEASE
10
(Escherichia
coli) 		5 / 10 PRO A  90
ILE A  16
ILE A  19
VAL A  88
ILE A   5
 None
 1.32A 5mzrA-4fzyA:
undetectable		 5mzrA-4fzyA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_C_PFLC409_1
(PROTON-GATED ION
CHANNEL)		 4fzy EXODEOXYRIBONUCLEASE
10
(Escherichia
coli) 		5 / 10 PRO A  90
ILE A  16
ILE A  19
VAL A  88
ILE A   5
 None
 1.35A 5mzrC-4fzyA:
undetectable		 5mzrC-4fzyA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 4fzy EXODEOXYRIBONUCLEASE
10
(Escherichia
coli) 		5 / 9 PRO A  90
ILE A  16
ILE A  19
VAL A  88
ILE A   5
 None
 1.32A 5mzrD-4fzyA:
undetectable		 5mzrD-4fzyA:
20.50