SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4g09'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_3
(HIV-1 PROTEASE)		 4g09 HISTIDINOL
DEHYDROGENASE
(Brucella
suis) 		5 / 12 LEU A 240
ALA A 243
GLY A 352
ILE A 351
ILE A 241
 None
 0.99A 1hxbB-4g09A:
undetectable		 1hxbB-4g09A:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)		 4g09 HISTIDINOL
DEHYDROGENASE
(Brucella
suis) 		4 / 8 VAL A 131
PRO A 212
TYR A 387
VAL A 369
 None
 1.07A 1jtvA-4g09A:
2.9		 1jtvA-4g09A:
23.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KAR_A_HSMA502_1
(HISTIDINOL
DEHYDROGENASE)		 4g09 HISTIDINOL
DEHYDROGENASE
(Brucella
suis) 		5 / 9 SER A 140
HIS A 262
ASP A 361
TYR A 362
HIS A 368
 0VD  A 505 (-3.2A)
ZN  A 501 (-3.3A)
0VD  A 505 (-2.3A)
0VD  A 505 (-4.4A)
0VD  A 505 (-3.6A)
 0.25A 1karA-4g09A:
51.4
1karB-4g09A:
51.0		 1karA-4g09A:
40.67
1karB-4g09A:
40.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KAR_B_HSMB503_1
(HISTIDINOL
DEHYDROGENASE)		 4g09 HISTIDINOL
DEHYDROGENASE
(Brucella
suis) 		5 / 9 SER A 140
HIS A 262
ASP A 361
TYR A 362
HIS A 368
 0VD  A 505 (-3.2A)
ZN  A 501 (-3.3A)
0VD  A 505 (-2.3A)
0VD  A 505 (-4.4A)
0VD  A 505 (-3.6A)
 0.31A 1karA-4g09A:
51.4
1karB-4g09A:
51.0		 1karA-4g09A:
40.67
1karB-4g09A:
40.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_1
(ASPARTYLPROTEASE)		 4g09 HISTIDINOL
DEHYDROGENASE
(Brucella
suis) 		6 / 11 ALA A 243
ASP A 244
GLY A 352
ILE A 351
VAL A 239
ILE A 241
 None
None
None
None
DMS  A 504 ( 4.7A)
None
 1.37A 1ohrA-4g09A:
undetectable		 1ohrA-4g09A:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4g09 HISTIDINOL
DEHYDROGENASE
(Brucella
suis) 		4 / 4 ALA A 152
VAL A 154
ALA A 149
HIS A  99
 None
 1.18A 1q23F-4g09A:
undetectable		 1q23F-4g09A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_2
(PROTEASE RETROPEPSIN)		 4g09 HISTIDINOL
DEHYDROGENASE
(Brucella
suis) 		6 / 12 LEU A 240
ALA A 243
ASP A 244
GLY A 352
ILE A 351
ILE A 241
 None
 1.41A 1rl8B-4g09A:
undetectable		 1rl8B-4g09A:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 4g09 HISTIDINOL
DEHYDROGENASE
(Brucella
suis) 		5 / 12 ALA A 243
ASP A 244
GLY A 352
ILE A 351
ILE A 241
 None
 1.10A 1sduB-4g09A:
undetectable		 1sduB-4g09A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 4g09 HISTIDINOL
DEHYDROGENASE
(Brucella
suis) 		5 / 12 ALA A 197
GLY A 199
ILE A 230
ASP A 231
GLY A 211
 None
 1.05A 1sqfA-4g09A:
2.5		 1sqfA-4g09A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_2
(HIV-1 PROTEASE)		 4g09 HISTIDINOL
DEHYDROGENASE
(Brucella
suis) 		6 / 11 ALA A 243
ASP A 244
GLY A 352
ILE A 351
VAL A 239
ILE A 241
 None
None
None
None
DMS  A 504 ( 4.7A)
None
 1.47A 2aquB-4g09A:
undetectable		 2aquB-4g09A:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_3
(POL POLYPROTEIN)		 4g09 HISTIDINOL
DEHYDROGENASE
(Brucella
suis) 		6 / 12 LEU A 240
ALA A 243
ASP A 244
GLY A 352
ILE A 351
ILE A 241
 None
 1.30A 2avvE-4g09A:
undetectable		 2avvE-4g09A:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2002_1
(SERUM ALBUMIN)		 4g09 HISTIDINOL
DEHYDROGENASE
(Brucella
suis) 		4 / 8 ARG A 342
ALA A 317
GLU A 315
VAL A 333
 None
 0.86A 2bxgA-4g09A:
undetectable		 2bxgA-4g09A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_1
(POL PROTEIN)		 4g09 HISTIDINOL
DEHYDROGENASE
(Brucella
suis) 		6 / 12 ALA A 243
ASP A 244
GLY A 353
GLY A 352
ILE A 351
ILE A 241
 None
 1.39A 2fxeA-4g09A:
undetectable		 2fxeA-4g09A:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_ACTA148_0
(UPF0066 PROTEIN
AF_0241)		 4g09 HISTIDINOL
DEHYDROGENASE
(Brucella
suis) 		3 / 3 VAL A 239
GLU A 330
GLU A 357
 DMS  A 504 ( 4.7A)
None
DMS  A 504 ( 3.6A)
 0.80A 2nv4A-4g09A:
undetectable		 2nv4A-4g09A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_1
(PROTEASE)		 4g09 HISTIDINOL
DEHYDROGENASE
(Brucella
suis) 		5 / 12 LEU A 240
ALA A 243
GLY A 353
GLY A 352
ILE A 351
 None
 0.95A 2o4kA-4g09A:
undetectable		 2o4kA-4g09A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_1
(PROTEASE RETROPEPSIN)		 4g09 HISTIDINOL
DEHYDROGENASE
(Brucella
suis) 		6 / 12 LEU A 240
ALA A 243
ASP A 244
GLY A 352
ILE A 351
ILE A 241
 None
 1.29A 2q64A-4g09A:
undetectable		 2q64A-4g09A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 4g09 HISTIDINOL
DEHYDROGENASE
(Brucella
suis) 		6 / 12 LEU A 240
ALA A 243
ASP A 244
GLY A 352
ILE A 351
ILE A 241
 None
 1.26A 2qakA-4g09A:
undetectable		 2qakA-4g09A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 4g09 HISTIDINOL
DEHYDROGENASE
(Brucella
suis) 		4 / 7 ILE A 324
ARG A 323
PHE A  12
GLU A  13
 None
 1.14A 2qebA-4g09A:
undetectable		 2qebA-4g09A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		 4g09 HISTIDINOL
DEHYDROGENASE
(Brucella
suis) 		4 / 7 ILE A 324
ARG A 323
PHE A  12
GLU A  13
 None
 1.16A 2qebB-4g09A:
undetectable		 2qebB-4g09A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_1
(PROTEASE RETROPEPSIN)		 4g09 HISTIDINOL
DEHYDROGENASE
(Brucella
suis) 		6 / 12 LEU A 240
ALA A 243
ASP A 244
GLY A 352
ILE A 351
ILE A 241
 None
 1.35A 2rkgA-4g09A:
undetectable		 2rkgA-4g09A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		 4g09 HISTIDINOL
DEHYDROGENASE
(Brucella
suis) 		4 / 6 LEU A  49
LEU A  50
ASP A  46
ILE A 203
 None
 1.05A 2rlfA-4g09A:
undetectable
2rlfB-4g09A:
undetectable		 2rlfA-4g09A:
7.95
2rlfB-4g09A:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 4g09 HISTIDINOL
DEHYDROGENASE
(Brucella
suis) 		4 / 8 SER A  53
THR A 200
ILE A 203
THR A 202
 None
 0.94A 3bpxA-4g09A:
undetectable
3bpxB-4g09A:
undetectable		 3bpxA-4g09A:
15.94
3bpxB-4g09A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_1
(HIV-1 PROTEASE)		 4g09 HISTIDINOL
DEHYDROGENASE
(Brucella
suis) 		6 / 12 LEU A 240
ALA A 243
ASP A 244
GLY A 352
ILE A 351
ILE A 241
 None
 1.37A 3cywA-4g09A:
undetectable		 3cywA-4g09A:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_1
(HIV-1 PROTEASE)		 4g09 HISTIDINOL
DEHYDROGENASE
(Brucella
suis) 		6 / 12 ALA A 243
ASP A 244
GLY A 352
ILE A 351
VAL A 239
ILE A 241
 None
None
None
None
DMS  A 504 ( 4.7A)
None
 1.44A 3d1yA-4g09A:
undetectable		 3d1yA-4g09A:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_1
(PROTEASE)		 4g09 HISTIDINOL
DEHYDROGENASE
(Brucella
suis) 		6 / 11 LEU A 240
ALA A 243
ASP A 244
GLY A 352
ILE A 351
ILE A 241
 None
 1.31A 3ektC-4g09A:
undetectable		 3ektC-4g09A:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_2
(PROTEASE)		 4g09 HISTIDINOL
DEHYDROGENASE
(Brucella
suis) 		5 / 11 ALA A 243
ASP A 244
GLY A 352
ILE A 351
ILE A 241
 None
 1.10A 3ektD-4g09A:
undetectable		 3ektD-4g09A:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_1
(PROTEASE)		 4g09 HISTIDINOL
DEHYDROGENASE
(Brucella
suis) 		6 / 10 LEU A 240
ALA A 243
ASP A 244
GLY A 352
ILE A 351
ILE A 241
 None
 1.32A 3ekvA-4g09A:
undetectable		 3ekvA-4g09A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_1
(PROTEASE)		 4g09 HISTIDINOL
DEHYDROGENASE
(Brucella
suis) 		6 / 10 ALA A 243
ASP A 244
GLY A 352
ILE A 351
VAL A 239
ILE A 241
 None
None
None
None
DMS  A 504 ( 4.7A)
None
 1.48A 3ekyA-4g09A:
undetectable		 3ekyA-4g09A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_2
(PROTEASE)		 4g09 HISTIDINOL
DEHYDROGENASE
(Brucella
suis) 		6 / 12 ALA A 243
ASP A 244
GLY A 352
ILE A 351
VAL A 239
ILE A 241
 None
None
None
None
DMS  A 504 ( 4.7A)
None
 1.39A 3el1B-4g09A:
undetectable		 3el1B-4g09A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)		 4g09 HISTIDINOL
DEHYDROGENASE
(Brucella
suis) 		4 / 8 ASP A 155
GLY A 180
SER A 182
ILE A 157
 None
 0.85A 3ihzB-4g09A:
undetectable		 3ihzB-4g09A:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4g09 HISTIDINOL
DEHYDROGENASE
(Brucella
suis) 		4 / 6 VAL A  41
ARG A  55
VAL A  34
PHE A  56
 None
None
None
GOL  A 503 (-4.1A)
 1.49A 3jx4A-4g09A:
undetectable
3jx4B-4g09A:
undetectable		 3jx4A-4g09A:
19.11
3jx4B-4g09A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_3
(HIV-1 PROTEASE)		 4g09 HISTIDINOL
DEHYDROGENASE
(Brucella
suis) 		6 / 12 LEU A 240
ALA A 243
ASP A 244
GLY A 352
ILE A 351
ILE A 241
 None
 1.32A 3k4vD-4g09A:
undetectable		 3k4vD-4g09A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM202_1
(PROTEIN S100-A4)		 4g09 HISTIDINOL
DEHYDROGENASE
(Brucella
suis) 		5 / 12 LEU A  49
SER A  47
ILE A  66
LEU A  61
ASP A  60
 None
 1.13A 3ko0M-4g09A:
undetectable
3ko0N-4g09A:
undetectable
3ko0O-4g09A:
undetectable
3ko0P-4g09A:
undetectable		 3ko0M-4g09A:
12.13
3ko0N-4g09A:
12.13
3ko0O-4g09A:
12.13
3ko0P-4g09A:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_1
(HIV-1 PROTEASE)		 4g09 HISTIDINOL
DEHYDROGENASE
(Brucella
suis) 		6 / 12 LEU A 240
ALA A 243
ASP A 244
GLY A 352
ILE A 351
ILE A 241
 None
 1.35A 3lzsA-4g09A:
undetectable		 3lzsA-4g09A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_2
(HIV-1 PROTEASE)		 4g09 HISTIDINOL
DEHYDROGENASE
(Brucella
suis) 		6 / 12 LEU A 240
ALA A 243
ASP A 244
GLY A 352
ILE A 351
ILE A 241
 None
 1.34A 3lzsB-4g09A:
undetectable		 3lzsB-4g09A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_1
(HIV-1 PROTEASE)		 4g09 HISTIDINOL
DEHYDROGENASE
(Brucella
suis) 		6 / 12 LEU A 240
ALA A 243
ASP A 244
GLY A 352
ILE A 351
ILE A 241
 None
 1.31A 3lzuA-4g09A:
undetectable		 3lzuA-4g09A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_A_ROCA101_2
(PROTEASE)		 4g09 HISTIDINOL
DEHYDROGENASE
(Brucella
suis) 		6 / 12 LEU A 240
ALA A 243
ASP A 244
GLY A 352
ILE A 351
ILE A 241
 None
 1.34A 3nduB-4g09A:
undetectable		 3nduB-4g09A:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_2
(PROTEASE)		 4g09 HISTIDINOL
DEHYDROGENASE
(Brucella
suis) 		6 / 11 ALA A 243
ASP A 244
GLY A 352
ILE A 351
VAL A 239
ILE A 241
 None
None
None
None
DMS  A 504 ( 4.7A)
None
 1.45A 3ndxB-4g09A:
undetectable		 3ndxB-4g09A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_3
(PROTEASE)		 4g09 HISTIDINOL
DEHYDROGENASE
(Brucella
suis) 		5 / 12 LEU A 240
ALA A 243
GLY A 352
ILE A 351
ILE A 241
 None
 0.99A 3oxcB-4g09A:
undetectable		 3oxcB-4g09A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_C_BEZC264_0
(CARNITINYL-COA
DEHYDRATASE)		 4g09 HISTIDINOL
DEHYDROGENASE
(Brucella
suis) 		4 / 6 ALA A 146
ILE A 157
LEU A 129
ALA A 175
 None
 0.89A 3r9sC-4g09A:
undetectable		 3r9sC-4g09A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_B_ROCB801_2
(PROTEASE)		 4g09 HISTIDINOL
DEHYDROGENASE
(Brucella
suis) 		5 / 12 LEU A 240
ALA A 243
GLY A 352
ILE A 351
ILE A 241
 None
 0.97A 3tkgB-4g09A:
undetectable		 3tkgB-4g09A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_2
(ASPARTYL PROTEASE)		 4g09 HISTIDINOL
DEHYDROGENASE
(Brucella
suis) 		6 / 10 LEU A 240
ALA A 243
ASP A 244
GLY A 352
ILE A 351
ILE A 241
 None
 1.34A 4dqfB-4g09A:
undetectable		 4dqfB-4g09A:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4g09 HISTIDINOL
DEHYDROGENASE
(Brucella
suis) 		5 / 12 GLY A 189
GLY A 188
ILE A 193
VAL A  30
ILE A  37
 GOL  A 503 (-3.6A)
None
None
None
None
 1.23A 4fglA-4g09A:
2.7
4fglB-4g09A:
undetectable		 4fglA-4g09A:
19.34
4fglB-4g09A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_2
(PROTEASE)		 4g09 HISTIDINOL
DEHYDROGENASE
(Brucella
suis) 		6 / 10 LEU A 240
ALA A 243
ASP A 244
GLY A 352
ILE A 351
ILE A 241
 None
 1.34A 4ll3B-4g09A:
undetectable		 4ll3B-4g09A:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_1
(PROTEASE)		 4g09 HISTIDINOL
DEHYDROGENASE
(Brucella
suis) 		6 / 10 LEU A 240
ALA A 243
ASP A 244
GLY A 352
ILE A 351
ILE A 241
 None
 1.32A 4ll3A-4g09A:
undetectable		 4ll3A-4g09A:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4g09 HISTIDINOL
DEHYDROGENASE
(Brucella
suis) 		5 / 7 TYR A 185
VAL A 206
ILE A 209
ILE A 193
ALA A 192
 None
 1.30A 4lv9B-4g09A:
undetectable		 4lv9B-4g09A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4g09 HISTIDINOL
DEHYDROGENASE
(Brucella
suis) 		5 / 12 LEU A  61
LEU A  50
GLY A 188
ALA A 192
VAL A  41
 None
 0.96A 4nkvB-4g09A:
undetectable		 4nkvB-4g09A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADD_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4g09 HISTIDINOL
DEHYDROGENASE
(Brucella
suis) 		4 / 6 VAL A  41
ARG A  55
VAL A  34
PHE A  56
 None
None
None
GOL  A 503 (-4.1A)
 1.47A 5addA-4g09A:
undetectable
5addB-4g09A:
undetectable		 5addA-4g09A:
19.11
5addB-4g09A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_1
(HIV-1 PROTEASE)		 4g09 HISTIDINOL
DEHYDROGENASE
(Brucella
suis) 		6 / 12 LEU A 240
ALA A 243
ASP A 244
GLY A 352
ILE A 351
ILE A 241
 None
 1.31A 5e5kA-4g09A:
undetectable		 5e5kA-4g09A:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4g09 HISTIDINOL
DEHYDROGENASE
(Brucella
suis) 		4 / 6 PHE A 277
VAL A 281
ILE A 241
ASP A 255
 None
 1.19A 5iwuA-4g09A:
undetectable		 5iwuA-4g09A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_1
(PROTEASE E35D-SQV)		 4g09 HISTIDINOL
DEHYDROGENASE
(Brucella
suis) 		6 / 12 ALA A 243
ASP A 244
GLY A 352
ILE A 351
VAL A 239
ILE A 241
 None
None
None
None
DMS  A 504 ( 4.7A)
None
 1.46A 5kqxA-4g09A:
undetectable		 5kqxA-4g09A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_1
(PROTEASE E35D-DRV)		 4g09 HISTIDINOL
DEHYDROGENASE
(Brucella
suis) 		5 / 12 LEU A 240
ALA A 243
GLY A 352
ILE A 351
ILE A 241
 None
 0.95A 5kqyA-4g09A:
undetectable		 5kqyA-4g09A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4g09 HISTIDINOL
DEHYDROGENASE
(Brucella
suis) 		4 / 8 HIS A 262
SER A 348
HIS A 368
SER A 140
 ZN  A 501 (-3.3A)
None
0VD  A 505 (-3.6A)
0VD  A 505 (-3.2A)
 0.92A 5m8rB-4g09A:
undetectable		 5m8rB-4g09A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4g09 HISTIDINOL
DEHYDROGENASE
(Brucella
suis) 		4 / 8 HIS A 262
SER A 348
HIS A 368
SER A 140
 ZN  A 501 (-3.3A)
None
0VD  A 505 (-3.6A)
0VD  A 505 (-3.2A)
 0.97A 5m8rD-4g09A:
undetectable		 5m8rD-4g09A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_0
(HIV-1 PROTEASE)		 4g09 HISTIDINOL
DEHYDROGENASE
(Brucella
suis) 		5 / 12 ALA A 243
ASP A 244
GLY A 352
ILE A 351
ILE A 241
 None
 1.18A 6difA-4g09A:
undetectable		 6difA-4g09A:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECF_I_DVAI3010_0
(VLM2
DODECADEPSIPEPTIDE)		 4g09 HISTIDINOL
DEHYDROGENASE
(Brucella
suis) 		3 / 3 PHE A  12
ARG A 323
ALA A  18
 None
 0.98A 6ecfB-4g09A:
undetectable		 6ecfB-4g09A:
24.83