SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4g0m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ETB_2_T442129_1 (TRANSTHYRETIN)	4g0m	PROTEIN ARGONAUTE 2 (Arabidopsis thaliana)	4 / 6	GLU A 600 THR A 698 ALA A 670 LEU A 594	SO4 A 806 (-3.6A) None None None	1.05A	1etb2-4g0mA: undetectable	1etb2-4g0mA: 22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5F8Y_A_X6XA202_1 (GALNAC/GAL-SPECIFIC LECTIN)	4g0m	PROTEIN ARGONAUTE 2 (Arabidopsis thaliana)	4 / 8	HIS A 659 GLY A 661 GLY A 660 HIS A 590	SO4 A 803 (-4.5A) None None SO4 A 803 ( 4.0A)	0.75A	5f8yA-4g0mA: undetectable	5f8yA-4g0mA: 20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6R2E_B_FFOB403_0 (THYMIDYLATE SYNTHASE)	4g0m	PROTEIN ARGONAUTE 2 (Arabidopsis thaliana)	5 / 10	LEU A 697 ASP A 675 LEU A 638 GLY A 677 MET A 635	None	1.48A	6r2eB-4g0mA: undetectable	6r2eB-4g0mA: 18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6R2E_C_FFOC404_0 (THYMIDYLATE SYNTHASE)	4g0m	PROTEIN ARGONAUTE 2 (Arabidopsis thaliana)	5 / 10	LEU A 697 ASP A 675 LEU A 638 GLY A 677 MET A 635	None	1.45A	6r2eC-4g0mA: undetectable	6r2eC-4g0mA: 18.60

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1ETB_2_T442129_1","TRANSTHYRETIN","4g0m","PROTEIN ARGONAUTE 2","Arabidopsis thaliana",4,"GLU A 600;THR A 698;ALA A 670;LEU A 594","SO4 A 806 (-3.6A);None;None;None","1.05A","1etb2-4g0mA:undetectable","1etb2-4g0mA:22.98"],["5F8Y_A_X6XA202_1","GALNAC\/GAL-SPECIFIC LECTIN","4g0m","PROTEIN ARGONAUTE 2","Arabidopsis thaliana",4,"HIS A 659;GLY A 661;GLY A 660;HIS A 590","SO4 A 803 (-4.5A);None;None;SO4 A 803 ( 4.0A)","0.75A","5f8yA-4g0mA:undetectable","5f8yA-4g0mA:20.62"],["6R2E_B_FFOB403_0","THYMIDYLATE SYNTHASE","4g0m","PROTEIN ARGONAUTE 2","Arabidopsis thaliana",5,"LEU A 697;ASP A 675;LEU A 638;GLY A 677;MET A 635","None","1.48A","6r2eB-4g0mA:undetectable","6r2eB-4g0mA:18.60"],["6R2E_C_FFOC404_0","THYMIDYLATE SYNTHASE","4g0m","PROTEIN ARGONAUTE 2","Arabidopsis thaliana",5,"LEU A 697;ASP A 675;LEU A 638;GLY A 677;MET A 635","None","1.45A","6r2eC-4g0mA:undetectable","6r2eC-4g0mA:18.60"]]