SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4g10'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 4g10 GLUTATHIONE
S-TRANSFERASE
HOMOLOG
(Sphingomonas
paucimobilis) 		4 / 5 PHE A 168
PHE A 164
TRP A 192
GLY A 136
 None
 1.24A 2qmzA-4g10A:
undetectable
2qmzB-4g10A:
undetectable		 2qmzA-4g10A:
20.36
2qmzB-4g10A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CO4_A_GCSA401_1
(CHITINASE)		 4g10 GLUTATHIONE
S-TRANSFERASE
HOMOLOG
(Sphingomonas
paucimobilis) 		3 / 3 GLU A 161
HIS A  95
HIS A  89
 None
 0.92A 3co4A-4g10A:
undetectable		 3co4A-4g10A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QJ7_A_SPMA264_1
(THYMIDYLATE SYNTHASE)		 4g10 GLUTATHIONE
S-TRANSFERASE
HOMOLOG
(Sphingomonas
paucimobilis) 		4 / 8 LEU A 211
ASP A 216
TYR A 177
SER A 234
 None
 1.00A 3qj7A-4g10A:
undetectable
3qj7D-4g10A:
undetectable		 3qj7A-4g10A:
22.44
3qj7D-4g10A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 4g10 GLUTATHIONE
S-TRANSFERASE
HOMOLOG
(Sphingomonas
paucimobilis) 		5 / 6 PHE A  17
ARG A  20
PRO A  58
GLU A  70
SER A  71
 GSH  A 300 (-3.6A)
None
GSH  A 300 (-4.2A)
GSH  A 300 (-3.0A)
GSH  A 300 (-2.6A)
 0.46A 3vlnA-4g10A:
21.6		 3vlnA-4g10A:
26.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 4g10 GLUTATHIONE
S-TRANSFERASE
HOMOLOG
(Sphingomonas
paucimobilis) 		4 / 6 GLY A 253
TRP A 252
GLU A 178
ARG A 124
 None
 1.36A 4bqfA-4g10A:
undetectable		 4bqfA-4g10A:
14.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G10_A_ACTA301_0
(GLUTATHIONE
S-TRANSFERASE
HOMOLOG)		 4g10 GLUTATHIONE
S-TRANSFERASE
HOMOLOG
(Sphingomonas
paucimobilis) 		6 / 6 PRO A  16
ILE A  39
TYR A 113
TYR A 214
TYR A 217
PHE A 235
 GSH  A 300 ( 4.4A)
None
ACT  A 301 (-4.5A)
ACT  A 301 (-4.5A)
None
ACT  A 301 ( 4.5A)
 0.01A 4g10A-4g10A:
45.6		 4g10A-4g10A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_2
(CYP51 VARIANT1)		 4g10 GLUTATHIONE
S-TRANSFERASE
HOMOLOG
(Sphingomonas
paucimobilis) 		3 / 3 PRO A 227
ILE A 121
SER A 233
 None
 0.77A 5fsaA-4g10A:
undetectable		 5fsaA-4g10A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXF_A_BEZA601_0
(EUGENOL OXIDASE)		 4g10 GLUTATHIONE
S-TRANSFERASE
HOMOLOG
(Sphingomonas
paucimobilis) 		5 / 9 TYR A  82
VAL A  62
LEU A  25
TYR A  77
ARG A  81
 None
 1.11A 5fxfA-4g10A:
0.4		 5fxfA-4g10A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXF_B_BEZB601_0
(EUGENOL OXIDASE)		 4g10 GLUTATHIONE
S-TRANSFERASE
HOMOLOG
(Sphingomonas
paucimobilis) 		5 / 10 TYR A  82
VAL A  62
LEU A  25
TYR A  77
ARG A  81
 None
 1.10A 5fxfB-4g10A:
undetectable		 5fxfB-4g10A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_C_ACTC1740_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT)		 4g10 GLUTATHIONE
S-TRANSFERASE
HOMOLOG
(Sphingomonas
paucimobilis) 		4 / 4 VAL A 131
GLU A 134
GLY A 112
LEU A 171
 None
 1.36A 5g5gC-4g10A:
undetectable		 5g5gC-4g10A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 4g10 GLUTATHIONE
S-TRANSFERASE
HOMOLOG
(Sphingomonas
paucimobilis) 		4 / 5 MET A 127
VAL A 131
GLY A 112
ALA A 111
 None
 1.00A 5k50A-4g10A:
undetectable		 5k50A-4g10A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 4g10 GLUTATHIONE
S-TRANSFERASE
HOMOLOG
(Sphingomonas
paucimobilis) 		4 / 7 HIS A  11
ILE A  12
TYR A 214
ARG A 170
 None
GSH  A 300 (-3.3A)
ACT  A 301 (-4.5A)
None
 1.25A 5kkzC-4g10A:
undetectable
5kkzE-4g10A:
undetectable		 5kkzC-4g10A:
20.15
5kkzE-4g10A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 4g10 GLUTATHIONE
S-TRANSFERASE
HOMOLOG
(Sphingomonas
paucimobilis) 		4 / 7 HIS A  11
ILE A  12
TYR A 214
ARG A 170
 None
GSH  A 300 (-3.3A)
ACT  A 301 (-4.5A)
None
 1.25A 5kkzK-4g10A:
undetectable
5kkzQ-4g10A:
undetectable		 5kkzK-4g10A:
20.66
5kkzQ-4g10A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_O_ASCO1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 4g10 GLUTATHIONE
S-TRANSFERASE
HOMOLOG
(Sphingomonas
paucimobilis) 		4 / 7 HIS A  11
ILE A  12
TYR A 214
ARG A 170
 None
GSH  A 300 (-3.3A)
ACT  A 301 (-4.5A)
None
 1.24A 5kkzM-4g10A:
undetectable
5kkzO-4g10A:
undetectable		 5kkzM-4g10A:
20.15
5kkzO-4g10A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4g10 GLUTATHIONE
S-TRANSFERASE
HOMOLOG
(Sphingomonas
paucimobilis) 		3 / 3 LEU A  59
ASN A  64
LEU A   7
 None
 0.70A 6exiD-4g10A:
undetectable		 6exiD-4g10A:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 4g10 GLUTATHIONE
S-TRANSFERASE
HOMOLOG
(Sphingomonas
paucimobilis) 		5 / 9 LEU A  25
VAL A  21
SER A  67
LEU A  68
ILE A  74
 None
 1.34A 6fdyU-4g10A:
undetectable		 6fdyU-4g10A:
23.43