SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4g19'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ALZ_A_DVAA6_0
(ILE-GRAMICIDIN C
VAL-GRAMICIDIN A)		 4g19 GLUTATHIONE
TRANSFERASE GTE1
(Phanerochaete
chrysosporium) 		4 / 4 ALA A 216
VAL A 214
TRP A  26
TRP A 220
 None
None
None
GOL  A 303 (-4.7A)
 1.43A 1alzA-4g19A:
undetectable
1alzB-4g19A:
undetectable		 1alzA-4g19A:
5.02
1alzB-4g19A:
5.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 4g19 GLUTATHIONE
TRANSFERASE GTE1
(Phanerochaete
chrysosporium) 		4 / 4 LEU A 194
GLY A 197
GLY A 201
THR A 203
 None
 0.94A 3si7A-4g19A:
undetectable		 3si7A-4g19A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)		 4g19 GLUTATHIONE
TRANSFERASE GTE1
(Phanerochaete
chrysosporium) 		4 / 6 THR A  81
TYR A  94
TYR A  99
TYR A  77
 None
None
ACT  A 304 ( 4.9A)
None
 1.34A 4df2A-4g19A:
undetectable		 4df2A-4g19A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4g19 GLUTATHIONE
TRANSFERASE GTE1
(Phanerochaete
chrysosporium) 		5 / 12 ALA A 243
PHE A 213
LEU A 177
VAL A 173
THR A 246
 None
 1.11A 4eckA-4g19A:
undetectable		 4eckA-4g19A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_A_NCTA501_1
(CYTOCHROME P450 2A6)		 4g19 GLUTATHIONE
TRANSFERASE GTE1
(Phanerochaete
chrysosporium) 		4 / 7 PHE A 149
ASN A  24
THR A 137
ILE A 134
 None
GSH  A 302 ( 3.8A)
None
None
 0.89A 4ejjA-4g19A:
undetectable		 4ejjA-4g19A:
18.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G19_A_ACTA301_0
(GLUTATHIONE
TRANSFERASE GTE1)		 4g19 GLUTATHIONE
TRANSFERASE GTE1
(Phanerochaete
chrysosporium) 		5 / 5 ASN A  24
TYR A  46
TRP A 122
PHE A 130
ARG A 153
 GSH  A 302 ( 3.8A)
GSH  A 302 ( 4.7A)
None
ACT  A 301 (-4.1A)
GSH  A 302 ( 2.4A)
 0.00A 4g19A-4g19A:
45.4		 4g19A-4g19A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 4g19 GLUTATHIONE
TRANSFERASE GTE1
(Phanerochaete
chrysosporium) 		5 / 5 ALA A   2
ILE A   5
LEU A  37
LYS A  38
ASN A  80
 ACT  A 304 (-3.1A)
None
ACT  A 304 (-4.2A)
None
ACT  A 304 ( 4.6A)
 0.05A 4g19A-4g19A:
45.4		 4g19A-4g19A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G19_B_ACTB301_0
(GLUTATHIONE
TRANSFERASE GTE1)		 4g19 GLUTATHIONE
TRANSFERASE GTE1
(Phanerochaete
chrysosporium) 		5 / 5 ASN A  24
TYR A  46
TRP A 122
PHE A 130
ARG A 153
 GSH  A 302 ( 3.8A)
GSH  A 302 ( 4.7A)
None
ACT  A 301 (-4.1A)
GSH  A 302 ( 2.4A)
 0.20A 4g19B-4g19A:
43.3		 4g19B-4g19A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G19_C_ACTC301_0
(GLUTATHIONE
TRANSFERASE GTE1)		 4g19 GLUTATHIONE
TRANSFERASE GTE1
(Phanerochaete
chrysosporium) 		4 / 5 ASN A  24
TYR A  46
PHE A 130
ARG A 153
 GSH  A 302 ( 3.8A)
GSH  A 302 ( 4.7A)
ACT  A 301 (-4.1A)
GSH  A 302 ( 2.4A)
 0.17A 4g19C-4g19A:
43.1		 4g19C-4g19A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G19_C_ACTC301_0
(GLUTATHIONE
TRANSFERASE GTE1)		 4g19 GLUTATHIONE
TRANSFERASE GTE1
(Phanerochaete
chrysosporium) 		4 / 5 TYR A  46
TRP A 122
PHE A 130
ARG A 153
 GSH  A 302 ( 4.7A)
None
ACT  A 301 (-4.1A)
GSH  A 302 ( 2.4A)
 0.73A 4g19C-4g19A:
43.1		 4g19C-4g19A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G19_D_ACTD302_0
(GLUTATHIONE
TRANSFERASE GTE1)		 4g19 GLUTATHIONE
TRANSFERASE GTE1
(Phanerochaete
chrysosporium) 		3 / 3 TYR A  46
PHE A 130
ARG A 153
 GSH  A 302 ( 4.7A)
ACT  A 301 (-4.1A)
GSH  A 302 ( 2.4A)
 0.09A 4g19D-4g19A:
43.7		 4g19D-4g19A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G19_D_ACTD305_0
(GLUTATHIONE
TRANSFERASE GTE1)		 4g19 GLUTATHIONE
TRANSFERASE GTE1
(Phanerochaete
chrysosporium) 		4 / 4 ILE A   5
LEU A  37
LYS A  38
ASN A  80
 None
ACT  A 304 (-4.2A)
None
ACT  A 304 ( 4.6A)
 0.57A 4g19D-4g19A:
43.7		 4g19D-4g19A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4g19 GLUTATHIONE
TRANSFERASE GTE1
(Phanerochaete
chrysosporium) 		5 / 12 LEU A 118
ALA A  89
PRO A  74
TYR A  30
ILE A 207
 None
None
GSH  A 302 (-4.4A)
None
None
 1.36A 5ljbA-4g19A:
undetectable		 5ljbA-4g19A:
17.60