SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4g1c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 4g1c NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ALA A 116
ALA A 120
LEU A 244
GLY A 294
LEU A 246
 None
 1.09A 1qabF-4g1cA:
undetectable		 1qabF-4g1cA:
19.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4g1c NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL
(Homo
sapiens) 		6 / 6 ALA A  59
SER A  62
PHE A  70
ASN A 141
ILE A 142
ASP A 143
 CNA  A 402 (-3.0A)
CNA  A 402 ( 4.1A)
CNA  A 402 (-3.2A)
CNA  A 402 (-4.1A)
CNA  A 402 (-4.7A)
CNA  A 402 (-3.7A)
 0.88A 1yc2A-4g1cA:
25.4		 1yc2A-4g1cA:
39.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4g1c NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 ALA A  59
ASN A 141
ILE A 142
ASP A 143
 CNA  A 402 (-3.0A)
CNA  A 402 (-4.1A)
CNA  A 402 (-4.7A)
CNA  A 402 (-3.7A)
 0.38A 1yc2D-4g1cA:
25.2		 1yc2D-4g1cA:
39.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4g1c NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 ALA A  59
PHE A  70
ILE A 142
ASP A 143
 CNA  A 402 (-3.0A)
CNA  A 402 (-3.2A)
CNA  A 402 (-4.7A)
CNA  A 402 (-3.7A)
 1.09A 1yc2D-4g1cA:
25.2		 1yc2D-4g1cA:
39.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 4g1c NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 7 ALA A  59
SER A  62
ASN A 141
ILE A 142
ASP A 143
 CNA  A 402 (-3.0A)
CNA  A 402 ( 4.1A)
CNA  A 402 (-4.1A)
CNA  A 402 (-4.7A)
CNA  A 402 (-3.7A)
 0.27A 1yc5A-4g1cA:
24.9		 1yc5A-4g1cA:
30.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZEA_A_DHIA6_0
(MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
H CHAIN
MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
L CHAIN
SHORT SYNTHETIC
D-AMINO ACID PEPTIDE
D2)		 4g1c NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 TRP A  99
ARG A 217
PHE A  91
 None
 1.40A 1zeaH-4g1cA:
undetectable
1zeaL-4g1cA:
undetectable		 1zeaH-4g1cA:
20.22
1zeaL-4g1cA:
18.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 4g1c NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 ALA A  59
ASN A 141
ILE A 142
ASP A 143
 CNA  A 402 (-3.0A)
CNA  A 402 (-4.1A)
CNA  A 402 (-4.7A)
CNA  A 402 (-3.7A)
 0.20A 2h4jA-4g1cA:
24.4		 2h4jA-4g1cA:
30.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 4g1c NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL
(Homo
sapiens) 		7 / 12 ALA A  59
THR A  69
ALA A  86
PHE A 101
TYR A 102
ILE A 142
LEU A 227
 CNA  A 402 (-3.0A)
CNA  A 402 (-3.8A)
None
None
None
CNA  A 402 (-4.7A)
None
 0.88A 2nyrA-4g1cA:
37.7		 2nyrA-4g1cA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 4g1c NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL
(Homo
sapiens) 		6 / 12 THR A  69
ALA A  82
ALA A  86
TYR A 102
ILE A 142
LEU A 227
 CNA  A 402 (-3.8A)
None
None
None
CNA  A 402 (-4.7A)
None
 1.07A 2nyrA-4g1cA:
37.7		 2nyrA-4g1cA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 4g1c NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL
(Homo
sapiens) 		7 / 12 THR A  69
ALA A  86
PHE A 101
TYR A 102
ILE A 142
PHE A 223
LEU A 227
 CNA  A 402 (-3.8A)
None
None
None
CNA  A 402 (-4.7A)
None
None
 0.95A 2nyrA-4g1cA:
37.7		 2nyrA-4g1cA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2NYR_B_SVRB401_3
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 4g1c NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL
(Homo
sapiens) 		7 / 12 TYR A 102
ARG A 105
ILE A 142
HIS A 158
PHE A 223
GLY A 224
LEU A 232
 None
CNA  A 402 ( 4.8A)
CNA  A 402 (-4.7A)
CNA  A 402 (-4.3A)
None
None
None
 0.86A 2nyrB-4g1cA:
38.3		 2nyrB-4g1cA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2NYR_B_SVRB401_3
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 4g1c NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL
(Homo
sapiens) 		6 / 12 TYR A 102
ARG A 105
ILE A 142
PHE A 223
GLY A 224
ASN A 226
 None
CNA  A 402 ( 4.8A)
CNA  A 402 (-4.7A)
None
None
None
 0.91A 2nyrB-4g1cA:
38.3		 2nyrB-4g1cA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 4g1c NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 ALA A  59
ALA A  82
ALA A  86
VAL A 220
 CNA  A 402 (-3.0A)
None
None
None
 0.76A 2nyrB-4g1cA:
38.3		 2nyrB-4g1cA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		 4g1c NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 VAL A  54
ILE A 157
PHE A 260
LEU A 232
ASP A 236
 None
 1.24A 2q6hA-4g1cA:
undetectable		 2q6hA-4g1cA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		 4g1c NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 VAL A  54
ILE A 157
PHE A 260
LEU A 232
ASP A 236
 None
 1.22A 2qeiA-4g1cA:
undetectable		 2qeiA-4g1cA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 4g1c NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 ASP A 143
SER A  62
SER A  57
LEU A 155
 CNA  A 402 (-3.7A)
CNA  A 402 ( 4.1A)
None
None
 0.84A 3m0wE-4g1cA:
undetectable
3m0wF-4g1cA:
undetectable
3m0wG-4g1cA:
undetectable
3m0wH-4g1cA:
undetectable		 3m0wE-4g1cA:
20.95
3m0wF-4g1cA:
20.95
3m0wG-4g1cA:
20.95
3m0wH-4g1cA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4g1c NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ASP A 143
ILE A 142
SER A  57
HIS A 146
HIS A 118
 CNA  A 402 (-3.7A)
CNA  A 402 (-4.7A)
None
None
None
 1.16A 3o1cA-4g1cA:
undetectable		 3o1cA-4g1cA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4g1c NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ASP A 143
ILE A 142
SER A  57
HIS A 146
HIS A 118
 CNA  A 402 (-3.7A)
CNA  A 402 (-4.7A)
None
None
None
 1.18A 3o1xA-4g1cA:
undetectable		 3o1xA-4g1cA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_C_ACTC1113_0
(BLR5658 PROTEIN)		 4g1c NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 ASN A 141
ALA A  59
GLY A  58
THR A 250
 CNA  A 402 (-4.1A)
CNA  A 402 (-3.0A)
CNA  A 402 ( 3.8A)
CNA  A 402 (-4.3A)
 1.29A 4bboC-4g1cA:
undetectable		 4bboC-4g1cA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 4g1c NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 GLU A 238
ARG A 134
HIS A  52
 None
 0.86A 4kf9A-4g1cA:
undetectable		 4kf9A-4g1cA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_B_MXMB606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4g1c NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 231
VAL A 235
LEU A 239
LEU A 232
ALA A 257
 None
 1.05A 4m11B-4g1cA:
undetectable		 4m11B-4g1cA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_B_SALB301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 4g1c NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 ALA A 272
VAL A 248
PHE A  43
ILE A 121
 None
 1.02A 5of1B-4g1cA:
undetectable		 5of1B-4g1cA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 4g1c NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 GLY A  60
ALA A  63
GLY A 249
GLU A 277
SER A 251
 CNA  A 402 (-3.0A)
CNA  A 402 (-3.5A)
CNA  A 402 (-3.2A)
CNA  A 402 (-3.4A)
CNA  A 402 (-2.7A)
 1.20A 5vw4A-4g1cA:
3.2		 5vw4A-4g1cA:
21.54