SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4g1g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_1
(HIV-1 PROTEASE)		 4g1g MATRIX PROTEIN
(Avian
avulavirus
1) 		5 / 10 LEU A 322
ALA A 320
ILE A 314
VAL A 208
ILE A 210
 None
 0.94A 1hsgA-4g1gA:
undetectable		 1hsgA-4g1gA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RK3_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 4g1g MATRIX PROTEIN
(Avian
avulavirus
1) 		4 / 4 LEU A  94
ILE A  43
ARG A  45
TYR A  62
 None
 1.40A 1rk3A-4g1gA:
undetectable		 1rk3A-4g1gA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 4g1g MATRIX PROTEIN
(Avian
avulavirus
1) 		5 / 11 LEU A 322
ALA A 320
ILE A 314
VAL A 208
ILE A 210
 None
 1.00A 1sduA-4g1gA:
undetectable		 1sduA-4g1gA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		 4g1g MATRIX PROTEIN
(Avian
avulavirus
1) 		5 / 12 THR A  60
ILE A  59
VAL A  97
ASN A  99
CYH A 110
 None
 1.01A 1wsvB-4g1gA:
0.8		 1wsvB-4g1gA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_3
(POL POLYPROTEIN)		 4g1g MATRIX PROTEIN
(Avian
avulavirus
1) 		5 / 12 LEU A 322
ALA A 320
ILE A 314
VAL A 208
ILE A 210
 None
 0.90A 2avvE-4g1gA:
undetectable		 2avvE-4g1gA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		 4g1g MATRIX PROTEIN
(Avian
avulavirus
1) 		4 / 8 VAL A 186
VAL A 181
HIS A 354
ASP A  55
 None
 0.93A 2ddwA-4g1gA:
undetectable		 2ddwA-4g1gA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_2
(HIV-1 PROTEASE)		 4g1g MATRIX PROTEIN
(Avian
avulavirus
1) 		5 / 12 LEU A 322
ALA A 320
ILE A 314
VAL A 208
ILE A 210
 None
 0.94A 3d1xB-4g1gA:
undetectable		 3d1xB-4g1gA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_2
(PROTEASE)		 4g1g MATRIX PROTEIN
(Avian
avulavirus
1) 		5 / 10 LEU A 322
ALA A 320
ILE A 314
VAL A 208
ILE A 210
 None
 0.93A 3em3B-4g1gA:
undetectable		 3em3B-4g1gA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_2
(PROTEASE)		 4g1g MATRIX PROTEIN
(Avian
avulavirus
1) 		5 / 12 LEU A 322
ALA A 320
ILE A 314
VAL A 208
ILE A 210
 None
 0.93A 3em6B-4g1gA:
undetectable		 3em6B-4g1gA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4g1g MATRIX PROTEIN
(Avian
avulavirus
1) 		5 / 10 ALA A 307
ASN A 234
ALA A 233
ILE A 210
LEU A 270
 None
 0.96A 3fl9F-4g1gA:
undetectable		 3fl9F-4g1gA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_2
(VITAMIN D3 RECEPTOR)		 4g1g MATRIX PROTEIN
(Avian
avulavirus
1) 		5 / 9 PHE A 294
ILE A 350
TYR A 302
LEU A 322
VAL A 345
 None
 1.49A 3m7rA-4g1gA:
undetectable		 3m7rA-4g1gA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_A_ROCA101_2
(PROTEASE)		 4g1g MATRIX PROTEIN
(Avian
avulavirus
1) 		5 / 12 LEU A 322
ALA A 320
ILE A 314
VAL A 208
ILE A 210
 None
 0.99A 3nduB-4g1gA:
undetectable		 3nduB-4g1gA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU3_B_478B401_1
(PROTEASE)		 4g1g MATRIX PROTEIN
(Avian
avulavirus
1) 		5 / 12 LEU A 322
ALA A 320
ILE A 314
VAL A 208
ILE A 210
 None
 0.97A 3nu3A-4g1gA:
undetectable		 3nu3A-4g1gA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_2
(HIV-1 PROTEASE)		 4g1g MATRIX PROTEIN
(Avian
avulavirus
1) 		5 / 11 LEU A 322
ALA A 320
ILE A 314
VAL A 208
ILE A 210
 None
 0.99A 3oxxB-4g1gA:
undetectable		 3oxxB-4g1gA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_2
(HIV-1 PROTEASE)		 4g1g MATRIX PROTEIN
(Avian
avulavirus
1) 		5 / 11 LEU A 322
ALA A 320
ILE A 314
VAL A 208
ILE A 210
 None
 0.91A 3oxxD-4g1gA:
undetectable		 3oxxD-4g1gA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_3
(PROTEASE)		 4g1g MATRIX PROTEIN
(Avian
avulavirus
1) 		5 / 12 LEU A 322
ALA A 320
ILE A 314
VAL A 208
ILE A 210
 None
 0.92A 3pwrB-4g1gA:
undetectable		 3pwrB-4g1gA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_D_LOCD502_1
(TUBULIN BETA CHAIN)		 4g1g MATRIX PROTEIN
(Avian
avulavirus
1) 		5 / 12 LEU A 206
LEU A 204
MET A 242
ALA A 282
ILE A 261
 None
 1.17A 3ut5D-4g1gA:
undetectable		 3ut5D-4g1gA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_1
(ASPARTYL PROTEASE)		 4g1g MATRIX PROTEIN
(Avian
avulavirus
1) 		5 / 12 LEU A 322
ALA A 320
ILE A 314
VAL A 208
ILE A 210
 None
 0.92A 4dqbA-4g1gA:
undetectable		 4dqbA-4g1gA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_1
(ASPARTYL PROTEASE)		 4g1g MATRIX PROTEIN
(Avian
avulavirus
1) 		5 / 12 LEU A 322
ALA A 320
ILE A 314
VAL A 208
ILE A 210
 None
 0.93A 4dqfA-4g1gA:
undetectable		 4dqfA-4g1gA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ1_B_NPSB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4g1g MATRIX PROTEIN
(Avian
avulavirus
1) 		4 / 8 TYR A 302
VAL A 325
ILE A 350
LEU A 264
 None
 0.83A 4jq1B-4g1gA:
undetectable		 4jq1B-4g1gA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 4g1g MATRIX PROTEIN
(Avian
avulavirus
1) 		5 / 12 TYR A 302
LEU A 206
VAL A 325
ILE A 350
LEU A 264
 None
 1.38A 4yvpB-4g1gA:
undetectable		 4yvpB-4g1gA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4g1g MATRIX PROTEIN
(Avian
avulavirus
1) 		4 / 8 ALA A 193
HIS A 238
LEU A 241
LEU A 290
 None
 0.95A 5dzkd-4g1gA:
undetectable
5dzkr-4g1gA:
undetectable		 5dzkd-4g1gA:
20.55
5dzkr-4g1gA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 4g1g MATRIX PROTEIN
(Avian
avulavirus
1) 		5 / 12 LEU A 206
LEU A 204
MET A 242
ALA A 282
ILE A 261
 None
 1.19A 5nm5B-4g1gA:
undetectable		 5nm5B-4g1gA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDZ_A_ADNA905_1
(ATP-CITRATE SYNTHASE)		 4g1g MATRIX PROTEIN
(Avian
avulavirus
1) 		4 / 6 ARG A 353
ASP A  47
LEU A  46
ASP A 185
 None
 1.03A 5tdzA-4g1gA:
undetectable		 5tdzA-4g1gA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 4g1g MATRIX PROTEIN
(Avian
avulavirus
1) 		5 / 12 ARG A  42
ILE A 304
LEU A 279
GLY A 269
ALA A 300
 None
 1.12A 5x66A-4g1gA:
undetectable
5x66B-4g1gA:
undetectable		 5x66A-4g1gA:
21.71
5x66B-4g1gA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_1
(PROTEASE)		 4g1g MATRIX PROTEIN
(Avian
avulavirus
1) 		5 / 12 LEU A 322
ALA A 320
ILE A 314
LEU A 224
ILE A 210
 None
 0.89A 6dh6B-4g1gA:
undetectable		 6dh6B-4g1gA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F5U_A_CQNA610_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 4g1g MATRIX PROTEIN
(Avian
avulavirus
1) 		5 / 10 VAL A 280
ALA A 300
LEU A 266
LEU A 264
LEU A 206
 None
 0.84A 6f5uA-4g1gA:
undetectable
6f5uB-4g1gA:
undetectable		 6f5uA-4g1gA:
12.15
6f5uB-4g1gA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 4g1g MATRIX PROTEIN
(Avian
avulavirus
1) 		5 / 10 ILE A 261
VAL A 280
ALA A 300
LEU A 266
LEU A 206
 None
 0.99A 6f6nA-4g1gA:
undetectable
6f6nB-4g1gA:
undetectable		 6f6nA-4g1gA:
12.15
6f6nB-4g1gA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 4g1g MATRIX PROTEIN
(Avian
avulavirus
1) 		5 / 10 VAL A 280
ALA A 300
LEU A 266
LEU A 264
LEU A 206
 None
 0.84A 6f6nA-4g1gA:
undetectable
6f6nB-4g1gA:
undetectable		 6f6nA-4g1gA:
12.15
6f6nB-4g1gA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBF_A_ACTA507_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 4g1g MATRIX PROTEIN
(Avian
avulavirus
1) 		3 / 3 LYS A 281
SER A 295
SER A 297
 None
 0.60A 6gbfA-4g1gA:
undetectable		 6gbfA-4g1gA:
22.15