SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4g1k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4g1k TRIOSEPHOSPHATE
ISOMERASE
(Burkholderia
thailandensis) 		5 / 12 ILE A 246
CYH A 247
ALA A 249
ALA A 250
ALA A 220
 None
 0.87A 1fbyA-4g1kA:
undetectable		 1fbyA-4g1kA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_B_9CRB1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4g1k TRIOSEPHOSPHATE
ISOMERASE
(Burkholderia
thailandensis) 		5 / 12 ILE A 246
CYH A 247
ALA A 249
ALA A 250
ALA A 220
 None
 0.85A 1fbyB-4g1kA:
undetectable		 1fbyB-4g1kA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA799_1
(ADENOSINE KINASE)		 4g1k TRIOSEPHOSPHATE
ISOMERASE
(Burkholderia
thailandensis) 		5 / 10 GLY A 211
VAL A 214
ALA A 187
ASN A 218
ILE A 228
 None
 1.06A 1likA-4g1kA:
undetectable		 1likA-4g1kA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 4g1k TRIOSEPHOSPHATE
ISOMERASE
(Burkholderia
thailandensis) 		5 / 11 VAL A 131
LEU A 155
LEU A 151
LEU A 121
LEU A 158
 None
None
None
EDO  A 304 (-4.1A)
None
 1.24A 1mx1B-4g1kA:
undetectable		 1mx1B-4g1kA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_A_9CRA201_1
(RXR-LIKE PROTEIN)		 4g1k TRIOSEPHOSPHATE
ISOMERASE
(Burkholderia
thailandensis) 		5 / 12 ILE A 246
CYH A 247
ALA A 249
ALA A 250
ALA A 220
 None
 0.81A 1xiuA-4g1kA:
undetectable		 1xiuA-4g1kA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4g1k TRIOSEPHOSPHATE
ISOMERASE
(Burkholderia
thailandensis) 		5 / 12 ILE A  42
VAL A   9
GLY A  11
LEU A  25
LEU A  58
 None
None
None
EDO  A 303 ( 4.5A)
None
 0.91A 3em0B-4g1kA:
undetectable		 3em0B-4g1kA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4g1k TRIOSEPHOSPHATE
ISOMERASE
(Burkholderia
thailandensis) 		5 / 12 ALA A 219
PHE A 223
ILE A  42
ALA A 245
VAL A   9
 None
 1.03A 3rukB-4g1kA:
undetectable		 3rukB-4g1kA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4g1k TRIOSEPHOSPHATE
ISOMERASE
(Burkholderia
thailandensis) 		4 / 8 GLY A  43
VAL A  44
ILE A 233
PHE A 223
 None
 0.84A 4fglD-4g1kA:
undetectable		 4fglD-4g1kA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4g1k TRIOSEPHOSPHATE
ISOMERASE
(Burkholderia
thailandensis) 		4 / 7 GLY A  43
VAL A  44
ILE A 233
PHE A 223
 None
 0.83A 4fglC-4g1kA:
undetectable		 4fglC-4g1kA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4g1k TRIOSEPHOSPHATE
ISOMERASE
(Burkholderia
thailandensis) 		5 / 12 ILE A  42
ALA A  41
PHE A 243
GLY A  32
VAL A  29
 None
 1.12A 5i71A-4g1kA:
undetectable		 5i71A-4g1kA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A211_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 4g1k TRIOSEPHOSPHATE
ISOMERASE
(Burkholderia
thailandensis) 		4 / 6 VAL A 113
LYS A 116
ALA A 117
VAL A 129
 None
 1.02A 5i8fA-4g1kA:
undetectable		 5i8fA-4g1kA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 4g1k TRIOSEPHOSPHATE
ISOMERASE
(Burkholderia
thailandensis) 		5 / 12 VAL A  29
ALA A  24
VAL A  44
GLY A  43
ILE A  42
 None
 0.82A 5j2tC-4g1kA:
undetectable		 5j2tC-4g1kA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_2
(PROTEASE E35D-SQV)		 4g1k TRIOSEPHOSPHATE
ISOMERASE
(Burkholderia
thailandensis) 		5 / 9 ARG A 248
VAL A  63
GLY A  11
ILE A 233
ILE A  42
 None
 1.01A 5kqxB-4g1kA:
undetectable		 5kqxB-4g1kA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)		 4g1k TRIOSEPHOSPHATE
ISOMERASE
(Burkholderia
thailandensis) 		4 / 6 GLU A 162
ARG A 118
ALA A 122
LEU A 121
 EDO  A 304 (-4.2A)
EDO  A 304 (-3.6A)
EDO  A 304 (-4.1A)
EDO  A 304 (-4.1A)
 1.15A 5phhA-4g1kA:
undetectable		 5phhA-4g1kA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH0_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4g1k TRIOSEPHOSPHATE
ISOMERASE
(Burkholderia
thailandensis) 		3 / 3 VAL A 168
VAL A 129
GLN A 150
 None
 0.68A 5qh0A-4g1kA:
undetectable		 5qh0A-4g1kA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH2_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4g1k TRIOSEPHOSPHATE
ISOMERASE
(Burkholderia
thailandensis) 		3 / 3 VAL A 168
VAL A 129
GLN A 150
 None
 0.68A 5qh2A-4g1kA:
undetectable		 5qh2A-4g1kA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHA_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4g1k TRIOSEPHOSPHATE
ISOMERASE
(Burkholderia
thailandensis) 		3 / 3 VAL A 168
VAL A 129
GLN A 150
 None
 0.67A 5qhaA-4g1kA:
undetectable		 5qhaA-4g1kA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4g1k TRIOSEPHOSPHATE
ISOMERASE
(Burkholderia
thailandensis) 		3 / 3 GLU A  81
HIS A  73
ARG A 119
 None
 0.87A 5uunA-4g1kA:
undetectable		 5uunA-4g1kA:
21.88