SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4g1p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_A_CAMA502_0
(CYTOCHROME P450-CAM)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 429
LEU A 181
VAL A  83
VAL A 164
 None
 1.06A 1dz4A-4g1pA:
undetectable		 1dz4A-4g1pA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_B_CAMB502_0
(CYTOCHROME P450-CAM)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 429
LEU A 181
VAL A  83
VAL A 164
 None
 1.08A 1dz4B-4g1pA:
undetectable		 1dz4B-4g1pA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_2
(ESTROGEN RECEPTOR)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 281
ASP A 415
MET A 311
LEU A 274
 None
 1.12A 1errB-4g1pA:
undetectable		 1errB-4g1pA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_2
(ALPHA-AMYLASE)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		3 / 3 TRP A 145
TYR A 100
LEU A  98
 None
 1.08A 1kxhA-4g1pA:
undetectable		 1kxhA-4g1pA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_B_CAMB1420_0
(CYTOCHROME P450-CAM)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 429
LEU A 181
VAL A  83
VAL A 164
 None
 0.99A 1o76B-4g1pA:
undetectable		 1o76B-4g1pA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_A_FUAA702_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		5 / 12 SER A 144
VAL A 409
PHE A   9
ALA A 402
ALA A 405
 None
 1.34A 1q23A-4g1pA:
2.9
1q23B-4g1pA:
2.7		 1q23A-4g1pA:
17.76
1q23B-4g1pA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_A_DAHA208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		5 / 11 ASP A 137
GLU A 172
TYR A 100
SER A 199
GLU A 171
 ZN  A 501 (-2.3A)
ZN  A 501 ( 2.0A)
None
None
GLY  A 503 (-3.2A)
 1.41A 1rnrA-4g1pA:
undetectable		 1rnrA-4g1pA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_1
(POL POLYPROTEIN)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 121
GLY A 140
ASP A 138
ASP A 137
GLY A 443
 None
None
None
ZN  A 501 (-2.3A)
None
 0.99A 1t7iA-4g1pA:
undetectable		 1t7iA-4g1pA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 429
LEU A 181
VAL A  83
VAL A 164
 None
 1.09A 1t88B-4g1pA:
undetectable		 1t88B-4g1pA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 471
LEU A   5
PHE A 152
VAL A 161
PRO A 160
 None
 1.25A 1vpoH-4g1pA:
undetectable
1vpoL-4g1pA:
undetectable		 1vpoH-4g1pA:
18.67
1vpoL-4g1pA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 475
LEU A   5
PHE A 152
VAL A 161
PRO A 160
 None
 1.34A 1vpoH-4g1pA:
undetectable
1vpoL-4g1pA:
undetectable		 1vpoH-4g1pA:
18.67
1vpoL-4g1pA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		5 / 12 PHE A   9
GLY A 463
GLY A 464
LEU A 408
LEU A 211
 None
 1.14A 1ya4B-4g1pA:
2.7		 1ya4B-4g1pA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC8_0
(ACTINOMYCIN D)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		3 / 3 PRO A 317
THR A 349
PRO A 351
 None
 0.83A 2d55C-4g1pA:
undetectable		 2d55C-4g1pA:
3.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FEU_A_CAMA1420_0
(CYTOCHROME P450-CAM)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 429
LEU A 181
VAL A  83
VAL A 164
 None
 1.07A 2feuA-4g1pA:
undetectable		 2feuA-4g1pA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_A_017A201_1
(PROTEASE)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 121
GLY A 140
ASP A 138
ASP A 137
GLY A 443
 None
None
None
ZN  A 501 (-2.3A)
None
 0.95A 2hs2A-4g1pA:
undetectable		 2hs2A-4g1pA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1291_1
(FICOLIN-2)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		4 / 4 ASP A 446
LEU A 204
GLY A 205
ARG A 313
 None
 1.25A 2j2pD-4g1pA:
undetectable
2j2pE-4g1pA:
undetectable		 2j2pD-4g1pA:
19.75
2j2pE-4g1pA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_2
(ESTROGEN RECEPTOR)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 281
ASP A 415
MET A 311
LEU A 274
 None
 1.16A 2jfaA-4g1pA:
undetectable		 2jfaA-4g1pA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M56_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 429
LEU A 181
VAL A  83
VAL A 164
 None
 1.08A 2m56A-4g1pA:
undetectable		 2m56A-4g1pA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_1
(PROTEASE)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 121
GLY A 140
ASP A 138
ASP A 137
GLY A 443
 None
None
None
ZN  A 501 (-2.3A)
None
 1.00A 2nnkA-4g1pA:
undetectable		 2nnkA-4g1pA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_1
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		3 / 3 SER A 360
ASP A 386
ASP A 354
 None
 0.75A 2plwA-4g1pA:
undetectable		 2plwA-4g1pA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_2
(ESTROGEN RECEPTOR)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 281
ASP A 415
MET A 311
LEU A 274
 None
 1.15A 2qxsA-4g1pA:
undetectable		 2qxsA-4g1pA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_2
(ESTROGEN RECEPTOR)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 281
ASP A 415
MET A 311
LEU A 274
 None
 1.15A 2qxsB-4g1pA:
undetectable		 2qxsB-4g1pA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUI_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 429
LEU A 181
VAL A  83
VAL A 164
 None
 1.08A 2zuiA-4g1pA:
undetectable		 2zuiA-4g1pA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 182
LEU A 181
THR A 435
VAL A 196
LEU A  98
 None
 1.17A 3a51C-4g1pA:
undetectable		 3a51C-4g1pA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB306_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		4 / 6 THR A 165
ILE A  61
SER A  50
LEU A  53
 None
 0.95A 3deuB-4g1pA:
undetectable		 3deuB-4g1pA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZU_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 182
GLN A 430
ILE A 198
LEU A 433
VAL A  83
 None
 1.07A 3dzuA-4g1pA:
undetectable		 3dzuA-4g1pA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_1
(PROTEASE)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 121
GLY A 140
ASP A 138
ASP A 137
GLY A 443
 None
None
None
ZN  A 501 (-2.3A)
None
 1.07A 3ektA-4g1pA:
undetectable		 3ektA-4g1pA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 429
LEU A 181
VAL A  83
VAL A 164
 None
 1.09A 3fwgA-4g1pA:
undetectable		 3fwgA-4g1pA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_2
(PROTEASE)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 121
GLY A 140
ASP A 138
ASP A 137
GLY A 443
 None
None
None
ZN  A 501 (-2.3A)
None
 1.05A 3gguB-4g1pA:
undetectable		 3gguB-4g1pA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		3 / 3 SER A 144
GLY A 140
SER A 199
 None
 0.62A 3loqA-4g1pA:
undetectable		 3loqA-4g1pA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_1
(HIV-1 PROTEASE)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 121
GLY A 140
ASP A 138
ASP A 137
GLY A 443
 None
None
None
ZN  A 501 (-2.3A)
None
 1.05A 3oxwA-4g1pA:
undetectable		 3oxwA-4g1pA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 176
LEU A  80
ILE A 384
GLN A 222
PRO A  76
 None
 1.25A 3w1wB-4g1pA:
undetectable		 3w1wB-4g1pA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRH_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 429
LEU A 181
VAL A  83
VAL A 164
 None
 1.07A 3wrhE-4g1pA:
undetectable		 3wrhE-4g1pA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRJ_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 429
LEU A 181
VAL A  83
VAL A 164
 None
 1.08A 3wrjE-4g1pA:
undetectable		 3wrjE-4g1pA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_2
(NEURAMINIDASE)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 418
ARG A 216
TRP A 314
 None
 1.48A 4b7nA-4g1pA:
undetectable		 4b7nA-4g1pA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_2
(NEURAMINIDASE)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 418
ARG A 216
TRP A 314
 None
 1.47A 4cpzC-4g1pA:
undetectable		 4cpzC-4g1pA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_2
(NEURAMINIDASE)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 418
ARG A 216
TRP A 314
 None
 1.38A 4cpzE-4g1pA:
undetectable		 4cpzE-4g1pA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_2
(NEURAMINIDASE)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 418
ARG A 216
TRP A 314
 None
 1.45A 4cpzF-4g1pA:
undetectable		 4cpzF-4g1pA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_2
(NEURAMINIDASE)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 418
ARG A 216
TRP A 314
 None
 1.49A 4cpzH-4g1pA:
undetectable		 4cpzH-4g1pA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_2
(ASPARTYL PROTEASE)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 121
GLY A 140
ASP A 138
ASP A 137
GLY A 443
 None
None
None
ZN  A 501 (-2.3A)
None
 1.05A 4dqcB-4g1pA:
undetectable		 4dqcB-4g1pA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 429
LEU A 181
VAL A  83
VAL A 164
 None
 1.10A 4ek1A-4g1pA:
undetectable		 4ek1A-4g1pA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 429
LEU A 181
VAL A  83
VAL A 164
 None
 1.10A 4g3rA-4g1pA:
undetectable		 4g3rA-4g1pA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 429
LEU A 181
VAL A  83
VAL A 164
 None
 1.02A 4g3rB-4g1pA:
undetectable		 4g3rB-4g1pA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		5 / 8 ARG A 216
LEU A 215
ASN A 201
ASP A 200
ILE A 198
 None
None
None
ZN  A 502 (-3.1A)
None
 1.41A 4k0bA-4g1pA:
undetectable		 4k0bA-4g1pA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KKY_X_CAMX503_0
(CAMPHOR
5-MONOOXYGENASE)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 429
LEU A 181
VAL A  83
VAL A 164
 None
 1.14A 4kkyX-4g1pA:
undetectable		 4kkyX-4g1pA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L49_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 429
LEU A 181
VAL A  83
VAL A 164
 None
 1.03A 4l49A-4g1pA:
undetectable		 4l49A-4g1pA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 429
LEU A 181
VAL A  83
VAL A 164
 None
 1.09A 4l4cA-4g1pA:
undetectable		 4l4cA-4g1pA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4E_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 429
LEU A 181
VAL A  83
VAL A 164
 None
 1.10A 4l4eA-4g1pA:
undetectable		 4l4eA-4g1pA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4F_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 429
LEU A 181
VAL A  83
VAL A 164
 None
 1.09A 4l4fA-4g1pA:
undetectable		 4l4fA-4g1pA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		4 / 7 GLU A 276
GLU A 278
GLU A 307
ARG A 315
 None
 1.00A 4mi4B-4g1pA:
undetectable
4mi4C-4g1pA:
undetectable		 4mi4B-4g1pA:
16.77
4mi4C-4g1pA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 224
GLU A 382
GLN A 222
LEU A 383
 None
 0.86A 4mj8A-4g1pA:
undetectable		 4mj8A-4g1pA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_2
(PROTEASE)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 121
GLY A 140
ASP A 138
ASP A 137
GLY A 443
 None
None
None
ZN  A 501 (-2.3A)
None
 1.00A 4njtB-4g1pA:
undetectable		 4njtB-4g1pA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCU_A_SAMA603_0
(CYSTATHIONINE
BETA-SYNTHASE)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 370
ASP A 367
THR A 223
ILE A 224
 None
 0.94A 4pcuA-4g1pA:
2.1		 4pcuA-4g1pA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCU_B_SAMB603_0
(CYSTATHIONINE
BETA-SYNTHASE)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		5 / 9 PHE A 370
ASP A 367
VAL A 251
THR A 223
ILE A 224
 None
 0.99A 4pcuA-4g1pA:
1.2
4pcuB-4g1pA:
1.1		 4pcuA-4g1pA:
23.39
4pcuB-4g1pA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		7 / 11 HIS A 102
ASP A 137
GLU A 171
GLU A 172
GLY A 420
GLY A 421
HIS A 450
 None
ZN  A 501 (-2.3A)
GLY  A 503 (-3.2A)
ZN  A 501 ( 2.0A)
None
CYS  A 504 ( 4.6A)
ZN  A 501 ( 3.2A)
 0.67A 4pqaA-4g1pA:
31.4		 4pqaA-4g1pA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_1
(ASPARTYL PROTEASE)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 121
GLY A 140
ASP A 138
ASP A 137
GLY A 443
 None
None
None
ZN  A 501 (-2.3A)
None
 0.98A 4q1wA-4g1pA:
undetectable		 4q1wA-4g1pA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		5 / 9 ALA A 405
THR A 406
ALA A 402
GLY A 463
GLY A 464
 None
 1.19A 4qwuK-4g1pA:
undetectable
4qwuL-4g1pA:
undetectable		 4qwuK-4g1pA:
20.22
4qwuL-4g1pA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		5 / 9 ALA A 405
THR A 406
ALA A 402
GLY A 463
GLY A 464
 None
 1.15A 4qwuY-4g1pA:
undetectable
4qwuZ-4g1pA:
undetectable		 4qwuY-4g1pA:
20.22
4qwuZ-4g1pA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 387
ALA A 388
SER A 173
ASP A 179
GLN A  69
 None
 1.27A 4rtpA-4g1pA:
undetectable		 4rtpA-4g1pA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_A_SAMA1546_0
(CYSTATHIONINE
BETA-SYNTHASE)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 370
ASP A 367
VAL A 251
THR A 223
ILE A 224
 None
 1.12A 4uuuA-4g1pA:
undetectable
4uuuB-4g1pA:
undetectable		 4uuuA-4g1pA:
16.56
4uuuB-4g1pA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_B_SAMB1548_0
(CYSTATHIONINE
BETA-SYNTHASE)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 370
ASP A 367
VAL A 251
THR A 223
ILE A 224
 None
 1.10A 4uuuB-4g1pA:
undetectable		 4uuuB-4g1pA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_A_ILEA601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		4 / 6 ALA A 405
THR A 406
VAL A 409
TYR A 410
 None
 0.59A 5eckA-4g1pA:
undetectable		 5eckA-4g1pA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_D_ILED601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		4 / 6 ALA A 405
THR A 406
VAL A 409
TYR A 410
 None
 0.63A 5eckD-4g1pA:
undetectable		 5eckD-4g1pA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_A_ILEA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		4 / 6 ALA A 405
THR A 406
VAL A 409
TYR A 410
 None
 0.57A 5eclA-4g1pA:
1.9		 5eclA-4g1pA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		4 / 7 ALA A 405
THR A 406
VAL A 409
TYR A 410
 None
 0.56A 5ecmD-4g1pA:
undetectable		 5ecmD-4g1pA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 405
THR A 406
VAL A 409
TYR A 410
 None
 0.49A 5ecnD-4g1pA:
undetectable		 5ecnD-4g1pA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		4 / 6 ALA A 405
THR A 406
VAL A 409
TYR A 410
 None
 0.67A 5ecoA-4g1pA:
2.4		 5ecoA-4g1pA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		4 / 7 ALA A 405
THR A 406
VAL A 409
TYR A 410
 None
 0.74A 5ecoD-4g1pA:
0.1		 5ecoD-4g1pA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		4 / 7 SER A 355
THR A 359
VAL A 362
ILE A 384
 None
 1.22A 5vkqA-4g1pA:
undetectable
5vkqB-4g1pA:
undetectable		 5vkqA-4g1pA:
14.28
5vkqB-4g1pA:
14.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		4 / 7 SER A 355
THR A 359
VAL A 362
ILE A 384
 None
 1.21A 5vkqC-4g1pA:
undetectable
5vkqD-4g1pA:
undetectable		 5vkqC-4g1pA:
14.28
5vkqD-4g1pA:
14.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 182
ALA A 432
LEU A 427
LEU A 433
VAL A  83
 None
 0.95A 5z12B-4g1pA:
undetectable		 5z12B-4g1pA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		5 / 12 GLU A 171
GLY A 174
SER A 346
ILE A 347
GLY A 387
 GLY  A 503 (-3.2A)
None
None
None
None
 0.77A 5zhmB-4g1pA:
undetectable		 5zhmB-4g1pA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWT_D_BEZD202_0
(PR 10 PROTEIN)		 4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1
(Saccharomyces
cerevisiae) 		3 / 3 PHE A  48
ASP A  44
LYS A  47
 None
 0.82A 6awtD-4g1pA:
3.1		 6awtD-4g1pA:
16.03