SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4g1u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GM7_B_PNNB1577_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 4g1u HEMIN TRANSPORT
SYSTEM PERMEASE
PROTEIN HMUU
(Yersinia
pestis) 		4 / 8 SER A  72
ALA A 244
PHE A 124
ILE A 247
 None
 0.96A 1gm7A-4g1uA:
undetectable
1gm7B-4g1uA:
2.1		 1gm7A-4g1uA:
19.67
1gm7B-4g1uA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4g1u HEMIN TRANSPORT
SYSTEM PERMEASE
PROTEIN HMUU
(Yersinia
pestis) 		4 / 4 LEU A  60
VAL A  64
CYH A  67
ALA A 284
 None
 1.29A 1mz9E-4g1uA:
undetectable		 1mz9E-4g1uA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_B_DEXB2999_1
(GLUCOCORTICOID
RECEPTOR)		 4g1u HEMIN TRANSPORT
SYSTEM PERMEASE
PROTEIN HMUU
(Yersinia
pestis) 		5 / 12 GLY A  73
GLN A  77
LEU A 279
ARG A 269
ILE A 201
 None
 1.48A 1p93B-4g1uA:
undetectable		 1p93B-4g1uA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_1
(HIV-1 PROTEASE)		 4g1u HEMIN TRANSPORT
SYSTEM PERMEASE
PROTEIN HMUU
(Yersinia
pestis) 		5 / 12 GLY A 126
ALA A  96
GLY A 101
ILE A 103
VAL A 251
 None
 1.03A 2b7zA-4g1uA:
undetectable		 2b7zA-4g1uA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_2
(HIV-1 PROTEASE)		 4g1u HEMIN TRANSPORT
SYSTEM PERMEASE
PROTEIN HMUU
(Yersinia
pestis) 		5 / 12 GLY A 126
ALA A  96
GLY A 101
ILE A 103
VAL A 251
 None
 1.03A 2b7zB-4g1uA:
undetectable		 2b7zB-4g1uA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_0
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 4g1u HEMIN TRANSPORT
SYSTEM PERMEASE
PROTEIN HMUU
(Yersinia
pestis) 		5 / 12 LEU A  69
ILE A 268
ILE A 247
ALA A 250
PHE A 259
 None
 1.07A 2ejtA-4g1uA:
undetectable		 2ejtA-4g1uA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		 4g1u HEMIN IMPORT
ATP-BINDING PROTEIN
HMUV
(Yersinia
pestis) 		4 / 8 ALA C 153
LEU C 189
THR C 186
HIS C 185
 None
 0.81A 2it4A-4g1uC:
undetectable		 2it4A-4g1uC:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 4g1u HEMIN IMPORT
ATP-BINDING PROTEIN
HMUV
(Yersinia
pestis) 		5 / 11 LEU C  53
ILE C  42
VAL C 227
LEU C 226
VAL C  30
 None
 0.94A 2kawA-4g1uC:
undetectable		 2kawA-4g1uC:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_1
(ANDROGEN RECEPTOR)		 4g1u HEMIN TRANSPORT
SYSTEM PERMEASE
PROTEIN HMUU
(Yersinia
pestis) 		5 / 12 LEU A 215
ASN A 216
LEU A 218
ARG A 139
ALA A 274
 None
 0.99A 2oz7A-4g1uA:
undetectable		 2oz7A-4g1uA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4g1u HEMIN TRANSPORT
SYSTEM PERMEASE
PROTEIN HMUU
(Yersinia
pestis) 		5 / 12 GLY A 282
GLY A 286
PHE A  13
VAL A  71
LEU A 209
 None
 1.22A 3dh0A-4g1uA:
undetectable		 3dh0A-4g1uA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_2
(PROTEASE)		 4g1u HEMIN TRANSPORT
SYSTEM PERMEASE
PROTEIN HMUU
(Yersinia
pestis) 		5 / 10 GLY A 126
ALA A  96
GLY A 101
ILE A 103
VAL A 251
 None
 1.10A 3nu9B-4g1uA:
undetectable		 3nu9B-4g1uA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_1
(PROTEASE)		 4g1u HEMIN TRANSPORT
SYSTEM PERMEASE
PROTEIN HMUU
(Yersinia
pestis) 		5 / 12 GLY A 126
ALA A  96
GLY A 101
ILE A 103
VAL A 251
 None
 1.05A 3ucbA-4g1uA:
undetectable		 3ucbA-4g1uA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 4g1u HEMIN TRANSPORT
SYSTEM PERMEASE
PROTEIN HMUU
(Yersinia
pestis) 		4 / 8 LEU A 137
ILE A 134
GLY A  91
ILE A 155
 None
 0.85A 3wxoA-4g1uA:
0.8		 3wxoA-4g1uA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_B_29EB603_1
(TRANSPORTER)		 4g1u HEMIN TRANSPORT
SYSTEM PERMEASE
PROTEIN HMUU
(Yersinia
pestis) 		5 / 12 VAL A 100
GLY A 248
SER A  93
SER A  94
GLY A  95
 None
 1.18A 4mmdB-4g1uA:
undetectable		 4mmdB-4g1uA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4g1u HEMIN TRANSPORT
SYSTEM PERMEASE
PROTEIN HMUU
(Yersinia
pestis) 		5 / 12 VAL A 264
ILE A 247
GLY A 258
GLY A  88
LEU A 290
 None
 1.03A 4mwzB-4g1uA:
undetectable		 4mwzB-4g1uA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4g1u HEMIN TRANSPORT
SYSTEM PERMEASE
PROTEIN HMUU
(Yersinia
pestis) 		5 / 10 VAL A  65
VAL A 309
LEU A 186
GLY A 258
LEU A 291
 None
 1.11A 4ph9A-4g1uA:
undetectable		 4ph9A-4g1uA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4g1u HEMIN TRANSPORT
SYSTEM PERMEASE
PROTEIN HMUU
(Yersinia
pestis) 		5 / 10 VAL A  65
VAL A 309
LEU A 186
GLY A 258
LEU A 291
 None
 1.11A 4ph9B-4g1uA:
undetectable		 4ph9B-4g1uA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA207_0
(OXIDOREDUCTASE)		 4g1u HEMIN IMPORT
ATP-BINDING PROTEIN
HMUV
(Yersinia
pestis) 		4 / 4 GLU C 146
GLY C 144
HIS C 182
ARG C 149
 None
 1.25A 4r82A-4g1uC:
undetectable
4r82B-4g1uC:
undetectable		 4r82A-4g1uC:
20.22
4r82B-4g1uC:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 4g1u HEMIN TRANSPORT
SYSTEM PERMEASE
PROTEIN HMUU
(Yersinia
pestis) 		4 / 8 SER A  93
GLY A  88
ILE A  75
GLY A 261
 None
 0.52A 5alcL-4g1uA:
undetectable		 5alcL-4g1uA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 4g1u HEMIN IMPORT
ATP-BINDING PROTEIN
HMUV
(Yersinia
pestis) 		4 / 6 CYH C  68
LEU C  57
HIS C  33
LEU C  12
 None
 1.01A 5hpuC-4g1uC:
undetectable
5hpuD-4g1uC:
undetectable		 5hpuC-4g1uC:
6.47
5hpuD-4g1uC:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 4g1u HEMIN IMPORT
ATP-BINDING PROTEIN
HMUV
(Yersinia
pestis) 		4 / 6 LEU C  83
CYH C  68
HIS C  69
LEU C  75
 None
 1.09A 5hpuC-4g1uC:
undetectable
5hpuD-4g1uC:
undetectable		 5hpuC-4g1uC:
6.47
5hpuD-4g1uC:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4g1u HEMIN TRANSPORT
SYSTEM PERMEASE
PROTEIN HMUU
(Yersinia
pestis) 		5 / 9 GLY A 184
ALA A 298
VAL A 309
MET A 307
ILE A 257
 None
 1.44A 5i3cA-4g1uA:
undetectable		 5i3cA-4g1uA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_1
(PROTEASE PR5-SQV)		 4g1u HEMIN TRANSPORT
SYSTEM PERMEASE
PROTEIN HMUU
(Yersinia
pestis) 		5 / 9 ASN A  82
ALA A  85
ASP A  86
ILE A  92
GLY A 152
 None
 1.28A 5kr2A-4g1uA:
undetectable		 5kr2A-4g1uA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_K_BO2K305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 4g1u HEMIN TRANSPORT
SYSTEM PERMEASE
PROTEIN HMUU
(Yersinia
pestis) 		5 / 11 THR A 293
ALA A 294
GLY A 286
GLY A 287
ALA A 288
 None
 0.97A 5lf3K-4g1uA:
undetectable
5lf3L-4g1uA:
undetectable		 5lf3K-4g1uA:
20.56
5lf3L-4g1uA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_Y_BO2Y305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 4g1u HEMIN TRANSPORT
SYSTEM PERMEASE
PROTEIN HMUU
(Yersinia
pestis) 		5 / 11 THR A 293
ALA A 294
GLY A 286
GLY A 287
ALA A 288
 None
 0.99A 5lf3Y-4g1uA:
undetectable
5lf3Z-4g1uA:
undetectable		 5lf3Y-4g1uA:
20.56
5lf3Z-4g1uA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NVP_A_ACAA18_1
(ENVELOPE
GLYCOPROTEIN,GP41)		 4g1u HEMIN IMPORT
ATP-BINDING PROTEIN
HMUV
(Yersinia
pestis) 		5 / 12 SER C  15
ASN C  74
LEU C  70
GLU C  13
LEU C  12
 None
 1.41A 5nvpA-4g1uC:
undetectable		 5nvpA-4g1uC:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		 4g1u HEMIN IMPORT
ATP-BINDING PROTEIN
HMUV
(Yersinia
pestis) 		5 / 12 ILE C  43
VAL C 227
LEU C 208
THR C 240
LEU C 241
 None
 1.15A 5tiwA-4g1uC:
undetectable		 5tiwA-4g1uC:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4g1u HEMIN TRANSPORT
SYSTEM PERMEASE
PROTEIN HMUU
(Yersinia
pestis) 		5 / 12 SER A 118
ALA A  96
TRP A 181
ALA A 123
GLY A 122
 None
 1.30A 5tzoA-4g1uA:
undetectable		 5tzoA-4g1uA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4g1u HEMIN TRANSPORT
SYSTEM PERMEASE
PROTEIN HMUU
(Yersinia
pestis) 		6 / 12 LEU A 200
SER A 118
ALA A  96
TRP A 181
ALA A 123
GLY A 122
 None
 1.19A 5tzoB-4g1uA:
undetectable		 5tzoB-4g1uA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_2
(ENDO-1,4-BETA-XYLANA
SE A)		 4g1u HEMIN IMPORT
ATP-BINDING PROTEIN
HMUV
(Yersinia
pestis) 		3 / 3 ARG C  87
PRO C  80
TYR C  60
 None
 1.01A 5tzoB-4g1uC:
undetectable		 5tzoB-4g1uC:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4g1u HEMIN TRANSPORT
SYSTEM PERMEASE
PROTEIN HMUU
(Yersinia
pestis) 		5 / 12 SER A 118
ALA A  96
TRP A 181
ALA A 123
GLY A 122
 None
 1.25A 5tzoC-4g1uA:
undetectable		 5tzoC-4g1uA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB505_0
(AMINE OXIDASE LKCE)		 4g1u HEMIN IMPORT
ATP-BINDING PROTEIN
HMUV
(Yersinia
pestis) 		3 / 3 HIS C  69
ASN C  74
LEU C  75
 None
 0.84A 6f7lB-4g1uC:
undetectable		 6f7lB-4g1uC:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4g1u HEMIN TRANSPORT
SYSTEM PERMEASE
PROTEIN HMUU
(Yersinia
pestis) 		4 / 8 GLN A 177
ILE A 103
ALA A 252
VAL A 251
 None
 1.08A 6hu9a-4g1uA:
undetectable
6hu9e-4g1uA:
undetectable		 6hu9a-4g1uA:
22.18
6hu9e-4g1uA:
14.80