SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4g25'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 4g25 PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		3 / 3 TRP A 547
VAL A 333
TRP A 290
 None
 1.32A 1gmkC-4g25A:
undetectable
1gmkD-4g25A:
undetectable		 1gmkC-4g25A:
3.75
1gmkD-4g25A:
3.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 4g25 PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		5 / 11 PHE A 414
THR A 419
ALA A 464
ALA A 462
LEU A 455
 None
 1.06A 1jinA-4g25A:
undetectable		 1jinA-4g25A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 4g25 PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		6 / 11 PHE A 414
VAL A 435
LEU A 465
ALA A 464
ALA A 462
LEU A 455
 None
 1.22A 1jinA-4g25A:
undetectable		 1jinA-4g25A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_B_IBPB2002_1
(SERUM ALBUMIN)		 4g25 PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		5 / 10 ALA A 227
ALA A 230
LEU A 218
LEU A 252
ALA A 251
 None
 1.00A 2bxgB-4g25A:
undetectable		 2bxgB-4g25A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_N_CHDN1604_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 4g25 PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		5 / 11 PHE A 508
GLY A 504
GLU A 360
THR A 361
THR A 363
 None
 1.27A 2eimG-4g25A:
undetectable
2eimN-4g25A:
undetectable
2eimO-4g25A:
undetectable		 2eimG-4g25A:
9.88
2eimN-4g25A:
19.54
2eimO-4g25A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 4g25 PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		5 / 12 ALA A 186
ASP A 197
GLY A 182
ASP A 190
PRO A 216
 None
 0.99A 2f8lA-4g25A:
undetectable		 2f8lA-4g25A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_B_DVAB6_0
(GRAMICIDIN D)		 4g25 PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		3 / 3 TRP A 459
ALA A 467
VAL A 435
 None
 0.81A 2izqA-4g25A:
undetectable
2izqB-4g25A:
undetectable		 2izqA-4g25A:
3.75
2izqB-4g25A:
3.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_C_ACTC1120_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 4g25 PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		3 / 3 LYS A 439
TYR A 466
PRO A 469
 None
 1.23A 2j9cC-4g25A:
undetectable		 2j9cC-4g25A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 4g25 PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		4 / 6 SER A 143
GLY A 215
GLU A 245
GLU A 248
 None
 1.16A 3k9fA-4g25A:
undetectable
3k9fB-4g25A:
undetectable
3k9fD-4g25A:
undetectable		 3k9fA-4g25A:
21.51
3k9fB-4g25A:
21.51
3k9fD-4g25A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_A_DVAA6_0
(GRAMICIDIN D)		 4g25 PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		3 / 3 ALA A 467
VAL A 435
TRP A 459
 None
 0.80A 3l8lA-4g25A:
undetectable
3l8lB-4g25A:
undetectable		 3l8lA-4g25A:
3.75
3l8lB-4g25A:
3.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 4g25 PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		5 / 12 GLY A 400
VAL A 490
ALA A 482
ALA A 481
LEU A 434
 None
 1.07A 3p2kC-4g25A:
undetectable		 3p2kC-4g25A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 4g25 PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		5 / 12 GLY A 400
VAL A 490
ALA A 482
ALA A 481
LEU A 434
 None
 0.95A 3p2kD-4g25A:
undetectable		 3p2kD-4g25A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_B_SALB404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 4g25 PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		4 / 7 ALA A 217
PRO A 216
TYR A 214
ARG A 212
 None
 1.07A 3twpB-4g25A:
2.6		 3twpB-4g25A:
22.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G24_A_ACAA1004_1
(PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL)		 4g25 PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		5 / 6 ALA A 401
ASN A 402
LEU A 405
VAL A 406
ASP A 493
 None
 0.07A 4g24A-4g25A:
51.5		 4g24A-4g25A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		 4g25 PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		5 / 11 ASP A 197
VAL A 233
PHE A 221
SER A 213
GLY A 215
 None
 1.26A 4mmaA-4g25A:
undetectable		 4mmaA-4g25A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		 4g25 PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		3 / 3 ARG A 561
TRP A 563
ILE A 537
 None
 1.02A 4mwxA-4g25A:
undetectable		 4mwxA-4g25A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YBN_A_ACTA303_0
(FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN)		 4g25 PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		3 / 3 VAL A 233
TYR A 214
ALA A 217
 None
 0.49A 4ybnA-4g25A:
undetectable		 4ybnA-4g25A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF402_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4g25 PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		5 / 7 LEU A 100
LEU A 104
ALA A 116
LEU A 130
ALA A 123
 None
 1.01A 4z90F-4g25A:
2.9
4z90G-4g25A:
3.0
4z90H-4g25A:
3.0
4z90J-4g25A:
2.9		 4z90F-4g25A:
19.77
4z90G-4g25A:
19.77
4z90H-4g25A:
19.77
4z90J-4g25A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4g25 PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		4 / 6 SER A 108
GLY A 160
ARG A 159
GLY A 156
 None
 0.75A 5cdnA-4g25A:
undetectable
5cdnB-4g25A:
undetectable		 5cdnA-4g25A:
22.74
5cdnB-4g25A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4g25 PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		4 / 6 LEU A 100
CYH A 107
HIS A 134
LEU A 138
 None
 1.15A 5hrqD-4g25A:
undetectable
5hrqG-4g25A:
undetectable
5hrqH-4g25A:
undetectable		 5hrqD-4g25A:
5.84
5hrqG-4g25A:
3.80
5hrqH-4g25A:
5.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_1
(PAVINE
N-METHYLTRANSFERASE)		 4g25 PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		4 / 5 PHE A 161
SER A 158
GLN A 201
ASP A 170
 None
 1.19A 5kpcA-4g25A:
undetectable		 5kpcA-4g25A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 4g25 PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		3 / 3 ASN A 380
TYR A 477
CYH A 373
 None
 0.77A 5lsuB-4g25A:
undetectable		 5lsuB-4g25A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		 4g25 PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		3 / 3 SER A 282
LYS A 281
SER A 280
 None
 0.84A 6az3P-4g25A:
undetectable		 6az3P-4g25A:
9.84