SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4g2a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA8_0
(GRAMICIDIN A)		 4g2a HYPOTHETICAL PROTEIN
(Legionella
pneumophila) 		4 / 4 GLY A  37
VAL A 119
TRP A  71
GLY A 173
 None
 1.26A 1ng8A-4g2aA:
undetectable		 1ng8A-4g2aA:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB8_0
(GRAMICIDIN A)		 4g2a HYPOTHETICAL PROTEIN
(Legionella
pneumophila) 		4 / 4 GLY A  37
VAL A 119
TRP A  71
GLY A 173
 None
 1.25A 1ng8B-4g2aA:
undetectable		 1ng8B-4g2aA:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PMZ_E_TUBE220_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4g2a HYPOTHETICAL PROTEIN
(Legionella
pneumophila) 		4 / 7 TRP A 245
TYR A  73
CYH A  75
TYR A 186
 None
 1.37A 3pmzE-4g2aA:
0.0		 3pmzE-4g2aA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		 4g2a HYPOTHETICAL PROTEIN
(Legionella
pneumophila) 		5 / 12 GLY A  35
ALA A 108
GLY A 109
ASN A  61
GLN A  66
 None
SO4  A 411 (-3.5A)
SO4  A 411 (-3.5A)
None
None
 1.19A 3v3oA-4g2aA:
undetectable		 3v3oA-4g2aA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4g2a HYPOTHETICAL PROTEIN
(Legionella
pneumophila) 		5 / 11 LEU A 341
LYS A 284
LEU A 285
GLU A 292
LEU A 296
 None
SO4  A 413 (-4.1A)
None
None
None
 1.03A 4wg0B-4g2aA:
undetectable
4wg0C-4g2aA:
undetectable
4wg0D-4g2aA:
undetectable		 4wg0B-4g2aA:
3.50
4wg0C-4g2aA:
3.50
4wg0D-4g2aA:
3.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4g2a HYPOTHETICAL PROTEIN
(Legionella
pneumophila) 		5 / 11 LEU A 341
LYS A 284
LEU A 285
GLU A 292
LEU A 296
 None
SO4  A 413 (-4.1A)
None
None
None
 1.01A 4wg0D-4g2aA:
undetectable
4wg0E-4g2aA:
undetectable
4wg0F-4g2aA:
undetectable		 4wg0D-4g2aA:
3.50
4wg0E-4g2aA:
3.50
4wg0F-4g2aA:
3.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4g2a HYPOTHETICAL PROTEIN
(Legionella
pneumophila) 		5 / 11 LEU A 341
LYS A 284
LEU A 285
GLU A 292
LEU A 296
 None
SO4  A 413 (-4.1A)
None
None
None
 1.05A 4wg0F-4g2aA:
undetectable
4wg0G-4g2aA:
undetectable
4wg0H-4g2aA:
undetectable		 4wg0F-4g2aA:
3.50
4wg0G-4g2aA:
3.50
4wg0H-4g2aA:
3.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4g2a HYPOTHETICAL PROTEIN
(Legionella
pneumophila) 		5 / 11 GLU A 292
LEU A 296
LYS A 284
LEU A 285
LEU A 341
 None
None
SO4  A 413 (-4.1A)
None
None
 1.07A 4wg0G-4g2aA:
undetectable
4wg0H-4g2aA:
undetectable
4wg0I-4g2aA:
undetectable		 4wg0G-4g2aA:
3.50
4wg0H-4g2aA:
3.50
4wg0I-4g2aA:
3.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_K_CHDK103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4g2a HYPOTHETICAL PROTEIN
(Legionella
pneumophila) 		5 / 11 GLU A 292
LEU A 296
LYS A 284
LEU A 285
LEU A 341
 None
None
SO4  A 413 (-4.1A)
None
None
 1.14A 4wg0I-4g2aA:
undetectable
4wg0J-4g2aA:
undetectable
4wg0K-4g2aA:
undetectable		 4wg0I-4g2aA:
3.50
4wg0J-4g2aA:
3.50
4wg0K-4g2aA:
3.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_H_BEZH201_0
(NS3 PROTEASE)		 4g2a HYPOTHETICAL PROTEIN
(Legionella
pneumophila) 		4 / 5 SER A  38
TYR A 186
GLY A  37
TYR A 170
 None
 1.28A 5yodH-4g2aA:
undetectable		 5yodH-4g2aA:
19.11