SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4g2c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPK_A_ACAA80_1
(PLASMINOGEN)		 4g2c DYP2
(Amycolatopsis
sp.
ATCC
39116) 		4 / 6 PRO A 290
ASP A 306
ASN A 215
ASP A 216
 ACT  A 504 ( 4.9A)
None
None
ACT  A 506 (-3.4A)
 1.33A 1hpkA-4g2cA:
undetectable		 1hpkA-4g2cA:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 4g2c DYP2
(Amycolatopsis
sp.
ATCC
39116) 		4 / 7 HIS A 323
LEU A 281
ASP A 414
PHE A 188
 HEM  A 501 (-3.3A)
None
None
HEM  A 501 ( 4.8A)
 1.07A 1ismB-4g2cA:
undetectable		 1ismB-4g2cA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZUC_B_T98B202_1
(PROGESTERONE
RECEPTOR)		 4g2c DYP2
(Amycolatopsis
sp.
ATCC
39116) 		5 / 12 LEU A 466
LEU A  57
ASN A  58
MET A  64
LEU A 141
 None
None
ACT  A 514 (-3.4A)
None
None
 1.11A 1zucB-4g2cA:
undetectable		 1zucB-4g2cA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)		 4g2c DYP2
(Amycolatopsis
sp.
ATCC
39116) 		5 / 12 VAL A  90
GLY A  91
LEU A  40
LEU A 143
LEU A  43
 None
 1.07A 2egvA-4g2cA:
undetectable		 2egvA-4g2cA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4g2c DYP2
(Amycolatopsis
sp.
ATCC
39116) 		4 / 4 SER A 332
GLY A 331
HIS A 323
ASP A 192
 None
None
HEM  A 501 (-3.3A)
ACT  A 513 ( 2.6A)
 1.06A 2oxtC-4g2cA:
undetectable		 2oxtC-4g2cA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		 4g2c DYP2
(Amycolatopsis
sp.
ATCC
39116) 		5 / 11 LEU A  11
LEU A  32
SER A 459
LEU A  27
LEU A  71
 None
 1.12A 2xn5A-4g2cA:
undetectable		 2xn5A-4g2cA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 4g2c DYP2
(Amycolatopsis
sp.
ATCC
39116) 		5 / 12 THR A 352
ASP A 373
ASP A 359
ASN A 361
GLU A 250
 None
 1.04A 2zw9B-4g2cA:
undetectable		 2zw9B-4g2cA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_B_NOGB2001_1
(PROGESTERONE
RECEPTOR)		 4g2c DYP2
(Amycolatopsis
sp.
ATCC
39116) 		5 / 12 LEU A 466
LEU A  57
ASN A  58
MET A  64
LEU A 141
 None
None
ACT  A 514 (-3.4A)
None
None
 1.29A 3d90B-4g2cA:
undetectable		 3d90B-4g2cA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAN_A_SVRA158_1
(UNCHARACTERIZED
PROTEIN AT3G22680)		 4g2c DYP2
(Amycolatopsis
sp.
ATCC
39116) 		5 / 11 ARG A 247
TYR A 243
VAL A 228
PRO A 229
PRO A 105
 None
 1.30A 3ganA-4g2cA:
undetectable		 3ganA-4g2cA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)		 4g2c DYP2
(Amycolatopsis
sp.
ATCC
39116) 		4 / 7 TYR A  87
MET A 379
LEU A 142
PHE A 381
 None
 1.09A 3nk2X-4g2cA:
undetectable		 3nk2X-4g2cA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 4g2c DYP2
(Amycolatopsis
sp.
ATCC
39116) 		5 / 12 GLN A 393
GLY A 420
GLY A 418
GLN A 445
ALA A 122
 HEM  A 501 (-4.3A)
None
None
None
None
 1.40A 3t7sC-4g2cA:
undetectable		 3t7sC-4g2cA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_A_SALA404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 4g2c DYP2
(Amycolatopsis
sp.
ATCC
39116) 		4 / 7 ALA A 296
PRO A 297
ARG A 284
ALA A 279
 None
None
HEM  A 501 ( 4.6A)
None
 0.98A 3twpA-4g2cA:
undetectable		 3twpA-4g2cA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_1
(THYROXINE-BINDING
GLOBULIN)		 4g2c DYP2
(Amycolatopsis
sp.
ATCC
39116) 		5 / 10 LEU A  11
LEU A  32
SER A 459
LEU A  27
LEU A  71
 None
 1.09A 4yiaA-4g2cA:
undetectable		 4yiaA-4g2cA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4g2c DYP2
(Amycolatopsis
sp.
ATCC
39116) 		5 / 12 GLY A 193
PHE A  44
PHE A 246
GLY A 452
LEU A 249
 HEM  A 501 (-2.8A)
None
None
None
HEM  A 501 ( 4.4A)
 1.34A 4ze1A-4g2cA:
undetectable		 4ze1A-4g2cA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPW_A_3CJA609_1
(LACTOPEROXIDASE)		 4g2c DYP2
(Amycolatopsis
sp.
ATCC
39116) 		4 / 5 GLN A 251
HIS A 187
GLU A 186
ARG A 369
 HEM  A 501 (-3.9A)
None
HEM  A 501 (-4.1A)
None
 1.42A 5hpwA-4g2cA:
0.0		 5hpwA-4g2cA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_0
(MINERALOCORTICOID
RECEPTOR)		 4g2c DYP2
(Amycolatopsis
sp.
ATCC
39116) 		5 / 12 LEU A 466
LEU A  57
ASN A  58
MET A  64
LEU A 141
 None
None
ACT  A 514 (-3.4A)
None
None
 1.19A 5mwyA-4g2cA:
undetectable		 5mwyA-4g2cA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4g2c DYP2
(Amycolatopsis
sp.
ATCC
39116) 		5 / 12 LEU A 141
GLY A 144
LEU A  60
LEU A  63
VAL A 158
 None
 1.02A 5twjA-4g2cA:
undetectable		 5twjA-4g2cA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4g2c DYP2
(Amycolatopsis
sp.
ATCC
39116) 		5 / 10 LEU A 141
GLY A 144
LEU A  60
LEU A  63
VAL A 158
 None
 1.03A 5twjB-4g2cA:
undetectable		 5twjB-4g2cA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		 4g2c DYP2
(Amycolatopsis
sp.
ATCC
39116) 		5 / 12 VAL A 245
PRO A 403
PHE A 378
PHE A 389
ILE A 324
 None
None
HEM  A 501 (-3.9A)
HEM  A 501 (-4.5A)
HEM  A 501 (-3.8A)
 1.25A 6becA-4g2cA:
undetectable
6becB-4g2cA:
undetectable
6becC-4g2cA:
undetectable		 6becA-4g2cA:
22.98
6becB-4g2cA:
22.98
6becC-4g2cA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4g2c DYP2
(Amycolatopsis
sp.
ATCC
39116) 		5 / 12 GLY A 193
TYR A 353
PHE A 246
GLY A 452
LEU A 249
 HEM  A 501 (-2.8A)
None
None
None
HEM  A 501 ( 4.4A)
 1.24A 6e8qA-4g2cA:
undetectable		 6e8qA-4g2cA:
10.97