SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4g2n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4g2n D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE,
NAD-BINDING
(Polaromonas
sp.
JS666) 		4 / 7 VAL A 118
LEU A 119
ALA A 171
LEU A 155
 None
 0.70A 1pthA-4g2nA:
undetectable		 1pthA-4g2nA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4g2n D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE,
NAD-BINDING
(Polaromonas
sp.
JS666) 		4 / 7 VAL A 118
LEU A 119
ALA A 171
LEU A 155
 None
 0.71A 1pthB-4g2nA:
undetectable		 1pthB-4g2nA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		 4g2n D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE,
NAD-BINDING
(Polaromonas
sp.
JS666) 		4 / 8 THR A  76
ALA A  78
LEU A  80
VAL A  53
 None
 0.60A 1sn5C-4g2nA:
undetectable		 1sn5C-4g2nA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_B_9CRB130_1
(TRANSTHYRETIN)		 4g2n D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE,
NAD-BINDING
(Polaromonas
sp.
JS666) 		4 / 7 THR A  76
ALA A  78
LEU A  80
VAL A  53
 None
 0.62A 1tyrB-4g2nA:
undetectable		 1tyrB-4g2nA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H77_A_T3A1_1
(THRA PROTEIN)		 4g2n D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE,
NAD-BINDING
(Polaromonas
sp.
JS666) 		5 / 12 ILE A 178
MET A 160
ALA A 213
LEU A 211
ILE A 163
 None
 0.96A 2h77A-4g2nA:
undetectable		 2h77A-4g2nA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 4g2n D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE,
NAD-BINDING
(Polaromonas
sp.
JS666) 		5 / 9 ALA A 168
ALA A 213
GLY A 159
GLY A 161
ILE A 163
 None
 1.20A 2v7bA-4g2nA:
5.4		 2v7bA-4g2nA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 4g2n D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE,
NAD-BINDING
(Polaromonas
sp.
JS666) 		5 / 9 ALA A 168
ALA A 213
GLY A 159
GLY A 161
ILE A 163
 None
 1.17A 2v7bB-4g2nA:
5.1		 2v7bB-4g2nA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4g2n D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE,
NAD-BINDING
(Polaromonas
sp.
JS666) 		4 / 6 GLY A 159
TYR A 180
GLY A 164
ASN A 182
 None
 1.10A 3e9rA-4g2nA:
undetectable		 3e9rA-4g2nA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 4g2n D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE,
NAD-BINDING
(Polaromonas
sp.
JS666) 		5 / 12 ILE A 178
MET A 160
ALA A 213
LEU A 211
ILE A 163
 None
 0.98A 3gwsX-4g2nA:
undetectable		 3gwsX-4g2nA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 4g2n D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE,
NAD-BINDING
(Polaromonas
sp.
JS666) 		4 / 8 ASP A 201
LEU A 204
ASP A 225
ASP A 227
 None
 0.89A 3n2oC-4g2nA:
undetectable
3n2oD-4g2nA:
undetectable		 3n2oC-4g2nA:
21.59
3n2oD-4g2nA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)		 4g2n D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE,
NAD-BINDING
(Polaromonas
sp.
JS666) 		4 / 8 THR A  76
ALA A  78
LEU A  80
VAL A  53
 None
 0.54A 4ik6B-4g2nA:
undetectable		 4ik6B-4g2nA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_B_IMNB201_1
(TRANSTHYRETIN)		 4g2n D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE,
NAD-BINDING
(Polaromonas
sp.
JS666) 		4 / 8 THR A  76
ALA A  78
LEU A  80
VAL A  53
 None
 0.60A 4ik7B-4g2nA:
undetectable		 4ik7B-4g2nA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1320_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 4g2n D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE,
NAD-BINDING
(Polaromonas
sp.
JS666) 		4 / 5 VAL A 238
LEU A 224
ILE A 212
LEU A 211
 None
 0.84A 4mghA-4g2nA:
3.8		 4mghA-4g2nA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4g2n D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE,
NAD-BINDING
(Polaromonas
sp.
JS666) 		3 / 3 PRO A 215
VAL A  82
HIS A 101
 None
 0.84A 4pevC-4g2nA:
6.6		 4pevC-4g2nA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4g2n D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE,
NAD-BINDING
(Polaromonas
sp.
JS666) 		5 / 12 ALA A 236
GLY A 156
GLY A 205
ARG A 153
LEU A 211
 GOL  A 401 (-4.1A)
None
None
GOL  A 401 (-3.8A)
None
 1.08A 5c0oH-4g2nA:
6.6		 5c0oH-4g2nA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 4g2n D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE,
NAD-BINDING
(Polaromonas
sp.
JS666) 		4 / 8 ALA A  78
HIS A  86
HIS A 101
THR A 102
 None
 1.21A 5db5A-4g2nA:
2.6
5db5B-4g2nA:
undetectable		 5db5A-4g2nA:
24.21
5db5B-4g2nA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4g2n D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE,
NAD-BINDING
(Polaromonas
sp.
JS666) 		3 / 3 ASP A  36
LEU A  30
ARG A  25
 None
 0.96A 5e8qA-4g2nA:
2.8		 5e8qA-4g2nA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)		 4g2n D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE,
NAD-BINDING
(Polaromonas
sp.
JS666) 		4 / 8 ILE A  44
LEU A  70
LEU A  95
ALA A  92
 None
 0.76A 5y7pE-4g2nA:
undetectable		 5y7pE-4g2nA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 4g2n D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE,
NAD-BINDING
(Polaromonas
sp.
JS666) 		4 / 5 PHE A  55
THR A  57
ASP A  36
GLU A  21
 None
 1.34A 5ybbA-4g2nA:
4.9		 5ybbA-4g2nA:
22.71