SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4g2r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB8_0
(GRAMICIDIN A)		 4g2r ACCD6,
CARBOXYLTRANSFERASE
BETA-SUBUNIT OF
ACYL-COA CARBOXYLASE
(Mycobacterium
tuberculosis) 		3 / 3 VAL A 130
VAL A 148
TRP A  94
 None
 0.78A 1bdwA-4g2rA:
undetectable
1bdwB-4g2rA:
undetectable		 1bdwA-4g2rA:
3.67
1bdwB-4g2rA:
3.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3009_0
(BETA-CARBONIC
ANHYDRASE)		 4g2r ACCD6,
CARBOXYLTRANSFERASE
BETA-SUBUNIT OF
ACYL-COA CARBOXYLASE
(Mycobacterium
tuberculosis) 		4 / 5 GLY A 142
LEU A 145
THR A 146
VAL A 114
 None
 0.82A 1ekjF-4g2rA:
undetectable
1ekjG-4g2rA:
undetectable		 1ekjF-4g2rA:
17.72
1ekjG-4g2rA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)		 4g2r ACCD6,
CARBOXYLTRANSFERASE
BETA-SUBUNIT OF
ACYL-COA CARBOXYLASE
(Mycobacterium
tuberculosis) 		3 / 3 ASP A 433
LEU A 436
HIS A 231
 None
 0.37A 1qknA-4g2rA:
undetectable		 1qknA-4g2rA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_B_SAMB4001_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 4g2r ACCD6,
CARBOXYLTRANSFERASE
BETA-SUBUNIT OF
ACYL-COA CARBOXYLASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 293
LEU A 289
ASP A 243
VAL A 244
PRO A 267
 None
 0.91A 1zq9B-4g2rA:
undetectable		 1zq9B-4g2rA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)		 4g2r ACCD6,
CARBOXYLTRANSFERASE
BETA-SUBUNIT OF
ACYL-COA CARBOXYLASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 336
LEU A 345
LEU A 344
LEU A 295
ALA A 300
 None
 0.99A 2egvB-4g2rA:
undetectable		 2egvB-4g2rA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 4g2r ACCD6,
CARBOXYLTRANSFERASE
BETA-SUBUNIT OF
ACYL-COA CARBOXYLASE
(Mycobacterium
tuberculosis) 		6 / 12 LEU A  22
SER A  30
PHE A  26
ARG A  53
ALA A  46
ALA A  45
 None
 1.44A 2oc8A-4g2rA:
undetectable		 2oc8A-4g2rA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1001_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4g2r ACCD6,
CARBOXYLTRANSFERASE
BETA-SUBUNIT OF
ACYL-COA CARBOXYLASE
(Mycobacterium
tuberculosis) 		4 / 6 MET A 269
SER A 299
PRO A 288
GLY A 293
 None
 1.49A 2y7pA-4g2rA:
undetectable		 2y7pA-4g2rA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_3
(PHOSPHOLIPASE A2)		 4g2r ACCD6,
CARBOXYLTRANSFERASE
BETA-SUBUNIT OF
ACYL-COA CARBOXYLASE
(Mycobacterium
tuberculosis) 		4 / 5 VAL A 114
VAL A 111
THR A 146
THR A  74
 None
 1.25A 3bjwG-4g2rA:
undetectable		 3bjwG-4g2rA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_1
(PHOSPHOLIPASE A2)		 4g2r ACCD6,
CARBOXYLTRANSFERASE
BETA-SUBUNIT OF
ACYL-COA CARBOXYLASE
(Mycobacterium
tuberculosis) 		4 / 5 VAL A 114
VAL A 111
THR A 146
THR A  74
 None
 1.22A 3bjwC-4g2rA:
undetectable		 3bjwC-4g2rA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_1
(PCZA361.24)		 4g2r ACCD6,
CARBOXYLTRANSFERASE
BETA-SUBUNIT OF
ACYL-COA CARBOXYLASE
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 361
GLU A 426
ASP A 419
 None
 0.72A 3g2oA-4g2rA:
undetectable		 3g2oA-4g2rA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4g2r ACCD6,
CARBOXYLTRANSFERASE
BETA-SUBUNIT OF
ACYL-COA CARBOXYLASE
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 355
THR A 450
THR A 363
 None
 0.60A 3k2hB-4g2rA:
undetectable		 3k2hB-4g2rA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4g2r ACCD6,
CARBOXYLTRANSFERASE
BETA-SUBUNIT OF
ACYL-COA CARBOXYLASE
(Mycobacterium
tuberculosis) 		4 / 6 GLU A 103
THR A  74
ALA A 107
ALA A 110
 None
 0.91A 3ns1C-4g2rA:
undetectable		 3ns1C-4g2rA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4g2r ACCD6,
CARBOXYLTRANSFERASE
BETA-SUBUNIT OF
ACYL-COA CARBOXYLASE
(Mycobacterium
tuberculosis) 		4 / 8 GLU A 103
THR A  74
ALA A 107
ALA A 110
 None
 0.93A 3ns1L-4g2rA:
undetectable		 3ns1L-4g2rA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_D_ADND301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4g2r ACCD6,
CARBOXYLTRANSFERASE
BETA-SUBUNIT OF
ACYL-COA CARBOXYLASE
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 223
GLY A 226
LEU A 276
ASP A 253
ILE A 251
 None
 1.08A 3wdmD-4g2rA:
undetectable		 3wdmD-4g2rA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		 4g2r ACCD6,
CARBOXYLTRANSFERASE
BETA-SUBUNIT OF
ACYL-COA CARBOXYLASE
(Mycobacterium
tuberculosis) 		4 / 8 ILE A 128
PHE A 261
LEU A 208
LEU A 309
 None
 0.90A 4qopC-4g2rA:
undetectable		 4qopC-4g2rA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)		 4g2r ACCD6,
CARBOXYLTRANSFERASE
BETA-SUBUNIT OF
ACYL-COA CARBOXYLASE
(Mycobacterium
tuberculosis) 		5 / 11 LEU A  19
PHE A  25
GLY A  29
LEU A  33
ALA A  45
 None
 1.19A 4wnuA-4g2rA:
undetectable		 4wnuA-4g2rA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_C_ACTC201_0
(NITROGEN REGULATORY
PROTEIN P-II)		 4g2r ACCD6,
CARBOXYLTRANSFERASE
BETA-SUBUNIT OF
ACYL-COA CARBOXYLASE
(Mycobacterium
tuberculosis) 		4 / 5 VAL A 270
VAL A 283
GLY A 282
PHE A 258
 None
 1.08A 5d4nA-4g2rA:
undetectable
5d4nC-4g2rA:
undetectable		 5d4nA-4g2rA:
11.63
5d4nC-4g2rA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4g2r ACCD6,
CARBOXYLTRANSFERASE
BETA-SUBUNIT OF
ACYL-COA CARBOXYLASE
(Mycobacterium
tuberculosis) 		4 / 8 GLY A 210
CYH A 310
ASP A 259
PHE A 258
 None
 0.90A 5hieD-4g2rA:
undetectable		 5hieD-4g2rA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 4g2r ACCD6,
CARBOXYLTRANSFERASE
BETA-SUBUNIT OF
ACYL-COA CARBOXYLASE
(Mycobacterium
tuberculosis) 		5 / 11 ASP A 243
ALA A 285
LYS A 302
GLU A 260
VAL A 283
 None
 1.29A 5hw4B-4g2rA:
undetectable		 5hw4B-4g2rA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 4g2r ACCD6,
CARBOXYLTRANSFERASE
BETA-SUBUNIT OF
ACYL-COA CARBOXYLASE
(Mycobacterium
tuberculosis) 		4 / 5 HIS A 402
HIS A 425
VAL A 398
ALA A 397
 None
 1.35A 5i3bB-4g2rA:
undetectable		 5i3bB-4g2rA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_2
(PROTEASE E35D-SQV)		 4g2r ACCD6,
CARBOXYLTRANSFERASE
BETA-SUBUNIT OF
ACYL-COA CARBOXYLASE
(Mycobacterium
tuberculosis) 		5 / 9 ARG A  37
LEU A  33
ILE A  90
GLY A  92
ILE A  93
 None
 1.08A 5kqxB-4g2rA:
undetectable		 5kqxB-4g2rA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB603_0
(ACETYLCHOLINESTERASE)		 4g2r ACCD6,
CARBOXYLTRANSFERASE
BETA-SUBUNIT OF
ACYL-COA CARBOXYLASE
(Mycobacterium
tuberculosis) 		4 / 7 TYR A 141
GLN A 127
ASP A 147
HIS A 192
 H1L  A 501 (-3.6A)
None
None
None
 1.01A 5ov9B-4g2rA:
1.8		 5ov9B-4g2rA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 4g2r ACCD6,
CARBOXYLTRANSFERASE
BETA-SUBUNIT OF
ACYL-COA CARBOXYLASE
(Mycobacterium
tuberculosis) 		5 / 10 ARG A 156
VAL A 157
LEU A 178
GLY A 133
GLY A 138
 None
H1L  A 502 (-4.9A)
None
None
H1L  A 501 (-3.4A)
 1.23A 6eu9B-4g2rA:
undetectable		 6eu9B-4g2rA:
11.51