SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4g2t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 4g2t SSFS6
(Streptomyces
sp.
SF2575) 		5 / 12 PRO A 278
HIS A 292
GLY A 294
GLY A  12
VAL A 317
 TYD  A 401 (-4.2A)
TYD  A 401 (-3.9A)
TYD  A 401 (-3.5A)
TYD  A 401 ( 3.7A)
None
 1.22A 1ffyA-4g2tA:
2.0		 1ffyA-4g2tA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 4g2t SSFS6
(Streptomyces
sp.
SF2575) 		5 / 11 ALA A 126
VAL A 150
LEU A 153
ALA A 154
LEU A 160
 None
 0.91A 1jinA-4g2tA:
undetectable		 1jinA-4g2tA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4g2t SSFS6
(Streptomyces
sp.
SF2575) 		4 / 6 GLY A  40
VAL A  14
ALA A  35
SER A  36
 None
 1.01A 1p6kA-4g2tA:
undetectable		 1p6kA-4g2tA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 4g2t SSFS6
(Streptomyces
sp.
SF2575) 		5 / 12 ILE A 282
LEU A 279
GLY A 197
ALA A 255
VAL A 254
 None
TYD  A 401 (-3.8A)
None
TYD  A 401 (-3.3A)
None
 1.01A 2oc8A-4g2tA:
undetectable		 2oc8A-4g2tA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4g2t SSFS6
(Streptomyces
sp.
SF2575) 		5 / 11 GLY A 121
THR A 127
LEU A 128
LEU A   4
LEU A 101
 None
 1.14A 3ndvA-4g2tA:
undetectable
3ndvB-4g2tA:
undetectable		 3ndvA-4g2tA:
23.52
3ndvB-4g2tA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4g2t SSFS6
(Streptomyces
sp.
SF2575) 		5 / 11 LEU A 101
GLY A 121
THR A 127
LEU A 128
LEU A   4
 None
 1.14A 3ndvA-4g2tA:
undetectable
3ndvB-4g2tA:
undetectable		 3ndvA-4g2tA:
23.52
3ndvB-4g2tA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4g2t SSFS6
(Streptomyces
sp.
SF2575) 		5 / 11 GLY A 121
THR A 127
LEU A 128
LEU A   4
LEU A 101
 None
 1.15A 3ndvC-4g2tA:
undetectable
3ndvD-4g2tA:
undetectable		 3ndvC-4g2tA:
23.52
3ndvD-4g2tA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4g2t SSFS6
(Streptomyces
sp.
SF2575) 		5 / 11 LEU A 101
GLY A 121
THR A 127
LEU A 128
LEU A   4
 None
 1.15A 3ndvC-4g2tA:
undetectable
3ndvD-4g2tA:
undetectable		 3ndvC-4g2tA:
23.52
3ndvD-4g2tA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 4g2t SSFS6
(Streptomyces
sp.
SF2575) 		5 / 12 LEU A 169
ILE A 130
ALA A 125
ILE A   6
ALA A  34
 None
 1.12A 3nxuB-4g2tA:
undetectable		 3nxuB-4g2tA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 4g2t SSFS6
(Streptomyces
sp.
SF2575) 		4 / 7 ALA A  34
PRO A  52
LEU A  32
LEU A   4
 None
 1.02A 4iomA-4g2tA:
undetectable		 4iomA-4g2tA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4g2t SSFS6
(Streptomyces
sp.
SF2575) 		3 / 3 LEU A 153
ARG A  87
MET A  74
 None
 1.00A 4m11C-4g2tA:
undetectable		 4m11C-4g2tA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA207_0
(OXIDOREDUCTASE)		 4g2t SSFS6
(Streptomyces
sp.
SF2575) 		4 / 4 GLU A 115
GLY A  12
HIS A 295
ARG A 138
 None
TYD  A 401 ( 3.7A)
None
None
 1.08A 4r82A-4g2tA:
undetectable
4r82B-4g2tA:
undetectable		 4r82A-4g2tA:
19.65
4r82B-4g2tA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 4g2t SSFS6
(Streptomyces
sp.
SF2575) 		5 / 12 GLU A 115
GLY A  12
GLU A  11
LEU A  63
ALA A 315
 None
TYD  A 401 ( 3.7A)
None
None
None
 1.10A 4wcxC-4g2tA:
undetectable		 4wcxC-4g2tA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 4g2t SSFS6
(Streptomyces
sp.
SF2575) 		4 / 6 SER A  10
ARG A  91
GLY A  90
GLU A 152
 None
 1.04A 5btaA-4g2tA:
undetectable
5btaB-4g2tA:
1.9
5btaC-4g2tA:
undetectable		 5btaA-4g2tA:
21.48
5btaB-4g2tA:
22.56
5btaC-4g2tA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_B_SALB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4g2t SSFS6
(Streptomyces
sp.
SF2575) 		4 / 7 LEU A 119
GLY A 149
ALA A 148
SER A 147
 None
 0.87A 5f1aB-4g2tA:
undetectable		 5f1aB-4g2tA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 4g2t SSFS6
(Streptomyces
sp.
SF2575) 		5 / 12 SER A 118
GLY A 149
ALA A 148
SER A 141
PHE A  13
 None
 1.46A 5wbvB-4g2tA:
undetectable		 5wbvB-4g2tA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4g2t SSFS6
(Streptomyces
sp.
SF2575) 		4 / 6 MET A  59
GLU A 316
TYR A  89
GLY A  90
 None
 0.94A 5x7pB-4g2tA:
undetectable		 5x7pB-4g2tA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_B_ADNB503_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 4g2t SSFS6
(Streptomyces
sp.
SF2575) 		4 / 5 LEU A  92
VAL A  62
GLU A  61
LEU A  57
 None
 0.91A 5xooB-4g2tA:
undetectable		 5xooB-4g2tA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)		 4g2t SSFS6
(Streptomyces
sp.
SF2575) 		4 / 5 LEU A 237
LEU A 245
THR A 218
PRO A 307
 None
 1.06A 6ew0F-4g2tA:
undetectable		 6ew0F-4g2tA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)		 4g2t SSFS6
(Streptomyces
sp.
SF2575) 		4 / 6 LEU A 237
LEU A 245
THR A 218
PRO A 307
 None
 1.06A 6ew0G-4g2tA:
undetectable		 6ew0G-4g2tA:
11.55