SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4g34'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
5 / 12 ALA A 923
LEU A1009
ILE A1070
ILE A1071
LEU A 937
None
1.09A 1xdkB-4g34A:
undetectable
1xdkB-4g34A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOT_B_2PMB401_1
(HISTAMINE
N-METHYLTRANSFERASE)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
5 / 12 PHE A1020
TYR A1018
PHE A1038
TYR A 989
GLU A1015
None
1.40A 2aotB-4g34A:
0.0
2aotB-4g34A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
7 / 12 LEU A 598
GLY A 599
GLY A 601
VAL A 606
LYS A 938
ASN A 941
ASP A 954
924  A1101 ( 4.1A)
None
None
924  A1101 ( 4.8A)
None
None
924  A1101 (-3.7A)
1.06A 2fumD-4g34A:
23.4
2fumD-4g34A:
27.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
4 / 7 LEU A1016
LEU A1013
ILE A1006
ARG A1064
None
1.23A 2hc4A-4g34A:
undetectable
2hc4A-4g34A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
4 / 6 LEU A 598
LYS A 621
VAL A 651
ILE A 885
924  A1101 ( 4.1A)
None
924  A1101 (-4.6A)
924  A1101 ( 4.6A)
0.42A 2hyyA-4g34A:
20.6
2hyyA-4g34A:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
4 / 6 LEU A 598
LYS A 621
VAL A 651
ILE A 885
924  A1101 ( 4.1A)
None
924  A1101 (-4.6A)
924  A1101 ( 4.6A)
0.54A 2hyyB-4g34A:
20.6
2hyyB-4g34A:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
5 / 11 LEU A1013
ILE A1070
ALA A 921
GLU A 993
LEU A 937
None
1.29A 2v0mD-4g34A:
undetectable
2v0mD-4g34A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
6 / 10 LEU A 598
VAL A 606
LYS A 621
VAL A 651
ILE A 885
VAL A 952
924  A1101 ( 4.1A)
924  A1101 ( 4.8A)
None
924  A1101 (-4.6A)
924  A1101 ( 4.6A)
None
0.76A 3cs9A-4g34A:
21.0
3cs9A-4g34A:
27.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
6 / 9 LEU A 598
VAL A 606
LYS A 621
VAL A 651
ILE A 885
VAL A 952
924  A1101 ( 4.1A)
924  A1101 ( 4.8A)
None
924  A1101 (-4.6A)
924  A1101 ( 4.6A)
None
0.77A 3cs9B-4g34A:
21.4
3cs9B-4g34A:
27.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
6 / 9 LEU A 598
VAL A 606
LYS A 621
VAL A 651
ILE A 885
VAL A 952
924  A1101 ( 4.1A)
924  A1101 ( 4.8A)
None
924  A1101 (-4.6A)
924  A1101 ( 4.6A)
None
0.75A 3cs9C-4g34A:
20.9
3cs9C-4g34A:
27.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
4 / 6 LEU A 598
LYS A 621
VAL A 651
ILE A 885
924  A1101 ( 4.1A)
None
924  A1101 (-4.6A)
924  A1101 ( 4.6A)
0.50A 3k5vA-4g34A:
16.5
3k5vA-4g34A:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
4 / 6 LEU A 598
LYS A 621
VAL A 651
ILE A 885
924  A1101 ( 4.1A)
None
924  A1101 (-4.6A)
924  A1101 ( 4.6A)
0.48A 3k5vB-4g34A:
18.8
3k5vB-4g34A:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
7 / 12 LEU A 598
GLY A 599
VAL A 606
ALA A 619
LYS A 621
VAL A 651
ASP A 954
924  A1101 ( 4.1A)
None
924  A1101 ( 4.8A)
924  A1101 (-3.5A)
None
924  A1101 (-4.6A)
924  A1101 (-3.7A)
0.67A 3lxkA-4g34A:
22.3
3lxkA-4g34A:
25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
5 / 11 LEU A 927
PHE A 926
SER A 929
ILE A 650
ALA A 641
None
1.14A 3mdtB-4g34A:
undetectable
3mdtB-4g34A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_2
(TYROSINE-PROTEIN
KINASE ABL1)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
4 / 6 VAL A 606
LYS A 621
VAL A 651
ILE A 885
924  A1101 ( 4.8A)
None
924  A1101 (-4.6A)
924  A1101 ( 4.6A)
0.39A 3mssD-4g34A:
20.3
3mssD-4g34A:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
6 / 12 VAL A 606
ALA A 619
CYH A 890
PHE A 943
PHE A 955
GLY A 956
924  A1101 ( 4.8A)
924  A1101 (-3.5A)
924  A1101 (-3.9A)
924  A1101 ( 4.2A)
924  A1101 ( 4.4A)
None
0.84A 3og7A-4g34A:
23.6
3og7A-4g34A:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
6 / 12 VAL A 606
ALA A 619
LYS A 621
CYH A 890
PHE A 955
GLY A 956
924  A1101 ( 4.8A)
924  A1101 (-3.5A)
None
924  A1101 (-3.9A)
924  A1101 ( 4.4A)
None
0.79A 3og7A-4g34A:
23.6
3og7A-4g34A:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
6 / 12 VAL A 606
LYS A 621
LEU A 642
CYH A 890
PHE A 955
GLY A 956
924  A1101 ( 4.8A)
None
924  A1101 (-3.9A)
924  A1101 (-3.9A)
924  A1101 ( 4.4A)
None
0.75A 3og7A-4g34A:
23.6
3og7A-4g34A:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
4 / 8 MET A 887
LEU A 883
ALA A 656
LEU A 658
924  A1101 (-3.7A)
None
None
None
0.82A 4ik6B-4g34A:
undetectable
4ik6B-4g34A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
4 / 6 LEU A 598
GLY A 599
VAL A 606
ALA A 619
924  A1101 ( 4.1A)
None
924  A1101 ( 4.8A)
924  A1101 (-3.5A)
0.26A 4o0wA-4g34A:
24.3
4o0wA-4g34A:
26.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_D_HQED503_1
(CATALASE)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
5 / 9 ILE A 620
PRO A 594
GLN A 886
TYR A 618
ASP A 614
None
1.47A 4qopD-4g34A:
0.0
4qopD-4g34A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
6 / 12 VAL A 606
ALA A 619
CYH A 890
PHE A 943
GLY A 953
PHE A 955
924  A1101 ( 4.8A)
924  A1101 (-3.5A)
924  A1101 (-3.9A)
924  A1101 ( 4.2A)
924  A1101 (-4.6A)
924  A1101 ( 4.4A)
0.99A 4rzvB-4g34A:
23.3
4rzvB-4g34A:
28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
6 / 12 VAL A 606
ALA A 619
CYH A 890
PHE A 943
PHE A 955
GLY A 956
924  A1101 ( 4.8A)
924  A1101 (-3.5A)
924  A1101 (-3.9A)
924  A1101 ( 4.2A)
924  A1101 ( 4.4A)
None
0.80A 4rzvB-4g34A:
23.3
4rzvB-4g34A:
28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
6 / 12 VAL A 606
ALA A 619
LYS A 621
CYH A 890
PHE A 955
GLY A 956
924  A1101 ( 4.8A)
924  A1101 (-3.5A)
None
924  A1101 (-3.9A)
924  A1101 ( 4.4A)
None
0.73A 4rzvB-4g34A:
23.3
4rzvB-4g34A:
28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
4 / 6 LEU A 598
VAL A 606
LYS A 621
ILE A 650
924  A1101 ( 4.1A)
924  A1101 ( 4.8A)
None
None
0.49A 4tyjA-4g34A:
21.6
4tyjA-4g34A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
6 / 12 VAL A 606
ALA A 619
CYH A 890
PHE A 943
GLY A 953
PHE A 955
924  A1101 ( 4.8A)
924  A1101 (-3.5A)
924  A1101 (-3.9A)
924  A1101 ( 4.2A)
924  A1101 (-4.6A)
924  A1101 ( 4.4A)
0.78A 4xv2A-4g34A:
23.6
4xv2A-4g34A:
27.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
6 / 12 VAL A 606
ALA A 619
LYS A 621
CYH A 890
GLY A 953
PHE A 955
924  A1101 ( 4.8A)
924  A1101 (-3.5A)
None
924  A1101 (-3.9A)
924  A1101 (-4.6A)
924  A1101 ( 4.4A)
0.92A 4xv2A-4g34A:
23.6
4xv2A-4g34A:
27.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
6 / 12 VAL A 606
CYH A 890
PHE A 943
GLY A 953
ASP A 954
PHE A 955
924  A1101 ( 4.8A)
924  A1101 (-3.9A)
924  A1101 ( 4.2A)
924  A1101 (-4.6A)
924  A1101 (-3.7A)
924  A1101 ( 4.4A)
1.43A 4xv2A-4g34A:
23.6
4xv2A-4g34A:
27.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
5 / 12 LYS A 930
GLY A 931
HIS A 934
HIS A 647
ILE A 650
None
1.49A 4ynmA-4g34A:
undetectable
4ynmA-4g34A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_C_SAMC2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
5 / 12 LYS A 930
GLY A 931
HIS A 934
HIS A 647
ILE A 650
None
1.45A 4ypaC-4g34A:
undetectable
4ypaC-4g34A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
6 / 12 VAL A 606
ALA A 619
CYH A 890
PHE A 943
GLY A 953
PHE A 955
924  A1101 ( 4.8A)
924  A1101 (-3.5A)
924  A1101 (-3.9A)
924  A1101 ( 4.2A)
924  A1101 (-4.6A)
924  A1101 ( 4.4A)
0.77A 5cswA-4g34A:
23.3
5cswA-4g34A:
28.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
5 / 12 VAL A 606
ALA A 619
LYS A 621
CYH A 890
PHE A 955
924  A1101 ( 4.8A)
924  A1101 (-3.5A)
None
924  A1101 (-3.9A)
924  A1101 ( 4.4A)
0.73A 5cswA-4g34A:
23.3
5cswA-4g34A:
28.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
6 / 12 VAL A 606
ALA A 619
CYH A 890
PHE A 943
GLY A 953
PHE A 955
924  A1101 ( 4.8A)
924  A1101 (-3.5A)
924  A1101 (-3.9A)
924  A1101 ( 4.2A)
924  A1101 (-4.6A)
924  A1101 ( 4.4A)
0.74A 5cswB-4g34A:
23.3
5cswB-4g34A:
28.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
6 / 12 VAL A 606
ALA A 619
LYS A 621
CYH A 890
GLY A 953
PHE A 955
924  A1101 ( 4.8A)
924  A1101 (-3.5A)
None
924  A1101 (-3.9A)
924  A1101 (-4.6A)
924  A1101 ( 4.4A)
0.92A 5cswB-4g34A:
23.3
5cswB-4g34A:
28.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
5 / 12 VAL A 606
LEU A 642
CYH A 890
PHE A 943
PHE A 955
924  A1101 ( 4.8A)
924  A1101 (-3.9A)
924  A1101 (-3.9A)
924  A1101 ( 4.2A)
924  A1101 ( 4.4A)
0.88A 5cswB-4g34A:
23.3
5cswB-4g34A:
28.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_1
(ESTROGEN RECEPTOR)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
5 / 12 LEU A1016
LEU A1017
MET A1052
GLY A1010
LEU A1009
None
0.95A 5gtrA-4g34A:
undetectable
5gtrA-4g34A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
6 / 12 VAL A 606
ALA A 619
LYS A 621
ILE A 885
PHE A 955
GLY A 956
924  A1101 ( 4.8A)
924  A1101 (-3.5A)
None
924  A1101 ( 4.6A)
924  A1101 ( 4.4A)
None
0.81A 5hesB-4g34A:
22.6
5hesB-4g34A:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
5 / 12 VAL A 606
ALA A 619
ILE A 885
PHE A 943
GLY A 953
924  A1101 ( 4.8A)
924  A1101 (-3.5A)
924  A1101 ( 4.6A)
924  A1101 ( 4.2A)
924  A1101 (-4.6A)
0.49A 5hieA-4g34A:
3.8
5hieA-4g34A:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
5 / 12 VAL A 606
ALA A 619
LYS A 621
ILE A 885
GLY A 953
924  A1101 ( 4.8A)
924  A1101 (-3.5A)
None
924  A1101 ( 4.6A)
924  A1101 (-4.6A)
0.75A 5hieA-4g34A:
3.8
5hieA-4g34A:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
5 / 12 VAL A 606
ALA A 619
ILE A 885
PHE A 943
GLY A 953
924  A1101 ( 4.8A)
924  A1101 (-3.5A)
924  A1101 ( 4.6A)
924  A1101 ( 4.2A)
924  A1101 (-4.6A)
0.49A 5hieB-4g34A:
22.1
5hieB-4g34A:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
5 / 12 VAL A 606
ALA A 619
LYS A 621
ILE A 885
GLY A 953
924  A1101 ( 4.8A)
924  A1101 (-3.5A)
None
924  A1101 ( 4.6A)
924  A1101 (-4.6A)
0.74A 5hieB-4g34A:
22.1
5hieB-4g34A:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
5 / 12 VAL A 606
ALA A 619
ILE A 885
PHE A 943
GLY A 953
924  A1101 ( 4.8A)
924  A1101 (-3.5A)
924  A1101 ( 4.6A)
924  A1101 ( 4.2A)
924  A1101 (-4.6A)
0.49A 5hieD-4g34A:
22.4
5hieD-4g34A:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
5 / 12 VAL A 606
ALA A 619
LYS A 621
ILE A 885
GLY A 953
924  A1101 ( 4.8A)
924  A1101 (-3.5A)
None
924  A1101 ( 4.6A)
924  A1101 (-4.6A)
0.75A 5hieD-4g34A:
22.4
5hieD-4g34A:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I6X_A_8PRA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
5 / 10 ASP A1005
ILE A1070
PHE A 917
SER A1008
GLY A1010
None
1.22A 5i6xA-4g34A:
undetectable
5i6xA-4g34A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
4 / 7 GLY A 599
GLY A 601
GLY A 604
VAL A 606
None
None
None
924  A1101 ( 4.8A)
0.34A 5izjB-4g34A:
21.7
5izjB-4g34A:
24.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
6 / 12 LEU A 598
VAL A 606
ALA A 619
LYS A 621
CYH A 890
PHE A 943
924  A1101 ( 4.1A)
924  A1101 ( 4.8A)
924  A1101 (-3.5A)
None
924  A1101 (-3.9A)
924  A1101 ( 4.2A)
0.36A 5vcyA-4g34A:
23.4
5vcyA-4g34A:
30.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
5 / 9 LEU A 598
ALA A 619
VAL A 651
MET A 887
CYH A 890
924  A1101 ( 4.1A)
924  A1101 (-3.5A)
924  A1101 (-4.6A)
924  A1101 (-3.7A)
924  A1101 (-3.9A)
0.61A 5w5vA-4g34A:
15.1
5w5vA-4g34A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA811_0
(GEPHYRIN)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
3 / 3 LEU A1017
LEU A 914
ARG A 910
None
0.63A 6fgcA-4g34A:
undetectable
6fgcA-4g34A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA810_0
(GEPHYRIN)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
3 / 3 LEU A1017
LEU A 914
ARG A 910
None
0.63A 6fgdA-4g34A:
undetectable
6fgdA-4g34A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_A_TRPA502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
4 / 7 ARG A1026
TYR A 989
LEU A1057
VAL A1033
None
1.35A 6g2pA-4g34A:
undetectable
6g2pA-4g34A:
23.89