SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4g38'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_1
(ASPARTYLPROTEASE)		 4g38 SULFITE REDUCTASE
[NADPH] HEMOPROTEIN
BETA-COMPONENT
(Escherichia
coli) 		6 / 11 ASP A 227
ALA A 394
GLY A  89
THR A 219
VAL A 221
ILE A 228
 None
 1.36A 1ohrA-4g38A:
undetectable		 1ohrA-4g38A:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 4g38 SULFITE REDUCTASE
[NADPH] HEMOPROTEIN
BETA-COMPONENT
(Escherichia
coli) 		5 / 12 ASP A 550
GLY A 506
ARG A 513
ILE A 514
ALA A 232
 None
None
None
None
SRM  A 604 ( 4.2A)
 1.04A 1oltA-4g38A:
undetectable		 1oltA-4g38A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		 4g38 SULFITE REDUCTASE
[NADPH] HEMOPROTEIN
BETA-COMPONENT
(Escherichia
coli) 		5 / 11 THR A  92
LEU A 137
VAL A 140
GLY A 141
ILE A  91
 None
 1.19A 1phgA-4g38A:
undetectable		 1phgA-4g38A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4g38 SULFITE REDUCTASE
[NADPH] HEMOPROTEIN
BETA-COMPONENT
(Escherichia
coli) 		4 / 7 ILE A 458
PHE A 450
LEU A 451
ILE A 527
 None
 0.91A 1yc2E-4g38A:
undetectable		 1yc2E-4g38A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 4g38 SULFITE REDUCTASE
[NADPH] HEMOPROTEIN
BETA-COMPONENT
(Escherichia
coli) 		5 / 12 VAL A 289
PHE A 274
THR A 219
LEU A 230
LEU A 311
 None
 1.26A 2jn3A-4g38A:
undetectable		 2jn3A-4g38A:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_0
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4g38 SULFITE REDUCTASE
[NADPH] HEMOPROTEIN
BETA-COMPONENT
(Escherichia
coli) 		5 / 12 SER A 530
MET A 474
PHE A 548
ILE A 472
PHE A 454
 None
 1.34A 3aocC-4g38A:
undetectable		 3aocC-4g38A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4g38 SULFITE REDUCTASE
[NADPH] HEMOPROTEIN
BETA-COMPONENT
(Escherichia
coli) 		4 / 6 ILE A 329
THR A 292
PHE A 319
PHE A 274
 None
 1.27A 3elzB-4g38A:
undetectable		 3elzB-4g38A:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_2
(HIV-1 PROTEASE)		 4g38 SULFITE REDUCTASE
[NADPH] HEMOPROTEIN
BETA-COMPONENT
(Escherichia
coli) 		6 / 11 ASP A 227
ALA A 394
ASN A 116
GLY A  89
VAL A 221
ILE A 228
 None
None
SRM  A 604 (-3.5A)
None
None
None
 1.39A 3lzvB-4g38A:
undetectable		 3lzvB-4g38A:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 4g38 SULFITE REDUCTASE
[NADPH] HEMOPROTEIN
BETA-COMPONENT
(Escherichia
coli) 		5 / 12 GLY A 484
GLY A 482
ASN A 481
ALA A 394
THR A 393
 None
SF4  A 603 ( 4.3A)
SRM  A 604 ( 3.4A)
None
None
 1.04A 4uckB-4g38A:
undetectable		 4uckB-4g38A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_2
(TUBULIN BETA CHAIN)		 4g38 SULFITE REDUCTASE
[NADPH] HEMOPROTEIN
BETA-COMPONENT
(Escherichia
coli) 		5 / 12 ASN A 160
THR A 393
VAL A 220
ALA A 170
ILE A 228
 None
 1.04A 4x1kD-4g38A:
undetectable		 4x1kD-4g38A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_D_LOCD502_2
(TUBULIN BETA CHAIN)		 4g38 SULFITE REDUCTASE
[NADPH] HEMOPROTEIN
BETA-COMPONENT
(Escherichia
coli) 		5 / 12 ASN A 160
THR A 393
VAL A 220
ALA A 170
ILE A 228
 None
 1.06A 4x1yD-4g38A:
undetectable		 4x1yD-4g38A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4g38 SULFITE REDUCTASE
[NADPH] HEMOPROTEIN
BETA-COMPONENT
(Escherichia
coli) 		4 / 4 GLY A 351
VAL A 349
PHE A 390
ILE A 400
 None
 1.14A 4xv2B-4g38A:
undetectable		 4xv2B-4g38A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4g38 SULFITE REDUCTASE
[NADPH] HEMOPROTEIN
BETA-COMPONENT
(Escherichia
coli) 		4 / 7 CYH A  84
LEU A  86
GLY A  88
GLY A  89
 None
 0.80A 5a06B-4g38A:
undetectable		 5a06B-4g38A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_A_ACTA202_0
(NITROGEN REGULATORY
PROTEIN P-II)		 4g38 SULFITE REDUCTASE
[NADPH] HEMOPROTEIN
BETA-COMPONENT
(Escherichia
coli) 		4 / 4 VAL A 253
GLY A 254
ARG A 269
VAL A 316
 None
 1.42A 5d4nA-4g38A:
undetectable
5d4nB-4g38A:
3.0		 5d4nA-4g38A:
12.34
5d4nB-4g38A:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MM4_B_TA1B501_1
(TUBULIN BETA CHAIN)		 4g38 SULFITE REDUCTASE
[NADPH] HEMOPROTEIN
BETA-COMPONENT
(Escherichia
coli) 		5 / 10 LEU A 398
ALA A 103
PHE A 122
THR A 119
LEU A 137
 None
None
None
SRM  A 604 (-4.2A)
None
 1.08A 5mm4B-4g38A:
undetectable		 5mm4B-4g38A:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4g38 SULFITE REDUCTASE
[NADPH] HEMOPROTEIN
BETA-COMPONENT
(Escherichia
coli) 		5 / 11 GLY A  89
ILE A 392
PHE A 122
ILE A 112
ILE A  99
 None
 0.99A 6ebzA-4g38A:
undetectable		 6ebzA-4g38A:
8.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4g38 SULFITE REDUCTASE
[NADPH] HEMOPROTEIN
BETA-COMPONENT
(Escherichia
coli) 		5 / 11 GLY A  89
ILE A 392
PHE A 122
ILE A 112
ILE A  99
 None
 1.00A 6ebzB-4g38A:
undetectable		 6ebzB-4g38A:
8.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4g38 SULFITE REDUCTASE
[NADPH] HEMOPROTEIN
BETA-COMPONENT
(Escherichia
coli) 		5 / 11 GLY A  89
ILE A 392
PHE A 122
ILE A 112
ILE A  99
 None
 1.01A 6ebzC-4g38A:
undetectable		 6ebzC-4g38A:
8.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4g38 SULFITE REDUCTASE
[NADPH] HEMOPROTEIN
BETA-COMPONENT
(Escherichia
coli) 		5 / 11 GLY A  89
ILE A 392
PHE A 122
ILE A 112
ILE A  99
 None
 1.01A 6ebzD-4g38A:
undetectable		 6ebzD-4g38A:
8.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)		 4g38 SULFITE REDUCTASE
[NADPH] HEMOPROTEIN
BETA-COMPONENT
(Escherichia
coli) 		5 / 10 GLY A 549
GLY A 547
VAL A 491
THR A 552
ILE A 558
 None
 1.04A 6exiB-4g38A:
undetectable		 6exiB-4g38A:
10.57